C M Wells

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions
    Sally Fram
    Division of Cancer Studies, King s College London, New Hunts House, Guys Campus, London, SE1 1UL, UK
    Cell Mol Life Sci 71:2759-73. 2014
  2. pmc Nox2 is required for macrophage chemotaxis towards CSF-1
    Sanjay Chaubey
    Cardiovascular Division, The James Black Centre, King s College London BHF Centre of Excellence, London, United Kingdom
    PLoS ONE 8:e54869. 2013
  3. pmc Hypoxia-induced invadopodia formation: a role for β-PIX
    Nur Fariesha Md Hashim
    Division of Cancer Studies, King s College London, London SE1 1UL, UK
    Open Biol 3:120159. 2013
  4. ncbi request reprint Rho family GTPases are activated during HGF-stimulated prostate cancer-cell scattering
    C M Wells
    Randall Division of Cell and Molecular Biophysics, Guy s Campus, King s College London, London, United Kingdom
    Cell Motil Cytoskeleton 62:180-94. 2005
  5. doi request reprint The emerging importance of group II PAKs
    Claire M Wells
    Division of Cancer Studies, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    Biochem J 425:465-73. 2010
  6. pmc PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion
    Claire M Wells
    Division of Cancer Studies, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    J Cell Sci 123:1663-73. 2010
  7. pmc PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity
    A D Whale
    Randall Division of Cell and Molecular Biophysics, King s College London, London, UK
    Oncogene 32:2114-20. 2013
  8. doi request reprint Imaging haematopoietic cells recruitment to an acute wound in vivo identifies a role for c-Met signalling
    K Falenta
    Division of Cardiovascular Medicine, King s College London, London, UK
    J Microsc 250:200-9. 2013

Collaborators

  • G E Jones
  • Serafim Kiriakidis
  • Sally Fram
  • K Falenta
  • Nur Fariesha Md Hashim
  • Sanjay Chaubey
  • A D Whale
  • David B Sacks
  • Helen King
  • Ewa Paleolog
  • Ajay M Shah
  • Alison C Cave
  • Anna E Dart
  • A Dart
  • Nicole S Nicholas
  • A Rodaway
  • M Holt

Detail Information

Publications8

  1. pmc A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions
    Sally Fram
    Division of Cancer Studies, King s College London, New Hunts House, Guys Campus, London, SE1 1UL, UK
    Cell Mol Life Sci 71:2759-73. 2014
    ....
  2. pmc Nox2 is required for macrophage chemotaxis towards CSF-1
    Sanjay Chaubey
    Cardiovascular Division, The James Black Centre, King s College London BHF Centre of Excellence, London, United Kingdom
    PLoS ONE 8:e54869. 2013
    ..Thus Nox2 is important in BMM cellular motion to CSF-1 stimulation and necessary for their directed migration towards a CSF-1 gradient, highlighting Nox2 dependent signalling as a potential anti-inflammatory target...
  3. pmc Hypoxia-induced invadopodia formation: a role for β-PIX
    Nur Fariesha Md Hashim
    Division of Cancer Studies, King s College London, London SE1 1UL, UK
    Open Biol 3:120159. 2013
    ..Indeed, we find that β-PIX expression is essential for invadopodia formation. In conclusion, we identify a new HIF-1α mechanistic pathway and suggest that β-PIX is a novel downstream signalling mediator during invadopodia formation...
  4. ncbi request reprint Rho family GTPases are activated during HGF-stimulated prostate cancer-cell scattering
    C M Wells
    Randall Division of Cell and Molecular Biophysics, Guy s Campus, King s College London, London, United Kingdom
    Cell Motil Cytoskeleton 62:180-94. 2005
    ..Furthermore we have also shown that the response of DU145 cells to HGF is dependent on a phosphatidylinositide 3-kinase pathway...
  5. doi request reprint The emerging importance of group II PAKs
    Claire M Wells
    Division of Cancer Studies, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    Biochem J 425:465-73. 2010
    ..This review will focus on the latest structural and functional results relating to the group II PAKs and discuss the emerging importance of group II PAKs in disease progression...
  6. pmc PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion
    Claire M Wells
    Division of Cancer Studies, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    J Cell Sci 123:1663-73. 2010
    ..Furthermore, we demonstrate that PAK4 can regulate RhoA activity via GEF-H1. Our results suggest that PAK4 is a pluripotent kinase that can regulate both actin cytoskeletal rearrangement and focal-adhesion dynamics...
  7. pmc PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity
    A D Whale
    Randall Division of Cell and Molecular Biophysics, King s College London, London, UK
    Oncogene 32:2114-20. 2013
    ..The existence of such a mutation may have implications for the development of PAK4-specific competitive ATP inhibitors should PAK4 be further explored for clinical inhibition...
  8. doi request reprint Imaging haematopoietic cells recruitment to an acute wound in vivo identifies a role for c-Met signalling
    K Falenta
    Division of Cardiovascular Medicine, King s College London, London, UK
    J Microsc 250:200-9. 2013
    ..This work demonstrates the versatility of using direct imaging assays for inhibitor studies and suggests that the HGF/c-Met signalling cascade plays an important role in the migration of haematopoietic cells in vivo...