Affiliation: King's College London
- Effects of the dual peroxisome proliferator-activated receptor-α/γ agonist aleglitazar on renal function in patients with stage 3 chronic kidney disease and type 2 diabetes: a Phase IIb, randomized studyLuis Ruilope
Hospital 12 de Octubre, Clinical Science, Madrid, Spain
BMC Nephrol 15:180. 2014..This Phase IIb safety study (AleNephro) in patients with stage 3 chronic kidney disease and type 2 diabetes, evaluated the renal effects of aleglitazar, a balanced peroxisome proliferator-activated receptor-α/γ agonist...
- Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effectGiancarlo Viberti
Department of Diabetes, Endocrinology, and Internal Medicine, GKT School of Medicine, Guy s Hospital, King s College London, London, UK
Circulation 106:672-8. 2002..The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria...
- Regression of albuminuria: latest evidence for a new approachGiancarlo Viberti
Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas School of Medicine, 5th Floor, Thomas Guy House, King s College London Guy s Hospital, London SE1 9RT, UK
J Hypertens Suppl 21:S24-8. 2003....
- [The kidney as a target organ in diabetic patients with arterial hypertension]Giancarlo Viberti
Département de Diabétologie, d Endocrinologie et de Médecine Interne, Ecole de Médecine GKT, Guy s Hospital, King s College, Londres, GB
Drugs 63:31-7. 2003..In both type 1 and type 2 diabetes mellitus, the level of arterial hypertension closely correlates with the subsequent decline in glomerular filtration rate and with accelerated renal damage...
- Thiazolidinediones-benefits on microvascular complications of type 2 diabetesGiancarlo Viberti
Department of Endocrinology, Diabetes and Internal Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
J Diabetes Complications 19:168-77. 2005..Reducing insulin resistance, therefore, has the potential to reduce both microvascular and macrovascular complications...
- A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and EuropeG Viberti
Unit for Metabolic Medicine, KCL Guy s Hospital, London, UK
Diabet Med 23:1289-94. 2006..To examine baseline characteristics of patients recruited into ADOPT, a multinational trial comparing three oral glucose-lowering monotherapies...
- A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetesGiancarlo Viberti
Guy s, King s, and St Thomas School of Medicine, King s College, London, U K
Diabetes Care 25:1737-43. 2002....
- Microalbuminuria and coronary heart disease in NIDDM: an incidence studyM B Mattock
Department of Diabetes, United Medical and Dental Schools of Guy s and St Thomas Hospital, London, UK
Diabetes 47:1786-92. 1998..Preexisting CHD is also a risk factor for incident microalbuminuria in men, however, suggesting that microalbuminuria and CHD are not causally related but rather reflect common determinants...
- Targeting albumin excretion rate in the treatment of the hypertensive diabetic patient with renal diseaseMichael J Krimholtz
Unit for Metabolic Medicine, Department of Diabetes Endocrinology and Internal Medicine, GKT School of Medicine, Kings College London, Guys Hospital, London, United Kingdom
J Am Soc Nephrol 16:S42-7. 2005..The fall in ACR was disproportionate to the fall of systemic BP and independent of it. The mechanism of the reduction in albuminuria seen with these agents in combination with an ACEI remains to be elucidated...
- [The need for strict control of cardiovascular risk factors in type 2 diabetic patients]G Viberti
Service de Diabetologie, Endocrinologie et Médecine interne, Ecole de Médecine Guy s, King s et Saint Thomas, Londres, GB
Presse Med 31:S5-8. 2002..Regular screening for microalbuminuria and renal dysfunction (creatinine clearance) is also recommended, as well as more rigorous objectives for lipid levels...
- Angiotensin converting enzyme inhibitors in diabetic patients with microalbuminuria or normoalbuminuriaG Viberti
Unit for Metabolic Medicine, UMDS, Guy s Hospital, London, England, United Kingdom
Kidney Int Suppl 63:S32-5. 1997....
- Effect of various diuretic treatments on rosiglitazone-induced fluid retentionJanaka Karalliedde
Unit for Metabolic Medicine, Department of Diabetes and Endocrinology, Cardiovascular Division, King s College London School of Medicine, Guy s Hospital, King s College London, London, London SE1 9RT, UK
J Am Soc Nephrol 17:3482-90. 2006....
- Mechanical forces in diabetic kidney disease: a trigger for impaired glucose metabolismLuigi Gnudi
Cardiovascular Division, King s College London, Guy s Hospital, London SE1 9RT, UK
J Am Soc Nephrol 18:2226-32. 2007..This mechanical and metabolic coupling suggests a novel pathophysiologic mechanism of injury in the kidney in diabetes and possibly other glomerular diseases...
- Valsartan improves arterial stiffness in type 2 diabetes independently of blood pressure loweringJanaka Karalliedde
Cardiovascular Division, King s College London School of Medicine, United Kingdom
Hypertension 51:1617-23. 2008..These 2 effects, which appear independent of each other, may explain the specific cardio-renal protective properties of ARBs...
- Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazoneGabriella Gruden
Department of Diabetes and Endocrinology, Cardiovascular Division, King s College, London, UK
J Am Soc Nephrol 16:688-96. 2005..In conclusion, stretching of mesangial cells stimulates their monocyte chemoattractant activity via an NF-kappaB-mediated, MCP-1-dependent pathway, and this effect is prevented by rosiglitazone...
- GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury?Luigi Gnudi
Department of Diabetes, Endocrinology, and Internal Medicine, King s College, 5th Floor, Thomas Guy House, Guy s Hospital, London SE1 9RT, UK
Hypertension 42:19-24. 2003..These studies suggest a novel link between hemodynamic and metabolic factors that may cooperate in inducing progressive glomerular injury in conditions characterized by glomerular hypertension...
- Proteinuria in diabetes: bystander or pathway to cardiorenal disease?Janaka Karalliedde
Cardiovascular Division, King s College London School of Medicine, London, United Kingdom
J Am Soc Nephrol 21:2020-7. 2010..Albuminuria of any degree is unlikely to be causally related to diabetic cardiovascular disease, but its onset might be useful to identify those subjects at cardiovascular risk and to detect and treat other modifiable risk factors...
- Aortic pulse wave velocity and albuminuria in patients with type 2 diabetesAndrew Smith
Unit for Metabolic Medicine, 5th Floor, Department of Diabetes and Endocrinology, Cardiovascular Division, GKT School of Medicine, King s College London, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
J Am Soc Nephrol 16:1069-75. 2005..The association of Ao-PWV with reduced GFR suggests that even modest renal dysfunction may affect the viscoelastic properties of large arteries...
- Evidence for renoprotection by blockade of the renin-angiotensin-aldosterone system in hypertension and diabetesJ Karalliedde
Unit for Metabolic Medicine, Department of Diabetes, Endocrinology and Internal Medicine, Cardiovascular Division, King s College London School of Medicine, King s College London, London, UK
J Hum Hypertens 20:239-53. 2006..In this way, agents that block the RAAS should be considered the drugs of first choice as they provide enhanced renoprotection compared with other classes of antihypertensive agents such as calcium channel blockers and beta-blockers...
- The need for tighter control of cardiovascular risk factors in diabetic patientsGiancarlo Viberti
Unit for Metabolic Medicine, Guy s Hospital, Kings College London, London, UK
J Hypertens Suppl 21:S3-6. 2003..There is a clear need to translate the results of clinical trials into everyday clinical practice...
- Sex differences in age-related stiffening of the aorta in subjects with type 2 diabetesLorenita De Angelis
Department of Diabetes and Endocrinology, Guy s and St Thomas Hospital, Center for Cardiovascular Biology and Medicine, King s College, London, UK
Hypertension 44:67-71. 2004..The interaction of diabetic status with age and with sex was significant (P=0.01). Type 2 diabetes is associated with a greater age-related stiffening of the aorta in women compared with men, and this is not explained by hypertension...
- Vascular endothelial growth factor receptors in human mesangium in vitro and in glomerular diseaseS Thomas
Department of Endocrinology, King s College London Guy s Hospital, London, United Kingdom
J Am Soc Nephrol 11:1236-43. 2000..In conclusion, flt-1, KDR, and neuropilin-1 are present on cultured HMC, and VEGF(165) induces HMC proliferation. In addition, the flt-1 and KDR receptors are expressed in the mesangium in mesangioproliferative disease...
- Direct regulation of insulin secretion by angiotensin II in human islets of LangerhansR D Ramracheya
Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology and Development, King s College London, Room 2 9N Hodgkin Building Guy s Campus, London SE1 1UL, UK
Diabetologia 49:321-31. 2006..This study aimed to identify the expression of angiotensin II receptors in isolated human islets and beta cells and to examine the functional consequences of their activation...
- Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic miceChing Hsin Ku
Cardiovascular Division, King s College London School of Medicine, Guy s Hospital, King s College London, London, UK
Diabetes 57:2824-33. 2008....
- IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanismGabriella Gruden
Department of Diabetes and Endocrinology, GKT School of Medicine, King s College London, London, England, United Kingdom
Kidney Int 63:1249-55. 2003..Furthermore, we studied the intracellular signaling pathway involved and the interaction of IGF-I with mechanical stretch, a known VEGF inducer...
- Circulating vascular progenitor cells in patients with type 1 diabetes and microalbuminuriaCecile Dessapt
Cardiovascular Division, King s College, London, UK
Diabetes Care 33:875-7. 2010..Patients with type 1 diabetes and microalbuminuria are at increased risk of cardiovascular disease (CVD). Abnormalities in vascular progenitor cells, which participate in vascular repair, may be implicated in this susceptibility...
- Hypertension and microalbuminuria: risk factors for cardiovascular disease in diabetesJanaka Karalliedde
Department of Diabetes, Endocrinology and Internal Medicine, GKT School of Medicine, King s College London, 5th Floor Thomas Guy House, KCL Guy s Hospital Campus, London SE1 9RT, UK
Curr Hypertens Rep 7:1-2. 2005
- Mechanical forces and TGFbeta1 reduce podocyte adhesion through alpha3beta1 integrin downregulationCecile Dessapt
King s College London, UK
Nephrol Dial Transplant 24:2645-55. 2009..This study investigated the role of mechanical forces and transforming growth factor beta1 (TGFbeta1) in podocyte adhesion and integrin expression...
- Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endotheliaBelinda Davis
Cardiovascular Division, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
J Am Soc Nephrol 18:2320-9. 2007....
- Microalbuminuria and cardiovascular riskJanaka Karalliedde
Department of Diabetes, Endocrinology and Internal Medicine, Guy s, King s and St Thomas GKT School of Medicine, King s College London, London, United Kingdom
Am J Hypertens 17:986-93. 2004..These drugs have successfully halted or delayed the progression to nephropathy and have reversed elevated rates of albumin excretion to normal values, even when blood pressure reduction has been minimal...
- Impaired glucose tolerance in obese children and adolescentsCecilia Invitti
N Engl J Med 347:290-2; author reply 290-2. 2002
- Albuminuria response to very high-dose valsartan in type 2 diabetes mellitusNorman K Hollenberg
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Hypertens 25:1921-6. 2007..We aimed to investigate whether high doses of valsartan, an angiotensin receptor blocker, are superior to conventional doses to reduce urinary albumin excretion rates (UAER) in such patients...
- Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT)Steven E Kahn
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
Diabetes Care 31:845-51. 2008..The purpose of this study was to examine possible factors associated with the increased risk of fractures observed with rosiglitazone in A Diabetes Outcome Progression Trial (ADOPT)...
- Does microalbuminuria predict diabetic nephropathy?Han Henrik Parving
Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
Diabetes Care 25:406-7. 2002
- Glycemic durability of rosiglitazone, metformin, or glyburide monotherapySteven E Kahn
Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
N Engl J Med 355:2427-43. 2006..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
- HDL composition predicts new-onset cardiovascular disease in patients with type 1 diabetesPer Henrik Groop
Folkhalsan Research Center, Biomedicum Helsinki, P O Box 63, FIN 00014 University of Helsinki, Finland
Diabetes Care 30:2706-7. 2007
- The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progressionSalvatore De Cosmo
Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza San Giovanni Rotondo FG, Italy
Nephrol Dial Transplant 17:1402-7. 2002..We investigated here whether the combination of the ACE DD genotype and the PC-1 Q121 variant predicts the development and/or progression of DN in type 1 diabetic patients...
- Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIERCarl Erik Mogensen
Medical Department M, Aarhus Komunehospital, Aarhus University Hospital, 8000 Aarhus, Denmark
Hypertension 41:1063-71. 2003..A BP-independent effect of the combination may increase renal protection...
- Prevalence and concomitants of glucose intolerance in European obese children and adolescentsCecilia Invitti
Department of Metabolic Diseases and Diabetes, Istituto Auxologico Italiano, Milan, Italy
Diabetes Care 26:118-24. 2003..The prevalence of glucose intolerance and its determinants and the relation of cardiovascular risk factors with levels of glycemia and degree of obesity were studied in grossly obese children of European origin...
- Determinants of response to insulin therapy following failure of oral agents in type 2 diabetesJanaka Karalliedde
Diabetes Care 28:2589-90. 2005
- Serum lipids and the progression of nephropathy in type 1 diabetesMerlin C Thomas
The Baker Heart Research Institute, Melbourne, Australia
Diabetes Care 29:317-22. 2006..However, different lipid variables may be important at different stages of nephropathy. This study examines the pattern of dyslipidemia associated with the progression of nephropathy in patients with type 1 diabetes...
- Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targetsJorge Plutzky
Department of Cardiovascular Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
J Diabetes Complications 16:401-15. 2002....
- The link between mechanical stretch and glucose metabolism--a conceptual advance in understanding diabetic (and non diabetic?) renal diseaseLuigi Gnudi
Nephrol Dial Transplant 22:318-21. 2007
- Podocyte number in normotensive type 1 diabetic patients with albuminuriaKathryn E White
Department of Medicine, Medical School, University of Newcastle upon Tyne, UK
Diabetes 51:3083-9. 2002..Longitudinal data provide evidence for an association between podocyte loss and AER, but whether cellular changes are a response to, a cause of, or concomitant with the progression of nephropathy remains uncertain...
- Period prevalence of abnormal glucose tolerance and cardiovascular risk factors among obese children attending an obesity centre in ItalyCecilia Invitti
Department of Metabolic Diseases and Diabetes, Istituto Auxologico Italiano, Via Ariosto 13, 20145 Milan, Italy
Nutr Metab Cardiovasc Dis 16:256-62. 2006..The aim of this study was to examine the prevalence of glucose intolerance and other cardiovascular risk factors in obese children over a 24-year period...
- Screening for chronic kidney disease in patients with diabetes: are we missing the point?Merlin C Thomas
Diabetes and Metabolic Division, Baker Heart Research Institute, Melbourne, Victoria, Australia
Nat Clin Pract Nephrol 4:2-3. 2008
- Obesity and the metabolic syndrome in children and adolescentsCecilia Invitti
N Engl J Med 351:1146-8; author reply 1146-8. 2004
- Accurate measurement of albuminuria at reduced costMike Krimholtz
Nephrol Dial Transplant 19:1934-5. 2004