Leonie S Taams

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Regulatory T cells in human disease and their potential for therapeutic manipulation
    Leonie S Taams
    Division of Infection, Immunity and Inflammatory Diseases, Guy s Hospital, King s College London, London, UK
    Immunology 118:1-9. 2006
  2. pmc Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, UK
    Hum Immunol 66:222-30. 2005
  3. ncbi request reprint Peripheral generation and function of CD4+CD25+ regulatory T cells
    L S Taams
    Infection and Immunity Research Group, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Curr Top Microbiol Immunol 293:115-31. 2005
  4. ncbi request reprint The generation and antigen-specificity of CD4+CD25+ regulatory T cells
    Leonie S Taams
    Dept Immunobiology, King s College London, St Thomas Street, London SE1 9RT, UK
    Inflamm Allergy Drug Targets 5:149-56. 2006
  5. pmc Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells
    Gina J Walter
    King s College London, London, UK
    Arthritis Rheum 65:627-38. 2013
  6. pmc Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
    Bina Menon
    King s College London and Guy s and St Thomas Hospitals Foundation NHS Trust, London, UK
    Arthritis Rheumatol 66:1272-81. 2014
  7. doi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
  8. doi request reprint FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells
    Ann L Jagger
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK
    J Autoimmun 38:29-38. 2012
  9. pmc Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis
    Gina J Walter
    King s College London, London, UK
    Arthritis Rheumatol 68:103-16. 2016
  10. pmc The peripheral generation of CD4+ CD25+ regulatory T cells
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 109:319-25. 2003

Collaborators

Detail Information

Publications26

  1. pmc Regulatory T cells in human disease and their potential for therapeutic manipulation
    Leonie S Taams
    Division of Infection, Immunity and Inflammatory Diseases, Guy s Hospital, King s College London, London, UK
    Immunology 118:1-9. 2006
    ..The purpose of this review was to summarize current knowledge on regulatory T-cell function in human disease, and to assess critically how this can be tailored to suit the therapeutic manipulation of immunity...
  2. pmc Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, UK
    Hum Immunol 66:222-30. 2005
    ..Together, these data demonstrate that CD4+CD25+ Tregs can exert direct suppressive effects on monocytes/macrophages, thereby affecting subsequent innate and adaptive immune responses...
  3. ncbi request reprint Peripheral generation and function of CD4+CD25+ regulatory T cells
    L S Taams
    Infection and Immunity Research Group, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Curr Top Microbiol Immunol 293:115-31. 2005
    ..These features make the CD4+CD25+ regulatory T cell subset an interesting target for immunotherapy of chronic inflammatory or autoimmune diseases...
  4. ncbi request reprint The generation and antigen-specificity of CD4+CD25+ regulatory T cells
    Leonie S Taams
    Dept Immunobiology, King s College London, St Thomas Street, London SE1 9RT, UK
    Inflamm Allergy Drug Targets 5:149-56. 2006
    ..The aim of this review is to summarize the evidence supporting these opposing viewpoints and to combine them into a general model for the origin, function and antigen-specificity of CD4+CD25+ regulatory T cells...
  5. pmc Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells
    Gina J Walter
    King s College London, London, UK
    Arthritis Rheum 65:627-38. 2013
    ....
  6. pmc Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
    Bina Menon
    King s College London and Guy s and St Thomas Hospitals Foundation NHS Trust, London, UK
    Arthritis Rheumatol 66:1272-81. 2014
    ....
  7. doi request reprint Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
    ..Culture of healthy monocytes with AALF liver homogenates, plasma, or rhSLPI induced monocytes with strikingly similar anti-inflammatory characteristics which were reversed by inhibiting the activity of SLPI...
  8. doi request reprint FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells
    Ann L Jagger
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection and Inflammatory Disease, King s College London, London SE1 1UL, UK
    J Autoimmun 38:29-38. 2012
    ....
  9. pmc Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis
    Gina J Walter
    King s College London, London, UK
    Arthritis Rheumatol 68:103-16. 2016
    ..The aim of this study was to determine whether Treg cells are intrinsically defective in RA...
  10. pmc The peripheral generation of CD4+ CD25+ regulatory T cells
    Arne N Akbar
    Department of Immunology and Molecular Pathology, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, London, UK
    Immunology 109:319-25. 2003
  11. pmc Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging
    Elaine Agius
    Department of Immunology, Division of Infection and Immunity, University College London, London, W1T 4JF, England, UK
    J Exp Med 206:1929-40. 2009
    ..This may be a predisposing factor for the development of malignancy and infection in the skin during aging...
  12. pmc Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses
    Wan Chien Cheng
    Division of Immunology, Infection and Inflammatory Disease, Centre for Molecular and Cellular Biology of Inflammation, King s College London, London, UK
    Eur J Immunol 46:2211-21. 2016
    ..Our data suggest that periodontal pathogens can activate monocytes, resulting in increased IL-17 production by human CD4(+) T cells, a process that appears enhanced in patients with PD. ..
  13. doi request reprint Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
    Charalambos Gustav Antoniades
    Institute of Liver Studies and Cellular Biology of Inflammation, King s College London, London, United Kingdom
    Hepatology 56:735-46. 2012
    ..Levels of CCL2, CCL3, interleukin (IL)-6, IL-10, and transforming growth factor-β1 were significantly elevated in AALF liver tissue relative to chronic liver disease controls...
  14. pmc Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
    Hayley G Evans
    Departments of Immunobiology and Nephrology and Transplantation, King s College London, London, United Kingdom
    Proc Natl Acad Sci U S A 104:17034-9. 2007
    ....
  15. pmc CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner
    Behdad Afzali
    Medical Research Council Centre for Transplantation, King s College London, King s Health Partners, Guy s Hospital, London, UK
    Eur J Immunol 43:2043-54. 2013
    ..As IL-17 production from this Treg-cell subpopulation is not accompanied by a loss of regulatory function, in the context of cell therapy, exclusion of these cells from the cell product may not be necessary. ..
  16. pmc Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma
    Machteld M Tiemessen
    Immunobiology Department, Division of Immunology, Infection and Inflammatory Disease, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    J Invest Dermatol 126:2217-23. 2006
    ..Our findings thus indicate a dysfunction of peripheral Tregs in certain CTCL patients, which correlates with tumor burden...
  17. pmc CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
    Machteld M Tiemessen
    Department of Immunobiology, Division of Immunology, Infection and Inflammatory Disease, King s College London School of Medicine at Guy s, King s College, and St Thomas Hospitals, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 104:19446-51. 2007
    ..Moreover, the data suggest that the Treg-mediated induction of AAM partly involves a novel, cytokine-independent pathway...
  18. ncbi request reprint Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
    Jocea M R van Amelsfort
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:732-42. 2007
    ..The purpose of the present study was to investigate whether particular proinflammatory mediators that are associated with RA could abrogate CD4+,CD25+ Treg-mediated suppression...
  19. ncbi request reprint CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    Jocea M R van Amelsfort
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2775-85. 2004
    ..We investigated the presence, phenotype, and function of CD4(+)CD25(+) regulatory T cells in peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA)...
  20. ncbi request reprint Identification of a CD4+CD25+ T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation
    Esther N M Nolte-'t Hoen
    Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Eur J Immunol 34:3016-27. 2004
    ..This suggests that the presence of CD4+CD25+CD134+ T cells indicates sites of active immune suppression...
  21. ncbi request reprint Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship
    Marca H M Wauben
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 165, 3508 TD Utrecht, The Netherlands
    Novartis Found Symp 252:211-20; discussion 220-5, 257-67. 2003
    ..We speculate that the quantity and quality of molecule reshuffling during cross-talk between T cells and APCs play a role in the regulation of the T cell response...
  22. ncbi request reprint Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 32:1621-30. 2002
    ..This would provide a mechanism for the generation of regulatory cells that induce tolerance to a wide array of antigens that may not be encountered in the thymus...
  23. pmc Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
    J Clin Invest 116:2423-33. 2006
    ....
  24. ncbi request reprint CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    Ismé M de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Pediatric Immunology and Immunology Advanced Center on Preclinical Immuno genomics Institute for Translational Medicine, Utrecht, The Netherlands
    J Immunol 172:6435-43. 2004
    ..These data suggest that CD4(+)CD25(bright) Treg cells play a role in determining the patient's fate toward either a favorable or unfavorable clinical course of disease...
  25. ncbi request reprint CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy
    Machteld M Tiemessen
    J Allergy Clin Immunol 110:934-6. 2002