Affiliation: King's College London
- Time to give up on a single explanation for autismFrancesca Happe
Francesca Happé, Angelica Ronald and Robert Plomin are at the Institute of Psychiatry, Kings College London, De Crispigny Park, London SE5 8AF, UK
Nat Neurosci 9:1218-20. 2006..Twin data suggest largely nonoverlapping genes acting on each of these traits. At the cognitive level, too, attempts at a single explanation for the symptoms of autism have failed. Implications for research and treatment are discussed...
- Association of autistic-like and internalizing traits during childhood: a longitudinal twin studyVictoria Hallett
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
Am J Psychiatry 167:809-17. 2010..The authors examined the longitudinal relationship between autistic-like and internalizing traits across middle to late childhood in a population-representative twin sample...
- The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural researchFrancesca Happe
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
Neuropsychol Rev 18:287-304. 2008..We discuss the implications of the fractionable-triad approach for both diagnosis and future research directions...
- Individual differences in theory of mind ability in middle childhood and links with verbal ability and autistic traits: a twin studyAngelica Ronald
Institute of Psychiatry, King s College London, London, UK
Soc Neurosci 1:412-25. 2006..The possible neural basis underlying this association is discussed...
- A twin study investigating the genetic and environmental aetiologies of parent, teacher and child ratings of autistic-like traits and their overlapAngelica Ronald
Social Genetic and Developmental, Psychiatry SGDP Centre, Institute of Psychiatry, De Crespigny Park, London, UK
Eur Child Adolesc Psychiatry 17:473-83. 2008..Genetic overlap was significant but moderate across all raters. These findings are discussed in relation to population screening for autism and future genetic research...
- Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sampleAngelica Ronald
Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 49:535-42. 2008..This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population...
- Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive componentsGráinne McLoughlin
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
J Abnorm Child Psychol 35:999-1008. 2007..This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder...
- Aetiological relationship between language performance and autistic-like traits in childhood: a twin studyKatharina Dworzynski
MRC Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, London, UK
Int J Lang Commun Disord 42:273-92. 2007..The basis for this association is poorly understood. How early language is related to each of the triad of impairments characteristic of ASDs is also in need of clarification...
- Origins of individual differences in imitation: links with language, pretend play, and socially insightful behavior in two-year-old twinsFiona McEwen
King s College Londonand Guy s Hospital, UK
Child Dev 78:474-92. 2007..Parents who encourage imitation may also tend to foster the development of language, pretence, and socially insightful behavior...
- Phenotypic and genetic overlap between autistic traits at the extremes of the general populationAngelica Ronald
Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
J Am Acad Child Adolesc Psychiatry 45:1206-14. 2006....
- Genetic heterogeneity between the three components of the autism spectrum: a twin studyAngelica Ronald
SGDP Centre, Institute of Psychiatry, King s College London, UK
J Am Acad Child Adolesc Psychiatry 45:691-9. 2006....
- Investigating the association between autistic-like and internalizing traits in a community-based twin sampleVictoria Hallett
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE58AF, UK
J Am Acad Child Adolesc Psychiatry 48:618-27. 2009..This study aimed to investigate the phenotypic and etiologic relation between internalizing and autistic-like traits using a community-based twin sample...
- The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autismAngelica Ronald
Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, UK
Dev Sci 8:444-58. 2005..Considering these behaviours separately might help clarify gene-brain-behaviour pathways in future research...
- Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhoodJonna Kuntsi
MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
Biol Psychiatry 57:647-54. 2005....
- Relationship between special abilities and autistic-like traits in a large population-based sample of 8-year-oldsPedro M Vital
Social Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 50:1093-101. 2009..The purpose of this study was to investigate the association between special abilities and ASD-like traits...
- Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1BJonathan Mill
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005....
- Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhoodVictoria Hallett
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
Depress Anxiety 26:316-24. 2009..This study aimed to examine both the phenotypic and genetic differentiation of ARB subtypes within the general population at age 7 and 9. It constituted a follow-up to an earlier study of ARBs in preschool children...
- A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samplesAngelica Ronald
Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Behav Genet 40:31-45. 2010..When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families...
- Relationship between symptom domains in autism spectrum disorders: a population based twin studyKatharina Dworzynski
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
J Autism Dev Disord 39:1197-210. 2009..Cross-twin cross-trait correlations suggested small shared genetic effects between RRBIs and other symptoms. These findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD...
- Genetic, environmental and gender influences on attachment disorder behavioursHelen Minnis
Section of Psychological Medicine, University of Glasgow, Glasgow, UK
Br J Psychiatry 190:490-5. 2007..Despite current interest in attachment disorder, there is concern about its discrimination from other disorders and an unproven assumption of an environmental aetiology...
- The etiology of behavior problems in 7-year-old twins: substantial genetic influence and negligible shared environmental influence for parent ratings and ratings by same and different teachersKimberly J Saudino
Psychology Department, Boston University, Boston, Massachusetts 02215, USA
J Abnorm Child Psychol 33:113-30. 2005..Sex-limitation models revealed similar results for males and females, although there was some evidence for greater heritability for boys, especially when twins were rated by the same teacher...
- Substantial genetic influence on mild mental impairment in early childhoodFrank M Spinath
Department of Psychology, University of Bielefeld, Bielefeld, Germany
Am J Ment Retard 109:34-43. 2004..49, which is significantly greater than heritability for the rest of the population in early childhood. These results suggest that mild mental impairment is a good target for neuroscience research on global brain function and dysfunction...
- Genetic research into autismAngelica Ronald
Science 311:952; author reply 952. 2006
- Tactile selective attention and body posture: assessing the multisensory contributions of vision and proprioceptionSalvador Soto-Faraco
University of Oxford, Oxford, England
Percept Psychophys 66:1077-94. 2004..These results suggest that tactile, spatially selective attention can operate according to an abstract spatial frame of reference, which is significantly modulated by multisensory contributions from both proprioception and vision...