Alberto Quaglia

Summary

Affiliation: King's College Hospital
Country: UK

Publications

  1. ncbi Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma
    Alberto Quaglia
    Department of Histopathology, Royal Free and University College Medical School, London, UK
    Liver Int 26:424-32. 2006
  2. ncbi Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Mod Pathol 20:701-9. 2007
  3. pmc Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver
    A Quaglia
    Department of Histopathology, Royal Free and University College Medical School, London NW3 2QG, UK
    World J Gastroenterol 11:6262-8. 2005
  4. doi Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Transpl 19:383-94. 2013
  5. doi The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injury
    Mahmoud Abu-Amara
    Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
    Transplantation 93:880-6. 2012
  6. doi Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury
    Sanjeev Kanoria
    Hepato Pancreatico Biliary and Liver Transplant Unit, University Department of Surgery, Royal Free Hospital and RFUCSM, UCL, London, UK
    Transpl Int 25:783-91. 2012
  7. doi The association of pretransplant ferritin level with waiting list and post-transplant survival. Does ferritin actually predict outcome?
    Mohammad A B Al-Freah
    Institute of Liver Studies, King s College Hospital, London, UK
    Transpl Int 26:1070-9. 2013
  8. doi Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease
    Emer Fitzpatrick
    Paediatric Liver, GI and Nutrition Centre, King s College London School of Medicine at King s College Hospital, London, UK
    J Pediatr Gastroenterol Nutr 56:72-6. 2013
  9. doi Hepatocellular adenoma in glycogen storage disorder type I: a clinicopathological and molecular study
    Stratigoula Sakellariou
    Institute of Liver Studies, King s College Hospital, London, UK
    Histopathology 60:E58-65. 2012
  10. doi Immunohistochemical phenotyping of the inflammatory infiltrate in de novo autoimmune hepatitis after liver transplantation in children
    Nedim Hadzic
    Department of Child Health, King s College Medical School at King s College Hospital, Denmark Hill, London, UK
    Pediatr Transplant 16:501-10. 2012

Detail Information

Publications52

  1. ncbi Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma
    Alberto Quaglia
    Department of Histopathology, Royal Free and University College Medical School, London, UK
    Liver Int 26:424-32. 2006
    ..We investigated cell cycle kinetics of nodular lesions in cirrhosis to differentiate hepatocellular carcinoma (HCC) from its precursor lesions...
  2. ncbi Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Mod Pathol 20:701-9. 2007
    ..This classification should help to advance clinical and research applications...
  3. pmc Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver
    A Quaglia
    Department of Histopathology, Royal Free and University College Medical School, London NW3 2QG, UK
    World J Gastroenterol 11:6262-8. 2005
    ..To design a classification tool for the histological assessment of hepatocellular carcinoma (HCC), dysplastic nodules (DN), and macroregenerative nodules (MRN) in cirrhotic liver...
  4. doi Distinct microRNA profiles are associated with the severity of hepatitis C virus recurrence and acute cellular rejection after liver transplantation
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Liver Transpl 19:383-94. 2013
    ..Selected miRNAs may serve as intragraft and serum biomarkers for recurrent HCV after LT and help to distinguish between ACR and recurrent HCV...
  5. doi The hepatic soluble guanylyl cyclase-cyclic guanosine monophosphate pathway mediates the protection of remote ischemic preconditioning on the microcirculation in liver ischemia-reperfusion injury
    Mahmoud Abu-Amara
    Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
    Transplantation 93:880-6. 2012
    ..The present study aimed to assess the role of hepatic sGC-cGMP in lower limb RIPC-induced protection against liver IR injury...
  6. doi Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury
    Sanjeev Kanoria
    Hepato Pancreatico Biliary and Liver Transplant Unit, University Department of Surgery, Royal Free Hospital and RFUCSM, UCL, London, UK
    Transpl Int 25:783-91. 2012
    ..03). There was a positive correlation (P = 0.02) between hepatic venous NO(x) levels and mitochondrial oxygenation. RIPC before IRI improves hepatic mitochondrial oxygenation and reduces acidosis and currently undergoing clinical study...
  7. doi The association of pretransplant ferritin level with waiting list and post-transplant survival. Does ferritin actually predict outcome?
    Mohammad A B Al-Freah
    Institute of Liver Studies, King s College Hospital, London, UK
    Transpl Int 26:1070-9. 2013
    ..030). Presence of graft siderosis (15.8% of patients) was not associated with survival. In conclusion, we found a limited role for SF as a prognostic indicator for pre- or post-transplant survival...
  8. doi Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease
    Emer Fitzpatrick
    Paediatric Liver, GI and Nutrition Centre, King s College London School of Medicine at King s College Hospital, London, UK
    J Pediatr Gastroenterol Nutr 56:72-6. 2013
    ..The aim of the present study was to compare tools for noninvasive assessment of liver fibrosis in a paediatric cohort...
  9. doi Hepatocellular adenoma in glycogen storage disorder type I: a clinicopathological and molecular study
    Stratigoula Sakellariou
    Institute of Liver Studies, King s College Hospital, London, UK
    Histopathology 60:E58-65. 2012
    ..In this retrospective study, our aim was to reclassify according to geno-phenotypic characteristics nodular lesions identified in hepatectomy specimens of such patients transplanted between 1998 and 2008 at our institution...
  10. doi Immunohistochemical phenotyping of the inflammatory infiltrate in de novo autoimmune hepatitis after liver transplantation in children
    Nedim Hadzic
    Department of Child Health, King s College Medical School at King s College Hospital, Denmark Hill, London, UK
    Pediatr Transplant 16:501-10. 2012
    ..A Th1 polarization of the inflammatory infiltrate characterizes dn-AIH, but also ACR and AIH...
  11. ncbi N-Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis
    Giuseppe Fusai
    University Department of Surgery and Liver Transplant Unit, Royal Free Hospital, Royal Free and University College Medical School, Pond Street, London NW3 2QG, U K
    Clin Sci (Lond) 109:465-73. 2005
    ..In conclusion, NAC administration decreased the extent of I/R injury in the steatotic liver, particularly during the late phase of reperfusion...
  12. ncbi Efficacy of loco-regional ablation therapy of HCC in a population of liver transplanted patients
    Filomena Morisco
    Liver Transplant and Hepatobiliary Medicine, Royal Free Hospital, London, UK
    Dig Dis Sci 53:1131-7. 2008
    ..The aim of this study was: to evaluate if LAT was able to induce complete necrosis of tumour mass; to determine the tumour recurrence rate after LT and factors associated with recurrence...
  13. doi Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation
    Alberto Quaglia
    Institute of Liver Studies, King s College Hospital and King s College, London, UK
    Histopathology 68:953-67. 2016
    ..New concepts create new responsibilities and opportunities for the pathologist to contribute to the understanding of liver pathology and communicate this with clinical colleagues and researchers. ..
  14. doi AST-to-platelet ratio index in non-invasive assessment of long-term graft fibrosis following pediatric liver transplantation
    Rashmi S D'Souza
    King s College London School of Medicine, London, UK
    Pediatr Transplant 20:222-6. 2016
    ..45 (sensitivity = 0.67; specificity = 0.79; PPV = 0.67; NPV = 0.79). APRI appears to be a useful non-invasive adjunct in the assessment of significant graft fibrosis in the long-term follow-up of pediatric liver transplant survivors...
  15. doi CXCL10 levels identify individuals with rapid fibrosis at 12 months post-transplant for hepatitis C virus and predict treatment response
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Clin Transplant 28:569-78. 2014
    ..We hypothesized that CXCL10 levels can distinguish between slow and fast fibrosis progression at 12 months, development of F ≥ 4 post-transplantation, and help predict treatment response in patients undergoing AVT...
  16. doi Hepatic steatosis estimated microscopically versus digital image analysis
    Andrew R Hall
    Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, UK
    Liver Int 33:926-35. 2013
    ....
  17. doi Two distinct pathways of carcinogenesis in primary sclerosing cholangitis
    Yoh Zen
    Institute of Liver Studies, King s College Hospital, London, UK
    Histopathology 59:1100-10. 2011
    ..To identify clinicopathological characteristics of cholangiocarcinoma and premalignant lesions arising in patients with primary sclerosing cholangitis (PSC)...
  18. ncbi The histopathology of regeneration in massive hepatic necrosis
    Clare Elizabeth Honor Craig
    Royal Free and University College Medical School, London, United Kingdom
    Semin Liver Dis 24:49-64. 2004
    ..Thus, more patients will be able to restore their own livers and avoid liver transplantation...
  19. ncbi Liver transplantation in cirrhotic patients with small hepatocellular carcinoma: an analysis of pre-operative imaging, explant histology and prognostic histologic indicators
    Shantanu Bhattacharjya
    Department of Surgery, Royal Free Hospital, Royal Free and University College School of Medicine, London, UK
    Dig Surg 21:152-9; discussion 159-60. 2004
    ..The selection of patients for liver transplantation is based on pre-operative imaging. The accuracy of imaging correlated with explant histology and the effect of tumour stage has not been evaluated in this selected population...
  20. doi Serum levels of CK18 M30 and leptin are useful predictors of steatohepatitis and fibrosis in paediatric NAFLD
    Emer Fitzpatrick
    Paediatric Liver, GI, and Nutrition Centre, King s College London School of Medicine at King s College Hospital, London, UK
    J Pediatr Gastroenterol Nutr 51:500-6. 2010
    ..Our aim was to evaluate a combination of serum biomarkers as a measure of disease activity in paediatric NAFLD...
  21. doi Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: Implications for follow-up and screening
    Andrew D Yeoman
    Institute of Liver Studies, King s College Hospital National Health Service NHS Foundation Trust, Denmark Hill, London, UK
    Hepatology 48:863-70. 2008
    ..5 months, range 12-195 months. Median survival in patients whose HCC was diagnosed on surveillance was 19 months (range 6-36 months) compared with 2 months (range 0-14 months) for patients presenting symptomatically (P = 0.042)...
  22. doi A comparison of four- versus three-pass transjugular biopsy using a 19-G Tru-Cut needle and a randomized study using a cassette to prevent biopsy fragmentation
    Shusang Vibhakorn
    Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG, UK
    Cardiovasc Intervent Radiol 32:508-13. 2009
    ..We conclude that at least four passes with TJLB should be performed when liver specimens are needed for grading and staging. Using a supportive cassette did not reduce fragmentation...
  23. doi Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver
    Mahmoud Abu-Amara
    Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
    Liver Transpl 17:610-9. 2011
    ..eNOS exerts its protective effects through the preservation of hepatic MBF. At 2 hours of reperfusion, eNOS protection is likely due to the increased activation of eNOS rather than increased expression...
  24. doi Liver disease in pregnancy
    Deepak Joshi
    Institute of Liver Studies, King s College Hospital, London, UK
    Lancet 375:594-605. 2010
    ..Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options...
  25. ncbi Vascular invasion and herniation by hepatocellular carcinoma in cirrhosis: A wolf in sheep's clothing?
    Alberto Quaglia
    Department of Histopathology, Royal Free Hospital, London, United Kingdom
    Arch Pathol Lab Med 129:639-44. 2005
    ..Intravascular free-floating tumor clusters (IvCs) of HCC are found histologically in the vicinity of HCC. Thrombus formation is not seen morphologically in association with these IvCs, which are usually covered by endothelium...
  26. doi Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct
    Yoh Zen
    Institute of Liver Studies, King s College Hospital, London, UK
    Mod Pathol 24:1079-89. 2011
    ....
  27. doi The Effect of Intraoperative N-Acetylcysteine on Hepatocellular Injury During Laparoscopic Bariatric Surgery. A Randomised Controlled Trial
    Ajay P Belgaumkar
    Department of Minimally Invasive, Bariatric and Laparoscopic HPB Surgery, King s College Hospital, Denmark Hill, London, SE5 9RS, UK
    Obes Surg 26:1254-65. 2016
    ..Fatty livers are more susceptible to ischaemic insults. This trial investigated whether the antioxidant N-acetylcysteine (NAC) reduced liver injury during laparoscopic sleeve gastrectomy (LSG)...
  28. doi Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure
    Charalambos Gustav Antoniades
    Section of Hepatology, St Mary s Hospital, Imperial College, London, UK Institute of Liver Sciences, King s College London, London, UK
    Hepatology 59:1564-76. 2014
    ..Culture of healthy monocytes with AALF liver homogenates, plasma, or rhSLPI induced monocytes with strikingly similar anti-inflammatory characteristics which were reversed by inhibiting the activity of SLPI...
  29. ncbi Immunosuppression and donor age with respect to severity of HCV recurrence after liver transplantation
    Dimitrios N Samonakis
    Royal Free Hospital, Liver Transplantation and Hepatobiliary Unit, London, UK
    Liver Transpl 11:386-95. 2005
    ..Maintenance azathioprine gave survival advantage...
  30. doi Laser microdissection microscopy: application to cell culture
    Ahlam Mustafa
    Institute of Liver Studies, King s College London School of Medicine, London, UK
    Methods Mol Biol 806:385-92. 2012
    ..RNA, DNA, and protein isolation is possible from a small number of cells and the material is suitable for further real-time PCR, ELISA, Western Blotting, and protein microarray analysis...
  31. doi Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells
    Maria Serena Longhi
    Institute of Liver Studies, King s College London School of Medicine at King s College Hospital, London, UK
    Hepatology 50:130-42. 2009
    ..03) and promoted IL-10 production (P = 0.009), leaving unchanged TLR4 expression in healthy subjects, whereas in patients with AILD it induced only a marginal increase in IL-10 production (P = 0.045 in ID and P = 0.13 in AD)...
  32. doi New monoallelic (partial tandem duplication) mutation of HNF1a gene in steatotic hepatocellular adenoma
    Stratigoula Sakellariou
    Institute of Liver Studies, King s College Hospital, London, UK
    Eur J Gastroenterol Hepatol 23:623-7. 2011
    ..Clinicopathological and molecular investigation of HCA cases with unique features could result in a better understanding of HCAs pathogenesis...
  33. ncbi Liver after hepatocyte transplantation for liver-based metabolic disorders in children
    Alberto Quaglia
    Institute of Liver Studies, King s College Hospital and King s College London School of Medicine, London, UK
    Cell Transplant 17:1403-14. 2008
    ..Further studies are needed to monitor donor hepatocytes in vivo, to quantify better the efficacy of the procedure and to find ways of improving engraftment and function...
  34. ncbi Effect of ischaemic preconditioning on hepatic oxygenation, microcirculation and function in a rat model of moderate hepatic steatosis
    Rahul S Koti
    University Department of Surgery and Liver Transplantation Unit, Royal Free and University College Medical School, The Royal Free Hospital, London NW3 2QG, U K
    Clin Sci (Lond) 108:55-63. 2005
    ..3+/-379.6 units/l respectively; P<0.01]. In conclusion, IPC has a hepatoprotective effect against I/R injury in livers with moderate steatosis. These data may have important clinical implications in liver surgery and transplantation...
  35. doi Immunoglobulin G4-positive plasma cell infiltration in explanted livers for primary sclerosing cholangitis
    Yoh Zen
    Institute of Liver Studies, King s College Hospital, London, UK
    Histopathology 58:414-22. 2011
    ..To explore whether immunoglobulin (Ig)G4-related sclerosing cholangitis (IgG4-SC) contributes to end-stage primary sclerosing cholangitis (PSC) in the United Kingdom...
  36. doi Planimetry of the porta hepatis in biliary atresia
    Aly Shalaby
    Department of Paediatric Surgery, King s College Hospital, London, UK
    Histopathology 69:943-949. 2016
    ..Orientation and digital analysis of the biliary remnants in the resected porta hepatis in infants with biliary atresia...
  37. doi BRAF V600E mutation in biliary proliferations associated with α1 -antitrypsin deficiency
    Napat Angkathunyakul
    Institute of Liver Studies, King s College Hospital, London, UK
    Histopathology . 2016
    ..Our observational study includes a detailed investigation of their immunohistochemical profile and BRAF V600E mutation status...
  38. ncbi Pigmented well-differentiated hepatocellular neoplasm with beta-catenin mutation
    Lara Neves Souza
    Institute of Liver Studies, King s College Hospital, Denmark Hill, SE5 9RS, London, UK
    Hepatobiliary Pancreat Dis Int 14:660-4. 2015
    ....
  39. pmc Intrahepatic bile duct mixed adenoneuroendocrine carcinoma: a case report and review of the literature
    Sean L Zheng
    Department of Hepato pancreato biliary Surgery, King s College Hospital, Denmark Hill, London, SE5 9RS, UK
    Diagn Pathol 10:204. 2015
    ..Mixed adeno-neuroendocrine carcinoma (MANEC) of the biliary tract is rare with only a few reported cases. Consequently, knowledge about their pathogenesis, histopathological characteristics and outcomes is sparce...
  40. pmc Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure*
    Lucia A Possamai
    1Department of Hepatology, Imperial College London, London, UK 2Institute of Liver Studies at King s College School of Medicine at King s College Hospital, London, UK 3Institute of Human Health and Performance, University College London, London, UK 4Department of Asthma Allergy and Lung Biology, King s College London, London, UK 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada
    Crit Care Med 41:2543-50. 2013
    ..To evaluate the role of hepatocellular and extrahepatic apoptosis during the evolution of acetaminophen-induced acute liver failure...
  41. ncbi Epithelial colonies cultured from human explanted liver in subacute hepatic failure exhibit hepatocyte, biliary epithelial, and stem cell phenotypic markers
    Clare Selden
    Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, Hampstead, London, United Kingdom
    Stem Cells 21:624-31. 2003
    ..Proliferating epithelial-like cells with combined hepatocyte- and biliary-epithelial-specific functional markers and a stem cell marker can be isolated from the nonparenchymal fraction of liver cells in subacute hepatic failure...
  42. ncbi Expression of c-kit (CD117) in neuroendocrine tumours--a target for therapy?
    Virginia Kostoula
    Department of Medicine, Royal Free Hospital and University of College Medical School, Pond Street, London, NW3 2QG, UK
    Oncol Rep 13:643-7. 2005
    ..It is possible that the polyclonal antibody is less specific. Studies need to be performed to determine if c-kit expression by NETs can be translated into therapeutic benefit by agents such as imatinib mesylate...
  43. ncbi Parathyroid carcinoma: a report of two cases and a concise review and update of the literature
    Humera Babar-Craig
    Department of Otorhinolaryngology, Royal Free Hospital, London, UK
    J Laryngol Otol 119:577-80. 2005
    ..Most studies in the literature are retrospective but recent trends in presentation, treatment options and complications have been reviewed and are summarized in this paper...
  44. ncbi Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosis
    Dimitrios N Samonakis
    Liver Transplantation and Hepatobiliary Unit and Histopathology Department, Royal Free Hospital, London, United Kingdom
    Liver Transpl 13:1305-11. 2007
    ..In 29 with HVPG <6 mmHg at 1 yr, none decompensated compared to 4 of 13 (31%) with PHT. In conclusion, HVPG correlates with fibrosis and its progression, due to recurrent HCV infection, assessed in TJB...
  45. ncbi Liver transplantation and recurrent hepatocellular carcinoma: predictive value of nodule size in a retrospective and explant study
    Alessandro Grasso
    Liver Transplantation and Hepatobiliary Medicine Unit, London UK, Royal Free Hospital London, United Kingdom
    Transplantation 81:1532-41. 2006
    ..Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) remains a major cause of post-LT death...
  46. doi A morphometric model to minimize subjectivity in the histological assessment of hepatocellular carcinoma and its precursors in cirrhosis
    Maurizio Vertemati
    Department of Human Morphology, University of Milan, Milan, Italy
    Microsc Res Tech 71:606-13. 2008
    ..To explore how morphometry can minimize subjectivity in the assessment of liver nodules in cirrhosis using a novel classification tool...
  47. ncbi Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers
    Ragai R Mitry
    Hepatology 46:2047-8; author reply 2048. 2007
  48. ncbi Noninvasive tests in the post-liver transplantation setting
    Evangelos Cholongitas
    Liver Transpl 13:626-7; author reply 628-9. 2007
  49. ncbi Hepatocellular carcinoma in a 12-year-old child with PiZZ alpha1-antitrypsin deficiency
    Nedim Hadzic
    Hepatology 43:194. 2006
  50. ncbi Liver transplantation for HCV cirrhosis: improved survival in recent years and increased severity of recurrent disease in female recipients: results of a long term retrospective study
    Luca S Belli
    Hepatology and Abdominal Organ Transplantation Unit, Niguarda Hospital, Milan, Italy
    Liver Transpl 13:733-40. 2007
    ..The combination of a female recipient receiving an older graft emerged as a strong risk factor for a severe recurrence...
  51. ncbi A systematic review of the quality of liver biopsy specimens
    Evangelos Cholongitas
    Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, Pond Street, Hampstead, London, England
    Am J Clin Pathol 125:710-21. 2006
    ..New studies are needed based on adequate liver biopsy samples to provide reliable estimation of grading and staging in chronic liver disease...
  52. ncbi Induction of autoimmune hepatitis by pegylated interferon in a liver transplant patient with recurrent hepatitis C virus
    Evangelos Cholongitas
    Transplantation 81:488-90. 2006