Jonathan Mill

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc A longitudinal twin study of skewed X chromosome-inactivation
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e17873. 2011
  2. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
  3. pmc Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
    C C Y Wong
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Mol Psychiatry 19:495-503. 2014
  4. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
  5. ncbi request reprint Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
  6. ncbi request reprint Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
  7. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
  8. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
  9. pmc DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
    Ruth Pidsley
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mol Brain 5:42. 2012
  10. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005

Detail Information

Publications42

  1. pmc A longitudinal twin study of skewed X chromosome-inactivation
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e17873. 2011
    ..These data have implications for our understanding about sex differences in complex disease, and the potential causes of phenotypic discordance between MZ female twins...
  2. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
    ..Overall, our data provide further evidence to support a role for DNA methylation differences in mediating phenotypic differences between MZ twins and in the etiology of both SZ and BD...
  3. pmc Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
    C C Y Wong
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Mol Psychiatry 19:495-503. 2014
    ..This study represents the first systematic epigenomic analyses of MZ twins discordant for ASD and implicates a role for altered DNA methylation in autism. ..
  4. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  5. ncbi request reprint Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup...
  6. ncbi request reprint Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, England
    Arch Gen Psychiatry 63:462-9. 2006
    ..A principal aim of genetic research is to provide new information that can resolve such clinical heterogeneity and that can be incorporated into diagnostic practice...
  7. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  8. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
    ..Previous research has suggested that activity and expression of COMT is altered in schizophrenia, and is mediated by one or more polymorphisms within the gene, including the functional Val158Met polymorphism...
  9. pmc DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
    Ruth Pidsley
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mol Brain 5:42. 2012
    ..Previously we reported evidence of a negative correlation between DNA methylation in this region and cerebellum weight in humans...
  10. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005
    ....
  11. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
    ..Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome...
  12. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
    ..57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD...
  13. pmc A longitudinal study of epigenetic variation in twins
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Epigenetics 5:516-26. 2010
    ..The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research...
  14. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
    ..These findings impact our understanding about the origin of individual phenotypic differences and have implications for genetic studies of complex disease...
  15. ncbi request reprint Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:11-3. 2005
    ..Although we found some evidence for the preferential transmission of a rare haplotype (long-allele/9-repeat-allele/T-allele; chi2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone...
  16. pmc Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    Matthew N Davies
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Genome Biol 13:R43. 2012
    ..We characterized intra- and inter-individual methylomic variation across whole blood and multiple regions of the brain from multiple donors...
  17. ncbi request reprint Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 125:38-42. 2004
    ..A global test incorporating all alleles of this marker, however, was not significant and thus this finding needs replication before any conclusions can be made...
  18. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
    ..Only few studies have reported association between promoter polymorphisms of the gene and ADHD...
  19. ncbi request reprint Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene
    Jonathan Mill
    MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:421-5. 2006
    ..Such epigenetic variation between genetically identical individuals may play a key role in the etiology of psychopathology, and explain the incomplete phenotypic concordance observed in MZ twins...
  20. doi request reprint Drugs and addiction: an introduction to epigenetics
    Chloe C Y Wong
    Institute of Psychiatry, SGDP Research Centre, King s College London, De Crespigny Park, Denmark Hill, UK
    Addiction 106:480-9. 2011
    ..The implications of these findings for molecular studies of addiction and the future development of novel therapeutic interventions are also discussed...
  21. pmc A data-driven approach to preprocessing Illumina 450K methylation array data
    Ruth Pidsley
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    BMC Genomics 14:293. 2013
    ..These metrics also have potential utility as quality scores for datasets...
  22. pmc Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus
    Christopher G Bell
    Medical Genomics, UCL Cancer Institute, University College London, London, United Kingdom
    PLoS ONE 5:e14040. 2010
    ....
  23. pmc Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    Emma L Meaburn
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Epigenetics 5:578-82. 2010
    ....
  24. pmc Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight
    Ruth Pidsley
    Institute of Psychiatry, King s College London, London, UK
    Epigenetics 7:155-63. 2012
    ....
  25. ncbi request reprint Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene
    Ursula M D'Souza
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, Box Number P082, Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 56:691-7. 2004
    ..The location of the polymorphism in the 5'regulatory region of the DRD4 gene and the fact that it consists of potential transcription factor binding sites suggest that it might confer differential transcriptional activity of the alleles...
  26. doi request reprint Stochastic choice of allelic expression in human neural stem cells
    Aaron R Jeffries
    King s College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, Department of Neuroscience, London, United Kingdom
    Stem Cells 30:1938-47. 2012
    ..We conclude that stochastic allelic expression is prevalent in neural stem cells, providing clonal diversity to developing tissues such as the human brain...
  27. ncbi request reprint Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, PO82, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neuroreport 14:1463-6. 2003
    ....
  28. doi request reprint Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
    Jonathan Mill
    Institute of Psychiatry, SGDP Research Centre, London, UK
    J Child Psychol Psychiatry 49:1020-30. 2008
    ..We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention...
  29. doi request reprint DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Methods 52:255-8. 2010
    ..This method generates accurate quantitative assessments of group DNA methylation averages, reducing the time, cost and amount of DNA starting material required for large-scale epigenetic investigation of disease phenotypes...
  30. doi request reprint Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5HTTLPR and their interaction
    Helena M S Zavos
    Institute of Psychiatry, King s College London, United Kingdom
    Depress Anxiety 29:400-8. 2012
    ..In light of this, we looked at the association between stressful life events, the serotonin transporter gene polymorphism (5HTTLPR), and anxiety sensitivity in a longitudinal sample of adolescents...
  31. doi request reprint Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research
    Ruth Pidsley
    Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 69:146-56. 2011
    ..In this article, we discuss methodologic and logistic issues related to epigenomic studies using postmortem brain tissue, before discussing the future implications of such research for our understanding of psychosis...
  32. pmc Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain
    Daniel Condliffe
    Institute of Psychiatry, King s College London, London, UK
    Neurobiol Aging 35:1850-4. 2014
    ..Our study further implicates a role for epigenetic alterations in AD. ..
  33. ncbi request reprint Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise
    Anna Sophie Rommel
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, The Institute of Psychiatry, King s College London
    J Am Acad Child Adolesc Psychiatry 52:900-10. 2013
    ..Findings on the impact of exercise in animals and typically developing human beings, and an overview of putative mechanisms involved, are also presented to provide the context in which to understand this review...
  34. ncbi request reprint Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes
    Ian W Craig
    SGDP Centre, Institute of Psychiatry, Box PO 82, Denmark Hill, London SE5, UK
    Eur J Hum Genet 12:639-46. 2004
    ..Six of the targets were represented by more than one probe set, which gave independent support for the conclusions reached...
  35. pmc Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats
    Nicholas E Ilott
    Medical Research Council MRC, Social, Genetic and Developmental Psychiatry SGDP Centre, Institute of Psychiatry, King s College London, London, United Kingdom Computational Genomics Analysis and Training CGAT, Medical Research Council MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 9:e88896. 2014
    ..These genes are associated with stress response pathways and therefore may reflect long-term effects of nutritional deprivation on the development of the stress system. ..
  36. pmc Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model
    Rebecca G Smith
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, King s College London, London, United Kingdom
    PLoS ONE 4:e8456. 2009
    ..In order to establish causality, this study used an animal model to investigate the effects of advanced paternal age on behavioural deficits in the offspring...
  37. doi request reprint Eating disorders, gene-environment interactions and epigenetics
    Iain C Campbell
    Section of Eating Disorders, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Neurosci Biobehav Rev 35:784-93. 2011
    ..For example, epigenetic changes associated with diet and weight may be reversible and those associated with cognitive processes may be accessible to pharmacological interventions...
  38. ncbi request reprint Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults...
  39. ncbi request reprint Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    Jonathan Mill
    Social, Genetic, and Developmental Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Med Genet 114:975-9. 2002
    ..These data provide direct evidence that the VNTR, or another polymorphism in linkage disequilibrium with the VNTR, is involved in regulating expression of this gene...
  40. doi request reprint Toward an integrated genetic and epigenetic approach to Alzheimer's disease
    Jonathan Mill
    Institute of Psychiatry, King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, London, UK
    Neurobiol Aging 32:1188-91. 2011
    ..Here, we briefly describe some methodological issues related to epigenomic studies using postmortem brain tissue in Alzheimer's disease, and argue for an integrated genetic-epigenetic approach to disease etiology...
  41. pmc Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    Sophia J Docherty
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Epigenetics Chromatin 2:3. 2009
    ..Such an approach can be readily applied to the assessment of disease phenotypes reducing the time, cost and amount of DNA starting material required for large-scale epigenetic analyses...
  42. ncbi request reprint Epigenetics, genomic mutations and cognitive function
    Abraham Reichenberg
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 14:377-90. 2009
    ..However, there is accumulating evidence that dynamic genomic and epigenetic alterations can modulate complex cognitive processes, and influence susceptibility to disorders associated with impaired cognitive functioning...