Genomes and Genes
Michelle K Lupton
Affiliation: King's College London
- Education, occupation and retirement age effects on the age of onset of Alzheimer's diseaseMichelle K Lupton
Department of Neuroscience, Institute of Psychiatry, Kings College London, UK
Int J Geriatr Psychiatry 25:30-6. 2010..To determine the effects of early life education, mid life employment and later life retirement age on the age of onset (AOO) of Alzheimer's disease (AD)...
- The role of ABCA1 gene sequence variants on risk of Alzheimer's diseaseMichelle K Lupton
Department of Neuroscience, Institute of Psychiatry, King s College London, London, UK QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
J Alzheimers Dis 38:897-906. 2014..In addition they highlight the importance of high throughput sequencing in the identification of rare variation undetected by GWAS, but with the potential to have a strong effect on risk of LOAD. ..
- Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variationPetroula Proitsi
King s College London, Institute of Psychiatry, De Crespigny Park, London, UK
Neurobiol Aging 33:1843.e9-17. 2012..Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD...
- No association of DPP6 with amyotrophic lateral sclerosis in an Italian populationIsabella Fogh
MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, UK
Neurobiol Aging 32:966-7. 2011..Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts...
- A blood gene expression marker of early Alzheimer's diseaseKatie Lunnon
King s College London, Institute of Psychiatry, King s Health Partners Centre for Neurodegeneration Research, London, UK
J Alzheimers Dis 33:737-53. 2013..However, we accept these results could also represent a marker of diseases sharing common etiology...
- Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementiaPetroula Proitsi
Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 33:791-803. 2012..This multiple indicators multiple causes (MIMIC) model efficiently captured the complexity of the interrelations between genetic variation, behavioral symptoms, and clinical variables...