Kristin R Laurens

Summary

Affiliation: King's College London
Country: UK

Publications

  1. pmc Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study
    Kristin R Laurens
    Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
    Soc Psychiatry Psychiatr Epidemiol 51:475-91. 2016
  2. doi request reprint Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: an item response theory analysis
    K R Laurens
    Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychol Med 42:1495-506. 2012
  3. doi request reprint Error-related processing dysfunction in children aged 9 to 12 years presenting putative antecedents of schizophrenia
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Biol Psychiatry 67:238-45. 2010
  4. doi request reprint Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years
    Maina Kariuki
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
    J Paediatr Child Health 52:882-8. 2016
  5. doi request reprint Neurocognitive performance in children aged 9-12 years who present putative antecedents of schizophrenia
    Alexis E Cullen
    King s College London, Department of Forensic and Neurodevelopmental Sciences Box P023, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 121:15-23. 2010
  6. pmc Mismatch negativity (MMN) and sensory auditory processing in children aged 9-12 years presenting with putative antecedents of schizophrenia
    Jason M Bruggemann
    School of Psychiatry, University of New South Wales, Sydney, Australia Neuroscience Research Australia, Sydney, Australia
    Int J Psychophysiol 89:374-80. 2013
  7. doi request reprint Amygdala hypoactivity to fearful faces in boys with conduct problems and callous-unemotional traits
    Alice P Jones
    Medical Research Council s Social, Genetic, and Developmental Psychiatry Centre, Department of Forensic Mental Health, Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 166:95-102. 2009
  8. pmc New South Wales Child Development Study (NSW-CDS): an Australian multiagency, multigenerational, longitudinal record linkage study
    Vaughan J Carr
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia Schizophrenia Research Institute, Sydney, New South Wales, Australia Department of Psychiatry, Monash University, Melbourne, Victoria, Australia
    BMJ Open 6:e009023. 2016
  9. ncbi request reprint Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, Box P023, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 90:130-46. 2007
  10. pmc Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia
    Alexis E Cullen
    To whom correspondence should be addressed Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Box P023, De Crespigny Park, London, SE5 8AF tel 44 20 7848 5678, fax 44 0 20 7848 0754, E mail
    Schizophr Bull 39:1318-27. 2013

Collaborators

Detail Information

Publications25

  1. pmc Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study
    Kristin R Laurens
    Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
    Soc Psychiatry Psychiatr Epidemiol 51:475-91. 2016
    ..This review summarises CHADS findings, discusses these in the context of recent theory regarding aetiology and prevention of schizophrenia, and highlights challenges to be addressed with future research...
  2. doi request reprint Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: an item response theory analysis
    K R Laurens
    Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychol Med 42:1495-506. 2012
    ..Nevertheless, these experiences confer increased risk for later psychotic disorder, and are associated with poorer health and quality of life...
  3. doi request reprint Error-related processing dysfunction in children aged 9 to 12 years presenting putative antecedents of schizophrenia
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Biol Psychiatry 67:238-45. 2010
    ..This study examined whether ASz children display brain function abnormalities during error processing that are similar to those exhibited by adults with schizophrenia...
  4. doi request reprint Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years
    Maina Kariuki
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
    J Paediatr Child Health 52:882-8. 2016
    ..This study aimed to examine the effects of hospitalisation for early life infection on early childhood development...
  5. doi request reprint Neurocognitive performance in children aged 9-12 years who present putative antecedents of schizophrenia
    Alexis E Cullen
    King s College London, Department of Forensic and Neurodevelopmental Sciences Box P023, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 121:15-23. 2010
    ..The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia...
  6. pmc Mismatch negativity (MMN) and sensory auditory processing in children aged 9-12 years presenting with putative antecedents of schizophrenia
    Jason M Bruggemann
    School of Psychiatry, University of New South Wales, Sydney, Australia Neuroscience Research Australia, Sydney, Australia
    Int J Psychophysiol 89:374-80. 2013
    ..This may reflect developmental and disease effects in a pre-prodromal phase of psychosis onset. Longitudinal follow-up is necessary to establish the developmental trajectory of MMN in at-risk children...
  7. doi request reprint Amygdala hypoactivity to fearful faces in boys with conduct problems and callous-unemotional traits
    Alice P Jones
    Medical Research Council s Social, Genetic, and Developmental Psychiatry Centre, Department of Forensic Mental Health, Institute of Psychiatry, King s College London, UK
    Am J Psychiatry 166:95-102. 2009
    ..Using functional MRI, the authors evaluated differences in neural response to emotional stimuli between boys with conduct problems and elevated levels of callous-unemotional traits and comparison boys...
  8. pmc New South Wales Child Development Study (NSW-CDS): an Australian multiagency, multigenerational, longitudinal record linkage study
    Vaughan J Carr
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia Schizophrenia Research Institute, Sydney, New South Wales, Australia Department of Psychiatry, Monash University, Melbourne, Victoria, Australia
    BMJ Open 6:e009023. 2016
    ..The research will assist in informing the development of public policy and intervention guidelines to help prevent or mitigate adverse long-term health and social outcomes...
  9. ncbi request reprint Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, Box P023, De Crespigny Park, London SE5 8AF, UK
    Schizophr Res 90:130-46. 2007
    ..The results suggest that questionnaire screening of community samples of children for the putative antecedents of schizophrenia spectrum disorders is feasible. Accuracy of identification will only be established by follow-up studies...
  10. pmc Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia
    Alexis E Cullen
    To whom correspondence should be addressed Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Box P023, De Crespigny Park, London, SE5 8AF tel 44 20 7848 5678, fax 44 0 20 7848 0754, E mail
    Schizophr Bull 39:1318-27. 2013
    ..Prospective studies following the brain development of at-risk children are needed. ..
  11. doi request reprint Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9-14 years
    Sandra L Matheson
    Schizophrenia Research Institute, Level 7, 45 Liverpool Street, Darlinghurst, NSW 2010, Sydney, Australia
    J Psychiatr Res 47:1061-8. 2013
    ..442, p = 0.051). Childhood social withdrawal may constitute a vulnerability marker for schizophrenia in the presence of other antecedents and/or genetic risk factors for schizophrenia...
  12. doi request reprint Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
    Johnny M Downs
    Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, London, United Kingdom
    Schizophr Res 144:99-104. 2013
    ..This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9-11years at study commencement...
  13. pmc Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses
    Kristin R Laurens
    Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, Australia
    BMC Psychiatry 15:205. 2015
    ..This systematic review synthesises the available evidence concerning developmental risk factors and antecedents of SSD and AP to identify those with the most robust support, and to highlight remaining evidence gaps...
  14. pmc Cortisol awakening response and diurnal cortisol among children at elevated risk for schizophrenia: relationship to psychosocial stress and cognition
    Alexis E Cullen
    Department of Forensic and Neurodevelopmental Sciences Box P023, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom Electronic address
    Psychoneuroendocrinology 46:1-13. 2014
    ..We speculate that the blunted CAR may constitute an early (potentially genetically mediated) marker of psychosis vulnerability, whilst elevated diurnal cortisol levels may emerge only proximally to disease onset. ..
  15. doi request reprint Systematic meta-analysis of insula volume in schizophrenia
    Alana M Shepherd
    University of New South Wales Research Unit for Schizophrenia Epidemiology, School of Psychiatry, Sydney, Australia
    Biol Psychiatry 72:775-84. 2012
    ..We provide the first meta-analysis of studies that conducted region-of-interest analyses of the magnitude of effect and pattern of insula volume reduction in schizophrenia compared with healthy control subjects...
  16. doi request reprint Cognitive impairment among children at-risk for schizophrenia
    Hannah Dickson
    Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, United Kingdom Electronic address
    J Psychiatr Res 50:92-9. 2014
    ..More accurate identification of children at-risk for schizophrenia and the specific deficits that they present provides opportunities for interventions such as cognitive remediation that may impact the development of the illness. ..
  17. doi request reprint Variation in psychosocial influences according to the dimensions and content of children's unusual experiences: potential routes for the development of targeted interventions
    Tamatha Ruffell
    King s College London, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 8AF, UK
    Eur Child Adolesc Psychiatry 25:311-9. 2016
    ..The development of targeted interventions is therefore indicated, and tailoring therapy according to presentation should further improve clinical outcomes for these young people...
  18. ncbi request reprint Conditional Disclosure on Pathways to Care: Coping Preferences of Young People at Risk of Psychosis
    Petra C Gronholm
    Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, United Kingdom
    Qual Health Res . 2016
    ..Our findings demonstrate the influence of stigma on young people's perceptions of a range of pre-clinical symptoms, and on how they seek support for these symptoms...
  19. pmc Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction
    Alana M Shepherd
    School of Psychiatry, University of New South Wales, Sydney NSW, Australia, and Schizophrenia Research Institute, Sydney NSW, Australia
    J Psychiatry Neurosci 40:58-68. 2015
    ..In view of the evidence for working memory dysfunction as a candidate intermediate phenotype for both disorders, we explored neuroanatomical distinctions between subtypes defined according to working memory (n-back task) performance...
  20. pmc Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: a support vector machine learning approach
    Ian C Gould
    Schizophrenia Research Institute, Darlinghurst, NSW, Australia School of Psychiatry, University of New South Wales, Australia
    Neuroimage Clin 6:229-36. 2014
    ..Consideration of sex-specific differences in brain organization is thus likely to assist future attempts to distinguish subgroups of schizophrenia patients on the basis of neuroanatomical features. ..
  21. doi request reprint Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits
    Stephane A De Brito
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College, London, UK
    Brain 132:843-52. 2009
    ..These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callous-unemotional conduct problems...
  22. doi request reprint Comparing algorithms for deriving psychosis diagnoses from longitudinal administrative clinical records
    Grant Sara
    Mental Health and Drug and Alcohol Office, NSW Ministry of Health, Sydney, Australia
    Soc Psychiatry Psychiatr Epidemiol 49:1729-37. 2014
    ..We sought to compare the relative performance of four methods for assigning a single diagnosis from longitudinal administrative clinical records when compared with reference diagnoses...
  23. doi request reprint Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia
    Alana M Shepherd
    University of New South Wales Research Unit for Schizophrenia Epidemiology, O Brien Centre at St Vincent s Hospital, 394 404 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Neurosci Biobehav Rev 36:1342-56. 2012
    ..This meta-review synthesises the available information from systematic reviews of structural alteration in both chronic and first-episode schizophrenia...
  24. pmc Mental health service use by young people: the role of caregiver characteristics
    Petra C Gronholm
    Health Service and Population Research Department, King s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom
    PLoS ONE 10:e0120004. 2015
    ..In view of caregivers' key role in young people's pathways to care, this study aimed to advance understanding of caregiver-related characteristics that influence service use among young people...
  25. doi request reprint Daily stressors and negative life events in children at elevated risk of developing schizophrenia
    Alexis E Cullen
    Alexis E Cullen, MSc, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK Helen L Fisher, PhD, CPsychol, AFBPsS, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK Ruth E Roberts, MSc, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK Carmine M Pariante, MD, MRCPsych, PhD, Section of Stress, Psychiatry and Immunology and Perinatal Psychiatry, Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK Kristin R Laurens, PhD, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King s College London, UK, and Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, and Schizophrenia Research Institute, Sydney, Australia
    Br J Psychiatry 204:354-60. 2014
    ..Psychological stress is implicated in the development of schizophrenia, but little is known about experiences of stress among children at elevated risk for the disorder...