Matthew J Kempton
Affiliation: King's College London
- Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorderMatthew J Kempton
Centre for Neuroimaging Sciences, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 65:1017-32. 2008..Despite 25 years of structural imaging in bipolar disorder, brain regions affected in the disorder are ill defined...
- Dehydration affects brain structure and function in healthy adolescentsMatthew J Kempton
Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
Hum Brain Mapp 32:71-9. 2011..Given the limited availability of brain metabolic resources, these findings suggest that prolonged states of reduced water intake may adversely impact executive functions such as planning and visuo-spatial processing...
- Effects of acute dehydration on brain morphology in healthy humansMatthew J Kempton
Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, United Kingdom
Hum Brain Mapp 30:291-8. 2009....
- Progressive lateral ventricular enlargement in schizophrenia: a meta-analysis of longitudinal MRI studiesMatthew J Kempton
Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, UK
Schizophr Res 120:54-62. 2010..To clarify this we conducted a meta-analysis of longitudinal studies measuring the lateral ventricles in patients with schizophrenia and a control group...
- The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: a fMRI studyMatthew J Kempton
Section of Neurobiology of Psychosis, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, King s College London, UK
Int J Neuropsychopharmacol 12:371-81. 2009..The COMT Val108/158Met polymorphism impacts on gender-related patterns of activation in limbic and paralimbic regions but the functional significance of any oestrogen-related COMT inhibition appears modest...
- A comprehensive testing protocol for MRI neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation methodMatthew J Kempton
King s College London, Institute of Psychiatry, Department of Neuroimaging, UK
Neuroimage 58:1051-9. 2011..We also demonstrate that the novel segmentation algorithm and FreeSurfer are both effective in determining lateral ventricular volume and are well suited for multicentre and longitudinal MRI studies...
- The effect of ageing on grey and white matter reductions in schizophreniaSubrata K Bose
MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK
Schizophr Res 112:7-13. 2009..This suggests that illness related factors may differentially affect grey and white matter, with implications for understanding the pathophysiology of schizophrenia and related psychotic disorders...
- Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorderMatthew J Kempton
Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 68:675-90. 2011..Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified...
- Molecular genetic gene-environment studies using candidate genes in schizophrenia: a systematic reviewGemma Modinos
Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom Electronic address
Schizophr Res 150:356-65. 2013..Finally, we discuss the potential of future prospects, such as new studies that combine hypothesis-based molecular genetic candidate approaches with agnostic genome-wide association studies in determining schizophrenia risk. ..
- A voxel-based morphometry comparison of the 3.0T ADNI-1 and ADNI-2 volumetric MRI protocolsSimon Brunton
King s College London, Institute of Psychiatry, Department of Neuroimaging Sciences, London, UK NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King s College, London, UK
Int J Geriatr Psychiatry 30:531-8. 2015..The aim of the current study was to investigate the compatibility of the 3.0 T ADNI-1 and ADNI-2 T1-weighted volumes using voxel-based morphometry (VBM)...
- Efficacy and safety of second-generation long-acting injections in schizophrenia: a meta-analysis of randomized-controlled trialsPaolo Fusar-Poli
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
Int Clin Psychopharmacol 28:57-66. 2013..These data suggest that SGLAI lack an advantage in reducing psychotic symptoms over oral medications. Their potential effects on relapse prevention should be better addressed by future randomized-controlled trials...
- Dissociable brain structural changes associated with predisposition, resilience, and disease expression in bipolar disorderMatthew J Kempton
Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
J Neurosci 29:10863-8. 2009....
- Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling StudyUlrich Reininghaus
Centre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
Schizophr Bull 42:712-22. 2016..Our findings suggest that stress sensitivity, aberrant salience, and threat anticipation are important psychological processes in the development of psychotic experiences in daily life in the early stages of the disorder. ..
- Virtual reality in the psychological treatment for mental health problems: An systematic review of recent evidenceLucia R Valmaggia
King s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom South London and Maudsley NHH Trust, London, United Kingdom Electronic address
Psychiatry Res 236:189-95. 2016..The reviewed studies confirm the effectiveness of VRT compared to treatment as usual, and show similar effectiveness when VRT is compared to conventional treatments. Current developments and future research are discussed. ..
- Serum brain-derived neurotrophic factor and cortical thickness are differently related in patients with schizophrenia and controlsAndré Zugman
Interdisciplinary Laboratory of Clinical Neurosciences LINC, Universidade Federal de Sao Paulo, Rua Pedro de Toledo, 669 3 andar fundos, Vila Clementino, Sao Paulo, SP, Brazil Department of Psychosis Study, Institute of Psychiatry, King s College London, 16 De Crespigny Park, SE5 8AF London, UK Electronic address
Psychiatry Res 234:84-9. 2015..BDNF levels and cortical thickness showed different patterns of correlation for patients and healthy controls in one cluster in the right hemisphere distributed across the supramarginal, postcentral, and inferior frontal cortices. ..
- How can neuroimaging facilitate the diagnosis and stratification of patients with psychosis?Matthew J Kempton
Department of Psychosis Studies, Institute of Psychiatry, King s College London, UK Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK Electronic address
Eur Neuropsychopharmacol 25:725-32. 2015..As many of these developments are already being applied in neuroimaging studies of Alzheimer's disease, we discuss what lessons have been learned from this field and how they may be applied to research in psychosis...
- Facial affect processing deficits in schizophrenia: a meta-analysis of antipsychotic treatment effectsAnthony S Gabay
Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
J Psychopharmacol 29:224-9. 2015..This highlights the need for further investigation into the neuropharmacological mechanisms associated with accurate emotion processing, to inform treatment options for these deficits in schizophrenia. ..
- Hippocampal hypertrophy and sleep apnea: a role for the ischemic preconditioning?Ivana Rosenzweig
Department of Neuroimaging, Institute of Psychiatry, King s College, London, United Kingdom Danish Epilepsy Centre, Dianalund, Denmark
PLoS ONE 8:e83173. 2013..The role for the ischemia/hypoxia preconditioning in the neuropathology of OSA is herein indicated, with possible further reaching clinical implications. ..
- Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical riskPaolo Fusar-Poli
Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
Arch Gen Psychiatry 69:220-9. 2012..However, the risk of transition to psychosis varies between centers, and some recent work suggests that the risk of transition may be declining...
- Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depressionLuke Clark
University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
Biol Psychiatry 57:183-7. 2005..This study aimed to replicate a deficit in sustained attention in euthymic bipolar patients and investigate sustained attention in first-degree relatives of bipolar probands and in remitted patients with major depressive disorder...