C G Kelly
Affiliation: King's College London
- DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4Karolin Hijazi
King s College London, Dental Institute, Oral Immunology, Tower Wing, Guy s Hospital, London, United Kingdom
PLoS ONE 6:e28307. 2011..DC-SIGN binding to the HIV envelope protein effectively increases exposure of the CD4 binding site, which in turn contributes to enhancement of infection...
- Anti-adhesive strategies in the prevention of infectious disease at mucosal surfacesC G Kelly
Department of Oral Medicine and Pathology, Floor 28 Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Expert Opin Investig Drugs 9:1711-21. 2000..Development of these novel antimicrobial agents is particularly timely in view of the increasing concern over the spread of antibiotic resistance...
- Specific microbicides in the prevention of HIV infectionC G Kelly
King s College London, Dental Institute, London, UK
J Intern Med 270:509-19. 2011....
- A synthetic peptide adhesion epitope as a novel antimicrobial agentC G Kelly
Department of Immunology, United Medical and Dental Schools of Guy s and St Thomas Hospitals, London, UK
Nat Biotechnol 17:42-7. 1999..This novel antimicrobial strategy, applying competitive peptide inhibitors of adhesion, may be used against other microorganisms in which adhesins mediate colonization of mucosal surfaces...
- CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokinesY Wang
Peter Gorer Department of Immunobiology, Guy's, King's, and St. Thomas' Medical School, KCL, London, United Kingdom
Immunity 15:971-83. 2001..Coimmunoprecipitation of Mtb HSP70 with CD40 indicates a physical association between these molecules. The results suggest that CD40 is critical in microbial HSP70 binding and stimulation of RANTES production...
- Functional domains of HSP70 stimulate generation of cytokines and chemokines, maturation of dendritic cells and adjuvanticityT Lehner
Mucosal Immunology Unit, Guy s, King s and St Thomas Hospital Medical and Dental Schools, London SE1 9RT, UK
Biochem Soc Trans 32:629-32. 2004..HSP70-CD40 interaction has been demonstrated in non-human primates to play a role in HIV infection, in protection against Mycobacterium tuberculosis and in conversion of tolerance to immunity...
- Tumour necrosis factor-alpha production stimulated by heat shock protein 70 and its inhibition in circulating dendritic cells and cells eluted from mucosal tissues in Crohn's diseaseT Whittall
Mucosal Immunology Unit and Dept of Oral Immunology, Guy s, King s and St Thomas Medical and Dental Schools, Guy s Hospital, London SE1 9RT, UK
Clin Exp Immunol 143:550-9. 2006..These inhibitory peptides target the CD40-CD40L and the emerging CD40-HSP70 co-stimulatory pathway. Our findings offer a novel strategy to prevent excessive production of TNF-alpha in Crohn's disease...