Affiliation: King's College London
- Determining the minimum clinically important differences for outcomes in the DOMINO trialRobert Howard
King s College London, Institute of Psychiatry, Department of Old Age Psychiatry, London, UK
Int J Geriatr Psychiatry 26:812-7. 2011..Many dementia treatment randomised controlled trials (RCTs) have not reported MCIDs and, where they have been done, observed differences have not reached these...
- Donepezil and memantine for moderate-to-severe Alzheimer's diseaseRobert Howard
Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
N Engl J Med 366:893-903. 2012..Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease...
- Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trialIracema Leroi
Institute of Brain, Behaviour and Mental Health, University of Manchester, Jean McFarlane Building, 3rd Floor, Oxford Rd, Manchester M13 9PL, UK
Trials 14:349. 2013....
- Cost-effectiveness of transcranial magnetic stimulation vs. electroconvulsive therapy for severe depression: a multi-centre randomised controlled trialMartin Knapp
Centre for the Economics of Mental Health, King s College London, Institute of Psychiatry, UK
J Affect Disord 109:273-85. 2008..Electroconvulsive therapy (ECT) has a long history of use in treating depression. Repetitive transcranial magnetic stimulation (rTMS) has been introduced more recently to the treatment spectrum. Its cost-effectiveness has not been explored...
- Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analysesRobert Howard
Division of Psychiatry, University College London, London, UK Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK Electronic address
Lancet Neurol 14:1171-81. 2015..We investigated the effects of continuation or discontinuation of donepezil and starting of memantine on subsequent nursing home placement in patients with moderate-to-severe Alzheimer's disease...
- Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)Clive Ballard
Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, UK
Am J Geriatr Psychiatry 17:726-33. 2009..Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way...
- Misunderstanding the intentions of others: an exploratory study of the cognitive etiology of persecutory delusions in very late-onset schizophrenia-like psychosisRosanna Moore
Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
Am J Geriatr Psychiatry 14:410-8. 2006..The objective of this study was to explore the cognitive etiology of persecutory delusion formation and maintenance in very late-onset schizophrenia-like psychosis (SLP)...
- The Effect of an Online Cognitive Training Package in Healthy Older Adults: An Online Randomized Controlled TrialAnne Corbett
Wolfson Centre for Age Related Diseases, King s College London, London, UK
J Am Med Dir Assoc 16:990-7. 2015..Online delivery provides a cost-effective means of implementing CT compared with in-person interventions, with the potential of providing an effective public health intervention for risk reduction...
- Differences between Alzheimer's disease and dementia with Lewy bodies: an fMRI study of task-related brain activityJustin Sauer
King s College London, MRC Centre for Neurodegeneration Research, Section of Old Age Psychiatry, Institute of Psychiatry London, UK
Brain 129:1780-8. 2006....
- Towards a therapeutic window of D2/3 occupancy for treatment of psychosis in Alzheimer's disease, with [18F]fallypride positron emission tomographyChloe Clark-Papasavas
Department of Old Age Psychiatry, Institute of Psychiatry, King s College London, London, UK
Int J Geriatr Psychiatry 29:1001-9. 2014..The study aimed to adapt [18F]fallypride imaging for use in occupancy studies in Alzheimer's disease (AD) and to investigate whether data acquisition could be made more tolerable by piloting the protocol in a small sample...
- Working memory task performance and chunking in early Alzheimer's diseaseJonathan Huntley
Department of Old Age Psychiatry, Institute of Psychiatry, King s College London, PO Box 70, London SE5 8AF, UK
Br J Psychiatry 198:398-403. 2011..Chunking is a powerful encoding strategy that significantly improves working memory performance in normal young people...
- The impact of journal advertisements on prescribers of cholinesterase inhibitorsJustin Sauer
Maudsley Hospital, South London and Maudlsey NHS Trust, London, UK
Int J Geriatr Psychiatry 17:976-8. 2002
- Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer diseaseSuzanne Reeves
Section of Old Age Psychiatry, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, Camberwell, London SE5 8AF, UK
Neurology 72:528-34. 2009..This study aimed to test the hypothesis that the symptom domains delusions and apathy would be associated with striatal dopamine (D2) receptor function in AD...
- A randomized, controlled trial with 6-month follow-up of repetitive transcranial magnetic stimulation and electroconvulsive therapy for severe depressionSavitha Eranti
Section of Old Age Psychiatry, Department of Biostatistics and Computing, Center for the Economics of Mental Health, Institute of Psychiatry, King s College London, and Department of Psychiatry, Pembury Hospital, Invicta Community Care NHS Trust, Kent, UK
Am J Psychiatry 164:73-81. 2007..The authors conducted a multicenter randomized, controlled trial to test the equivalence of rTMS with ECT...
- Neuroleptic drugs in dementia: benefits and harmClive Ballard
Medical Research Council Centre for Neurodegeneration Research, King s College London, De Crespigny Park, London SE5 8AF, UK
Nat Rev Neurosci 7:492-500. 2006..We recommend that these treatments be limited to the short-term treatment of psychiatric symptoms associated with serious distress or risk...
- The importance of high quality trials of cognitive interventions in Alzheimer's diseaseJonathan Huntley
Department of Old Age Psychiatry, King s College London, London, UK
Int Psychogeriatr 28:705-6. 2016..Exercise and cognitive-based interventions have received the most attention, but we are still a long way from understanding whether any can offer real benefit to patients with AD (Huntley et al., 2015). ..
- Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older peopleJoel T Dunn
St Thomas PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King s College London, London, UK
J Cereb Blood Flow Metab 33:1098-103. 2013..The adapted protocol is feasible for use across neuropsychiatric disorders in which dopamine has been implicated and is sufficiently sensitive to detect within-subject changes between 2.7% and 5.5% in striatal and limbic regions. ..
- Prescription of antipsychotics in people with dementiaClive Ballard
Clive Ballard, MD, MRCPsych, Anne Corbett, PhD, Wolfson Centre for Age Related Diseases, King s College London Robert Howard, MD, MRCPsych, Institute of Psychiatry, King s College London, UK
Br J Psychiatry 205:4-5. 2014..The study also suggests that antipsychotics may confer risks of increased mortality in older people without dementia. ..
- The cerebellum and decision making under uncertaintyNigel Blackwood
Division of Psychological Medicine, Institute of Psychiatry, PO Box 70, De Crespigny Park, London SE5 8AZ, UK
Brain Res Cogn Brain Res 20:46-53. 2004..We hypothesise that the neo-cerebellum constructs internal working models of uncertain events in the external world, and that such probabilistic models subserve the predictive capacity central to induction...
- Are Black Caribbean patients more likely to receive an incorrect diagnosis of very-late-onset schizophrenia-like psychosis than their white British counterparts?Suzanne Reeves
Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
Am J Geriatr Psychiatry 11:674-7. 2003....
- Tract-specific anisotropy measurements in diffusion tensor imagingRichard A Kanaan
King s College London, Institute of Psychiatry, London, UK
Psychiatry Res 146:73-82. 2006..The problems of both methods are explored, particularly of high variance and ROI definition. The potential benefits of the tractographic method for neuropsychiatric conditions with subtle and diffuse pathology are outlined...