Matthew J Hill
Affiliation: King's College London
- Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gainMatthew J Hill
Division of Psychiatry and Neuroscience, Queen s University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT97BL, UK
Pharmacogenomics 12:727-34. 2011..Establishing associated polymorphisms as causal variants may aid in the identification of the molecular mechanisms of phenotypic variation...
- Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: evidence of cis-acting variation and tissue specific regulationMatthew James Hill
Neuropsychiatric Genetics Research Group, Trinity College Dublin, Institute of Molecular Medicine, Ireland
Psychiatr Genet 21:281-6. 2011..To identify cis-acting regulatory variants influencing the expression of the schizophrenia susceptibility gene chitinase 3-like 1 gene (CHI3L1) in human lymphoblasts and post-mortem brain tissue...
- 5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activityMatthew J Hill
Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, James Street, Dublin, D8, Ireland
Brain Res 1149:14-7. 2007..Both -759C/T and -697G/C polymorphic sites are likely to play a role in basal promoter activity. Resistance to weight gain may, in part, be mediated by the consequences of reduced 5-HT(2C) receptor expression...
- Functionality of promoter microsatellites of arginine vasopressin receptor 1A (AVPR1A): implications for autismKatherine E Tansey
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
Mol Autism 2:3. 2011..abstract:..
- The 5-HT2C receptor and antipsychoticinduced weight gain - mechanisms and geneticsGavin P Reynolds
Division of Psychiatry and Neuroscience, Queen s University Belfast, Belfast, UK
J Psychopharmacol 20:15-8. 2006..These findings demonstrate the value of pharmacogenetics in determining liability to a major side effect of antipsychotic treatment, and indicate both the molecular and physiological mechanisms underlying this side effect...
- Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studiesKatherine E Tansey
Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin 8, Ireland
Neurosci Lett 474:163-7. 2010..Data presented here does not support the role of common genetic variation in OXTR in the aetiology of autism spectrum disorders in Caucasian samples...