Karen E Harman

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3
    K E Harman
    St John s Institute of Dermatology, King s Collrggr Hospita, London, UK
    Clin Exp Dermatol 25:236-40. 2000
  2. ncbi request reprint The use of two substrates to improve the sensitivity of indirect immunofluorescence in the diagnosis of pemphigus
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, and Department of Oral Medicine and Pathology, Guy s Hospital, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College, London, U K
    Br J Dermatol 142:1135-9. 2000
  3. ncbi request reprint A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 143:343-8. 2000
  4. ncbi request reprint The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 144:775-80. 2001
  5. ncbi request reprint New laboratory techniques for the assessment of acquired immunobullous disorders
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College, London, UK
    Clin Exp Dermatol 27:40-6. 2002
  6. ncbi request reprint The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris
    Karen E Harman
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 146:684-7. 2002
  7. pmc Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
    Dedee F Murrell
    Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia
    J Am Acad Dermatol 58:1043-6. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3
    K E Harman
    St John s Institute of Dermatology, King s Collrggr Hospita, London, UK
    Clin Exp Dermatol 25:236-40. 2000
    ..The Dsg 1 and Dsg 3 ELISAs also provided objective, quantitative, reproducible data which allowed differentiation of PV from PF and in view of these advantages, they are likely to become a routine technique in diagnostic laboratories...
  2. ncbi request reprint The use of two substrates to improve the sensitivity of indirect immunofluorescence in the diagnosis of pemphigus
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, and Department of Oral Medicine and Pathology, Guy s Hospital, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College, London, U K
    Br J Dermatol 142:1135-9. 2000
    ..This combination of substrates should not only increase the sensitivity of detecting pemphigus antibodies, but will aid in the differentiation of PV from PF. It is also possible that the data might be more useful for disease monitoring...
  3. ncbi request reprint A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 143:343-8. 2000
    ..Pemphigus vulgaris (PV) is characterized by pathogenic autoantibodies to desmoglein (Dsg) 3, but additional antibodies to Dsg1, the pemphigus foliaceus antigen, are detectable in some cases...
  4. ncbi request reprint The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Br J Dermatol 144:775-80. 2001
    ..However, IIF is not able to measure separately Dsg1 and 3 antibodies, unlike enzyme-linked immunosorbent assays (ELISA), which utilize recombinant proteins...
  5. ncbi request reprint New laboratory techniques for the assessment of acquired immunobullous disorders
    K E Harman
    St John s Institute of Dermatology, St Thomas Hospital, Guy s, King s and St Thomas School of Medicine and Dentistry, King s College, London, UK
    Clin Exp Dermatol 27:40-6. 2002
    ..The use of recombinant antigens has provided the latest generation of diagnostic techniques that are likely to make a major impact on routine diagnosis of immunobullous disorders...
  6. ncbi request reprint The transition of pemphigus vulgaris into pemphigus foliaceus: a reflection of changing desmoglein 1 and 3 autoantibody levels in pemphigus vulgaris
    Karen E Harman
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, U K
    Br J Dermatol 146:684-7. 2002
    ..It is not known whether the transition to PF is permanent or whether disease relapses in the future may be associated with the re-emergence of Dsg3 antibodies, oral ulceration and a PV phenotype...
  7. pmc Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
    Dedee F Murrell
    Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia
    J Am Acad Dermatol 58:1043-6. 2008
    ..These should assist in development of consistent reporting of outcomes in future studies...