C J Burns
Affiliation: King's College London
- Glucose-stimulated insulin secretion from rat islets of Langerhans is independent of mitogen-activated protein kinase activationC J Burns
Biomedical Sciences Division, King s College London, United Kingdom
Biochem Biophys Res Commun 239:447-50. 1997..These results suggest that although MAPK may be activated by insulin secretagogues in adult rodent islets, this can be dissociated from the exocytotic release of insulin...
- ERKs regulate cyclic AMP-induced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) geneS L Gyles
Endocrinology and Reproduction Research Group and The Randall Centre, Guy's, King's and St. Thomas's School of Biomedical Sciences, King's College London, London SE1 1UL, United Kingdom
J Biol Chem 276:34888-95. 2001..These observations suggest that the activation of ERK2/1 by increasing cAMP is an obligatory and regulated stage in the stimulation of steroid synthesis by cyclic AMP-generating stimuli...
- Interdependence of steroidogenesis and shape changes in Y1 adrenocortical cells: studies with inhibitors of phosphoprotein phosphatasesB J Whitehouse
Endocrinology and Reproduction Research Group, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 1UL, UK
J Endocrinol 172:583-93. 2002....
- Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymeraseM G LaPorte
ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, PA 19341, USA
Bioorg Med Chem Lett 16:100-3. 2006..These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series...