Genomes and Genes
David L H Bennett
Affiliation: King's College London
- Interview: Key questions in pain research: clinical observations informing research and vice versaDavid Bennett
Neurorestoration Group, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, London Bridge, London, SE1 1UL, UK
Pain Manag 1:123-5. 2011..He is a member of the Wellcome Trust-funded London Pain Consortium and Vice-Director of the 'Europain' Investigational Medicines Initiative. He is also an Associate Editor of Pain Management. ..
- Neurotrophic factors: important regulators of nociceptive functionD L Bennett
Dept Physiology, St Thomas Hospital Medical School, Lambeth Palace Rd, London, SE1 7EH, UK
Neuroscientist 7:13-7. 2001..This review highlights some of the key roles played by these molecules and in particular the role of NGF in the peripheral sensitization of nociceptors and brain-derived neurotrophic factor (BDNF) as a central pain modulator...
- Artemin has potent neurotrophic actions on injured C-fibresDavid L H Bennett
Wolfson Centre for Age Related Disease, King s College London, Guy s Campus, London, UK
J Peripher Nerv Syst 11:330-45. 2006..Given the potent neurotrophic actions of ARTN on C-fibres, it may therefore provide potential for the treatment of nerve injury, particularly in the maintenance of small fibre function...
- The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective studyD L H Bennett
Department of Neurorestoration, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, King s College London, London Bridge, London SE11UL, UK
J Neurol Neurosurg Psychiatry 79:1376-81. 2008..Previous studies have suggested that combined nerve and muscle biopsy (usually of the superficial peroneal nerve and peroneus brevis muscle) produces a higher diagnostic yield than nerve biopsy alone in the investigation of vasculitis...
- Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injuryMargarita Calvo
Wolfson Center for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
J Neurosci 30:5437-50. 2010..Furthermore, consequent to such changes, the mechanical pain-related hypersensitivity and cold allodynia were reduced. NRG1-erbB signaling therefore represents a novel pathway regulating the injury response of microglia...
- A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the ratJames R Perkins
The Wolfson Centre for Age Related Diseases, Wolfson Wing, Hodgkin Building, King s College London, Guy s Campus, London Bridge, London SE1 1UL, UK
Mol Pain 10:7. 2014..Finally we take advantage of the "agnostic" approach of RNA-seq to discover areas of expression outside of annotated exons that show marked changes in expression following nerve injury...
- Characterisation and mechanisms of bradykinin-evoked pain in man using iontophoresisKathryn J Paterson
Wolfson Centre for Age Related Disease, King s College London, London, UK
Pain 154:782-92. 2013..In naïve skin, B2R signaling predominates, however, cutaneous inflammation results in enhanced B1R responses...
- Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthoodFlorence R Fricker
Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
J Neurosci 31:3225-33. 2011..Juxtacrine Neuregulin-1 signaling is therefore dispensable for maintenance of the myelin sheath in adult animals but has a key role in reparative processes after nerve injury...
- PainNetworks: a web-based resource for the visualisation of pain-related genes in the context of their network associationsJames R Perkins
Institute of Structural and Molecular Biology, University College London, London, UK
Pain 154:2586.e1-12. 2013..We expect this resource to grow over time and become a valuable asset to the pain community. ..
- The mechanisms of microgliosis and pain following peripheral nerve injuryMargarita Calvo
Wolfson CARD, Kings College London, UK
Exp Neurol 234:271-82. 2012..Modulating microglial functions offers a novel therapeutic opportunity following nerve injury which ideally would involve reducing the pro-inflammatory nature of these cells whilst retaining their potential beneficial functions...
- α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damageRyan Patel
Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX1 2JD, United Kingdom, and University of Cincinnati, College of Medicine, Cincinnati, Ohio 45229
J Neurosci 33:16412-26. 2013..Thus, α2δ-1 is essential for rapid development of mechanical hypersensitivity in a nerve injury model of neuropathic pain. ..
- CXCL5 mediates UVB irradiation-induced painJohn M Dawes
Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
Sci Transl Med 3:90ra60. 2011..Our findings demonstrate that the chemokine CXCL5 is a peripheral mediator of UVB-induced inflammatory pain, likely in humans as well as rats...
- Neuregulin-1 controls an endogenous repair mechanism after spinal cord injuryKatalin Bartus
The Wolfson Centre for Age Related Diseases, Regeneration Group, King s College London, Guy s Campus, London Bridge, London, UK
Brain 139:1394-416. 2016..media-1vid110.1093/brain/aww039_video_abstractaww039_video_abstract. ..
- Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransductionKathryn Paterson
Wolfson Centre for Age Related Disease, King s College London, London
Ann Neurol 75:591-6. 2014..Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent...
- Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenanceFlorence R Fricker
Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
J Neurosci 29:7667-78. 2009..Sensory neuronal survival and axonal maintenance, however, are not dependent on axon-derived neuregulin-1 signaling in adulthood...
- Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritisMatthew Thakur
Neuropharmacology of Pain Group, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
PLoS ONE 7:e33730. 2012..This significant neuropathic component needs to be taken into account when interpreting studies using this model, particularly at doses greater than 1 mg MIA...
- Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stagesNicholas D James
The Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
J Neurosci 31:18543-55. 2011..Thus, using a clinically relevant SCI model, we have identified a population of axons present at chronic injury stages that are intact but fail to conduct and are therefore a prime target for therapeutic strategies to restore function...
- Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathwayMargarita Calvo
Wolfson CARD, Kings College London, Hodgkin Building, Guys Campus, SE1 1UL, London, United Kingdom
Glia 59:554-68. 2011....
- Relationship between dry eye symptoms and pain sensitivityJelle Vehof
Department of Twin Research and Genetic Epidemiology, King s College London, St Thomas Hospital, Waterloo, London, England2Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands
JAMA Ophthalmol 131:1304-8. 2013..Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these symptoms and objective signs at the ocular surface...
- ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) dataJames R Perkins
Institute of Structural and Molecular Biology, University College of London, London, UK
BMC Genomics 13:296. 2012..So far nothing in R exists to unite these methods, together with other functions to read in and normalise the data using the chosen reference gene(s)...
- The role of the immune system in the generation of neuropathic painMargarita Calvo
Department of Neurorestoration, Wolfson CARD, King s College London, London, UK
Lancet Neurol 11:629-42. 2012..An important challenge for the future is to establish to what extent this immune response initiates or maintains neuropathic pain in patients and thus whether it is amenable to therapy...
- A gain-of-function mutation in TRPA1 causes familial episodic pain syndromeBarbara Kremeyer
Department of Genetics, Evolution and Environment, University College London, London, UK
Neuron 66:671-80. 2010..TRPA1 antagonists inhibit the mutant channel, promising a useful therapy for this disorder. Our findings provide evidence that variation in the TRPA1 gene can alter pain perception in humans...
- The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathyAndreas C Themistocleous
aNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdombDiabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomcStructural and Molecular Biology, Division of Biosciences, University College London, London, United KingdomdPain Research Group, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, United KingdomePain Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom
Pain 157:1132-45. 2016..3%) with NeuP. This study provides a firm basis to rationalise further phenotyping of painful DPN, for instance, stratification of patients with DPN for analgesic drug trials. ..
- Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling studyTudor J C Phillips
Pain Research Group, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK
Pain 155:1846-60. 2014..HIV-SN participants had higher plasma triglyceride, concentrations depression, anxiety and catastrophizing scores, and prevalence of insomnia than HIV participants without HIV-SN. ..
- Systems biology approaches to finding novel pain mediatorsAna Antunes-Martins
The Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London, UK
Wiley Interdiscip Rev Syst Biol Med 5:11-35. 2013....
- Molecular forms of NGF in human and rat neuropathic tissues: decreased NGF precursor-like immunoreactivity in human diabetic skinYiangos Yiangou
Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
J Peripher Nerv Syst 7:190-7. 2002..The different molecular forms derived from prepro-NGF are likely to be of importance in sensory mechanisms, and deserve further investigation...
- Crosstalk between the nociceptive and immune systems in host defence and diseaseStephen B McMahon
King s College London, Wolfson Centre for Age Related Diseases, Guy s Campus, London SE1 1UL, UK
Nat Rev Neurosci 16:389-402. 2015....
- Intermediate Charcot-Marie-Tooth disease due to a novel Trp101Stop myelin protein zero mutation associated with debilitating neuropathic painJuan D Ramirez
Wolfson Centre for Age Related Diseases, King s College London, London, UK
Pain 153:1763-8. 2012..In this kindred, the neuropathy was relatively mild in severity, however, neuropathic pain was an important and disabling outcome...