Genomes and Genes
M Albert Basson
Affiliation: King's College London
- Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during developmentM Albert Basson
Department of Anatomy and Program in Developmental Biology, University of California San Francisco, CA 94158, USA
Development 135:889-98. 2008..We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development...
- Signaling in cell differentiation and morphogenesisM Albert Basson
Department of Craniofacial Development, King s College London, United Kingdom
Cold Spring Harb Perspect Biol 4:. 2012..I also discuss how signaling pathways downstream from these signals are regulated and how they induce specific cellular responses that ultimately affect cell fate and morphogenesis...
- Functional Insights into Chromatin Remodelling from Studies on CHARGE SyndromeM Albert Basson
King s College London, Department of Craniofacial Development and Stem Cell Biology and MRC Centre for Developmental Neurobiology, Floor 27, Guy s Hospital Tower Wing, London, SE1 9RT, UK Electronic address
Trends Genet 31:600-11. 2015..The emerging picture from this work suggests that the mechanisms by which CHD7 fine-tunes gene expression are context specific, consistent with the pleiotropic nature of CHARGE syndrome. ..
- Sprouty1 is a critical regulator of GDNF/RET-mediated kidney inductionM Albert Basson
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
Dev Cell 8:229-39. 2005..These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations...
- Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellumTian Yu
Department of Craniofacial Development, King s College London, London, UK
Development 138:2957-68. 2011..Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types...
- Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesisJennifer R Gardiner
Department of Craniofacial Development, King s College London, 27th Floor, Guy s Tower, London SE1 9RT, UK
Development 139:3456-66. 2012....
- Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1M Albert Basson
Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Dev Biol 299:466-77. 2006..Epithelial cysts develop in Spry1-deficient kidneys that share several molecular characteristics with those observed in human disease, suggesting that Spry1 null mice may be useful animal models for cystic hyperplasia...
- Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesisAbigail Jackson
Department of Craniofacial Development and Stem Cell Biology, King s College, London, United Kingdom
Dev Dyn 243:1143-51. 2014..In particular, the question as to how Tbx1 expression in the pharyngeal endoderm regulates pharyngeal pouch morphogenesis in the mouse embryo is not known...
- Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signalingSubreena Simrick
Department of Craniofacial Development and Stem Cell Biology, King s College London, Guy s Tower, London, United Kingdom
Dev Dyn 241:1310-24. 2012..Heterozygosity of Tbx1, the mouse homolog of the candidate TBX1 gene, results in mild defects dependent on genetic background, whereas complete inactivation results in severe malformations in multiple tissues...
- Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palateAndrew D Economou
Department of Craniofacial Development, King s College London, UK
Nat Genet 44:348-51. 2012..These findings demonstrate a reaction-diffusion mechanism that is likely to be widely relevant in vertebrate development...
- Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryoSubreena Simrick
Department of Craniofacial Development, King s College London, Floor 27, Guy s Tower, London, SE1 9RT, UK
Dev Biol 358:147-55. 2011....
- Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndromeTian Yu
Department of Craniofacial Development and Stem Cell Biology, King s College London, London, United Kingdom
elife 2:e01305. 2013..DOI: http://dx.doi.org/10.7554/eLife.01305.001. ..
- Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase CSimge Akbulut
Division of Hematology and Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Biol Cell 21:3487-96. 2010..These data highlight an important action of Spry, which may allow these proteins to influence signaling through multiple receptors...
- Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain regionWei Lin
Medical Research Council, National Institute for Medical Research, London, UK
Genesis 41:110-5. 2005..Altogether, our results demonstrate that Sef and Sproutys function synergistically to regulate Gbx2 expression in the anterior hindbrain...
- Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum developmentJames M Clegg
Centre for Integrative Physiology, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom, Centre for Glycobiology, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom, and Department of Craniofacial Development and Stem Cell Biology, King s College London, London SE5 9RW, United Kingdom
J Neurosci 34:2389-401. 2014..Overall, our data fit a model in which Hs2st and Hs6st1 normally generate conditions conducive to CC development by generating an HS-containing environment that keeps Erk signaling in check. ..
- Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in miceVictoria Randall
Molecular Medicine Unit, Institute of Child Health, London, United Kingdom
J Clin Invest 119:3301-10. 2009..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
- CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampusKieran M Jones
King s College London, Department of Craniofacial Development and Stem Cell Biology, Guy s Hospital Tower Wing, London, UK
Stem Cells 33:196-210. 2015..As CHD7 haplo-insufficiency is associated with a range of cognitive disabilities in CHARGE syndrome, our observations may have implications for understanding the basis of these deficits...
- Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signalingJacqueline M Mason
Mount Sinai School of Medicine, Department of Medicine, Division of Hematology and Oncology, Box 1079, One Gustave L Levy Place, New York, NY 10029, USA
Trends Cell Biol 16:45-54. 2006..New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response...
- Expression of fibroblast growth factors (Fgfs) in murine tooth developmentThantrira Porntaveetus
Department of Craniofacial Development, Dental Institute, King s College London, Guy s Hospital, London, UK
J Anat 218:534-43. 2011..We also analysed teeth in Fgf15(-/-) and Fgf15(-/-) ;Fgf8(+/-) mutant mice. Neither mutant showed significant abnormalities in tooth development, indicating likely functional redundancy...
- Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and developmentYuichiro Yaguchi
Department of Craniofacial Development, MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London, United Kingdom
Dev Dyn 238:2058-72. 2009..These data suggest that FGF signaling functions throughout cerebellar development to regulate many processes that shape the formation of a functional cerebellum...
- Itch-/- alphabeta and gammadelta T cells independently contribute to autoimmunity in Itchy miceValentino Parravicini
Division of Molecular Immunology, Medical Research Council, National Institute for Medical Research, London, UK
Blood 111:4273-7282. 2008..In addition, disruption of Itch in innate gammadelta T cells can influence autoimmune pathology and might therefore require distinct therapeutic intervention...
- An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisorsOphir D Klein
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
Development 135:377-85. 2008..These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult...