Philip Asherson

Summary

Affiliation: King's College London
Country: UK

Publications

  1. doi request reprint Adult attention-deficit hyperactivity disorder: key conceptual issues
    Philip Asherson
    MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King s College London, London, UK Electronic address
    Lancet Psychiatry 3:568-78. 2016
  2. doi request reprint The effects of atomoxetine on emotional control in adults with ADHD: An integrated analysis of multicenter studies
    P Asherson
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park SE5 8AF, United Kingdom Electronic address
    Eur Psychiatry 30:511-20. 2015
  3. pmc Efficacy of atomoxetine in adults with attention deficit hyperactivity disorder: an integrated analysis of the complete database of multicenter placebo-controlled trials
    Philip Asherson
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, London, UK
    J Psychopharmacol 28:837-46. 2014
  4. pmc Management of adult attention deficit hyperactivity disorder in UK primary care: a survey of general practitioners
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    Health Qual Life Outcomes 11:22. 2013
  5. pmc Persistence of pharmacological treatment into adulthood, in UK primary care, for ADHD patients who started treatment in childhood or adolescence
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Psychiatry 12:219. 2012
  6. pmc The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Pediatr 12:78. 2012
  7. pmc Adult ADHD patient experiences of impairment, service provision and clinical management in England: a qualitative study
    Lauren Matheson
    Department of Clinical Health care, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0FL, UK
    BMC Health Serv Res 13:184. 2013
  8. pmc Rates of undiagnosed attention deficit hyperactivity disorder in London drug and alcohol detoxification units
    Zoe Huntley
    MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Kings College London, London, SE 58AF, UK
    BMC Psychiatry 12:223. 2012
  9. pmc European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
    Sandra J J Kooij
    PsyQ, psycho medische programma s, Department Adult ADHD, Carel Reinierszkade 197, Den Haag, The Netherlands
    BMC Psychiatry 10:67. 2010
  10. doi request reprint Quantitative and molecular genetics of ADHD
    Philip Asherson
    MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Kings College London, London, UK
    Curr Top Behav Neurosci 9:239-72. 2012

Collaborators

Detail Information

Publications82

  1. doi request reprint Adult attention-deficit hyperactivity disorder: key conceptual issues
    Philip Asherson
    MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King s College London, London, UK Electronic address
    Lancet Psychiatry 3:568-78. 2016
    ....
  2. doi request reprint The effects of atomoxetine on emotional control in adults with ADHD: An integrated analysis of multicenter studies
    P Asherson
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park SE5 8AF, United Kingdom Electronic address
    Eur Psychiatry 30:511-20. 2015
    ..To investigate the effects of atomoxetine on emotional control in adults with ADHD...
  3. pmc Efficacy of atomoxetine in adults with attention deficit hyperactivity disorder: an integrated analysis of the complete database of multicenter placebo-controlled trials
    Philip Asherson
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, London, UK
    J Psychopharmacol 28:837-46. 2014
    ..3% vs 25.3% in the short-term and 44.0% vs 31.4% after six months (all p<0.001). Overall, ATX had a clinically significant effect in adults with ADHD, with reductions in core symptoms and clinically meaningful responder rates...
  4. pmc Management of adult attention deficit hyperactivity disorder in UK primary care: a survey of general practitioners
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    Health Qual Life Outcomes 11:22. 2013
    ....
  5. pmc Persistence of pharmacological treatment into adulthood, in UK primary care, for ADHD patients who started treatment in childhood or adolescence
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Psychiatry 12:219. 2012
    ....
  6. pmc The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care
    Suzanne McCarthy
    School of Pharmacy, University College Cork, Cork, Ireland
    BMC Pediatr 12:78. 2012
    ..The aim of this study was to investigate the annual prevalence and incidence of pharmacologically treated ADHD in children, adolescents and adults in UK primary care...
  7. pmc Adult ADHD patient experiences of impairment, service provision and clinical management in England: a qualitative study
    Lauren Matheson
    Department of Clinical Health care, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0FL, UK
    BMC Health Serv Res 13:184. 2013
    ....
  8. pmc Rates of undiagnosed attention deficit hyperactivity disorder in London drug and alcohol detoxification units
    Zoe Huntley
    MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Kings College London, London, SE 58AF, UK
    BMC Psychiatry 12:223. 2012
    ..One of the most prevalent and impairing comorbidities of ADHD in adults are substance use disorders. We estimate rates of ADHD in patients with substance abuse disorders and delineate impairment in the co-morbid group...
  9. pmc European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
    Sandra J J Kooij
    PsyQ, psycho medische programma s, Department Adult ADHD, Carel Reinierszkade 197, Den Haag, The Netherlands
    BMC Psychiatry 10:67. 2010
    ..The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe...
  10. doi request reprint Quantitative and molecular genetics of ADHD
    Philip Asherson
    MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Kings College London, London, UK
    Curr Top Behav Neurosci 9:239-72. 2012
    ....
  11. doi request reprint Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD
    Kaixin Zhou
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:1481-7. 2008
    ..Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD...
  12. ncbi request reprint The serotonin transporter gene as a QTL for ADHD
    Sarah Curran
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 134:42-7. 2005
    ..0054 for the global test and an empirical P value = 0.00081 for the largest local test. Thus, we show here that SLC6A4, which has a major influence on brain serotonin availability, may be a QTL for ADHD...
  13. ncbi request reprint A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy
    Keeley Joanne Brookes
    Medical Research Council Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 63:74-81. 2006
    ..The dopamine transporter gene (DAT1) is associated with ADHD in several studies, with an average 1.2 odds ratio and evidence of heterogeneity across data sets...
  14. doi request reprint High-density SNP screen of sodium channel genes by haplotype tagging and DNA pooling for association with idiopathic generalized epilepsy
    Andrew Makoff
    Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London, United Kingdom
    Epilepsia 51:694-8. 2010
    ..The association of rs3943809 with the febrile seizure subgroup (p = 0.0004) remains significant after the conservative Bonferroni correction for multiple testing...
  15. pmc Cognitive-electrophysiological indices of attentional and inhibitory processing in adults with ADHD: familial effects
    Gráinne McLoughlin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Behav Brain Funct 7:26. 2011
    ..We now compare these data further to additional data from first-degree relatives (fathers) of children with ADHD to identify whether this pattern of abnormal processing shares familial influences with ADHD in adults...
  16. ncbi request reprint Population differences in the International Multi-Centre ADHD Gene Project
    Benjamin M Neale
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genet Epidemiol 32:98-107. 2008
    ..Any case-control sample employing an Israeli sample with Northern Europeans must consider stratification. A Northern European tag set, however, appears to be appropriate for capturing the variation across populations...
  17. doi request reprint DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage
    Wai Chen
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:1450-60. 2008
    ..In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings...
  18. pmc Hyperactive-impulsive symptom scores and oppositional behaviours reflect alternate manifestations of a single liability
    Alexis C Wood
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London, SE5 8AF, UK
    Behav Genet 39:447-60. 2009
    ..In middle childhood, symptoms of hyperactivity-impulsivity and oppositional behaviour may represent the same underlying liability, whereas the inattentive domain is more distinct...
  19. doi request reprint Is overactivity a core feature in ADHD? Familial and receiver operating characteristic curve analysis of mechanically assessed activity level
    Alexis C Wood
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Am Acad Child Adolesc Psychiatry 48:1023-30. 2009
    ..Furthermore, we aimed to investigate the degree of shared familial influences on these measures and the ADHD diagnosis...
  20. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
    ..57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD...
  21. pmc Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    BMC Psychiatry 7:10. 2007
    ....
  22. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
    ..Only few studies have reported association between promoter polymorphisms of the gene and ADHD...
  23. pmc Genome-wide association scan of attention deficit hyperactivity disorder
    Benjamin M Neale
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:1337-44. 2008
    ..We additionally identify a systemic bias in family-based association, and suggest that variable missing genotype rates may be the source of this bias...
  24. pmc High heritability for a composite index of children's activity level measures
    Alexis C Wood
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, P O Box 80, De Crespigny Park, London SE5 8AF, UK
    Behav Genet 38:266-76. 2008
    ..The high heritabilities found are encouraging in this respect...
  25. pmc Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings
    Kaixin Zhou
    MRC Social Genetic Developmental and Psychiatry Centre, King s College London, London, UK
    Biol Psychiatry 64:571-6. 2008
    ..The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL)...
  26. pmc Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components
    Gráinne McLoughlin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    J Abnorm Child Psychol 35:999-1008. 2007
    ..This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder...
  27. ncbi request reprint Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder
    Keeley J Brookes
    MRC Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Biol Psychiatry 60:1053-61. 2006
    ....
  28. pmc Performance monitoring is altered in adult ADHD: a familial event-related potential investigation
    Gráinne McLoughlin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE58AF, UK
    Neuropsychologia 47:3134-42. 2009
    ..It is not yet known whether these processes show the same abnormalities and familial effects in adults...
  29. pmc Genetic influences on attention deficit hyperactivity disorder symptoms from age 2 to 3: a quantitative and molecular genetic investigation
    Nicholas E Ilott
    SGDP Research Centre, Institute of Psychiatry, Kings College, London, UK
    BMC Psychiatry 10:102. 2010
    ..A further objective in the study was to observe whether genetic association with a number of candidate markers reflects results from the quantitative genetic analysis...
  30. ncbi request reprint DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London
    Am J Med Genet B Neuropsychiatr Genet 134:115-8. 2005
    ..We conclude that none of the markers show significant evidence of association with ADHD although we cannot rule out small genetic effects...
  31. doi request reprint Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample
    Angelica Ronald
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 49:535-42. 2008
    ..This study takes an individual differences approach to determine the degree of phenotypic and aetiological overlap between autistic traits and ADHD behaviours in the general population...
  32. pmc Why cognitive performance in ADHD may not reveal true potential: findings from a large population-based sample
    Jonna Kuntsi
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park Box P080, London SE5 8AF, UK
    J Int Neuropsychol Soc 15:570-9. 2009
    ..The degree to which cognitive impairments in ADHD can be modulated by energetic or motivational factors has important implications for clinical and educational interventions...
  33. ncbi request reprint Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
    Philip Asherson
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, SE5 8AF UK
    Am J Psychiatry 164:674-7. 2007
    ....
  34. pmc Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Behav Brain Funct 6:48. 2010
    ..A recent study has reported that a polymorphism (rs1801260) at the 3'-untranslated region of the CLOCK gene is associated with adult ADHD...
  35. ncbi request reprint Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B
    Jonathan Mill
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 133:68-73. 2005
    ....
  36. pmc Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study
    Charlotte Tye
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    J Child Psychol Psychiatry 53:706-15. 2012
    ..Very low-frequency (VLF; <0.5 Hz) electroencephalographic (EEG) activity represents a promising indicator of risk for ADHD, but it currently remains unclear as to whether it is heritable or genetically linked to the disorder...
  37. pmc Electrophysiological evidence for abnormal preparatory states and inhibitory processing in adult ADHD
    Gráinne McLoughlin
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Behav Brain Funct 6:66. 2010
    ..It is not yet known if this pattern of abnormal processing is evident in adult ADHD...
  38. pmc DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls
    Yannis Paloyelis
    MRC SDGP Centre, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 35:2414-26. 2010
    ..The lack of magnitude effects in the hypothetical task suggests that discounting in this task may be influenced by different processes in ADHD-CT than in healthy controls...
  39. pmc The genetic association between ADHD symptoms and reading difficulties: the role of inattentiveness and IQ
    Yannis Paloyelis
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Abnorm Child Psychol 38:1083-95. 2010
    ....
  40. ncbi request reprint Family-based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: no evidence for association in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 139:11-3. 2005
    ..Although we found some evidence for the preferential transmission of a rare haplotype (long-allele/9-repeat-allele/T-allele; chi2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone...
  41. pmc Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder
    Yannis Paloyelis
    King s College London, Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, UK
    J Am Acad Child Adolesc Psychiatry 51:722-732.e9. 2012
    ..We investigated striatal responsivity to rewards in ADHD combined type (ADHD-CT) using functional magnetic resonance imaging (fMRI), and whether it is modulated by variation in the dopamine transporter gene (DAT1)...
  42. pmc Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    BMC Res Notes 6:29. 2013
    ..In this study we examine the role of the rs1344706 polymorphism that previously showed association with BD and is known to alter expression of the gene in two clinical family-based ADHD samples from the UK and Taiwan...
  43. pmc A longitudinal twin study on the association between ADHD symptoms and reading
    Corina U Greven
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 53:234-42. 2012
    ..However, the stability and change of these genetic influences and the predictive relationships underlying this association longitudinally remain unclear...
  44. pmc Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder
    Kaixin Zhou
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 147:1392-8. 2008
    ..In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes...
  45. pmc Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects
    Penny Andreou
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 37:1703-15. 2007
    ..Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD...
  46. pmc No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study
    Keeley Joanne Brookes
    MRC Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    BMC Med Genet 6:31. 2005
    ..Here we investigate two markers within the DRD4 gene in a Taiwanese population, the exon 3 variable number tandem repeat (VNTR) and a 5' 120 base-pair duplication...
  47. pmc Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ
    Celeste H M Cheung
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 53:864-73. 2012
    ..This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs...
  48. pmc Cognitive and neurophysiological markers of ADHD persistence and remission
    Celeste H M Cheung
    Celeste H M Cheung, MSc, King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King s College London, UK Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland Tobias Banaschewski, MD, PhD, Gifu University
    Br J Psychiatry 208:548-55. 2016
    ..Attention-deficit hyperactivity disorder (ADHD) persists in around two-thirds of individuals in adolescence and early adulthood...
  49. pmc Commonalities in EEG Spectral Power Abnormalities Between Women With ADHD and Women With Bipolar Disorder During Rest and Cognitive Performance
    Anna Sophie Rommel
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK
    Brain Topogr 29:856-866. 2016
    ..82, p = 0.084) groups. Our results provide evidence for commonalities in brain dysfunction between ADHD and BD. Absolute theta power may play a role as a marker of neurobiological processes in both disorders...
  50. ncbi request reprint Genetic influences on mechanically-assessed activity level in children
    Alexis C Wood
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, UK
    J Child Psychol Psychiatry 48:695-702. 2007
    ..Yet it is poorly understood, due partly to limitations on parent and teacher ratings, which are typically used as measurements of these symptoms...
  51. pmc Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder
    Charlotte Tye
    MRC Social Genetic Developmental Psychiatry Centre SGDP, Institute of Psychiatry, London, UK
    Expert Rev Mol Med 13:e9. 2011
    ..Such research will aid in the precise characterisation of the clinical deficits seen in ADHD and guide the development of novel intervention and prevention strategies for those at risk...
  52. pmc Reaction time, inhibition, working memory and 'delay aversion' performance: genetic influences and their interpretation
    Jonna Kuntsi
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 36:1613-24. 2006
    ..We further aimed to illustrate how test-retest reliability of the measures affects the estimates...
  53. pmc Attention-Deficit/Hyperactivity Disorder Remission Is Linked to Better Neurophysiological Error Detection and Attention-Vigilance Processes
    Giorgia Michelini
    MRC Social, Genetic and Developmental Psychiatry Centre, London, United Kingdom
    Biol Psychiatry 80:923-932. 2016
    ..We examined whether cognitive and neurophysiological impairments on a performance-monitoring task distinguish between ADHD persisters and remitters...
  54. ncbi request reprint Attention-Deficit Hyperactivity Disorder in the post-genomic era
    Philip Asherson
    MRC Social Genetic Developmental, Psychiatry Research Centre, Institute of Psychiatry, Kings College London, De Crespigny Park, London SE5 8AF, UK
    Eur Child Adolesc Psychiatry 13:I50-70. 2004
    ..ADHD is a common and complex genetic disorder. Genetic risk factors are expected to be multiple, have small effect sizes when considered individually and to interact with each other and with environmental factors...
  55. doi request reprint A longitudinal twin study on the association between inattentive and hyperactive-impulsive ADHD symptoms
    Corina U Greven
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    J Abnorm Child Psychol 39:623-32. 2011
    ..Thus, hyperactivity-impulsivity may serve to exacerbate inattentiveness over time. Findings are discussed in the context of developmental changes in ADHD symptoms...
  56. pmc Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
    Jonathan Mill
    Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry SGDP Centre, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    BMC Genet 6:3. 2005
    ....
  57. ncbi request reprint Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood
    Jonna Kuntsi
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 57:647-54. 2005
    ....
  58. ncbi request reprint Attention deficit hyperactivity disorder
    Jonna Kuntsi
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuromolecular Med 8:461-84. 2006
    ..Such research is only at its beginning, but is illustrated by recent findings of an association between DAT1 and increased response variability in ADHD...
  59. pmc Actigraph data are reliable, with functional reliability increasing with aggregation
    Alexis C Wood
    Institute of Psychiatry, Kings College London, London, England
    Behav Res Methods 40:873-8. 2008
    ..We also examined possible instrumental effects on actigraph data and found these to be nonsignificant, further supporting the reliability and validity of actigraph data as a method of activity level assessment...
  60. pmc Are ADHD symptoms associated with delay aversion or choice impulsivity? A general population study
    Yannis Paloyelis
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    J Am Acad Child Adolesc Psychiatry 48:837-46. 2009
    ..In this study, we examined the association of attention-deficit/hyperactivity disorder (ADHD) symptoms with choice impulsivity and tested the specific hypothesis derived from delay aversion theory...
  61. pmc The aetiological association between the dynamics of cortisol productivity and ADHD
    Rebecca Pinto
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK
    J Neural Transm (Vienna) 123:991-1000. 2016
    ....
  62. pmc Self-report of ADHD shows limited agreement with objective markers of persistence and remittance
    Ebba Du Rietz
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, 16 De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom Electronic address
    J Psychiatr Res 82:91-9. 2016
    ..2015; Brit J Psychiat http://dx.doi.org/10.1192/bjp.bp.114.145185)...
  63. doi request reprint Caregiver burden as people with autism spectrum disorder and attention-deficit/hyperactivity disorder transition into adolescence and adulthood in the United Kingdom
    Tim Cadman
    Institute of Psychiatry, King s College London, UK
    J Am Acad Child Adolesc Psychiatry 51:879-88. 2012
    ..g., adhd)...
  64. pmc Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating
    Rachel H Flomen
    Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
    Eur J Hum Genet 21:76-81. 2013
    ..Four out of six previous association studies found association of different psychiatric phenotypes with the same 2-bp deletion allele...
  65. doi request reprint Increased cerebral perfusion in adult attention deficit hyperactivity disorder is normalised by stimulant treatment: a non-invasive MRI pilot study
    Ruth L O'Gorman
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 42:36-41. 2008
    ....
  66. doi request reprint Behavioral, neurocognitive and treatment overlap between attention-deficit/hyperactivity disorder and mood instability
    Caroline Skirrow
    MRC Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Expert Rev Neurother 9:489-503. 2009
    ..This research suggests that mood instability and symptoms of ADHD may be interlinked and that mood instability may be better understood as a core feature of the ADHD syndrome...
  67. pmc The IMAGE project: methodological issues for the molecular genetic analysis of ADHD
    Jonna Kuntsi
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Behav Brain Funct 2:27. 2006
    ....
  68. pmc Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Times
    Sarah Naomi James
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London
    Biol Psychiatry Cogn Neurosci Neuroimaging 1:539-547. 2016
    ..We used skin conductance (SC) as a measure of peripheral arousal and aimed to investigate its phenotypic and familial association with RTV in a large sample of ADHD and control sibling pairs...
  69. ncbi request reprint No association of single nucleotide polymorphisms in the micro-opioid receptor subunit gene with idiopathic generalized epilepsy
    Catherine Barratt
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, London, United Kingdom
    Epilepsia 47:1728-31. 2006
    ..Our results provide no support for association of A118G with either IAE or IGE and also exclude association in our sample of a small-to-moderate gene effect with IGE from a large part of OPRM1...
  70. ncbi request reprint Clinical assessment and treatment of attention deficit hyperactivity disorder in adults
    Philip Asherson
    MRC Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, London, SE5 8AF, UK
    Expert Rev Neurother 5:525-39. 2005
    ..Psychotherapeutic interventions also have an important role. These guidelines will assist psychiatrists and other adult mental health workers in identifying and treating individuals with adult ADHD...
  71. pmc Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits
    Rebecca Pinto
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 171:982-92. 2016
    ..2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc. ..
  72. pmc Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD
    Charlotte Tye
    King s College London, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK
    J Child Psychol Psychiatry 57:1414-1423. 2016
    ..However, it is not clear whether different indices of RTV and changes to RTV according to task conditions are able to discriminate between the two disorders...
  73. pmc Functional MRI in ADHD: a systematic literature review
    Yannis Paloyelis
    MRC Social Genetic Developmental Psychiatry Centre P080, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Expert Rev Neurother 7:1337-56. 2007
    ....
  74. doi request reprint Neurophysiological responses to faces and gaze direction differentiate children with ASD, ADHD and ASD+ADHD
    Charlotte Tye
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, UK
    Dev Cogn Neurosci 5:71-85. 2013
    ..Children with ASD+ADHD are an additive co-occurrence with deficits of both disorders. Elucidating the neural basis of the overlap between ASD and ADHD is likely to inform aetiological investigation and clinical assessment...
  75. ncbi request reprint European clinical guidelines for hyperkinetic disorder -- first upgrade
    Eric Taylor
    Dept of Child and Adolescent Psychiatry, Institute of Psychiatry Kings College London, De Crespigny Park, London, SE5 8AF, UK
    Eur Child Adolesc Psychiatry 13:I7-30. 2004
    ..The validity of clinical guidelines changes over time, because new evidence-based knowledge and experience develop...
  76. pmc Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Res Notes 2:71. 2009
    ..Several genes on the X chromosome have been studied as candidate risk factors for ADHD including the 5-HT2C receptor (HTR2C) gene. Association between polymorphisms in HTR2C and ADHD were reported in a recent study...
  77. pmc Association of Preterm Birth With Attention-Deficit/Hyperactivity Disorder-Like and Wider-Ranging Neurophysiological Impairments of Attention and Inhibition
    Anna Sophie Rommel
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, The Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
    J Am Acad Child Adolesc Psychiatry 56:40-50. 2017
    ..Yet data on direct comparisons across ADHD and preterm birth on cognitive-neurophysiological measures are limited...
  78. ncbi request reprint Validation of the Mind Excessively Wandering Scale and the Relationship of Mind Wandering to Impairment in Adult ADHD
    Florence D Mowlem
    Institute of Psychiatry, Psychology and Neuroscience, King s College London, UK
    J Atten Disord . 2016
    ..This study investigates excessive mind wandering (MW) in adult ADHD using a new scale: the Mind Excessively Wandering Scale (MEWS)...
  79. doi request reprint Are all the 18 DSM-IV and DSM-5 criteria equally useful for diagnosing ADHD and predicting comorbid conduct problems?
    Alexandra Garcia Rosales
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Eur Child Adolesc Psychiatry 24:1325-37. 2015
    ..Fourth, specific ADHD items are associated with ADHD + CD status. The DSM-IV diagnostic items were valid and not redundant; however, some carried more weight than others. All items were associated with impairment...
  80. doi request reprint Emotional lability, comorbidity and impairment in adults with attention-deficit hyperactivity disorder
    Caroline Skirrow
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
    J Affect Disord 147:80-6. 2013
    ..However, it is not known whether EL may be accounted for by comorbid psychiatric conditions or symptoms. This study evaluates the influence of comorbid clinical symptoms on EL, and investigates the relationship between EL and impairment...
  81. doi request reprint Under diagnosis of adult ADHD: cultural influences and societal burden
    Philip Asherson
    Institute of Psychiatry, London, UK
    J Atten Disord 16:20S-38S. 2012
    ..To explore the literature focusing on cultural influences in the diagnosis of adult ADHD and respective societal burden...
  82. pmc The identification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agencies
    Susan J Young
    King s College London, Institute of Psychiatry, UK
    BMC Psychiatry 11:32. 2011
    ..In time this will provide better justice for both offenders and society...