B H Anderton

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi request reprint Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK SE5 8AF
    Mol Med Today 6:54-9. 2000
  2. ncbi request reprint Ageing of the brain
    Brian H Anderton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
    Mech Ageing Dev 123:811-7. 2002
  3. ncbi request reprint Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
  4. ncbi request reprint Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry
    G M Gibb
    Department of Neuroscience, Institute of Psychiatry, London, UK
    FEBS Lett 485:99-103. 2000
  5. ncbi request reprint Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy
    G M Gibb
    Department of Neuroscience, Box PO 38, Institute of Psychiatry KCL, De Crespigny Park, London SE5 8AF, UK
    Brain Res Mol Brain Res 121:95-101. 2004
  6. ncbi request reprint Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, London, United Kingdom
    Neurobiol Aging 16:389-97; discussion 398-402. 1995
  7. ncbi request reprint Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau
    D A Latimer
    Department of Neuroscience, Institute of Psychiatry, London, UK
    FEBS Lett 365:42-6. 1995
  8. ncbi request reprint Quantitative analysis of tau isoform transcripts in sporadic tauopathies
    J W Connell
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Brain Res Mol Brain Res 137:104-9. 2005
  9. ncbi request reprint Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells
    T G Mack
    Department of Neuroscience and Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK
    Neuroscience 108:701-12. 2001
  10. ncbi request reprint Functional differences of tau isoforms containing 3 or 4 C-terminal repeat regions and the influence of oxidative stress
    M A Utton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 276:34288-97. 2001

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK SE5 8AF
    Mol Med Today 6:54-9. 2000
    ..Recent genetic discoveries provide some clues, suggesting that components of two developmentally important signalling pathways, Notch and wingless, or the vertebrate homologue of wingless, Wnt, are involved...
  2. ncbi request reprint Ageing of the brain
    Brian H Anderton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
    Mech Ageing Dev 123:811-7. 2002
    ..The interplay between genetic and environmental factors probably determines the degree of pathological brain ageing and whether or not individuals develop dementia...
  3. ncbi request reprint Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    C H Reynolds
    Department of Neuroscience, Institute of Psychiatry, King s College London, England
    J Neurochem 74:1587-95. 2000
    ..Thus, the three MAP kinases and GSK3beta are importantly all strong candidates as tau kinases that may be involved in the pathogenic hyperphosphorylation of tau in Alzheimer's disease...
  4. ncbi request reprint Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry
    G M Gibb
    Department of Neuroscience, Institute of Psychiatry, London, UK
    FEBS Lett 485:99-103. 2000
    ..Additionally, of the 15 peptides phosphorylated in the presence or absence of apoE, subtle differences, some isoform-specific, in the relative amounts of phosphorylation were observed...
  5. ncbi request reprint Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy
    G M Gibb
    Department of Neuroscience, Box PO 38, Institute of Psychiatry KCL, De Crespigny Park, London SE5 8AF, UK
    Brain Res Mol Brain Res 121:95-101. 2004
    ..We conclude that there is distinct molecular heterogeneity in the involvement of tau isoforms in the tau pathology in PSP...
  6. ncbi request reprint Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, London, United Kingdom
    Neurobiol Aging 16:389-97; discussion 398-402. 1995
    ..These results suggest that aberrant regulation of GSK-3 alpha/beta may be a pathogenic mechanism in Alzheimer's disease...
  7. ncbi request reprint Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau
    D A Latimer
    Department of Neuroscience, Institute of Psychiatry, London, UK
    FEBS Lett 365:42-6. 1995
    ..The findings imply that GSK-3 beta may be a stronger candidate than MAP kinase for inducing tau hyperphosphorylation in vivo...
  8. ncbi request reprint Quantitative analysis of tau isoform transcripts in sporadic tauopathies
    J W Connell
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Brain Res Mol Brain Res 137:104-9. 2005
    ....
  9. ncbi request reprint Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells
    T G Mack
    Department of Neuroscience and Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK
    Neuroscience 108:701-12. 2001
    ..We conclude that the missense tau mutations primarily result in an excess of neuronal tau, which may interfere with important cellular functions such as axonal transport...
  10. ncbi request reprint Functional differences of tau isoforms containing 3 or 4 C-terminal repeat regions and the influence of oxidative stress
    M A Utton
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 276:34288-97. 2001
    ....
  11. ncbi request reprint Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes
    J W Connell
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    FEBS Lett 493:40-4. 2001
    ..The findings imply that the R406W mutation in tau exerts long-range conformational effects on the structure of tau...
  12. ncbi request reprint Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease
    N J Cairns
    Department of Neuropathology, Institute of Psychiatry, De Crespigny Park, London, UK
    Neurosci Lett 230:49-52. 1997
    ..These data demonstrate that the tau in GCIs is different from the abnormally phosphorylated tau found in AD and is similar to normal adult tau. The mechanism causing the abnormal accumulation of tau in GCIs remains to be elucidated...
  13. ncbi request reprint Molecular motors implicated in the axonal transport of tau and alpha-synuclein
    Michelle A Utton
    Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 118:4645-54. 2005
    ....
  14. ncbi request reprint Presenilin 1 independently regulates beta-catenin stability and transcriptional activity
    R Killick
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    J Biol Chem 276:48554-61. 2001
    ....
  15. ncbi request reprint Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase
    Pascal Derkinderen
    Department of Neuroscience, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 25:6584-93. 2005
    ..These results show that phosphorylation of tau on Tyr-394 is a physiological event that is potentially part of a signal relay and suggest that Abl could have a pathogenic role in Alzheimer's disease...
  16. ncbi request reprint Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos
    N D James
    Ludwig Institute for Cancer Research, London, UK
    Neurobiol Aging 17:235-41. 1996
    ..These results suggest that activation of protein phosphorylation in neurons can result in changes in cytoskeletal proteins that might contribute to neuronal degeneration...
  17. ncbi request reprint The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies
    D P Hanger
    Department of Neuroscience, P O Box 38, Institute of Psychiatry KCL, De Crespigny Park, 8AF, London SE5, UK
    FEBS Lett 531:538-42. 2002
    ..Therefore the overall expression of individual tau isoforms does not predict which tau isoforms are deposited in all tauopathies and different mechanisms must operate that result in the deposition of specific tau isoforms...
  18. pmc Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments
    Steven Ackerley
    Department of Neuroscience, The Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
    J Cell Biol 161:489-95. 2003
    ..Thus, phosphorylation of NFH slows neurofilament transport, and this is due to increased pausing in neurofilament movement...
  19. ncbi request reprint Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, Department of Neuroscience, King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    J Biol Chem 282:23645-54. 2007
    ....
  20. ncbi request reprint Identification of phosphorylation sites on neurofilament proteins by nanoelectrospray mass spectrometry
    J C Betts
    Department of Neuroscience, The Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, United Kingdom
    J Biol Chem 272:12922-7. 1997
    ..The techniques used enable sequence data and characterization of posttranslational modifications to be obtained for each individual subunit directly from polyacrylamide gels...
  21. ncbi request reprint Alzheimer's disease: clues from flies and worms
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, King s College London, UK
    Curr Biol 9:R106-9. 1999
    ..Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked...
  22. ncbi request reprint Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
    Anirban R Saha
    Department of Neuroscience, PO Box 38, Institute of Psychiatry, King s College London, De Crespigny Park, London, SE5 8AF, UK
    J Cell Sci 117:1017-24. 2004
    ....
  23. ncbi request reprint New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
    D P Hanger
    Department of Neuroscience, Institute of Psychiatry, London, England, UK
    J Neurochem 71:2465-76. 1998
    ..We identified 22 phosphorylation sites in PHF-tau, including five sites not previously identified. The combination of our new data with previous reports shows that PHF-tau can be phosphorylated on at least 25 different sites...
  24. ncbi request reprint Kinase activities increase during the development of tauopathy in htau mice
    Ian Kelleher
    King s College London, Department of Neuroscience, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, London, UK
    J Neurochem 103:2256-67. 2007
    ..These data suggest that cdk5 and p38 may be associated with pathological changes in wild-type human tau during the progressive development of tauopathy...
  25. doi request reprint Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease
    Wendy Noble
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, Department of Neuroscience, PO37, De Crespigny Park, London, SE5 8AF, UK
    FASEB J 23:739-50. 2009
    ..These results suggest a possible novel therapeutic role for minocycline in the treatment of AD and related tauopathies...
  26. doi request reprint Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
    Diane P Hanger
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
    Trends Mol Med 15:112-9. 2009
    ..A list of tau phosphorylation sites identified in the tauopathies and in controls accompanies this review...
  27. doi request reprint Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin
    Inmaculada Cuchillo-Ibanez
    MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry P037, De Crespigny Park, SE5 8AF London, UK
    FASEB J 22:3186-95. 2008
    ..Hyperphosphorylated tau in Alzheimer's disease appearing first in distal portions of axons may result from aberrant axonal transport of phosphorylated tau reported here...
  28. doi request reprint Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    C Hugh Reynolds
    The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
    J Biol Chem 283:18177-86. 2008
    ....
  29. ncbi request reprint Dynamic properties of APC-decorated microtubules in living cells
    Rejith Dayanandan
    Department of Neuroscience, Institute of Psychiatry, King s College London, United Kingdom
    Cell Motil Cytoskeleton 54:237-47. 2003
    ....
  30. ncbi request reprint The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons
    Michelle A Utton
    Department of Neuroscience, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    J Neurosci 22:6394-400. 2002
    ....
  31. ncbi request reprint Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport
    Janet Brownlees
    Department of Neuroscience, The Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 11:2837-44. 2002
    ..Our results demonstrate that aberrant neurofilament assembly and transport can induce neurological disease, and further implicate defective neurofilament metabolism in the pathogenesis of human neurodegenerative diseases...
  32. ncbi request reprint Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases
    Ritchie Williamson
    Department of Neuroscience, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    J Neurosci 22:10-20. 2002
    ..This cascade of signaling events contains the earliest biochemical changes in neurons to be described in response to Abeta exposure and may be critical for subsequent neurodegenerative changes...
  33. ncbi request reprint Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism
    Ritchie Williamson
    MRC Centre for Neurodegeneration Research, Department of Neuroscience Box 037, Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    FASEB J 22:1552-9. 2008
    ..These results identify fyn-dependent Abeta redistribution and accumulation in lipid rafts as being key to ADDL-induced cell death and defines a mechanism by which oligomers of Abeta and tau accumulate in lipid rafts...
  34. ncbi request reprint Truncated apoE forms tangle-like structures in a neuronal cell line
    M Cecilia Ljungberg
    Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 13:867-70. 2002
    ..Further understanding of the basis of this cell specificity might add to understanding of the cell specificity of tangles in AD...
  35. ncbi request reprint Profound sex-specific effects on incubation times for transmission of bovine spongiform encephalopathy to mice
    Oduola O Abiola
    Department of Neuroscience, Genetic and Developmental Psychiatry Research Centre, KCL Institute of Psychiatry, London, UK
    Intervirology 45:56-8. 2002
    ..Research into this phenomenon may provide clues to the prophylaxis of BSE and have possible implications for new variant Creutzfeldt-Jakob disease in humans...
  36. ncbi request reprint Apolipoprotein E (apoE) uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells
    M C Ljungberg
    Department of Neuroscience, Institute of Psychiatry, King s College London, Denmark Hill De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 341:69-73. 2003
    ..In order to further examine the intracellular fate of apoE we demonstrate that apoE-Enhanced green fluorescent protein chimeric protein can be taken up from medium by recipient cells and tracked within these cells for extended periods...
  37. ncbi request reprint Dendritic changes in Alzheimer's disease and factors that may underlie these changes
    B H Anderton
    Department of Neuroscience, Institute of Psychiatry, London, U K
    Prog Neurobiol 55:595-609. 1998
    ..We also discuss transgenic approaches developed to model and understand cytoskeletal abnormalities...
  38. ncbi request reprint Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation
    T Revesz
    Department of Neuropathology, Institute of Neurology, London, UK
    Acta Neuropathol 97:170-6. 1999
    ..In FAB severe cytoskeletal pathology is present in areas most affected by amyloid plaque deposits, thus suggesting a localised neurotoxic effect of the poorly characterised amyloidogenic peptide characteristic of this condition...
  39. ncbi request reprint Efficient gene delivery to primary neuron cultures using a synthetic peptide vector system
    Louise Collins
    Department of Clinical Sciences, Institute of Liver Studies, Guy s, King s and St Thomas School of Medicine, King s College Hospital, London, UK
    J Neurosci Methods 125:113-20. 2003
    ..This synthetic peptide provides a safe, readily standardised and flexible DNA vector system well suited to ex vivo gene delivery to neurons for experimental and clinical applications...
  40. ncbi request reprint Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy
    H R Morris
    Department of Molecular Pathogenesis, Institute of Neurology, Queen Square, London, UK
    Brain 125:969-75. 2002
    ....
  41. pmc Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing
    Teresa Rodriguez-Martin
    Department of Clinical Neuroscience, MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London SE5 8AF, UK
    Hum Mol Genet 18:3266-73. 2009
    ..In conclusion, RNA trans-splicing could provide the basis of therapeutic strategies for impaired alternative splicing caused by pathogenic mutations in cis-acting splicing elements...
  42. ncbi request reprint GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt
    Ayodeji A Asuni
    King s College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Eur J Neurosci 24:3387-92. 2006
    ..In the light of these findings GSK3alpha warrants further investigation regarding its involvement in Wnt signalling and tauopathies such as Alzheimer's disease...
  43. ncbi request reprint Gigaxonin is associated with the Golgi and dimerises via its BTB domain
    Valerie C Cullen
    Departments of Neuroscience and Neurology, PO Box P037, Institute of Psychiatry, Kings College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Neuroreport 15:873-6. 2004
    ..Confocal microscope studies of gigaxonin-transfected COS-7 cells and cultured neurones revealed that a proportion of gigaxonin localises to the Golgi and endoplasmic reticulum...
  44. pmc Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition
    Ritchie Williamson
    MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, UK
    BMC Neurosci 11:120. 2010
    ..However successful separation of raft from non-raft domains in cells is dependent on matching the detergent used for raft isolation to the specific tissue under investigation...
  45. pmc Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies
    Teresa Rodriguez-Martin
    Medical Research Council Centre for Neurodegeneration, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 102:15659-64. 2005
    ..Our results demonstrate that an alternatively spliced exon can be replaced by trans-splicing and open the way to novel therapeutic applications of SMaRT for tauopathies and other disorders linked to aberrant alternative splicing...
  46. ncbi request reprint In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta
    A E Aplin
    Department of Neuroscience, Institute of Psychiatry, London, England
    J Neurochem 67:699-707. 1996
    ..The ability of GSK-3beta to phosphorylate APPcyt and tau provides a putative link between the two lesions and indicates a critical role of GSK-3beta in the pathogenesis of Alzheimer's disease...
  47. pmc Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons
    M E Cheetham
    Department of Neuroscience, Institute of Psychiatry, Denmark Hill, London, U K
    Biochem J 284:469-76. 1992
    ..These findings suggest that the DnaJ-DnaK (Hsp70) interaction is general to eukaryotes and, indeed, to higher organisms...
  48. ncbi request reprint p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis
    Steven Ackerley
    Departments of Neuroscience and Neurology, The Institute of Psychiatry, Kings College, London, UK
    Mol Cell Neurosci 26:354-64. 2004
    ..Thus, p38 kinases may contribute to the aberrant phosphorylation of NFM and NFH side-arms in ALS...
  49. ncbi request reprint The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease
    Karelle Leroy
    Laboratory of Histology, Neuroanatomy and Neuropathology, Universite Libre de Bruxelles, School of Medicine, 808 Route de Lennik, Bldg C 10, 1070 Brussels, Belgium
    Acta Neuropathol 103:91-9. 2002
    ....
  50. ncbi request reprint Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta
    Janice L Holton
    Department of Molecular Pathogenesis, Queen Square Brain Bank, London, United Kingdom
    J Neuropathol Exp Neurol 61:254-67. 2002
    ..The significance of concurrent ADan and Abeta deposition in FDD is under further investigation...
  51. pmc The microtubule-associated protein tau is phosphorylated by Syk
    Thibaud Lebouvier
    INSERM, U643, Nantes, F 44000, France
    Biochim Biophys Acta 1783:188-92. 2008
    ..These results bring another clue to the intriguing overlaps between tauopathies and synucleinopathies and provide new insights into the role of Syk in neuronal physiology...