- Nanoparticle growth and surface chemistry changes in cell-conditioned culture mediumMichaela Kendall
School of Metallurgy and Materials, University of Birmingham, Birmingham B15 2TT, UK Child Health, Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Philos Trans R Soc Lond B Biol Sci 370:20140100. 2015..We conclude that interference with extracellular peptide balance and oxidoreductase activity via sequestration is worthy of further study, as increased oxidative stress via this new mechanism may be important for cell toxicity. ..
- Surfactant protein D (SP-D) alters cellular uptake of particles and nanoparticlesMichaela Kendall
European Centre of Environment and Human Health, Peninsula College of Medicine and Dentistry, University of Exeter, Truro, Cornwall, TR1 3HD, UK
Nanotoxicology 7:963-73. 2013..AMs and LDCs showed decreased uptake of NPs in SP-D deficient mice compared to wild-type mice. These data confirmed an interaction between SP-D and NPs, and subsequent enhanced NP uptake...
- Health impact and toxicological effects of nanomaterials in the lungMichaela Kendall
Truro III Division, Faculty of Medicine, European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, University of Exeter, Southampton General Hospital, Southampton, UK
Respirology 17:743-58. 2012..Human exposures via medical and dental applications appear important in terms of dose and toxicity, and may need to be assessed for risk on a case-by-case basis...
- Molecular adsorption at particle surfaces: a PM toxicity mediation mechanismMichaela Kendall
Public Health Department, School of Medicine, Uludag University, Gorukle Bursa, Turkey
Inhal Toxicol 16:99-105. 2004..The biological implication is that molecular adsorption at nonbiological particulate matter (PM) surfaces in BALF may mediate the toxicity of PM via one or both of these mechanisms, as in the case of biological particles...
- Urban PM2.5 surface chemistry and interactions with bronchoalveolar lavage fluidMichaela Kendall
EPA PM Health Effects Research Center, New York University School of Medicine, Tuxedo, New York 10987, USA
Inhal Toxicol 16:115-29. 2004..Similarly, ToF-SIMS analysis suggests the bioavailability of Na(+) and Al(+) as well as NH(+)(4) and Si(+)...
- Fine airborne urban particles (PM2.5) sequester lung surfactant and amino acids from human lung lavageMichaela Kendall
Public Health, Uludag Univ, Bursa, 16059, Turkey
Am J Physiol Lung Cell Mol Physiol 293:L1053-8. 2007..Disruption of normal surfactant function, both physical and immunological, is possible but unproven. Further work on this PM-opsonin interaction is recommended...
- Particle and nanoparticle interactions with fibrinogen: the importance of aggregation in nanotoxicologyMichaela Kendall
European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, The Knowledge Spa, Truro, Cornwall
Nanotoxicology 5:55-65. 2011..Interaction of particles and NPs with pro-coagulant polymers may therefore dictate the NP surface dose presentation to cells/organs and subsequent cellular effects, in and ex vivo...
- Personal exposures to traffic-related air pollution and acute respiratory health among Bronx schoolchildren with asthmaAriel Spira-Cohen
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987 5007, USA
Environ Health Perspect 119:559-65. 2011..Previous studies have reported relationships between adverse respiratory health outcomes and residential proximity to traffic pollution, but have not shown this at a personal exposure level...
- Surfactant protein A (SP-A) inhibits agglomeration and macrophage uptake of toxic amine modified nanoparticlesZofi McKenzie
a Department of Child Health, Clinical and Experimental Sciences, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK
Nanotoxicology 9:952-62. 2015..Thus we have demonstrated that SP-A promotes uptake of non-toxic U-PS particles but inhibits the clearance of potentially toxic A-PS particles by blocking uptake into macrophages...
- Factors affecting personal exposure to thoracic and fine particles and their componentsShao I Hsu
Columbia University, Public Health, New York, New York, USA
J Expo Sci Environ Epidemiol 22:439-47. 2012..23) was much more spatially heterogeneous. Thus, CMS measurements can adequately reflect personal exposures for spatially uniform components, such as sulfate, but they are not adequate for components from more local sources...
- Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitroZofi McKenzie
Child Health, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Philos Trans R Soc Lond B Biol Sci 370:20140049. 2015..Furthermore, the nanoparticle concentration, surface chemistry and cell type under investigation are important factors in determining the extent of these modulations. ..
- Personal exposures to traffic-related particle pollution among children with asthma in the South Bronx, NYAriel Spira-Cohen
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
J Expo Sci Environ Epidemiol 20:446-56. 2010....
- Airborne particulate-associated polyaromatic hydrocarbons, n-alkanes, elemental and organic carbon in three European citiesMichaela Kendall
US EPA Particulate Matter Center, Nelson Institute of Environmental Medicine, NYU, 57 Old Forge Road, Tuxedo, NY 10987, USA
J Environ Monit 4:890-6. 2002..In addition, two PAH compounds (pyrene and fluoranthene) previously associated with diesel exhaust, were correlated with OC and EC concentrations at the London and Vienna sites...
- Comparisons of the dust/smoke particulate that settled inside the surrounding buildings and outside on the streets of southern New York City after the collapse of the World Trade Center, September 11, 2001Lih Ming Yiin
Division of Environmental and Occupational Health, School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
J Air Waste Manag Assoc 54:515-28. 2004..In summary, the indoor dust/smoke was similar in concentration to the outdoor dust/smoke but had a greater percentage of mass <53 microm in diameter...
- Lung lining liquid modifies PM(2.5) in favor of particle aggregation: a protective mechanismMichaela Kendall
Imperial College of Science, Technology, and Medicine, London SW7 2BP, United Kingdom
Am J Physiol Lung Cell Mol Physiol 282:L109-14. 2002..5), which leads to enhanced particle aggregation. We propose that this is an important protective mechanism that aids particle clearance in the lung...