David A Harrison

Summary

Affiliation: Intensive Care National Audit and Research Centre
Country: UK

Publications

  1. ncbi Winter excess mortality in intensive care in the UK: an analysis of outcome adjusted for patient case mix and unit workload
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, WC1H 9HR London, UK
    Intensive Care Med 30:1900-7. 2004
  2. pmc Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database
    Dheeraj Gupta
    Department of Respiratory Medicine, Birmingham Heartlands Solihull NHS Trust, Birmingham, UK
    Crit Care 8:R112-21. 2004
  3. pmc Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: the Intensive Care National Audit & Research Centre Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care 8:R99-111. 2004
  4. pmc Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 11:S1. 2007
  5. doi Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial
    Sheila E Harvey
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Crit Care Med 36:1714-21. 2008
  6. ncbi Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United Kingdom
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care Med 34:1378-88. 2006
  7. doi The effects of critical care outreach services before and after critical care: a matched-cohort analysis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    J Crit Care 25:196-204. 2010
  8. ncbi A new measure of acute physiological derangement for patients with exacerbations of obstructive airways disease: the COPD and Asthma Physiology Score
    Martin J Wildman
    Department of Respiratory Medicine, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Respir Med 101:1994-2002. 2007
  9. pmc Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database
    Jonathan A Hyam
    Department of Neurosurgery, Charing Cross Hospital, London, UK
    Crit Care 10:S2. 2006
  10. ncbi A new risk prediction model for critical care: the Intensive Care National Audit & Research Centre (ICNARC) model
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, London, UK
    Crit Care Med 35:1091-8. 2007

Detail Information

Publications33

  1. ncbi Winter excess mortality in intensive care in the UK: an analysis of outcome adjusted for patient case mix and unit workload
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, WC1H 9HR London, UK
    Intensive Care Med 30:1900-7. 2004
    ..To investigate whether mortality in UK intensive care units is higher in winter than in non-winter and to explore the importance of variations in case mix and increased pressure on ICUs...
  2. pmc Characteristics and outcome for admissions to adult, general critical care units with acute severe asthma: a secondary analysis of the ICNARC Case Mix Programme Database
    Dheeraj Gupta
    Department of Respiratory Medicine, Birmingham Heartlands Solihull NHS Trust, Birmingham, UK
    Crit Care 8:R112-21. 2004
    ....
  3. pmc Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: the Intensive Care National Audit & Research Centre Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care 8:R99-111. 2004
    ..The paper also describes the case mix, outcome and activity of the admissions in the Case Mix Programme Database (CMPD)...
  4. pmc Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 11:S1. 2007
    ..We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database...
  5. doi Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial
    Sheila E Harvey
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Crit Care Med 36:1714-21. 2008
    ..K. intensive care units and to generate hypotheses to guide future research by examining subsets of patients included in the PAC-Man Study...
  6. ncbi Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United Kingdom
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care Med 34:1378-88. 2006
    ..To assess the performance of published risk prediction models in common use in adult critical care in the United Kingdom and to recalibrate these models in a large representative database of critical care admissions...
  7. doi The effects of critical care outreach services before and after critical care: a matched-cohort analysis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    J Crit Care 25:196-204. 2010
    ..The purpose of the study was to evaluate the effect of visits from critical care outreach services (CCOS) before admission to and following discharge from critical care...
  8. ncbi A new measure of acute physiological derangement for patients with exacerbations of obstructive airways disease: the COPD and Asthma Physiology Score
    Martin J Wildman
    Department of Respiratory Medicine, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Respir Med 101:1994-2002. 2007
    ..This depends on the severity of the acute deterioration and the patient's functional reserve. There are currently no validated disease-specific scores that measure the severity of the acute exacerbation...
  9. pmc Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database
    Jonathan A Hyam
    Department of Neurosurgery, Charing Cross Hospital, London, UK
    Crit Care 10:S2. 2006
    ..This report describes the case mix and outcome (mortality, intensive care unit (ICU) and hospital length of stay) for admissions to ICU for head injury and evaluates the predictive ability of five risk adjustment models...
  10. ncbi A new risk prediction model for critical care: the Intensive Care National Audit & Research Centre (ICNARC) model
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, London, UK
    Crit Care Med 35:1091-8. 2007
    ..To develop a new model to improve risk prediction for admissions to adult critical care units in the UK...
  11. pmc The impact of the introduction of critical care outreach services in England: a multicentre interrupted time-series analysis
    Haiyan Gao
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 11:R113. 2007
    ..We undertook a multicentre interrupted time-series analysis of the impact of CCOS, as characterised by the case mix, outcome and activity of admissions to adult, general critical care units in England...
  12. doi The association between deprivation and hospital mortality for admissions to critical care units in England
    Catherine A Welch
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, WC1H 9HR, London, UK
    J Crit Care 25:382-90. 2010
    ..It is important to be aware if an association exists because risk prediction models do not adjust for deprivation...
  13. ncbi Systematic review and evaluation of physiological track and trigger warning systems for identifying at-risk patients on the ward
    Haiyan Gao
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, WC1H 9HR, UK
    Intensive Care Med 33:667-79. 2007
    ....
  14. pmc Case mix, outcome and activity for patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database
    Colin A Hutchison
    University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, B15 2TH, UK
    Crit Care 11:R50. 2007
    ....
  15. ncbi The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, United Kingdom
    Crit Care Med 35:1703-8. 2007
    ..Some scores cannot be applied until several days into hospital admission. We thus sought to develop a new and more sensitive outcome prediction score--the Pancreatitis Outcome Prediction (POP) Score--for these high-risk patients...
  16. pmc The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database
    David A Harrison
    Intensive Care National Audit and Research Centre ICNARC, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 10:R42. 2006
    ..We interrogated a high quality clinical database to examine trends in the incidence and mortality of severe sepsis over a nine-year period...
  17. pmc Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock
    Paul R Mouncey
    Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK
    Health Technol Assess 19:i-xxv, 1-150. 2015
    ..However, adoption has been limited and uncertainty remains over its clinical effectiveness and cost-effectiveness...
  18. ncbi The Protocolised Management in Sepsis (ProMISe) trial statistical analysis plan
    G Sarah Power
    Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, United Kingdom
    Crit Care Resusc 15:311-7. 2013
    ..The rationale for the ProMISe trial derives from a single-centre United States RCT that reported a reduction in hospital mortality from 46.5% to 30.5%...
  19. pmc Is Drotrecogin alfa (activated) for adults with severe sepsis, cost-effective in routine clinical practice?
    M Zia Sadique
    Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London, WC1H 9SH, UK
    Crit Care 15:R228. 2011
    ..There is little evidence on whether DrotAA is cost-effective in routine clinical practice. We assessed whether DrotAA is cost-effective in routine practice for adult patients with severe sepsis and multiple organ systems failing...
  20. doi Outcome prediction in critical care: the ICNARC model
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Curr Opin Crit Care 14:506-12. 2008
    ..To describe the background to, rationale for, and structure and performance of the Intensive Care National Audit & Research Centre risk prediction model...
  21. pmc Drotrecogin alfa (activated): real-life use and outcomes for the UK
    Kathryn M Rowan
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK
    Crit Care 12:R58. 2008
    ..1% absolute reduction in 28-day mortality. Drotrecogin alfa (activated; DrotAA) was subsequently approved for use in patients with severe sepsis...
  22. pmc A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES)
    Sheila E Harvey
    Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, UK
    Health Technol Assess 20:1-144. 2016
    ..Early nutritional support is therefore recommended to address deficiencies in nutritional state and related disorders in metabolism. However, evidence is conflicting regarding the optimum route (parenteral or enteral) of delivery...
  23. pmc Identification and characterisation of the high-risk surgical population in the United Kingdom
    Rupert M Pearse
    William Harvey Research Institute, Queen Mary s School of Medicine and Dentistry, London, UK
    Crit Care 10:R81. 2006
    ..The aim of the present study was to estimate the size of the high-risk general surgical population and to describe the outcome and intensive care unit (ICU) resource use...
  24. doi Effect of specialist retrieval teams on outcomes in children admitted to paediatric intensive care units in England and Wales: a retrospective cohort study
    Padmanabhan Ramnarayan
    Children s Acute Transport Service, Great Ormond Street Hospital, London, UK
    Lancet 376:698-704. 2010
    ..We studied the outcome of children transferred from local hospitals to PICUs...
  25. doi Psychometric assessment of the Family Satisfaction in the Intensive Care Unit questionnaire in the United Kingdom
    David A Harrison
    Clinical Trials Unit, Intensive Care National Audit and Research Centre, London, United Kingdom Electronic address
    J Crit Care . 2016
    ..To establish the psychometric properties of the Family Satisfaction in the Intensive Care Unit 24-item (FS-ICU-24) questionnaire in the United Kingdom...
  26. pmc External Validation and Recalibration of Risk Prediction Models for Acute Traumatic Brain Injury among Critically Ill Adult Patients in the United Kingdom
    David A Harrison
    1 Clinical Trials Unit, Intensive Care National Audit and Research Centre, Napier House, London, United Kingdom
    J Neurotrauma 32:1522-37. 2015
    ..The published models for unfavorable outcome at six months had poor calibration in the UK critical care setting and the models recalibrated to this setting should be used in future research. ..
  27. ncbi The CALORIES trial: statistical analysis plan
    Sheila E Harvey
    Intensive Care National Audit and Research Centre, London, United Kingdom
    Crit Care Resusc 16:248-54. 2014
    ..The trial derives from the need for a large, pragmatic RCT to determine the optimal route of delivery for early nutritional support in the critically ill...
  28. pmc Risk-adjusted survival for adults following in-hospital cardiac arrest by day of week and time of day: observational cohort study
    Emily J Robinson
    Intensive Care National Audit and Research Centre, London, UK
    BMJ Qual Saf . 2015
    ..Data from the UK National Cardiac Arrest Audit (NCAA) indicate that crude hospital survival was worse after in-hospital cardiac arrest (IHCA) at night versus day, and at weekends versus weekdays, despite similar frequency of events...
  29. ncbi Differences in Impact of Definitional Elements on Mortality Precludes International Comparisons of Sepsis Epidemiology-A Cohort Study Illustrating the Need for Standardized Reporting
    Manu Shankar-Hari
    1Department of Critical Care Medicine, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom 2Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom 3Intensive Care National Audit and Research Centre, London, United Kingdom
    Crit Care Med 44:2223-2230. 2016
    ..We hypothesised that there have been changes over time in the sepsis definitional elements (infection and organ dysfunction), and these may have impacted on hospital mortality...
  30. doi Development and validation of the new ICNARC model for prediction of acute hospital mortality in adult critical care
    Paloma Ferrando-Vivas
    Intensive Care National Audit and Research Centre ICNARC, London, UK
    J Crit Care . 2016
    ..To develop and validate an improved risk model to predict acute hospital mortality for admissions to adult critical care units in the UK...
  31. doi Relationship between patients' outcomes and the changes in serum creatinine and urine output and RIFLE classification in a large critical care cohort database
    Steve K Harris
    University College, London, UK
    Kidney Int 88:369-77. 2015
    ..Thus, although the RIFLE classification may be attempted in large population cohorts, there is significant heterogeneity of both renal and, in particular, vital outcomes within each class. ..
  32. doi Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients
    Alastair J O'Brien
    Department of Clinical Pharmacology, University College London, 5 University Street, London WC1E 6JF, UK
    Intensive Care Med 38:991-1000. 2012
    ..Patients with decompensated liver cirrhosis who are admitted to intensive care units (ICU) are perceived, within the UK, as having a particularly poor prognosis...
  33. ncbi Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial
    Sheila Harvey
    Intensive Care National Audit and Research Centre, London, UK
    Lancet 366:472-7. 2005
    ..Our aim was, therefore, to ascertain whether hospital mortality is reduced in critically ill patients when they are managed with a PAC...