Myriam Hemberger

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Genetic-epigenetic intersection in trophoblast differentiation: implications for extraembryonic tissue function
    Myriam Hemberger
    Laboratory for Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Epigenetics 5:24-9. 2010
  2. ncbi request reprint Epigenetic landscape required for placental development
    M Hemberger
    The Babraham Institute, Babraham Research Campus, Cambridge, CB223AT, United Kingdom
    Cell Mol Life Sci 64:2422-36. 2007
  3. ncbi request reprint IFPA award in placentology lecture - characteristics and significance of trophoblast giant cells
    M Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Placenta 29:S4-9. 2008
  4. ncbi request reprint Stem cells from fetal membranes - a workshop report
    M Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Placenta 29:S17-9. 2008
  5. ncbi request reprint Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells
    Myriam Hemberger
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 271:362-71. 2004
  6. doi request reprint ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta
    Myriam Hemberger
    Laboratory for Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Hum Mol Genet 19:2456-67. 2010
  7. pmc Random versus directionally persistent cell migration
    Ryan J Petrie
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA e mails
    Nat Rev Mol Cell Biol 10:538-49. 2009
  8. doi request reprint Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal
    Myriam Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Nat Rev Mol Cell Biol 10:526-37. 2009
  9. doi request reprint Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
  10. pmc Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
    Ray Kit Ng
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nat Cell Biol 10:1280-90. 2008

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Genetic-epigenetic intersection in trophoblast differentiation: implications for extraembryonic tissue function
    Myriam Hemberger
    Laboratory for Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Epigenetics 5:24-9. 2010
    ..The unique trophoblast epigenotype is instrumental for normal trophoblast differentiation and placental function, and consequently trophoblast is particularly susceptible to regrogramming failures...
  2. ncbi request reprint Epigenetic landscape required for placental development
    M Hemberger
    The Babraham Institute, Babraham Research Campus, Cambridge, CB223AT, United Kingdom
    Cell Mol Life Sci 64:2422-36. 2007
    ....
  3. ncbi request reprint IFPA award in placentology lecture - characteristics and significance of trophoblast giant cells
    M Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Placenta 29:S4-9. 2008
    ..Recent advances have recognized that the giant cell population is more diverse than previously recognized and future studies will have to show how these subtypes differ functionally and how their differentiation is controlled...
  4. ncbi request reprint Stem cells from fetal membranes - a workshop report
    M Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Placenta 29:S17-9. 2008
    ..In this report we summarize contributions to a workshop in which newest insights into the characteristics, subtypes and molecular determinants of stem cells from trophoblast and endometrial tissues were presented...
  5. ncbi request reprint Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells
    Myriam Hemberger
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 271:362-71. 2004
    ..The TS cell system is a valuable tool to identify and quantitatively study regulators of trophoblast invasion...
  6. doi request reprint ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta
    Myriam Hemberger
    Laboratory for Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Hum Mol Genet 19:2456-67. 2010
    ....
  7. pmc Random versus directionally persistent cell migration
    Ryan J Petrie
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA e mails
    Nat Rev Mol Cell Biol 10:538-49. 2009
    ....
  8. doi request reprint Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal
    Myriam Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Nat Rev Mol Cell Biol 10:526-37. 2009
    ..The intersection of major epigenetic reprogramming and programming events in the early embryo creates plasticity followed by commitment to the principal cell lineages of the early conceptus...
  9. doi request reprint Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
    ..These results suggest that Activin rather than TGF-beta (or Nodal) acts directly on TS cells influencing both TS cell maintenance and cell fate, depending on whether the cells are also exposed to FGF4...
  10. pmc Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
    Ray Kit Ng
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nat Cell Biol 10:1280-90. 2008
    ..This epigenetic restriction of cell lineage fate provides a molecular mechanism for Waddington's concept of canalization of developmental pathways...
  11. doi request reprint Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling
    Mark Screen
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Development 135:3311-20. 2008
    ..Our findings provide evidence for the highly specialized functions of closely related cysteine cathepsin proteases in extra-embryonic development, and reinforce their importance for a successful outcome of pregnancy...
  12. ncbi request reprint Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Development 133:4203-10. 2006
    ..Our findings establish a model for how epigenetic gene silencing by non-coding RNA may depend on distance from the non-coding RNA and on lineage and differentiation specific factors...
  13. pmc Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes
    Cassandra R Farthing
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
    PLoS Genet 4:e1000116. 2008
    ..Epigenetic reprogramming in the germline prior to fertilisation and the reprogramming of key pluripotency genes in the early embryo is thus crucial for transmission of pluripotency...
  14. doi request reprint DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary
    Claire E Senner
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Stem Cells 30:2732-45. 2012
    ....
  15. pmc Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth
    Zofia Madeja
    Laboratory for Epigenetics, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom
    Proc Natl Acad Sci U S A 108:4012-7. 2011
    ..Thus, maternal-fetal immune interactions are instrumental to optimize reproductive success. This cross-talk has important implications for human disorders of pregnancy, such as preeclampsia and fetal growth restriction...
  16. doi request reprint Health during pregnancy and beyond: Fetal trophoblast cells as chief co-ordinators of intrauterine growth and reproductive success
    Myriam Hemberger
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Ann Med 44:325-37. 2012
    ....
  17. pmc Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast
    Francesco Cambuli
    1 Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK 2 Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Nat Commun 5:5538. 2014
    ..Thus, even ES cells in ground-state pluripotency cannot fully overcome the boundaries that separate the first cell lineages but retain an epigenetic memory of their ES cell origin. ..
  18. ncbi request reprint Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives
    Myriam Hemberger
    Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    Dev Biol 257:371-81. 2003
    ..These data show that wildtype ES cells contain a small population of cells with trophectoderm potential and that absence of Parp1 renders ES cells more susceptible to adopting a trophoblast phenotype...
  19. ncbi request reprint Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion
    Myriam Hemberger
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 227:185-91. 2003
    ..These results show that trophoblast giant cells have the intrinsic capacity to attract and increase blood flow and to gradually displace the vascular endothelium resulting in the formation of canals entirely lined by trophoblast cells...
  20. ncbi request reprint Unique receptor repertoire in mouse uterine NK cells
    Hakim Yadi
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 181:6140-7. 2008
    ..Thus, the Ly49 repertoire and the expression of other differentiation markers strikingly distinguish uNK cells from peripheral NK cells, suggesting that a selection process shapes the receptor repertoire of mouse uNK cells...
  21. ncbi request reprint Epigenetic arbitration of cell fate decisions: tipping the bias
    Myriam Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom
    Dev Cell 12:176-8. 2007
    ..This represents the first link of global epigenetic instructions associated with specification of early cell lineages...
  22. ncbi request reprint Defining pathways that enforce cell lineage specification in early development and stem cells
    Stephen Roper
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Cell Cycle 8:1515-25. 2009
    ....
  23. pmc Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks
    Paulina A Latos
    Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Genes Dev 29:2435-48. 2015
    ..These data place Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC proliferation and differentiation. ..
  24. doi request reprint PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis
    Laure Gambardella
    Inositide Laboratory, The Babraham Institute, Cambridge CB22 3AT, UK
    Sci Signal 3:ra76. 2010
    ..Our work delineates a previously unknown signaling pathway that controls angiogenesis immediately downstream of PI3Kα through ARAP3 to the Rho and Arf family of small GTPases...
  25. pmc Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway
    Felix Krueger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK
    Cell Signal 21:1846-56. 2009
    ..These results provide important new insights into the regulation of the Cdx2 tumour suppressor by linking it to ERK1/2, a pathway which is frequently activated in CRC...
  26. pmc ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
    Stephen J Roper
    Epigenetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Nucleic Acids Res 42:8914-27. 2014
    ..These findings place Parp1 and Parp7 at the genetic-epigenetic interface of pluripotency networks, fine-tuning the transcriptional heterogeneity and thereby determining the developmental plasticity of ES cells. ..
  27. ncbi request reprint cDNA subtraction and cloning in the field of trophoblast/placental development
    Myriam Hemberger
    Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary, Alberta, Canada
    Methods Mol Biol 254:49-66. 2004
  28. ncbi request reprint The importance of cysteine cathepsin proteases for placental development
    Aikaterini Varanou
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    J Mol Med (Berl) 84:305-17. 2006
    ..Overall, the distribution and abnormal expression levels in pre-eclamptic placentas indicate that cysteine cathepsins may play important roles during normal placentation and in the etiology of pre-eclampsia...
  29. pmc Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation
    Alexander Murray
    Epigenetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    Sci Rep 6:25112. 2016
    ....
  30. pmc Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction
    Hong Wa Yung
    Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK
    J Pathol 228:554-64. 2012
    ..Placental dysmorphogenesis potentially affects fetal growth through reduced exchange capacity...
  31. ncbi request reprint Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
    ..We propose that the Igf2 gene, and perhaps other imprinted genes, control both the placental supply of, and the genetic demand for, maternal nutrients to the mammalian fetus...
  32. pmc Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells
    Paulina A Latos
    1 Epigenetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK 2 Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Nat Commun 6:7776. 2015
    ..Our findings provide new insights into both the general and context-dependent wiring of transcription factor networks in stem cells by master transcription factors. ..
  33. doi request reprint Immune balance at the foeto-maternal interface as the fulcrum of reproductive success
    Myriam Hemberger
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    J Reprod Immunol 97:36-42. 2013
    ..These insights will pave the way towards unravelling the mutual and synergistic interactions between trophoblast and its surrounding maternal environment, and in doing so help understand pregnancy pathologies...
  34. ncbi request reprint Genes and development--a workshop report
    J C Cross
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary Faculty of Medicine, HSC Room 2279, 3330 Hospital Drive, N W, Calgary, Alberta T2N 4N1, Canada
    Placenta 25:S39-41. 2004
  35. ncbi request reprint Genes governing placental development
    M Hemberger
    Dept of Biochemistry and Molecular Biology, University of Calgary, Faculty of Medicine, HSC Room 2279, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Trends Endocrinol Metab 12:162-8. 2001
    ..Conserved gene expression patterns in humans should enable the elucidation of the molecular basis of human placental dysfunction...
  36. ncbi request reprint Genes, development and evolution of the placenta
    J C Cross
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Alberta, Canada
    Placenta 24:123-30. 2003
    ..Such information is aiding the comparison of the human and mouse placenta. In addition, the prospect of a conserved function clearly suggests potential mechanisms for explaining complications of human placental development...
  37. ncbi request reprint Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta
    J C Cross
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, HSC Room 2279, 3330 Hospital Drive, N W, Alta, T2N 4N1, Calgary, Canada
    Mol Cell Endocrinol 187:207-12. 2002
    ..As in primates, murine trophoblast cells also invade into the uterine arteries of the mother. However, in normal pregnancy, dilation of the uterine arteries may be largely mediated by the effect of uterine natural killer cells...
  38. ncbi request reprint Genetic and genomic approaches to study placental development
    M Hemberger
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Cytogenet Genome Res 105:257-69. 2004
    ..In conclusion, the intelligent combination of genetic and genomic approaches will substantially accelerate the progress in identifying the key molecular pathways of placental development...
  39. ncbi request reprint The role of the X chromosome in mammalian extra embryonic development
    M Hemberger
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Cytogenet Genome Res 99:210-7. 2002
    ..Given that the placenta represents a postzygotic barrier to reproduction, evolutionary constraints may be responsible for the presence of placental genes on the X chromosome that are often co-expressed in brain and testis...
  40. ncbi request reprint Proliferation and growth factor expression in abnormally enlarged placentas of mouse interspecific hybrids
    Ulrich Zechner
    Max Planck Institut fur Molekulare Genetik, Berlin, Germany
    Dev Dyn 224:125-34. 2002
    ..This finding suggests that abnormal expression of both Igf2 and Esx1 contributes to abnormal placental development in mouse interspecific hybrids. However, Esx1 is not regulated by IGF2...
  41. ncbi request reprint Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta
    S Lee Adamson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Dev Biol 250:358-73. 2002
    ..These studies provide important insights into how the fetoplacental unit interacts with the maternal intrauterine vascular system during pregnancy in mice...
  42. pmc Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta
    Geng Tian
    Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Dev Dyn 237:1517-25. 2008
    ..However, absence of both LIM-3 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr. Thus, LHX3 and LHX4 appear to be dispensable for placental development and function...
  43. pmc Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development
    Michael A Gonzalez
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, UK
    Genes Dev 20:1880-4. 2006
    ..Geminin is also down-regulated in TGCs of wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication...
  44. ncbi request reprint Carboxypeptidase E in the mouse placenta
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, 75236 Uppsala, Sweden
    Differentiation 74:648-60. 2006
    ....
  45. pmc DNA methylation in placentas of interspecies mouse hybrids
    Sabine Schütt
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Genetics 165:223-8. 2003
    ..Thus, our results strongly suggest that generalized changes in methylation patterns do not occur in trophoblast cells of such hybrids...
  46. ncbi request reprint The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors
    Haruko Masumiya
    Department of Bio Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan
    FEBS Lett 553:141-4. 2003
    ..Thus, not only RYR2 but also RYR3 may participate in pacemaker activity...