M F Greaves

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint Biological models for leukaemia and lymphoma
    Mel F Greaves
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    IARC Sci Publ . 2004
  2. ncbi request reprint Cancer causation: the Darwinian downside of past success?
    Mel Greaves
    Cell Biology and the Leukaemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Lancet Oncol 3:244-51. 2002
  3. pmc Childhood leukaemia
    Mel Greaves
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB
    BMJ 324:283-7. 2002
  4. ncbi request reprint Molecular genetics, natural history and the demise of childhood leukaemia
    M Greaves
    LRF Centre for the Cell and Molecular Biology of Leukaemia, Chester Beatty Laboratories, London, U K
    Eur J Cancer 35:173-85. 1999
  5. ncbi request reprint Molecular genetics, natural history and the demise of childhood leukaemia
    M Greaves
    LRF Centre for the Cell and Molecular Biology of Leukaemia, Institute of Cancer Research, Chester Beatty Laboratories, London, U K
    Eur J Cancer 35:1941-53. 1999
  6. ncbi request reprint Leukemia in twins: lessons in natural history
    Mel F Greaves
    Leukemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, London SW3 6JB, United Kingdom
    Blood 102:2321-33. 2003
  7. ncbi request reprint Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes
    A M Ford
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom
    Blood 98:558-64. 2001
  8. ncbi request reprint Molecular tracking of leukemogenesis in a triplet pregnancy
    A T Maia
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Blood 98:478-82. 2001
  9. ncbi request reprint Rapid positive selection of CD34+ cells using magnetic microspheres coated with monoclonal antibody QBEND/10 linked via a cleavable disulphide bond
    P G Grimsley
    Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK
    Leukemia 7:898-908. 1993
  10. ncbi request reprint Multilineage phenotypes of interleukin-3-dependent progenitor cells
    A M Ford
    Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, England
    Blood 79:1962-71. 1992

Collaborators

  • M Y Gordon
  • T Enver
  • G M Taylor
  • M T Smith
  • C J Harrison
  • J L Wiemels
  • Ana Teresa Maia
  • Georgia Chenevix-Trench
  • Douglas F Easton
  • E Navarro
  • G Jimenez
  • Christopher Greenman
  • A M Ford
  • Li Chong Chan
  • Z Xiao
  • Andy Yates
  • Sarah O'Meara
  • Katy Hills
  • Peter Campbell
  • Sok Kean Khoo
  • Anthony R Green
  • Tim Avis
  • Simon Forbes
  • Raffaella Smith
  • Sara Widaa
  • Esther E Schmidt
  • Calli Tofts
  • Leendert Looijenga
  • Christopher Hunter
  • Kris Gray
  • Rebecca Shepherd
  • Graham Bignell
  • Ed Dicks
  • Dave Richardson
  • Andy Menzies
  • Jennifer Varian
  • Michael R Stratton
  • Philip Stephens
  • Andy Jenkinson
  • Jon Teague
  • Jon Hinton
  • Claire Stevens
  • Gillian L Dalgliesh
  • Sarah Edkins
  • Jody Clements
  • Ewan Birney
  • Helen Davies
  • Adam Butler
  • Janet Perry
  • Bhudipa Choudhury
  • P Andrew Futreal
  • David N Louis
  • Min Han Tan
  • Suet Yi Leung
  • Tatiana Mironenko
  • Alexandra Small
  • David Jones
  • Anna deFazio
  • Gemma Buck
  • Tony Webb
  • Rachel Harrison
  • Keiran Raine
  • Daniel P Cahill
  • Bin Tean Teh
  • Syd Barthorpe
  • Sofie West
  • Imre Vastrik
  • Jennifer Cole
  • Barbara L Weber
  • Gurpreet Bhamra
  • Peter Goldstraw
  • Yoke Eng Chiew
  • Kelly Halliday
  • Siu Tsan Yuen
  • Andrew G Nicholson
  • Richard Wooster
  • Francis Brasseur
  • Chi Wai Lee
  • Hui Leung Yuen
  • Yu Lung Lau
  • Shau Yin Ha
  • Tai Hing Lam
  • Chi Keung Li
  • Patrick M P Yuen
  • Freda E Alexander
  • Chi Kong Li
  • Sherry L Patheal
  • Nai Kong Leung
  • J K Wiencke
  • M R Segal

Detail Information

Publications15

  1. ncbi request reprint Biological models for leukaemia and lymphoma
    Mel F Greaves
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    IARC Sci Publ . 2004
    ..The natural history of leukaemic subtypes provides a useful framework for molecular epidemiological studies and significant advances have been made in this respect with infant and childhood acute lymphoblastic leukaemia...
  2. ncbi request reprint Cancer causation: the Darwinian downside of past success?
    Mel Greaves
    Cell Biology and the Leukaemia Research Fund Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Lancet Oncol 3:244-51. 2002
    ..A case is made here for a Darwinian perspective on breast and prostate cancers, for which current understanding of causation is limited and contentious...
  3. pmc Childhood leukaemia
    Mel Greaves
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB
    BMJ 324:283-7. 2002
  4. ncbi request reprint Molecular genetics, natural history and the demise of childhood leukaemia
    M Greaves
    LRF Centre for the Cell and Molecular Biology of Leukaemia, Chester Beatty Laboratories, London, U K
    Eur J Cancer 35:173-85. 1999
    ..Even for a classic case of a cancer that is intrinsically curable by systematic chemotherapy i.e. childhood ALL, prevention may turn out to be the preferred option...
  5. ncbi request reprint Molecular genetics, natural history and the demise of childhood leukaemia
    M Greaves
    LRF Centre for the Cell and Molecular Biology of Leukaemia, Institute of Cancer Research, Chester Beatty Laboratories, London, U K
    Eur J Cancer 35:1941-53. 1999
    ..Even for a classic case of a cancer that is intrinsically curable by systematic chemotherapy i.e. childhood ALL, prevention may turn out to be the preferred option...
  6. ncbi request reprint Leukemia in twins: lessons in natural history
    Mel F Greaves
    Leukemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, London SW3 6JB, United Kingdom
    Blood 102:2321-33. 2003
    ..We argue that these insights provide a very useful framework for attempts to understand etiologic mechanisms...
  7. ncbi request reprint Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes
    A M Ford
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom
    Blood 98:558-64. 2001
    ..Blood. 2001;98:558-564)..
  8. ncbi request reprint Molecular tracking of leukemogenesis in a triplet pregnancy
    A T Maia
    Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Blood 98:478-82. 2001
    ..These data support a multihit temporal model for the pathogenesis of the common form of childhood leukemia...
  9. ncbi request reprint Rapid positive selection of CD34+ cells using magnetic microspheres coated with monoclonal antibody QBEND/10 linked via a cleavable disulphide bond
    P G Grimsley
    Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK
    Leukemia 7:898-908. 1993
    ..Furthermore, granulocyte-macrophage colony-forming cells were retained in the positive fraction. This methodology can be used to purify other cell types, including T and B lymphocytes...
  10. ncbi request reprint Multilineage phenotypes of interleukin-3-dependent progenitor cells
    A M Ford
    Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, England
    Blood 79:1962-71. 1992
    ....
  11. ncbi request reprint Molecular characterization of genomic AML1-ETO fusions in childhood leukemia
    Z Xiao
    Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK
    Leukemia 15:1906-13. 2001
    ..Breakpoints in general displayed similar complexity of duplications, deletions, and insertions to other common pediatric leukemia translocations (TEL-AML1, MLL-AF4, PML-RARA, CBFB-MYH11) that we and others have analyzed...
  12. pmc Activation of the beta-globin locus control region precedes commitment to the erythroid lineage
    G Jimenez
    Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, United Kingdom
    Proc Natl Acad Sci U S A 89:10618-22. 1992
    ..These results show that the beta-globin LCR is in an active chromatin configuration prior to erythroid commitment and indicate a significant role for selective gene repression in lineage specification...
  13. ncbi request reprint Origins of chromosome translocations in childhood leukaemia
    Mel F Greaves
    LRF Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nat Rev Cancer 3:639-49. 2003
    ..How, when and where do translocations arise? And can these insights aid our understanding of the natural history, pathogenesis and causes of leukaemia?..
  14. ncbi request reprint Is the timing of exposure to infection a major determinant of acute lymphoblastic leukaemia in Hong Kong?
    Li Chong Chan
    Haematology Section, Department of Pathology, University of Hong Kong, Hong Kong
    Paediatr Perinat Epidemiol 16:154-65. 2002
    ..These results provide support for the delayed exposure hypothesis in an affluent geographical setting in which population exposure to infectious agents is quite distinct from the settings of previous case-control studies...
  15. pmc Patterns of somatic mutation in human cancer genomes
    Christopher Greenman
    Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 446:153-8. 2007
    ..Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated...