Institute of Psychiatry

Summary

Organization: Institute of Psychiatry
Country: UK

Top Publications

  1. ncbi Cross-cultural adaptation and preliminary validation of a zygosity determination questionnaire for twins in Sri Lanka
    A Sumathipala
    Section of Epidemiology and General Practice, Institute of Psychiatry, Kings College, University of London, UK
    Twin Res 3:205-12. 2000
  2. ncbi Temporal relationships between physical symptoms and psychiatric disorder. Results from a national birth cohort
    M Hotopf
    Institute of Psychiatry, London
    Br J Psychiatry 173:255-61. 1998
  3. ncbi Is there a Gulf War syndrome?
    K Ismail
    Gulf War Illness Research Unit, Guy s, King s, and St Thomas s Medical School, London, UK
    Lancet 353:179-82. 1999
  4. ncbi Molecular cloning of human GABABR1 and its tissue distribution
    A Makoff
    Departments of Psychological Medicine and Neuroscience, Institute of Psychiatry, Denmark Hill, London, SE7 8AF, UK
    Brain Res Mol Brain Res 64:137-40. 1999
  5. ncbi Methods for diagnosis and treatment of stimulus-correlated motion in generic brain activation studies using fMRI
    E T Bullmore
    Department of Biostatistics and Computing, Institute of Psychiatry, London, UK
    Hum Brain Mapp 7:38-48. 1999
  6. ncbi What are we changing with neurocognitive rehabilitation? Illustrations from two single cases of changes in neuropsychological performance and brain systems as measured by SPECT
    T Wykes
    Department of Pyschology, Institute of Psychiatry, London, UK
    Schizophr Res 34:77-86. 1998
  7. ncbi Finding your marbles: does preschoolers' strategic behavior predict later understanding of mind?
    C Hughes
    Medical Research Council Child and Adolescent Psychiatry Unit, Institute of Psychiatry, London
    Dev Psychol 34:1326-39. 1998
  8. ncbi Trick or treat?: uneven understanding of mind and emotion and executive dysfunction in "hard-to-manage" preschoolers
    C Hughes
    MRC Child and Adolescent Psychiatry Unit, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 39:981-94. 1998
  9. ncbi Psychiatric epidemiology
    A Pickles
    MRC Child Psychiatry Unit, Institute of Psychiatry, London, UK
    Stat Methods Med Res 7:235-51. 1998
  10. pmc Neural responses to facial and vocal expressions of fear and disgust
    M L Phillips
    Department of Psychological Medicine, King s College School of Medicine and Dentistry, London, UK
    Proc Biol Sci 265:1809-17. 1998

Scientific Experts

Detail Information

Publications62

  1. ncbi Cross-cultural adaptation and preliminary validation of a zygosity determination questionnaire for twins in Sri Lanka
    A Sumathipala
    Section of Epidemiology and General Practice, Institute of Psychiatry, Kings College, University of London, UK
    Twin Res 3:205-12. 2000
    ..Comparison of the zygosity determination by using this adapted questionnaire with results from analysis of genetic markers on Sri Lankan twins is needed for final validation of the translated questionnaire...
  2. ncbi Temporal relationships between physical symptoms and psychiatric disorder. Results from a national birth cohort
    M Hotopf
    Institute of Psychiatry, London
    Br J Psychiatry 173:255-61. 1998
    ..Physical symptoms and psychiatric disorder are associated. We aimed to investigate which comes first...
  3. ncbi Is there a Gulf War syndrome?
    K Ismail
    Gulf War Illness Research Unit, Guy s, King s, and St Thomas s Medical School, London, UK
    Lancet 353:179-82. 1999
    ..We investigated whether the pattern of symptom reporting by veterans of the Gulf War differed from that in active servicemen who had not fought in the Gulf War or who had fought in other conflicts...
  4. ncbi Molecular cloning of human GABABR1 and its tissue distribution
    A Makoff
    Departments of Psychological Medicine and Neuroscience, Institute of Psychiatry, Denmark Hill, London, SE7 8AF, UK
    Brain Res Mol Brain Res 64:137-40. 1999
    ..3% sequence identity and the receptors sharing 98.6% amino acid sequence identity. Northern blotting has shown that the receptor is brain-specific with a widespread distribution throughout the brain but none detected in the spinal cord...
  5. ncbi Methods for diagnosis and treatment of stimulus-correlated motion in generic brain activation studies using fMRI
    E T Bullmore
    Department of Biostatistics and Computing, Institute of Psychiatry, London, UK
    Hum Brain Mapp 7:38-48. 1999
    ..Failure to control for SCM in this way substantially exaggerated the number of voxels, apparently demonstrating a between-group difference in task response...
  6. ncbi What are we changing with neurocognitive rehabilitation? Illustrations from two single cases of changes in neuropsychological performance and brain systems as measured by SPECT
    T Wykes
    Department of Pyschology, Institute of Psychiatry, London, UK
    Schizophr Res 34:77-86. 1998
    ..Further investigation of whether it is possible to change idiosyncratic strategy use is needed if we are to develop the efficacy of this remediation technique...
  7. ncbi Finding your marbles: does preschoolers' strategic behavior predict later understanding of mind?
    C Hughes
    Medical Research Council Child and Adolescent Psychiatry Unit, Institute of Psychiatry, London
    Dev Psychol 34:1326-39. 1998
    ..Shallice, 1982). The results of the study support recent proposals (C. Hughes, 1996; J. Russell, 1996) that young children's understanding of mind is grounded in their growing competence in strategic planning and mental flexibility...
  8. ncbi Trick or treat?: uneven understanding of mind and emotion and executive dysfunction in "hard-to-manage" preschoolers
    C Hughes
    MRC Child and Adolescent Psychiatry Unit, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 39:981-94. 1998
    ..Moreover, executive function was associated with performance on the theory of mind tasks for the hard-to-manage group alone, suggesting both direct and indirect links between executive dysfunction and disruptive behaviour...
  9. ncbi Psychiatric epidemiology
    A Pickles
    MRC Child Psychiatry Unit, Institute of Psychiatry, London, UK
    Stat Methods Med Res 7:235-51. 1998
    ..Equally, such difficulties can be regarded as challenges that offer the statistician a critical role...
  10. pmc Neural responses to facial and vocal expressions of fear and disgust
    M L Phillips
    Department of Psychological Medicine, King s College School of Medicine and Dentistry, London, UK
    Proc Biol Sci 265:1809-17. 1998
    ....
  11. ncbi Substance misuse and psychiatric comorbidity: an overview of the OPCS National Psychiatric Morbidity Survey
    M Farrell
    National Addiction Centre, Institute of Psychiatry, London, UK
    Addict Behav 23:909-18. 1998
    ..Future service planning needs to take account of the striking disparity of prevalence of psychiatric disorders in different subsections of the population...
  12. ncbi Genotype-environment correlations in late childhood and early adolescence: antisocial behavioral problems and coercive parenting
    T G O'Connor
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, United Kingdom
    Dev Psychol 34:970-81. 1998
    ....
  13. pmc Multiple risk factors in the development of externalizing behavior problems: group and individual differences
    K Deater-Deckard
    Institute of Psychiatry, London
    Dev Psychopathol 10:469-93. 1998
    ..However, this moderation effect varied depending on the predictor and outcome variables included in the model...
  14. ncbi Application of the extremum stack to neurological MRI
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, London, UK
    IEEE Trans Med Imaging 17:371-82. 1998
    ....
  15. ncbi Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Int Clin Psychopharmacol 13:23-32. 1998
    ..The presence of an oxytocin response to ipsapirone suggests that oxytocin is a potential marker for serotonergic function in neuroendocrine challenge studies, but this awaits further study...
  16. ncbi Mapping of grey matter changes in schizophrenia
    I C Wright
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Schizophr Res 35:1-14. 1999
    ..Analysis of the main effect of schizophrenia on regional grey matter revealed significant reductions in (a) the right temporal pole, insula and amygdala, (b) the left temporal pole, insula and dorsolateral prefrontal cortex...
  17. ncbi Early diagnosis and the clinical genetics of Alzheimer's disease
    S Lovestone
    Institute of Psychiatry, London, UK
    J Neurol 246:69-72. 1999
    ..For late-onset AD significant problems remain to be overcome before the advances in molecular genetics have a direct clinical application..
  18. ncbi Measuring met and unmet need of drug misusers: integration of quantitative and qualitative data
    J Fountain
    National Addiction Centre, The Maudsley, Institute of Psychiatry, London, UK
    Eur Addict Res 6:97-103. 2000
    ....
  19. ncbi Increased dendritic MAP2 expression in the hippocampus in schizophrenia
    D Cotter
    Department of Neuropathology, Institute of Psychiatry, London, UK
    Schizophr Res 41:313-23. 2000
    ..These findings add to the growing literature indicating the presence of synaptodendritic abnormalities in schizophrenia...
  20. ncbi Group treatment of auditory hallucinations. Exploratory study of effectiveness
    T Wykes
    Department of Psychology, Institute of Psychiatry, London
    Br J Psychiatry 175:180-5. 1999
    ..Cognitive-behavioural therapy has been shown to be effective in reducing psychotic symptoms, but few patients have access to these services. Group cognitive treatment may provide a less costly service with similar benefits...
  21. ncbi Glutamate receptors and transporters in genetic and acquired models of epilepsy
    B S Meldrum
    Department of Clinical Neurosciences, Institute of Psychiatry, De Crespigny Park, London, UK
    Epilepsy Res 36:189-204. 1999
    ..Changes are found in some acquired syndromes, including enhanced NMDA receptor responses in dentate granule cells in patients with hippocampal sclerosis...
  22. pmc Protracted elevation of neuronal nitric oxide synthase immunoreactivity in axotomised adult pudendal motor neurons
    A H Pullen
    Sobell Department of Neurophysiology, Institute of Neurology, London, UK
    J Anat 194:547-65. 1999
    ..Based on evidence from related analyses of synaptology, we argue that acute axotomy induced alterations in presynaptic complement which increased overall Ca2+ influx and thereby stimulated NOS1-ir...
  23. ncbi Towards a cognitive phenotype for autism: increased prevalence of executive dysfunction and superior spatial span amongst siblings of children with autism
    C Hughes
    MRC Child Psychiatry Unit, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 40:705-18. 1999
    ..There were no group differences in working memory performance. The implications of these findings for the broader phenotype of autism is discussed...
  24. ncbi Motor learning by imagery is differentially affected in Parkinson's and Huntington's diseases
    L Yaguez
    Neurological Therapy Centre, University of Dusseldorf, Germany
    Behav Brain Res 102:115-27. 1999
    ..Furthermore, the deficits found in PD patients might also be related to their limited attentional resources and difficulties in employing predictive motor strategies...
  25. ncbi Heroin chasers and heroin injectors: differences observed in a community sample in London, UK
    J Strang
    National Addiction Centre Institute of Psychiatry Maudsley Hospital, London, UK
    Am J Addict 8:148-60. 1999
    ..Heroin chasers display distinctly different personal and drug-taking characteristics and will need to be the subject of separate research studies and clinical programs...
  26. ncbi School performance in Finnish children and later development of schizophrenia: a population-based longitudinal study
    M Cannon
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 56:457-63. 1999
    ..We examined whether children who are diagnosed as having schizophrenia in adulthood could be distinguished from their peers on performance in elementary school...
  27. ncbi Removal of extracerebral tissues in dual-echo magnetic resonance images via linear scale-space features
    J Suckling
    Department of Health Care of the Elderly, King s College School Medicine and Dentistry, London, UK
    Magn Reson Imaging 17:247-56. 1999
    ..Validity is affirmed by demonstrating that cerebral volumes estimated by this method for all 12 images are highly correlated (R = 0.98) with estimates obtained by an expert human operator...
  28. pmc The effects of detection and treatment on the outcome of major depression in primary care: a naturalistic study in 15 cities
    D Goldberg
    Institute of Psychiatry, London
    Br J Gen Pract 48:1840-4. 1998
    ..This study reports the responses of patients with confirmed depressive illnesses to different treatments in the WHO Mental Disorders in General Health Care study, conducted in 15 cities around the world...
  29. ncbi Psychological training improves mental health and job-finding among unemployed people
    J Proudfoot
    Institute of Psychiatry, University of London, UK
    Int Arch Occup Environ Health 72:S40-2. 1999
    ....
  30. ncbi The anatomy of conscious vision: an fMRI study of visual hallucinations
    D H Ffytche
    Institute of Psychiatry, London, UK
    Nat Neurosci 1:738-42. 1998
    ....
  31. ncbi Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma
    H S Markus
    Department of Clinical Neurosciences, King s College School of Medicine and Dentistry and the Institute of Psychiatry, London, UK
    Stroke 29:1908-11. 1998
    ..We determined whether it was also a risk factor for transient ischemic attack (TIA) and ischemic stroke and for carotid atheroma...
  32. ncbi Reduced sensitivity to linguistic context in schizophrenic thought disorder: evidence from on-line monitoring for words in linguistically anomalous sentences
    G R Kuperberg
    Maudsley Hospital, London, United Kingdom
    J Abnorm Psychol 107:423-34. 1998
    ..These findings are consistent with the theory that schizophrenic thought disorder arises from a deficit in the use of linguistic context to process and produce speech...
  33. ncbi Functional magnetic resonance image analysis of a large-scale neurocognitive network
    E T Bullmore
    Department of Biostatistics and Computing, Institute of Psychiatry, London, United Kingdom p3
    Neuroimage 4:16-33. 1996
    ..These results are provisionally interpreted in terms of underlying hemodynamic events and cognitive psychological theory...
  34. ncbi Cost-effectiveness of clozapine. A UK clinic-based study
    K J Aitchison
    Section of Clinical Neuropharmacology, Institute of Psychiatry, London
    Br J Psychiatry 171:125-30. 1997
    ..Studies regarding clozapine in the USA have demonstrated clear cost-effectiveness, despite the high prescription costs. There are no prior UK studies...
  35. ncbi Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach
    M J Brammer
    Department of Biostatistics, Institute of Psychiatry, London
    Magn Reson Imaging 15:763-70. 1997
    ....
  36. pmc Comparative analysis of nitric oxide synthase immunoreactivity in the sacral spinal cord of the cat, macaque and human
    A H Pullen
    Sobell Department of Neurophysiology, Institute of Neurology, London, UK
    J Anat 191:161-75. 1997
    ..Finally, a comparison between cat sacral and thoracic spinal cord showed bNOS-ir in motor neurons of S2 was subject to less animal and rostrocaudal segment variation than in T10...
  37. ncbi Effect of acute subcutaneous nicotine on prepulse inhibition of the acoustic startle reflex in healthy male non-smokers
    V Kumari
    Department of Psychology, University of London, UK
    Psychopharmacology (Berl) 132:389-95. 1997
    ....
  38. ncbi A specific and sensitive ELISA for measuring S-100b in cerebrospinal fluid
    A J Green
    Department of Neuroimmunology, National Hospital for Neurology and Neurosurgery, London, UK
    J Immunol Methods 205:35-41. 1997
    ..Serial CSF samples taken from a patient with an infected in-dwelling shunt showed a dramatic decline, suggesting that S-100b is rapidly cleared...
  39. ncbi The effects of standardization and reference values on patient classification for spine and femur dual-energy X-ray absorptiometry
    A Simmons
    East Kent Osteoporosis Screening and Research Unit, Kent and Canterbury Hospital, UK
    Osteoporos Int 7:200-6. 1997
    ..The choice of standardization technique, however, must be addressed in light of the results presented here...
  40. ncbi An inverse correlation between expression of NCAM-A and the matrix-metalloproteinases gelatinase-A and gelatinase-B in human glioma cells in vitro
    S L Maidment
    Department of Neuropathology, Institute of Psychiatry, Denmark Hill, London, UK
    Cancer Lett 116:71-7. 1997
    ..Our results suggest that downregulation of NCAM-A may contribute to tumour invasiveness by promoting both cell disaggregation and protease secretion...
  41. pmc Human body-segment tilts induced by galvanic stimulation: a vestibularly driven balance protection mechanism
    B L Day
    MRC Human Movement and Balance Unit, Institute of Neurology, London, UK
    J Physiol 500:661-72. 1997
    ....
  42. ncbi Deafness and vertigo
    M Gresty
    Medical Research Council Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Curr Opin Neurol 10:36-42. 1997
    ..Fortunately for the sufferer, a clearly focussed view is emerging of the pharmacology of overlapping and interrelated problems of emesis, vertigo and migraine which promises an early solution to their integrated management...
  43. ncbi Use of a decibel threshold in detecting Doppler embolic signals
    H S Markus
    Department of Neurology, King s College School of Medicine and Dentistry, London, UK
    Stroke 28:692-5. 1997
    ..Potentially different methods of measurement could result in different intensity measurements for the same embolic signal. We determined the effect of these differences using commercial transcranial Doppler systems...
  44. ncbi Analysing human developmental abnormalities
    R M Winter
    Mothercare Unit of Clinical Genetics and Foetal Medicine, Institute of Child Health, London, UK
    Bioessays 18:965-71. 1996
    ..The importance of the study of clinical malformations to the understanding of embryological development in humans and other organisms is discussed and reviewed...
  45. ncbi IL-4 and IL-13 receptors: are they one and the same?
    R E Callard
    Immunobiology Unit, Institute of Child Health, London, UK
    Immunol Today 17:108-10. 1996
    ..Indeed, as discussed here by Robin Callard and colleagues, the IL-13 receptor appears to be a functional receptor for IL-4...
  46. ncbi Uptake of Ga-67 into rat cerebral hemisphere and cerebellum. Comparison with Fe-59
    A Radunovic
    Physiology Group, King s College London, UK
    Biometals 10:343-9. 1997
    ..Purified 67Ga-transferrin was also taken up into both brain regions examined in the presence of OX-26. These results indicate that the transport of non-transferrin bound gallium is an important mechanism for gallium uptake into brain...
  47. ncbi Depressive symptoms in children and adolescents: etiological links between normality and abnormality: a research note
    T C Eley
    Institute of Child Health, London, U K
    J Child Psychol Psychiatry 38:861-5. 1997
    ..0-2.3). The common environment did not contribute significantly in any of the analyses but showed a trend for a greater role in extreme group membership. These results are in good agreement with previous data...
  48. ncbi Volitional control of anticipatory ocular smooth pursuit after viewing, but not pursuing, a moving target: evidence for a re-afferent velocity store
    G Barnes
    Medical Research Council, Human Movement and Balance Unit, London, UK
    Exp Brain Res 116:445-55. 1997
    ..Furthermore, a high level of expectancy of target appearance can facilitate the release of this stored information in darkness...
  49. ncbi Impaired sensorimotor gating in patients with non-epileptic seizures
    H R Pouretemad
    Department of Psychological Medicine, Institute of Psychiatry, University of London, UK
    Epilepsy Res 31:1-12. 1998
    ..Overall, the anxiety subscale was the only element that was negatively correlated with PPI. It is suggested that anxiety may contribute to impairment of PPI in patients with NES...
  50. ncbi Adoption results for self-reported personality: evidence for nonadditive genetic effects?
    R Plomin
    Social, Genetic and Developmental Psychiatry Research Centre, London, England
    J Pers Soc Psychol 75:211-8. 1998
    ..These findings have important implications for attempts to identify specific genes responsible for genetic influence on personality...
  51. ncbi An adoption study of depressive symptoms in middle childhood
    T C Eley
    Institute of Psychiatry, London, U K
    J Child Psychol Psychiatry 39:337-45. 1998
    ..Although the power of the sibling data is low, the combined findings from the two designs suggest that genetic effects on depressive symptoms in childhood may be somewhat smaller than previously estimated in twin studies...
  52. ncbi Family systems and adolescent development: shared and nonshared risk and protective factors in nondivorced and remarried families
    T G O'Connor
    Institute of Psychiatry, Department of Psychology, London, UK
    Dev Psychopathol 10:353-75. 1998
    ..These results illustrate how family systems theory provides a specific example of contextualism as regards the development of psychopathology in adolescence...
  53. ncbi Serial precision of metabolite peak area ratios and water referenced metabolite peak areas in proton MR spectroscopy of the human brain
    A Simmons
    Department of Clinical Neurosciences, Institute of Psychiatry, London, UK
    Magn Reson Imaging 16:319-30. 1998
    ..These results allow us to repudiate Marshall's assertion regarding disappointing repeatability of in vivo MRS...
  54. ncbi Symptomatic haemodynamically significant carotid occlusion treated by posterior circulation revascularization
    R P White
    Department of Clinical Neuroscience, King s College School of Medicine and Dentistry and Institute of Psychiatry, London, UK
    Cerebrovasc Dis 8:148-51. 1998
    ..The measurement of middle cerebral artery reactivity using transcranial Doppler can identify such cases of haemodynamic impairment and monitor the effect of therapy...
  55. ncbi Treatment of posttraumatic stress disorder by exposure and/or cognitive restructuring: a controlled study
    I Marks
    Institute of Psychiatry and Bethlem Maudsley Hospital, London, England
    Arch Gen Psychiatry 55:317-25. 1998
    ..Unanswered questions from controlled studies of posttraumatic stress disorder concern the value of cognitive restructuring alone without prolonged exposure therapy and whether its combination with prolonged exposure is enhancing...
  56. ncbi Does dysplasia cause anatomical dysconnectivity in schizophrenia?
    E T Bullmore
    Department of Psychological Medicine and Biostatistics, Institute of Psychiatry, De Crespigny Park, London, UK
    Schizophr Res 30:127-35. 1998
    ..We conclude that anatomical dysconnectivity (between frontal and temporal cortex) in schizophrenia may be caused by dysplasia...
  57. ncbi Increased mitochondrial superoxide dismutase activity in Parkinson's disease but not amyotrophic lateral sclerosis motor cortex
    A Radunovic
    Department of Clinical Neurosciences, Institute of Psychiatry and King s College School of Medicine and Dentistry, London, UK
    Neurosci Lett 239:105-8. 1997
    ..Our findings indicate the presence of an altered antioxidant defence system in PD but not ALS upper motor neurons, suggesting that oxidative stress may be a widespread phenomenon in PD...
  58. ncbi The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia
    E T Bullmore
    Institute of Psychiatry, Department of Psychological Medicine, Denmark Hill, London, UK
    Schizophr Res 28:143-56. 1997
    ....
  59. ncbi Expression of adhesion molecules on human fetal cerebral vessels: relationship to microglial colonisation during development
    P Rezaie
    Department of Neuropathology, Institute of Psychiatry, London, UK
    Brain Res Dev Brain Res 104:175-89. 1997
    ..We conclude that fetal microglia usually occur at highly vascularised sites within the developing human fetal brain and are more specifically associated with the expression of ICAM-2 on cerebral endothelium...
  60. pmc Helicobacter pylori infection: a risk factor for ischaemic cerebrovascular disease and carotid atheroma
    H S Markus
    Department of Clinical Neuroscience, King s College School of Medicine and Dentistry and the Institute of Psychiatry, London, UK
    J Neurol Neurosurg Psychiatry 64:104-7. 1998
    ..The objective was to determine whether it is also a risk factor for ischaemic cerebrovascular disease..
  61. ncbi Serotonergic function and negative and depressive symptomatology in schizophrenia and major depression
    K M Abel
    Institute of Psychiatry, London, UK
    Psychoneuroendocrinology 22:539-48. 1997
    ..We wished to explore whether these symptoms could be distinguished biologically by directly comparing serotonergic function in these two illnesses...
  62. ncbi Digital image databasing
    S Brown
    Department of Medical Illustration, Institute of Child Health, London, UK
    J Audiov Media Med 18:157-62. 1995
    ....