Genomes and Genes
Institute of Cancer Research
Organization: Institute of Cancer Research
- Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemiasA S Moore
Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, UK
Leukemia 24:671-8. 2010..Here we review the growing body of evidence supporting the use of Aurora kinase inhibitors as effective agents for AML and Ph+ leukemias...
- Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spreadCecilia Hindorf
Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
Cancer Biother Radiopharm 22:357-66. 2007..Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine...
- Molecular biology for the radiation oncologist: the 5Rs of radiobiology meet the hallmarks of cancerK Harrington
The Institute of Cancer Research, Targeted Therapy Laboratory, Cancer Research UK, Centre for Cell and Molecular Biology, London, UK
Clin Oncol (R Coll Radiol) 19:561-71. 2007..Future articles will focus on the specific hallmarks of cancer and will highlight the opportunities that exist for designing new combination treatment regimens...
- Immunophenotyping and differential diagnosis of hairy cell leukemiaEstella Matutes
Department of Haemato Oncology, The Royal Marsden Hospital and Institute of Cancer Research, 203 Fulham Road, London, SW3 6JJ, UK
Hematol Oncol Clin North Am 20:1051-63. 2006..Immunophenotyping is an essential tool for the diagnosis of these two disorders, for monitoring and assessing response to therapy, and for distinguishing them from other B-cell malignancies...
- Spatial and acoustic pressure dependence of microbubble-mediated gene delivery targeted using focused ultrasoundAhad A Rahim
The Institute of Cancer Research, Gene Therapy Group, Department of Cell and Molecular Biology, 237 Fulham Road, Chelsea, London SW3 6JB, UK
J Gene Med 8:1347-57. 2006..In this study we evaluate the targeting ability and spatial distribution of gene delivery using focused ultrasound...
- Cancer in children and adolescents in Europe: developments over 20 years and future challengesK Pritchard-Jones
Section of Paediatric Oncology, Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey SM2 5PT, UK
Eur J Cancer 42:2183-90. 2006..Survival rates increased for nearly all types of cancer in children and adolescents. The implications of these findings for aetiological factors and treatment delivery for cancer in children and adolescents are discussed...
- A UK-based investigation of inter- and intra-observer reproducibility of Gleason grading of prostatic biopsiesJ Melia
Department of Histopathology, Addenbrooke s Hospital, Cambridge, UK
Histopathology 48:644-54. 2006..Gleason score has important implications for patient management but morphological reproducibility data for British practice are limited. Using literature-based criteria nine uropathologists took part in a reproducibility study...
- The impact of expression profiling on prognostic and predictive testing in breast cancerJ S Reis-Filho
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
J Clin Pathol 59:225-31. 2006..Although the results are promising, further optimisation and standardisation of the technique and properly designed clinical trials are required before microarrays can reliably be used as tools for clinical decision making...
- The effect of changing from one to two views at incident (subsequent) screens in the NHS breast screening programme in England: impact on cancer detection and recall ratesR G Blanks
Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, UK
Clin Radiol 60:674-80. 2005..To assess the effect on cancer detection and recall rates of changing from one to two views for incident (subsequent) screens...
- Mechanisms predisposing to childhood overgrowth and cancerNazneen Rahman
Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Curr Opin Genet Dev 15:227-33. 2005..Elucidation of the mechanisms underlying cancer in overgrowth syndromes might yield important insights into the molecular basis of childhood tumors...
- Breast cancer metastasis: when, where, how?Suzanne A Eccles
Tumour Biology and Metastasis, Cancer Research UK Centre for Cancer Therapeutics, McElwain Laboratories, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Lancet 365:1006-7. 2005
- The use of gel dosimetry for verification of electron and photon treatment plans in carcinoma of the scalpJ V Trapp
Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
Phys Med Biol 49:1625-35. 2004....
- Evaluation of the response to treatment of solid tumours - a consensus statement of the International Cancer Imaging SocietyJ E Husband
Academic Department of Diagnostic Radiology, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
Br J Cancer 90:2256-60. 2004..The growing need to introduce a multimodality approach to monitoring response is recognized. ICIS welcomes a dialogue with the authors of RECIST to address issues raised in this review...
- Inhibiting the phosphoinositide 3-kinase pathway for cancer treatmentP Workman
Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, U K
Biochem Soc Trans 32:393-6. 2004..Prototype inhibitors show evidence of anticancer activity in vitro and in vivo animal models. The recent development of isoform-selective inhibitors shows considerable promise for cancer treatment...
- Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenomaR A Hubner
Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK
Br J Cancer 97:1449-56. 2007....
- Sex ratio in the offspring of parents with chronic radiation exposure from nuclear testing in KazakhstanNadejda Y Mudie
Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Radiat Res 168:600-7. 2007..In conclusion, no significant association was found between radiation exposure level and sex ratio, but some previously suggested demographic factors were positively associated with sex ratio...
- Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trialMitch Dowsett
Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, United Kingdom
J Clin Oncol 26:1059-65. 2008....
- Evaluation of magnetic resonance diffusion and spectroscopy measurements as predictive biomarkers in stage 1 cervical cancerGeoffrey S Payne
CRUK EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, MRI Unit, Downs Road, Sutton, Surrey, SM2 5PT, UK
Gynecol Oncol 116:246-52. 2010....
- Strategies for stalling malignancy: targeting cancer's addiction to Hsp90Chrisostomos Prodromou
Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
Curr Top Med Chem 9:1352-68. 2009..This review aims to identify potential drug targets, based on the current structural knowledge of the Hsp90-chaperone machine, that could be targeted with the aim of disrupting its functioning and promoting an anti-cancer activity...
- A population-based audit of ethnicity and breast cancer risk in one general practice catchment area in North London, UK: implications for practiceMichelle Ferris
Institute of Cancer Research and Royal Marsden NHS Trust, London and Sutton, Surrey, SM2 5NG, UK
Hered Cancer Clin Pract 5:157-60. 2007..This is the first general practice population-based study in the UK to address this issue and has implications for general practitioners who care for patients from the Ashkenazi community...
- Structure-based design of molecular cancer therapeuticsRob L M Van Montfort
Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, Chelsea, London SW3 6JB, UK
Trends Biotechnol 27:315-28. 2009..Structure-based design approaches have also been successfully applied to the protein-protein interaction targets p53-MDM2 and the Bcl-2 family...
- Optimization and assessment of quantitative 124I imaging on a Philips Gemini dual GS PET/CT systemRebecca A Gregory
Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, UK
Eur J Nucl Med Mol Imaging 36:1037-48. 2009..Quantitative (124)I PET imaging is challenging as (124)I has a complex decay scheme. In this study the performance of a Philips Gemini dual GS PET/CT system was optimized and assessed for (124)I...
- Characterization of dose-dependent Young's modulus for a radiation-sensitive polymer gelRemo A Crescenti
Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, SM2 5PT, UK
Phys Med Biol 54:843-57. 2009..g. variation in coefficient of friction) and inhomogeneous polymerization. Elastography combined with a calibration should also be capable of mapping dose in three dimensions...
- Concepts of epigenetics in prostate cancer developmentC S Cooper
Male Urological Cancer Research Centre, Institute of Cancer Research, Sutton, Surrey, UK
Br J Cancer 100:240-5. 2009..The recent discovery of the role of small RNAs in governing the epigenetic status of individual genes offers exciting new possibilities in therapeutics and chemoprevention...
- Survival from testicular cancer in England and Wales up to 2001R A Huddart
The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
Br J Cancer 99:S83-5. 2008
- Imatinib in advanced gastrointestinal stromal tumour: when is 800 mg the correct dose?Ian Judson
Sarcoma Unit, Royal Marsden Hospital, London, UK
Curr Opin Oncol 20:433-7. 2008..This review looks at the evidence and asks whether this should be standard treatment from diagnosis...
- Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrenceRichard A Hubner
Institute of Cancer Research, Section of Cancer Genetics, Sutton SM2 5NG, United Kingdom
Int J Cancer 123:586-93. 2008..02). These findings indicate dairy products, and in particular milk, have chemopreventive activity against CRA recurrence...
- Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6'split apart' probesJ S Reis-Filho
Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
Histopathology 52:840-6. 2008..It has been demonstrated that SCs of the breast consistently harbour the t(12;15)ETV6-NTRK3 translocation. The aim was to determine whether ACCs also harbour ETV6 gene rearrangements and are thus variants of SCs...
- Two-point Dixon fat-water separation: improving reliability and accuracy in phase correction algorithmsMaria A Schmidt
Department of Medical Physics, St George s Hospital, London, UK
J Magn Reson Imaging 27:1122-9. 2008..To propose an advanced phase-correction region-growing algorithm for two-point fat-water separation suitable for parotid assessment, and to evaluate the general performance of phase-correction algorithms...
- Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenograftsYuen Li Chung
Cancer Research UK, Biomedical Magnetic Resonance Research Group, Department of Basic Medical Sciences, St George s University of London, London, UK
Neoplasia 10:303-13. 2008..The phosphocholine and phosphomonoester increases may have the potential to act as pharmacodynamic markers for noninvasively monitoring tumor response after treatment with LAQ824 or other HDAC inhibitors...
- Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndromeW Lim
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Br J Cancer 89:308-13. 2003..To obtain precise estimates of risk associated with PJS requires further studies of genotype-phenotype especially with respect to LKB1/STK11 negative cases, as this group is likely to be heterogeneous...
- Association between leptin receptor gene polymorphisms and early-onset prostate cancerZ Kote-Jarai
Translational Cancer Genetics, and Molecular Epidemiology, The Institute of Cancer Research, Surrey, UK
BJU Int 92:109-12. 2003....
- Communication and awareness about dying in the 1990sD Field
Centre for Cancer and Palliative Care Studies, Royal Marsden NHS Trust, London, UK
Palliat Med 13:459-68. 1999..This paper examines this apparent paradox by analysing the complex tensions and conflicts of such communication through a discussion of existing literature on modes of communication and patient awareness...
- Evaluation of compensation in breast radiotherapy: a planning study using multiple static fieldsE M Donovan
Joint Department of Physics, Royal Marsden NHS Trust and Institute of Cancer Research, Sutton, Surrey, UK
Int J Radiat Oncol Biol Phys 46:671-9. 2000..We present the results of the study to verify the algorithm, and to assess improvements to the dosimetry...
- Detecting low penetrance genes in cancer: the way aheadR S Houlston
Section of Cancer Genetics, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
J Med Genet 37:161-7. 2000..Here, we review the strategies available for identifying cancer predisposition genes of low and moderate penetrance...
- Meeting report on 8th International Symposium on Platinum and Other Metal Coordination Compounds in Cancer ChemotherapyL R Kelland
CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK
J Inorg Biochem 77:121-4. 1999..g., BNP-7787, DIMESNA) are ongoing. Preclinically, there is interest in trans platinum complexes, terpyridine platinum(II) complexes and other metal-containing agents (ruthenium and gold)...
- Bcl10 in chronic lymphocytic leukaemia and T-cell prolymphocytic leukaemiaM R Yuille
Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey
Br J Haematol 107:384-5. 1999..No pathogenic mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not involved in the development of CLL or T-PLL and that its involvement may be restricted to other haematological malignancies...
- Polycyclic aromatic hydrocarbons in the dietD H Phillips
Institute of Cancer Research, Haddow Laboratories, Cotswold Road, Sutton SM2 5NG, UK
Mutat Res 443:139-47. 1999..More recently, biomonitoring procedures have been developed to assess human exposure to PAHs and these have also indicated that diet is a major source of exposure. Exposure to nitro-PAHs through food consumption appears to be very low...
- Genetic predisposition to ocular melanomaR S Houlston
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
Eye (Lond) 13:43-6. 1999..At present the identification of such individuals is restricted to the small number belonging to BRCA2 families and those with the atypical mole syndrome...
- Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocolsD H Phillips
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
Mutagenesis 14:301-15. 1999..Use of these standards and procedures has reduced interlaboratory variability in quantitation of DNA adducts...
- Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cellsM R Osborne
Section of Molecular Carcinogenesis, Haddow Laboratories, Sutton, Surrey, UK
Carcinogenesis 20:293-7. 1999..All these results indicate that idoxifene is much less genotoxic than tamoxifen, and should therefore be a safer drug...
- Myb proteins in life, death and differentiationK Weston
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK
Curr Opin Genet Dev 8:76-81. 1998..Regulation of Myb proteins by phosphorylation and intermolecular cooperation has recently been demonstrated, together with a new role for the proteins, in the control of apoptosis...
- Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cellsC Patience
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
J Virol 72:2671-6. 1998..Although both HERV-K and RTVL-H sequences were found in association with the particles, beta-Gal transcripts were not detected, indicating that HERV Gag proteins do not efficiently package MLV-based vectors...
- Extraction of primary signal from EPIDs using only forward convolutionV N Hansen
Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Med Phys 24:1477-84. 1997..The radiological thickness of this breast phantom, as extracted using the above convolution model, was found to be within 2.8 mm (1 sd) of the true radiological thickness...
- Loss of the chromosomal region 5q11-q31 in the myeloid cell line HL-60: characterization by comparative genomic hybridization and fluorescence in situ hybridizationJ Shipley
Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, England, UK
Genes Chromosomes Cancer 15:182-6. 1996..The HL-60 cell line may be a useful model to investigate the role of potential tumour suppressor genes associated with loss of 5q material in myeloid leukaemias...
- Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fractionT A Smith
Department of Nuclear Medicine, Royal Marsden Hospital and Institute of Cancer Research, Sutton, Surrey, UK
Int J Radiat Oncol Biol Phys 47:219-23. 2000..The purpose of this study was to assess whether or not changes in the uptake of deoxyglucose (DG) may reflect differences in proliferative fraction independent of other metabolic changes induced by using therapeutic agents...
- Results from the UK NHS breast screening programme 1994-1999R G Blanks
Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, Surrey, UK
J Med Screen 7:195-8. 2000..To present results from the NHS breast screening programme (NHSBSP) from 1994 through to 1999 and to examine the extent to which interim targets are being achieved...
- High intensity focused ultrasound for the treatment of tumorsG R ter Haar
Joint Department of Physics, Royal Marsden Hospital Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom
Echocardiography 18:317-22. 2001..The burgeoning field of HIFU focused ultrasound surgery (FUS) are reviewed in this article...
- Radical radiotherapy for prostate cancerC C Parker
Academic Radiotherapy, Institute of Cancer Research, Royal Marsden Hospital, Surrey SM2 5PT, UK
Cancer Treat Rev 29:161-9. 2003..Finally, future developments will be described, including hypofractionation and dose individualisation, which have the potential to further improve the outcome of external beam radiotherapy for prostate cancer...
- Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetesS P Laing
Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Diabetologia 46:760-5. 2003..The Diabetes UK cohort, essentially one of patients with Type 1 diabetes, now has sufficient follow-up to report all heart disease, and specifically ischaemic heart disease, mortality rates by age...
- RHO-GTPases and cancerErik Sahai
Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Nat Rev Cancer 2:133-42. 2002..A branch of the RAS family--the RHO proteins--is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets?..
- Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamicsPaul Workman
Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SN2 5NG, United Kingdom
Mol Cancer Ther 2:131-8. 2003
- The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS)M O Leach
Section of Magnetic Resonance, The Institute of Cancer Research and The Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK
J Exp Clin Cancer Res 21:107-14. 2002..15 cancers have been detected to date, from a total of 1236 screening measurements. This event rate and the tumour grades reported are compared with recent reports from other studies in women at high risk of breast cancer...
- Smoking-related DNA and protein adducts in human tissuesDavid H Phillips
Institute of Cancer Research, Haddow Laboratories, Cotswold Road, Sutton SM2 5NG, UK
Carcinogenesis 23:1979-2004. 2002..This paper reviews the literature on smoking-related DNA and protein adducts in human tissues and shows how such studies have provided mechanistic insight into the epidemiological associations between smoking and cancer...
- Cerebrovascular mortality in patients with pituitary adenomaM Brada
Neuro oncology Unit and Academic Unit of Radiotherapy, Downs Road, Sutton, Surrey, UK
Clin Endocrinol (Oxf) 57:713-7. 2002..To assess cerebrovascular mortality in a UK cohort of patients with pituitary adenoma known to have increased incidence of cerebrovascular accidents (CVA)...
- Controversies and advances in the management of Wilms' tumourK Pritchard-Jones
The Institute of Cancer Research Royal Marsden Hospital, Section of Paediatric Oncology, Sutton, Surrey, UK
Arch Dis Child 87:241-4. 2002..The proportion of children with heritable disease is uncertain and there remains a need to collect data on the need for screening in this susceptible population...
- Diffusion MRI for prediction of response of rectal cancer to chemoradiationAndrzej Dzik-Jurasz
UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
Lancet 360:307-8. 2002..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
- An algorithm for the optimum combination of data from arbitrary magnetic resonance phased array probesT Prock
CRC Clinical MR Research Group, The Institute of Cancer Research, Royal Marsden NHS Trust, Sutton, Surrey, UK
Phys Med Biol 47:N39-46. 2002..5 T (Dzik-Jurasz A S K, Murphy P S, George M, Prock T, Collins D J, Swift I and Leach M O 2001 Magn. Reson. Med. at press), showing improvements of combined spectral SNR of up to 34% over the maximum SNR from a single element...
- Automated CT marker segmentation for image registration in radionuclide therapyP Papavasileiou
Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK
Phys Med Biol 46:N269-79. 2001..The mean residual 3D registration errors (+/- 1 SD) computed for the simulated and patient studies were 1.8 +/- 0.3 mm and 4.3 +/- 0.5 mm respectively...
- Technology evaluation: leukemia therapy, University of PennsylvaniaR M Orr
CRC Centre for Cancer Therapeutics The Institute of Cancer Research, Sutton, Surrey, UK
Curr Opin Mol Ther 1:399-403. 1999..New phase I studies are starting in 1999, with INX-3001 (University of Pennsylvania c-myb AS PS) supported by the NIH and Inex Pharmaceuticals Corporation...
- Monte Carlo calculation of output factors for circular, rectangular, and square fields of electron accelerators (6-20 MeV)F Verhaegen
Physics Department, Royal Marsden Hospital Institute of Cancer Research, Fulham Road, London SW3 6JJ, United
Med Phys 28:938-49. 2001..Good agreement between calculated and measured output factors was obtained for most field sizes for this second accelerator...
- Epidermal growth factor receptor expression on human breast luminal and basal cells in vitroP Monaghan
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
Epithelial Cell Biol 4:52-62. 1995..Observations made by SEM on cells at the edges of such confluent islands showed that cultured basal cells expressed much higher levels of EGFR on their basal, as compared with their upper surfaces...