Institute of Cancer Research

Summary

Organization: Institute of Cancer Research
Country: UK

Top Publications

  1. doi Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias
    A S Moore
    Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, UK
    Leukemia 24:671-8. 2010
  2. ncbi Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread
    Cecilia Hindorf
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
    Cancer Biother Radiopharm 22:357-66. 2007
  3. ncbi Molecular biology for the radiation oncologist: the 5Rs of radiobiology meet the hallmarks of cancer
    K Harrington
    The Institute of Cancer Research, Targeted Therapy Laboratory, Cancer Research UK, Centre for Cell and Molecular Biology, London, UK
    Clin Oncol (R Coll Radiol) 19:561-71. 2007
  4. ncbi Immunophenotyping and differential diagnosis of hairy cell leukemia
    Estella Matutes
    Department of Haemato Oncology, The Royal Marsden Hospital and Institute of Cancer Research, 203 Fulham Road, London, SW3 6JJ, UK
    Hematol Oncol Clin North Am 20:1051-63. 2006
  5. ncbi Spatial and acoustic pressure dependence of microbubble-mediated gene delivery targeted using focused ultrasound
    Ahad A Rahim
    The Institute of Cancer Research, Gene Therapy Group, Department of Cell and Molecular Biology, 237 Fulham Road, Chelsea, London SW3 6JB, UK
    J Gene Med 8:1347-57. 2006
  6. ncbi Cancer in children and adolescents in Europe: developments over 20 years and future challenges
    K Pritchard-Jones
    Section of Paediatric Oncology, Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey SM2 5PT, UK
    Eur J Cancer 42:2183-90. 2006
  7. ncbi A UK-based investigation of inter- and intra-observer reproducibility of Gleason grading of prostatic biopsies
    J Melia
    Department of Histopathology, Addenbrooke s Hospital, Cambridge, UK
    Histopathology 48:644-54. 2006
  8. pmc The impact of expression profiling on prognostic and predictive testing in breast cancer
    J S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Clin Pathol 59:225-31. 2006
  9. ncbi The effect of changing from one to two views at incident (subsequent) screens in the NHS breast screening programme in England: impact on cancer detection and recall rates
    R G Blanks
    Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, UK
    Clin Radiol 60:674-80. 2005
  10. ncbi Mechanisms predisposing to childhood overgrowth and cancer
    Nazneen Rahman
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Curr Opin Genet Dev 15:227-33. 2005

Scientific Experts

Detail Information

Publications62

  1. doi Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias
    A S Moore
    Section of Paediatric Oncology, The Institute of Cancer Research, Sutton, UK
    Leukemia 24:671-8. 2010
    ..Here we review the growing body of evidence supporting the use of Aurora kinase inhibitors as effective agents for AML and Ph+ leukemias...
  2. ncbi Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread
    Cecilia Hindorf
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
    Cancer Biother Radiopharm 22:357-66. 2007
    ..Treatment efficacy could, therefore, depend on the radionuclide used. The aim of this study was to investigate dosimetry at a cellular level for three isotopes of radioiodine...
  3. ncbi Molecular biology for the radiation oncologist: the 5Rs of radiobiology meet the hallmarks of cancer
    K Harrington
    The Institute of Cancer Research, Targeted Therapy Laboratory, Cancer Research UK, Centre for Cell and Molecular Biology, London, UK
    Clin Oncol (R Coll Radiol) 19:561-71. 2007
    ..Future articles will focus on the specific hallmarks of cancer and will highlight the opportunities that exist for designing new combination treatment regimens...
  4. ncbi Immunophenotyping and differential diagnosis of hairy cell leukemia
    Estella Matutes
    Department of Haemato Oncology, The Royal Marsden Hospital and Institute of Cancer Research, 203 Fulham Road, London, SW3 6JJ, UK
    Hematol Oncol Clin North Am 20:1051-63. 2006
    ..Immunophenotyping is an essential tool for the diagnosis of these two disorders, for monitoring and assessing response to therapy, and for distinguishing them from other B-cell malignancies...
  5. ncbi Spatial and acoustic pressure dependence of microbubble-mediated gene delivery targeted using focused ultrasound
    Ahad A Rahim
    The Institute of Cancer Research, Gene Therapy Group, Department of Cell and Molecular Biology, 237 Fulham Road, Chelsea, London SW3 6JB, UK
    J Gene Med 8:1347-57. 2006
    ..In this study we evaluate the targeting ability and spatial distribution of gene delivery using focused ultrasound...
  6. ncbi Cancer in children and adolescents in Europe: developments over 20 years and future challenges
    K Pritchard-Jones
    Section of Paediatric Oncology, Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey SM2 5PT, UK
    Eur J Cancer 42:2183-90. 2006
    ..Survival rates increased for nearly all types of cancer in children and adolescents. The implications of these findings for aetiological factors and treatment delivery for cancer in children and adolescents are discussed...
  7. ncbi A UK-based investigation of inter- and intra-observer reproducibility of Gleason grading of prostatic biopsies
    J Melia
    Department of Histopathology, Addenbrooke s Hospital, Cambridge, UK
    Histopathology 48:644-54. 2006
    ..Gleason score has important implications for patient management but morphological reproducibility data for British practice are limited. Using literature-based criteria nine uropathologists took part in a reproducibility study...
  8. pmc The impact of expression profiling on prognostic and predictive testing in breast cancer
    J S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Clin Pathol 59:225-31. 2006
    ..Although the results are promising, further optimisation and standardisation of the technique and properly designed clinical trials are required before microarrays can reliably be used as tools for clinical decision making...
  9. ncbi The effect of changing from one to two views at incident (subsequent) screens in the NHS breast screening programme in England: impact on cancer detection and recall rates
    R G Blanks
    Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, UK
    Clin Radiol 60:674-80. 2005
    ..To assess the effect on cancer detection and recall rates of changing from one to two views for incident (subsequent) screens...
  10. ncbi Mechanisms predisposing to childhood overgrowth and cancer
    Nazneen Rahman
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Curr Opin Genet Dev 15:227-33. 2005
    ..Elucidation of the mechanisms underlying cancer in overgrowth syndromes might yield important insights into the molecular basis of childhood tumors...
  11. ncbi Breast cancer metastasis: when, where, how?
    Suzanne A Eccles
    Tumour Biology and Metastasis, Cancer Research UK Centre for Cancer Therapeutics, McElwain Laboratories, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Lancet 365:1006-7. 2005
  12. ncbi The use of gel dosimetry for verification of electron and photon treatment plans in carcinoma of the scalp
    J V Trapp
    Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey SM2 5PT, UK
    Phys Med Biol 49:1625-35. 2004
    ....
  13. pmc Evaluation of the response to treatment of solid tumours - a consensus statement of the International Cancer Imaging Society
    J E Husband
    Academic Department of Diagnostic Radiology, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 90:2256-60. 2004
    ..The growing need to introduce a multimodality approach to monitoring response is recognized. ICIS welcomes a dialogue with the authors of RECIST to address issues raised in this review...
  14. ncbi Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment
    P Workman
    Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, U K
    Biochem Soc Trans 32:393-6. 2004
    ..Prototype inhibitors show evidence of anticancer activity in vitro and in vivo animal models. The recent development of isoform-selective inhibitors shows considerable promise for cancer treatment...
  15. pmc Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma
    R A Hubner
    Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK
    Br J Cancer 97:1449-56. 2007
    ....
  16. ncbi Sex ratio in the offspring of parents with chronic radiation exposure from nuclear testing in Kazakhstan
    Nadejda Y Mudie
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Radiat Res 168:600-7. 2007
    ..In conclusion, no significant association was found between radiation exposure level and sex ratio, but some previously suggested demographic factors were positively associated with sex ratio...
  17. doi Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial
    Mitch Dowsett
    Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, United Kingdom
    J Clin Oncol 26:1059-65. 2008
    ....
  18. doi Evaluation of magnetic resonance diffusion and spectroscopy measurements as predictive biomarkers in stage 1 cervical cancer
    Geoffrey S Payne
    CRUK EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, MRI Unit, Downs Road, Sutton, Surrey, SM2 5PT, UK
    Gynecol Oncol 116:246-52. 2010
    ....
  19. ncbi Strategies for stalling malignancy: targeting cancer's addiction to Hsp90
    Chrisostomos Prodromou
    Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, UK
    Curr Top Med Chem 9:1352-68. 2009
    ..This review aims to identify potential drug targets, based on the current structural knowledge of the Hsp90-chaperone machine, that could be targeted with the aim of disrupting its functioning and promoting an anti-cancer activity...
  20. pmc A population-based audit of ethnicity and breast cancer risk in one general practice catchment area in North London, UK: implications for practice
    Michelle Ferris
    Institute of Cancer Research and Royal Marsden NHS Trust, London and Sutton, Surrey, SM2 5NG, UK
    Hered Cancer Clin Pract 5:157-60. 2007
    ..This is the first general practice population-based study in the UK to address this issue and has implications for general practitioners who care for patients from the Ashkenazi community...
  21. doi Structure-based design of molecular cancer therapeutics
    Rob L M Van Montfort
    Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, Chelsea, London SW3 6JB, UK
    Trends Biotechnol 27:315-28. 2009
    ..Structure-based design approaches have also been successfully applied to the protein-protein interaction targets p53-MDM2 and the Bcl-2 family...
  22. doi Optimization and assessment of quantitative 124I imaging on a Philips Gemini dual GS PET/CT system
    Rebecca A Gregory
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, UK
    Eur J Nucl Med Mol Imaging 36:1037-48. 2009
    ..Quantitative (124)I PET imaging is challenging as (124)I has a complex decay scheme. In this study the performance of a Philips Gemini dual GS PET/CT system was optimized and assessed for (124)I...
  23. doi Characterization of dose-dependent Young's modulus for a radiation-sensitive polymer gel
    Remo A Crescenti
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, SM2 5PT, UK
    Phys Med Biol 54:843-57. 2009
    ..g. variation in coefficient of friction) and inhomogeneous polymerization. Elastography combined with a calibration should also be capable of mapping dose in three dimensions...
  24. pmc Concepts of epigenetics in prostate cancer development
    C S Cooper
    Male Urological Cancer Research Centre, Institute of Cancer Research, Sutton, Surrey, UK
    Br J Cancer 100:240-5. 2009
    ..The recent discovery of the role of small RNAs in governing the epigenetic status of individual genes offers exciting new possibilities in therapeutics and chemoprevention...
  25. pmc Survival from testicular cancer in England and Wales up to 2001
    R A Huddart
    The Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 99:S83-5. 2008
  26. doi Imatinib in advanced gastrointestinal stromal tumour: when is 800 mg the correct dose?
    Ian Judson
    Sarcoma Unit, Royal Marsden Hospital, London, UK
    Curr Opin Oncol 20:433-7. 2008
    ..This review looks at the evidence and asks whether this should be standard treatment from diagnosis...
  27. doi Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence
    Richard A Hubner
    Institute of Cancer Research, Section of Cancer Genetics, Sutton SM2 5NG, United Kingdom
    Int J Cancer 123:586-93. 2008
    ..02). These findings indicate dairy products, and in particular milk, have chemopreventive activity against CRA recurrence...
  28. doi Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6'split apart' probes
    J S Reis-Filho
    Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Histopathology 52:840-6. 2008
    ..It has been demonstrated that SCs of the breast consistently harbour the t(12;15)ETV6-NTRK3 translocation. The aim was to determine whether ACCs also harbour ETV6 gene rearrangements and are thus variants of SCs...
  29. doi Two-point Dixon fat-water separation: improving reliability and accuracy in phase correction algorithms
    Maria A Schmidt
    Department of Medical Physics, St George s Hospital, London, UK
    J Magn Reson Imaging 27:1122-9. 2008
    ..To propose an advanced phase-correction region-growing algorithm for two-point fat-water separation suitable for parotid assessment, and to evaluate the general performance of phase-correction algorithms...
  30. pmc Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts
    Yuen Li Chung
    Cancer Research UK, Biomedical Magnetic Resonance Research Group, Department of Basic Medical Sciences, St George s University of London, London, UK
    Neoplasia 10:303-13. 2008
    ..The phosphocholine and phosphomonoester increases may have the potential to act as pharmacodynamic markers for noninvasively monitoring tumor response after treatment with LAQ824 or other HDAC inhibitors...
  31. pmc Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome
    W Lim
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 89:308-13. 2003
    ..To obtain precise estimates of risk associated with PJS requires further studies of genotype-phenotype especially with respect to LKB1/STK11 negative cases, as this group is likely to be heterogeneous...
  32. ncbi Association between leptin receptor gene polymorphisms and early-onset prostate cancer
    Z Kote-Jarai
    Translational Cancer Genetics, and Molecular Epidemiology, The Institute of Cancer Research, Surrey, UK
    BJU Int 92:109-12. 2003
    ....
  33. ncbi Communication and awareness about dying in the 1990s
    D Field
    Centre for Cancer and Palliative Care Studies, Royal Marsden NHS Trust, London, UK
    Palliat Med 13:459-68. 1999
    ..This paper examines this apparent paradox by analysing the complex tensions and conflicts of such communication through a discussion of existing literature on modes of communication and patient awareness...
  34. ncbi Evaluation of compensation in breast radiotherapy: a planning study using multiple static fields
    E M Donovan
    Joint Department of Physics, Royal Marsden NHS Trust and Institute of Cancer Research, Sutton, Surrey, UK
    Int J Radiat Oncol Biol Phys 46:671-9. 2000
    ..We present the results of the study to verify the algorithm, and to assess improvements to the dosimetry...
  35. pmc Detecting low penetrance genes in cancer: the way ahead
    R S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    J Med Genet 37:161-7. 2000
    ..Here, we review the strategies available for identifying cancer predisposition genes of low and moderate penetrance...
  36. ncbi Meeting report on 8th International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
    L R Kelland
    CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK
    J Inorg Biochem 77:121-4. 1999
    ..g., BNP-7787, DIMESNA) are ongoing. Preclinically, there is interest in trans platinum complexes, terpyridine platinum(II) complexes and other metal-containing agents (ruthenium and gold)...
  37. ncbi Bcl10 in chronic lymphocytic leukaemia and T-cell prolymphocytic leukaemia
    M R Yuille
    Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey
    Br J Haematol 107:384-5. 1999
    ..No pathogenic mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not involved in the development of CLL or T-PLL and that its involvement may be restricted to other haematological malignancies...
  38. ncbi Polycyclic aromatic hydrocarbons in the diet
    D H Phillips
    Institute of Cancer Research, Haddow Laboratories, Cotswold Road, Sutton SM2 5NG, UK
    Mutat Res 443:139-47. 1999
    ..More recently, biomonitoring procedures have been developed to assess human exposure to PAHs and these have also indicated that diet is a major source of exposure. Exposure to nitro-PAHs through food consumption appears to be very low...
  39. ncbi Genetic predisposition to ocular melanoma
    R S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Eye (Lond) 13:43-6. 1999
    ..At present the identification of such individuals is restricted to the small number belonging to BRCA2 families and those with the atypical mole syndrome...
  40. ncbi Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols
    D H Phillips
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
    Mutagenesis 14:301-15. 1999
    ..Use of these standards and procedures has reduced interlaboratory variability in quantitation of DNA adducts...
  41. ncbi Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells
    M R Osborne
    Section of Molecular Carcinogenesis, Haddow Laboratories, Sutton, Surrey, UK
    Carcinogenesis 20:293-7. 1999
    ..All these results indicate that idoxifene is much less genotoxic than tamoxifen, and should therefore be a safer drug...
  42. ncbi Myb proteins in life, death and differentiation
    K Weston
    CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK
    Curr Opin Genet Dev 8:76-81. 1998
    ..Regulation of Myb proteins by phosphorylation and intermolecular cooperation has recently been demonstrated, together with a new role for the proteins, in the control of apoptosis...
  43. pmc Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cells
    C Patience
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Virol 72:2671-6. 1998
    ..Although both HERV-K and RTVL-H sequences were found in association with the particles, beta-Gal transcripts were not detected, indicating that HERV Gag proteins do not efficiently package MLV-based vectors...
  44. ncbi Extraction of primary signal from EPIDs using only forward convolution
    V N Hansen
    Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Med Phys 24:1477-84. 1997
    ..The radiological thickness of this breast phantom, as extracted using the above convolution model, was found to be within 2.8 mm (1 sd) of the true radiological thickness...
  45. ncbi Loss of the chromosomal region 5q11-q31 in the myeloid cell line HL-60: characterization by comparative genomic hybridization and fluorescence in situ hybridization
    J Shipley
    Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, England, UK
    Genes Chromosomes Cancer 15:182-6. 1996
    ..The HL-60 cell line may be a useful model to investigate the role of potential tumour suppressor genes associated with loss of 5q material in myeloid leukaemias...
  46. ncbi Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fraction
    T A Smith
    Department of Nuclear Medicine, Royal Marsden Hospital and Institute of Cancer Research, Sutton, Surrey, UK
    Int J Radiat Oncol Biol Phys 47:219-23. 2000
    ..The purpose of this study was to assess whether or not changes in the uptake of deoxyglucose (DG) may reflect differences in proliferative fraction independent of other metabolic changes induced by using therapeutic agents...
  47. ncbi Results from the UK NHS breast screening programme 1994-1999
    R G Blanks
    Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, Surrey, UK
    J Med Screen 7:195-8. 2000
    ..To present results from the NHS breast screening programme (NHSBSP) from 1994 through to 1999 and to examine the extent to which interim targets are being achieved...
  48. ncbi High intensity focused ultrasound for the treatment of tumors
    G R ter Haar
    Joint Department of Physics, Royal Marsden Hospital Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom
    Echocardiography 18:317-22. 2001
    ..The burgeoning field of HIFU focused ultrasound surgery (FUS) are reviewed in this article...
  49. ncbi Radical radiotherapy for prostate cancer
    C C Parker
    Academic Radiotherapy, Institute of Cancer Research, Royal Marsden Hospital, Surrey SM2 5PT, UK
    Cancer Treat Rev 29:161-9. 2003
    ..Finally, future developments will be described, including hypofractionation and dose individualisation, which have the potential to further improve the outcome of external beam radiotherapy for prostate cancer...
  50. ncbi Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes
    S P Laing
    Section of Epidemiology, Brookes Lawley Building, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Diabetologia 46:760-5. 2003
    ..The Diabetes UK cohort, essentially one of patients with Type 1 diabetes, now has sufficient follow-up to report all heart disease, and specifically ischaemic heart disease, mortality rates by age...
  51. ncbi RHO-GTPases and cancer
    Erik Sahai
    Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Rev Cancer 2:133-42. 2002
    ..A branch of the RAS family--the RHO proteins--is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets?..
  52. ncbi Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics
    Paul Workman
    Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SN2 5NG, United Kingdom
    Mol Cancer Ther 2:131-8. 2003
  53. ncbi The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS)
    M O Leach
    Section of Magnetic Resonance, The Institute of Cancer Research and The Royal Marsden Hospital, Downs Road, Sutton, Surrey, SM2 5PT, UK
    J Exp Clin Cancer Res 21:107-14. 2002
    ..15 cancers have been detected to date, from a total of 1236 screening measurements. This event rate and the tumour grades reported are compared with recent reports from other studies in women at high risk of breast cancer...
  54. ncbi Smoking-related DNA and protein adducts in human tissues
    David H Phillips
    Institute of Cancer Research, Haddow Laboratories, Cotswold Road, Sutton SM2 5NG, UK
    Carcinogenesis 23:1979-2004. 2002
    ..This paper reviews the literature on smoking-related DNA and protein adducts in human tissues and shows how such studies have provided mechanistic insight into the epidemiological associations between smoking and cancer...
  55. ncbi Cerebrovascular mortality in patients with pituitary adenoma
    M Brada
    Neuro oncology Unit and Academic Unit of Radiotherapy, Downs Road, Sutton, Surrey, UK
    Clin Endocrinol (Oxf) 57:713-7. 2002
    ..To assess cerebrovascular mortality in a UK cohort of patients with pituitary adenoma known to have increased incidence of cerebrovascular accidents (CVA)...
  56. pmc Controversies and advances in the management of Wilms' tumour
    K Pritchard-Jones
    The Institute of Cancer Research Royal Marsden Hospital, Section of Paediatric Oncology, Sutton, Surrey, UK
    Arch Dis Child 87:241-4. 2002
    ..The proportion of children with heritable disease is uncertain and there remains a need to collect data on the need for screening in this susceptible population...
  57. ncbi Diffusion MRI for prediction of response of rectal cancer to chemoradiation
    Andrzej Dzik-Jurasz
    UK Cancer Research Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Royal Marsden NHS Trust, Downs Road, Sutton SM2 5PT, UK
    Lancet 360:307-8. 2002
    ..67, p=0.01) and chemoradiation (r=-0.83, p=0.001). Persistence of low ADC in responders after chemotherapy could represent loss of a non-viable fraction of the treated tumour...
  58. ncbi An algorithm for the optimum combination of data from arbitrary magnetic resonance phased array probes
    T Prock
    CRC Clinical MR Research Group, The Institute of Cancer Research, Royal Marsden NHS Trust, Sutton, Surrey, UK
    Phys Med Biol 47:N39-46. 2002
    ..5 T (Dzik-Jurasz A S K, Murphy P S, George M, Prock T, Collins D J, Swift I and Leach M O 2001 Magn. Reson. Med. at press), showing improvements of combined spectral SNR of up to 34% over the maximum SNR from a single element...
  59. ncbi Automated CT marker segmentation for image registration in radionuclide therapy
    P Papavasileiou
    Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK
    Phys Med Biol 46:N269-79. 2001
    ..The mean residual 3D registration errors (+/- 1 SD) computed for the simulated and patient studies were 1.8 +/- 0.3 mm and 4.3 +/- 0.5 mm respectively...
  60. ncbi Technology evaluation: leukemia therapy, University of Pennsylvania
    R M Orr
    CRC Centre for Cancer Therapeutics The Institute of Cancer Research, Sutton, Surrey, UK
    Curr Opin Mol Ther 1:399-403. 1999
    ..New phase I studies are starting in 1999, with INX-3001 (University of Pennsylvania c-myb AS PS) supported by the NIH and Inex Pharmaceuticals Corporation...
  61. ncbi Monte Carlo calculation of output factors for circular, rectangular, and square fields of electron accelerators (6-20 MeV)
    F Verhaegen
    Physics Department, Royal Marsden Hospital Institute of Cancer Research, Fulham Road, London SW3 6JJ, United
    Med Phys 28:938-49. 2001
    ..Good agreement between calculated and measured output factors was obtained for most field sizes for this second accelerator...
  62. ncbi Epidermal growth factor receptor expression on human breast luminal and basal cells in vitro
    P Monaghan
    Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK
    Epithelial Cell Biol 4:52-62. 1995
    ..Observations made by SEM on cells at the edges of such confluent islands showed that cultured basal cells expressed much higher levels of EGFR on their basal, as compared with their upper surfaces...