Mark H Wilson
Affiliation: Imperial College Healthcare NHS Trust
- Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressureMark H Wilson
Institute of Pre hospital Care, London s Air Ambulance, The Royal London Hospital, Queen Mary College, London, UK
J Cereb Blood Flow Metab 36:1338-50. 2016..This article reviews the Monro-Kellie doctrine, categorises venous outflow limitation conditions, relates physiological mechanisms to clinical conditions and suggests specific management options. ..
- Cerebral venous system and anatomical predisposition to high-altitude headacheMark H Wilson
The Traumatic Brain Injury Centre, St Mary s Hospital, Imperial College, London, W1 2NY United Kingdom
Ann Neurol 73:381-9. 2013..We postulated that HAH results when hypoxia-associated increases in cerebral blood flow occur in the context of restricted venous drainage, and is worsened when cerebral compliance is reduced. We explored this hypothesis in 3 studies...
- The headache of high altitude and microgravity--similarities with clinical syndromes of cerebral venous hypertensionMark H Wilson
National Hospital for Neurology and Neurosurgery and University College London, London, United Kingdom
High Alt Med Biol 12:379-86. 2011..It may also enable us to trigger headaches for study and hence enable us to develop new treatment strategies...
- Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia--an ultrasound and MRI studyMark H Wilson
Centre for Altitude, Space and Extreme Environment Medicine, Institute of Human Health and Performance, Charterhouse Building, UCL Archway Campus, University College London, London, UK
J Cereb Blood Flow Metab 31:2019-29. 2011....
- Stroke at high altitude diagnosed in the field using portable ultrasoundMark H Wilson
Institute for Human Health and Performance, Ground Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, Archway, London, UK
Wilderness Environ Med 22:54-7. 2011..The patient was then evacuated to a hospital in Kathmandu over the next 48 hours. This case report suggests that portable ultrasound could be used in the prehospital arena to enable early diagnosis of thrombotic stroke...
- The cerebral venous system and hypoxiaMark H Wilson
The Centre for Altitude, Space and Extreme Environment Medicine, University College London, London, United Kingdom The Birmingham Medical Research Expeditionary Society, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom Imperial Neurotrauma Centre, Imperial College, St Mary s Hospital, London, United Kingdom Institute of Pre Hospital Care, London s Air Ambulance, Royal London Hospital, Whitechapel, United Kingdom and
J Appl Physiol (1985) 120:244-50. 2016..An inability to drain the hypoxemic induced increase in cerebral blood flow could be an underappreciated regulatory mechanism of intracranial pressure. ..
- The cerebral effects of ascent to high altitudesMark H Wilson
Centre for Altitude, Space and Extreme Environment Medicine, University College London, London, UK
Lancet Neurol 8:175-91. 2009..The effects of hypobaric hypoxia might also provide new insights into the understanding of hypoxia in the clinical setting...
- Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxiaDenny Z H Levett
Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, London, N19 5LW, UK
BMC Med Res Methodol 10:98. 2010..The aim of this study was to describe the spectrum of adaptive responses in humans exposed to graded EHH and identify factors (physiological and genetic) associated with inter-individual variation in these responses...
- Changes in pupil dynamics at high altitude--an observational study using a handheld pupillometerMark H Wilson
London Helicopter Emergency Medical Service, The Helipad, The Royal London Hospital, Whitechapel, London, UK
High Alt Med Biol 9:319-25. 2008..There appears to be a marked diurnal variation in pupil size. The measurements clearly demonstrated an effect of hypoxia on cerebral function, but these changes did not relate to moderate AMS...
- Intracranial pressure at altitudeMark H Wilson
1 The Brain Injury Centre St Mary s Hospital, Imperial College, London, United Kingdom
High Alt Med Biol 15:123-32. 2014..This article reviews the literature both supporting and refuting an increase in ICP as the underlying mechanism of headaches and other related neurological sequelae experienced at high altitude...