Julian R Walters

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis
    Julian R F Walters
    Department of Gastroenterology, Imperial College, London, United Kingdom
    Clin Gastroenterol Hepatol 7:1189-94. 2009
  2. doi request reprint Defining primary bile acid diarrhea: making the diagnosis and recognizing the disorder
    Julian R F Walters
    Section of Hepatology and Gastroenterology, Department of Medicine, Imperial College London and, Imperial College Healthcare, London, UK
    Expert Rev Gastroenterol Hepatol 4:561-7. 2010
  3. ncbi request reprint Cell and molecular biology of the small intestine: new insights into differentiation, growth and repair
    Julian R F Walters
    Gastroenterology Section, Department of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Curr Opin Gastroenterol 20:70-6. 2004
  4. pmc Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption
    Sara Balesaria
    Gastroenterology Dept, Imperial College Healthcare, Hammersmith Hospital, London, UK
    Am J Physiol Gastrointest Liver Physiol 297:G1193-7. 2009
  5. pmc Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-one in the Diagnosis of Patients With Possible Bile Acid Diarrhea
    Sanjeev S Pattni
    Department of Medicine, Section of Hepatology and Gastroenterology, Imperial College London and Imperial College Healthcare, London, UK
    Clin Transl Gastroenterol 3:e18. 2012
  6. pmc Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids
    Justine H Zhang
    Section of Hepatology and Gastroenterology, Department of Medicine, Imperial College Londonand Imperial College Healthcare, London, UK
    Am J Physiol Gastrointest Liver Physiol 304:G940-8. 2013
  7. doi request reprint Coeliac disease and the risk of infections
    Julian R F Walters
    Department of Gastroenterology, Imperial College Healthcare NHS Trust and Imperial College London, UK
    Gut 57:1034-5. 2008
  8. ncbi request reprint The role of the intestine in bone homeostasis
    Julian R Walters
    Faculty of Medicine, Imperial College London, London W12 0NN, UK
    Eur J Gastroenterol Hepatol 15:845-9. 2003
  9. ncbi request reprint The effects of Vitamin D metabolites on expression of genes for calcium transporters in human duodenum
    Julian R F Walters
    Department of Gastroenterology, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    J Steroid Biochem Mol Biol 103:509-12. 2007
  10. ncbi request reprint Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women
    Julian R F Walters
    Gastroenterology Section, Division of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    J Bone Miner Res 21:1770-7. 2006

Collaborators

Detail Information

Publications24

  1. doi request reprint A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis
    Julian R F Walters
    Department of Gastroenterology, Imperial College, London, United Kingdom
    Clin Gastroenterol Hepatol 7:1189-94. 2009
    ..Fibroblast growth factor 19 (FGF19), produced in the ileum in response to bile acid absorption, regulates hepatic bile acid synthesis. We proposed that FGF19 is involved in bile acid diarrhea and measured its levels in patients with BAM...
  2. doi request reprint Defining primary bile acid diarrhea: making the diagnosis and recognizing the disorder
    Julian R F Walters
    Section of Hepatology and Gastroenterology, Department of Medicine, Imperial College London and, Imperial College Healthcare, London, UK
    Expert Rev Gastroenterol Hepatol 4:561-7. 2010
    ..The identification of FGF19 as the central mechanism opens up new areas for development in the diagnosis and treatment of primary bile acid diarrhea...
  3. ncbi request reprint Cell and molecular biology of the small intestine: new insights into differentiation, growth and repair
    Julian R F Walters
    Gastroenterology Section, Department of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Curr Opin Gastroenterol 20:70-6. 2004
    ..This paper will discuss recent research that has provided new insights into the molecular and cell biology of the small intestine...
  4. pmc Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption
    Sara Balesaria
    Gastroenterology Dept, Imperial College Healthcare, Hammersmith Hospital, London, UK
    Am J Physiol Gastrointest Liver Physiol 297:G1193-7. 2009
    ....
  5. pmc Fibroblast Growth Factor 19 and 7α-Hydroxy-4-Cholesten-3-one in the Diagnosis of Patients With Possible Bile Acid Diarrhea
    Sanjeev S Pattni
    Department of Medicine, Section of Hepatology and Gastroenterology, Imperial College London and Imperial College Healthcare, London, UK
    Clin Transl Gastroenterol 3:e18. 2012
    ..Our aim is to evaluate the diagnostic value of FGF19 in a large and prospective group of patients with chronic diarrhea, previously investigated with C4...
  6. pmc Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids
    Justine H Zhang
    Section of Hepatology and Gastroenterology, Department of Medicine, Imperial College Londonand Imperial College Healthcare, London, UK
    Am J Physiol Gastrointest Liver Physiol 304:G940-8. 2013
    ..We concluded that FGF19 expression in human ileum is very highly responsive to BA. Changes in FGF19 induction are a potential mechanism involved in disorders of BA homeostasis...
  7. doi request reprint Coeliac disease and the risk of infections
    Julian R F Walters
    Department of Gastroenterology, Imperial College Healthcare NHS Trust and Imperial College London, UK
    Gut 57:1034-5. 2008
  8. ncbi request reprint The role of the intestine in bone homeostasis
    Julian R Walters
    Faculty of Medicine, Imperial College London, London W12 0NN, UK
    Eur J Gastroenterol Hepatol 15:845-9. 2003
    ..Bone changes are found in many intestinal disorders including lactose intolerance, coeliac disease, short bowel syndrome, small intestinal bacterial overgrowth and Crohn's disease...
  9. ncbi request reprint The effects of Vitamin D metabolites on expression of genes for calcium transporters in human duodenum
    Julian R F Walters
    Department of Gastroenterology, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    J Steroid Biochem Mol Biol 103:509-12. 2007
    ..TRPV6 expression also increased with 25(OH)D(3). CYP27B1 expression was found in all samples, and CYP24 transcripts were detected after incubation with 1,25(OH)(2)D(3) or 25(OH)D(3)...
  10. ncbi request reprint Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women
    Julian R F Walters
    Gastroenterology Section, Division of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom
    J Bone Miner Res 21:1770-7. 2006
    ..In human duodenum, expression of the calcium channel TRPV6 was directly related to blood 1,25-dihydroxyvitamin D in men, but effects of age with lower median vitamin D receptor levels were more significant in women...
  11. ncbi request reprint Duodenal expression of the epithelial calcium transporter gene TRPV6: is there evidence for Vitamin D-dependence in humans?
    Julian R F Walters
    Gastroenterology Section, Faculty of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    J Steroid Biochem Mol Biol 89:317-9. 2004
    ..In the GG genotype group, but not the AG, duodenal TRPV6 expression increased with 1,25(OH)(2)D(3). We postulate that lower levels of expression of VDR in the GG group produce greater sensitivity to 1,25(OH)(2)D(3)...
  12. ncbi request reprint Recent findings in the cell and molecular biology of the small intestine
    Julian R F Walters
    Gastroenterology Section, Department of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Curr Opin Gastroenterol 21:135-40. 2005
    ..Recently published research exploring new aspects of the molecular and cell biology of the small intestine is reviewed...
  13. doi request reprint Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea
    Sara Balesaria
    Gastroenterology Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
    Eur J Gastroenterol Hepatol 20:413-22. 2008
    ....
  14. doi request reprint Short bowel syndrome: the role of GLP-2 on improving outcome
    Katharina Wallis
    Division of Medicine, Imperial College Healthcare, Hammersmith Hospital, London, UK
    Curr Opin Clin Nutr Metab Care 12:526-32. 2009
    ..This review summarizes our current understanding of GLP-2 physiology and provides an update on clinical trials in short bowel syndrome and related conditions...
  15. ncbi request reprint Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor
    Paul A Kitchen
    St Mark s Hospital, Imperial College London, Harrow, United Kingdom
    JPEN J Parenter Enteral Nutr 29:248-54. 2005
    ..We report studies aimed to determine whether there may be synergistic effects of these 2 peptides...
  16. doi request reprint Recent advances in the understanding of bile acid malabsorption
    Sanjeev Pattni
    Department of Gastroenterology, Hammersmith Hospital, Imperial Healthcare NHS Trust, London W12 0HS, UK
    Br Med Bull 92:79-93. 2009
    ..Idiopathic BAM (IBAM, primary bile acid diarrhoea) is the condition where no definitive cause for low SeHCAT retention can be identified...
  17. ncbi request reprint Human ileal bile acid-binding protein promoter and the effects of CDX2
    Natalie F Barley
    Gastroenterology Section, Faculty of Medicine, Imperial College London, UK
    Biochim Biophys Acta 1630:138-43. 2003
    ..3-q34) defined the major transcription start site and identified conserved elements. A consensus element for the caudal-related homeobox factor CDX2 was functional in gel-shift assays and in transfection experiments...
  18. doi request reprint Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain
    Ayesha Akbar
    Department of Gastroenterology, Imperial College London, UK
    Gut 59:767-74. 2010
    ..We investigated TRPV1-immunoreactive fibres in rectosigmoid biopsies taken from such patients with correlation to abdominal pain severity...
  19. ncbi request reprint Coeliac disease often goes undiagnosed
    Julian R F Walters
    Hammersmith Hospital, London
    Practitioner 251:43, 45, 47 passim. 2007
  20. ncbi request reprint A common CTLA4 haplotype associated with coeliac disease
    Karen A Hunt
    Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK
    Eur J Hum Genet 13:440-4. 2005
    ..Loss of tolerance to dietary antigens in coeliac disease may be mediated in part by heritable variants in co-signalling genes regulating T-cell responses...
  21. ncbi request reprint Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2
    Alison Howard
    Institute for Cell and Molecular Biosciences, University of Newcastle Medical School, Newcastle upon Tyne, UK
    J Nutr 134:2957-64. 2004
    ..The importance of maintaining amino acid supply for intestinal mucosal cells is illustrated...
  22. pmc Newly identified genetic risk variants for celiac disease related to the immune response
    Karen A Hunt
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Nat Genet 40:395-402. 2008
    ..Type 1 diabetes and celiac disease share HLA-DQ, IL2-IL21, CCR3 and SH2B3 risk regions. Thus, this extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways...
  23. pmc A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    David A van Heel
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
    Nat Genet 39:827-9. 2007
    ..3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease...
  24. pmc Calcium and vitamin D in preventing fractures: dietary intake of calcium needs to be considered
    Julian R F Walters
    BMJ 331:108; author reply 109. 2005