S D Taylor-Robinson
Affiliation: Imperial College
- Applications of magnetic resonance spectroscopy to chronic liver diseaseS D Taylor-Robinson
Department of Medicine A, Imperial College School of Medicine, London
Clin Med (Lond) 1:54-60. 2001..Future trends are considered: for example, the use of MRS as a non-invasive tool to assess the effectiveness of liver-directed gene therapy...
- Operation Lifeline SudanS D Taylor-Robinson
Gastroenterology Unit, Imperial College School of Medicine, London, UK
J Med Ethics 28:49-51. 2002..Nevertheless, OLS may serve as a model for how medical aid can be delivered in an even-handed way to the populations of countries where there is civil war, irrespective of where they may live...
- Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998S D Taylor-Robinson
Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Campus, South Wharf Street, London W2 1PG, UK
Gut 48:816-20. 2001..We further analysed the mortality statistics to determine which anatomical subcategories were involved...
- A comparison of 31P magnetic resonance spectroscopy and microbubble-enhanced ultrasound for characterizing hepatitis c-related liver diseaseA K P Lim
Imaging Sciences Department, Institute of Clinical Sciences Centre, Faculty of Medicine, London, UK
J Viral Hepat 18:e530-4. 2011..00). (31) P MRS and HVTT show much promise as noninvasive imaging tests for assessing the severity of chronic liver disease. Both are equally effective and highly sensitive in detecting cirrhosis...
- Optimal combinations of ultrasound-based and serum markers of disease severity in patients with chronic hepatitis CJ F L Cobbold
Department of Hepatology and Gastroenterology, Division of Medicine, Imperial College London, London, UK
J Viral Hepat 17:537-45. 2010..Combination of APRI with either ELF or TE effectively predicts fibrosis stage, but combinations of three or more tests lead to redundancy of information and increased cost...
- Hepatic vein transit times of a microbubble agent in assessing response to antiviral treatment in patients with chronic hepatitis CA K P Lim
Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
J Viral Hepat 17:778-83. 2010..These results are encouraging and indicate that these tests could be potentially used as markers of response to treatment and could obviate the need for serial biopsies in antiviral future treatment studies...
- Non-invasive diagnosis of hepatic cirrhosis by transit-time analysis of an ultrasound contrast agentT Albrecht
Department of Imaging, Hammersmith Hospital, Imperial College of Science, Technology, and Medicine, London, UK
Lancet 353:1579-83. 1999..We investigated this first pass in patients with diffuse liver disease and in normal controls to assess whether it provides useful differential diagnostic information...
- DNA adducts, detected by 32P postlabelling, in human cholangiocarcinomaS A Khan
The Liver Centre, Division of Medicine A, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, South Wharf St, London W2 1PG, UK
Gut 52:586-91. 2003..It is a key step in chemically induced carcinogenesis. We hypothesise that the increase in CCa mortality is caused by a rise in a genotoxic environmental agent(s), causing cholangiocyte DNA damage...
- Liver microbubble transit time compared with histology and Child-Pugh score in diffuse liver disease: a cross sectional studyM J K Blomley
Imaging Sciences Department, Clinical Sciences Division, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Rd, London, UK
Gut 52:1188-93. 2003..A previous pilot study showed that early arrival time of a microbubble in a hepatic vein is a sensitive indicator of cirrhosis...
- Incorporation of metabolite prior knowledge for data analysis: biochemical implications of dynamic 31P NMR ex vivo pig liver studiesK K Changani
Department of Surgery, Royal Free Hospital and Medical School, Hampstead, London, UK
NMR Biomed 12:197-204. 1999..Moreover, this kind of analysis approach could be advantageous in many complex in vivo NMR spectroscopy applications...
- Cerebral microglial activation in patients with hepatitis C: in vivo evidence of neuroinflammationV P B Grover
Liver Unit, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK
J Viral Hepat 19:e89-96. 2012..This provides further in vivo evidence for a neurotropic role for HCV...
- Hepatitis C and hepatic steatosisJ H Patel
Liver Unit, Imperial College London, St Mary s Hospital Campus, 10th Floor QEQM Building, Praed Street, London W2 1NY, UK
QJM 103:293-303. 2010..Furthermore, simple lifestyle alterations showed positive effects on parameters of disease activity. These insights raise the possibility of novel treatment options...
- Fatigue and primary biliary cirrhosis: association of globus pallidus magnetisation transfer ratio measurements with fatigue severity and blood manganese levelsD M Forton
Liver Unit, Faculty of Medicine, St Mary s Hospital Campus, Imperial College London, London, UK
Gut 53:587-92. 2004..We examined the hypothesis that a CNS abnormality related to cholestasis, rather than cirrhosis per se, underlies this symptom...
- MR-guided laser thermal ablation of primary and secondary liver tumoursE A Dick
Department of Interventional MRI, St Mary s Hospital Campus, Faculty of Medicine, Imperial College, Praed St, London, UK
Clin Radiol 58:112-20. 2003..To test the hypothesis that magnetic resonance (MR)-guided hepatic tumour ablation is (i) safe and feasible, (ii) is associated with favourable patient survival, and (iii) decreases viable tumour...
- Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus documentS A Khan
Liver Unit, Department of Medicine A, Imperial College School of Medicine, St Mary s Hospital Campus, South Wharf Street, London W2 1PG, UK
Gut 51:VI1-9. 2002
- Cholangiocarcinoma and its managementS A Khan
Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, London, UK
Gut 56:1755-6. 2007
- Cerebral dysfunction in chronic hepatitis C infectionD M Forton
Hepatology Section, Division of Medicine A, Faculty of Medicine, Imperial College London, UK
J Viral Hepat 10:81-6. 2003....
- Whole body fat: content and distributionE L Thomas
Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
Prog Nucl Magn Reson Spectrosc 73:56-80. 2013..Finally, we will discuss how MRI/MRS techniques are helping in changing the perception of what is healthy and what is normal and desirable body-fat content and distribution. ..
- Cerebral bioenergetics in stable chronic obstructive pulmonary diseaseR Mathur
Department of Medicine, Imperial College School of Medicine, London, UK
Am J Respir Crit Care Med 160:1994-9. 1999..2 +/- 0.6, p = 0.01) was reduced in patients as compared with controls. This alteration in phosphorus-containing metabolites within cerebral cells provides evidence of extensive use of anaerobic metabolism in hypoxic COPD patients...
- Unfriendly chemicals in pancreatic cancerS A Khan
Division of Medicine A, Faculty of Medicine, St Mary s Campus, Imperial College, London
Pancreatology 3:7-8. 2003
- Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals?A Winston
Division of Medicine, Imperial College London, London, UK
J Viral Hepat 17:419-26. 2010..021). Acute HCV in HIV-1 infected subjects is associated with CNS involvement. Clinicians should be vigilant of early CNS involvement when assessing subjects with acute HCV...
- Hepatocellular adenoma: diagnostic difficulties and novel imaging techniquesA K P Lim
Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
Br J Radiol 75:695-9. 2002..We have described two new imaging techniques not previously described in characterization of hepatic adenomata, namely ultrasound with contrast agent and MR spectroscopy...
- Reversible alterations in brain metabolites during therapy for disseminated nocardiosis using proton magnetic resonance spectroscopyC D Marcus
The Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Metab Brain Dis 14:231-7. 1999..This case illustrates reversible MR-measurable metabolite changes in the brain of an HIV-seropositive patient without HIV-1 encephalitis who underwent treatment for cerebral nocardiosis...
- Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopyK K Changani
Magnetic Resonance Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Gut 49:557-64. 2001....
- Magnetic resonance spectroscopy of high-energy phosphates and lactate immediately after coronary artery bypass surgeryD N Harris
Department of Anaesthesia, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Perfusion 13:328-33. 1998..92 +/- 0.37 vs 6.39 +/- 2.67, p = 0.03). This suggests rebound replacement of energy stores following recovery from temporary cerebral ischaemia during CPB: intra-operative studies would be needed to test this hypothesis further...
- Research collaborations in Tajikistan: lessons to be learntN Massie
From the Department of Medicine, Imperial College London, St Mary s Campus, South Wharf Road, London W2 1NY, UK
QJM 108:761-3. 2015..Through this lens, present-day technical, organizational and socio-political challenges can be appropriately considered, with a view to improving academic collaboration in the future...
- Neuropsychological tools in hepatology: a survival guide for the clinicianS Montagnese
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
J Viral Hepat 19:307-15. 2012....
- New insights into hepatitis CD M Forton
Department of Medicine A, Imperial College and Liver Centre, St Mary s Hospital, London
Clin Med 2:554-9. 2002..Viral mechanisms of antiviral resistance parallel those of viral persistence, and include the intriguing possibility that hepatitis C may infect immunologically privileged sites such as the central nervous system...
- Ablative therapy for liver tumoursE A Dick
Department of Interventional Magnetic Resonance Imaging, Imperial College School of Medicine, St Mary s Hospital, London, UK
Gut 50:733-9. 2002..The merits of this newly emerging technique are discussed, together with future developments, such as focused ultrasound therapy, which holds the promise of non-invasive thermoablation treatment on an outpatient basis...
- Hepatic vein transit times using a microbubble agent can predict disease severity non-invasively in patients with hepatitis CA K P Lim
Imaging Sciences Department, MRC Clinical Services Centre, Faculty of Medicine, Imperial College, The Robert Steiner MR Unit, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Gut 54:128-33. 2005..We investigated the utility of hepatic vein transit times (HVTT) for grading and staging diffuse liver disease in a cohort of patients with hepatitis C virus (HCV) infection using an ultrasound microbubble contrast agent as a tracer...
- Fatigue in primary biliary cirrhosisD M Forton
Gut 54:438. 2005
- Non-invasive evaluation of hepatic fibrosis using magnetic resonance and ultrasound techniquesJ F L Cobbold
Gut 55:1670; author reply 1670. 2006