Christoph M Tang

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Available carbon source influences the resistance of Neisseria meningitidis against complement
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    J Exp Med 201:1637-45. 2005
  2. pmc Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
    Elisabeth Kugelberg
    Centre for Molecular Microbiology and Infection, Flowers Building, Armstrong Road, Imperial College London, London SW7 2AZ, United Kingdom
    Vaccine 26:I34-9. 2008
  3. pmc Identification of meningococcal genes necessary for colonization of human upper airway tissue
    Rachel M Exley
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 77:45-51. 2009
  4. pmc Neisseria meningitidis lactate permease is required for nasopharyngeal colonization
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, Armstrong Rd, London SW7 2AZ, United Kingdom
    Infect Immun 73:5762-6. 2005
  5. pmc A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies
    Maria Jose Uria
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Imperial College London, London SW7 2AZ, England, UK
    J Exp Med 205:1423-34. 2008
  6. ncbi request reprint Interactions between Neisseria meningitidis and the complement system
    Muriel C Schneider
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK
    Trends Microbiol 15:233-40. 2007
  7. pmc Modulation of Shigella virulence in response to available oxygen in vivo
    Benoit Marteyn
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Nature 465:355-8. 2010
  8. pmc Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis
    Jan Silhan
    Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
    Nucleic Acids Res 40:2065-75. 2012
  9. doi request reprint Sequence conservation of pilus subunits in Neisseria meningitidis
    Ana Cehovin
    The Centre for Molecular Microbiology and Infection, CMMI Flowers Building, Imperial College London, Armstrong Road, London SW7 2AZ, UK
    Vaccine 28:4817-26. 2010
  10. doi request reprint Secreted proteins of Neisseria meningitidis protect mice against infection
    Yanwen Li
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Vaccine 27:2320-5. 2009

Collaborators

Detail Information

Publications33

  1. pmc Available carbon source influences the resistance of Neisseria meningitidis against complement
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    J Exp Med 201:1637-45. 2005
    ..The findings highlight the intimate relationship between bacterial physiology and resistance to innate immune killing in the meningococcus...
  2. pmc Mechanisms in Neisseria meningitidis for resistance against complement-mediated killing
    Elisabeth Kugelberg
    Centre for Molecular Microbiology and Infection, Flowers Building, Armstrong Road, Imperial College London, London SW7 2AZ, United Kingdom
    Vaccine 26:I34-9. 2008
    ..Here we discuss the mechanisms of meningococcal resistance against complement-mediated killing and the influence of both bacterial and host genetic factors...
  3. pmc Identification of meningococcal genes necessary for colonization of human upper airway tissue
    Rachel M Exley
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 77:45-51. 2009
    ..We have identified novel meningococcal colonization factors, and this should provide insights into the survival of this important pathogen in its natural habitat...
  4. pmc Neisseria meningitidis lactate permease is required for nasopharyngeal colonization
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, Armstrong Rd, London SW7 2AZ, United Kingdom
    Infect Immun 73:5762-6. 2005
    ..Studies with other strains defective for the uptake of specific nutrients should provide valuable information about the environment in which N. meningitidis persists during carriage...
  5. pmc A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies
    Maria Jose Uria
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Imperial College London, London SW7 2AZ, England, UK
    J Exp Med 205:1423-34. 2008
    ..The strains with IS1301 in the IGR avoided complement-mediated lysis in the presence of bactericidal antibodies directed at the outer membrane protein, PorA, or raised against whole cells...
  6. ncbi request reprint Interactions between Neisseria meningitidis and the complement system
    Muriel C Schneider
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK
    Trends Microbiol 15:233-40. 2007
    ..meningitidis avoids complement-mediated killing, and how polymorphisms in genes encoding human complement proteins affect susceptibility to this important human pathogen...
  7. pmc Modulation of Shigella virulence in response to available oxygen in vivo
    Benoit Marteyn
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Nature 465:355-8. 2010
    ..This would reverse the anaerobic block of Ipa secretion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence...
  8. pmc Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis
    Jan Silhan
    Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
    Nucleic Acids Res 40:2065-75. 2012
    ....
  9. doi request reprint Sequence conservation of pilus subunits in Neisseria meningitidis
    Ana Cehovin
    The Centre for Molecular Microbiology and Infection, CMMI Flowers Building, Imperial College London, Armstrong Road, London SW7 2AZ, UK
    Vaccine 28:4817-26. 2010
    ..These data have important implications for the re-consideration of pilus subunits as vaccine antigens...
  10. doi request reprint Secreted proteins of Neisseria meningitidis protect mice against infection
    Yanwen Li
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Vaccine 27:2320-5. 2009
    ..FACS analysis of intact bacteria treated with anti-MSPs confirmed surface-binding of antibodies...
  11. pmc Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, Armstrong Road, London SW7 2AZ, United Kingdom
    Infect Immun 75:1318-24. 2007
    ..Lactate is a micronutrient in the genital tract that contributes to the survival of the gonococcus...
  12. pmc The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and disease
    Elisabeth Kugelberg
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9413. 2010
    ..Novel polymorphisms associated with IS1301 in the IGR of UK MenB isolates do not lead to the resistance phenotype seen for IS1301 in the IGR of MenC isolates...
  13. pmc Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates
    Muriel C Schneider
    Centre for Molecular Microbiology and Infection, Imperial College, London SW7 2AZ, UK
    Nature 458:890-3. 2009
    ..The structure also indicates the molecular basis of the host-specificity of the interaction between fH and the meningococcus, and informs attempts to develop novel therapeutics and vaccines...
  14. pmc Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis
    Duo Lu
    Centre for Structural Biology, Division of Molecular Biosciences and Department of Microbiology, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 109:16852-7. 2012
    ..Our data reveal subtle differences in AP-site recognition and kinetics between the human and bacterial enzymes that may reflect different evolutionary pressures...
  15. pmc Immunization with live Neisseria lactamica protects mice against meningococcal challenge and can elicit serum bactericidal antibodies
    Yanwen Li
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 74:6348-55. 2006
    ....
  16. pmc Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium
    Thomas C Sutherland
    Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    Infect Immun 78:3832-47. 2010
    ..The Calu-3 model should be suitable for dissecting the pathogenesis of infections caused by other respiratory pathogens, as well as the meningococcus...
  17. pmc Vaccination with attenuated Neisseria meningitidis strains protects against challenge with live Meningococci
    Yanwen Li
    Centre for Molecular Microbiology and Infection, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
    Infect Immun 72:345-51. 2004
    ....
  18. pmc Galectin-3 binds Neisseria meningitidis and increases interaction with phagocytic cells
    Paola Quattroni
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Imperial College London, London, UK
    Cell Microbiol 14:1657-75. 2012
    ..We found that Gal-3(-/-) mice had significantly lower levels of bacteraemia compared with wild-type mice after challenge with live bacteria, indicating that galectin-3 confers an advantage to N. meningitidis during systemic infection...
  19. ncbi request reprint Functional significance of factor H binding to Neisseria meningitidis
    Muriel C Schneider
    Centre for Molecular Microbiology and Infection, Imperial College London, UK
    J Immunol 176:7566-75. 2006
    ..meningitidis to avoid complement-mediated killing in the presence of human serum. Therefore, the recruitment of fH provides another mechanism by which this important human pathogen evades host innate immunity...
  20. ncbi request reprint Identification of novel antigens that protect against systemic meningococcal infection
    Yaohui Sun
    Centre for Molecular Microbiology and Infection, Faculty of Medicine, Imperial College London, Armstrong Road, London SW7 2AZ, UK
    Vaccine 23:4136-41. 2005
    ..Both LctP and ExbB are expressed by a wide range of pathogenic isolates of N. meningitidis. Targeting bacterial factors required for pathogenesis may lead to new vaccines to protect individuals from this important human pathogen...
  21. pmc A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis
    Krzysztofa Nagorska
    Centre for Molecular Microbiology and Infection Division of Molecular Biosciences, Imperial College London, London, UK
    Mol Microbiol 83:1064-79. 2012
    ..This network is likely to reflect successful adaptation to the human nasopharynx, and might provide a paradigm for DNA repair in other prokaryotes...
  22. pmc The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing
    Qian Zhang
    Department of Microbiology, Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 285:34259-68. 2010
    ..Instead, expression of PPX modifies the interaction of N. meningitidis with the alternative pathway of complement activation...
  23. doi request reprint Mechanisms of avoidance of host immunity by Neisseria meningitidis and its effect on vaccine development
    Helena Lo
    Centre for Molecular Microbiology and Infection, Department of Microbiology, Imperial College London, London, UK
    Lancet Infect Dis 9:418-27. 2009
    ....
  24. ncbi request reprint Optimization of virulence functions through glucosylation of Shigella LPS
    Nicholas P West
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Science 307:1313-7. 2005
    ..Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in Shigella...
  25. doi request reprint Mechanisms of meningococcal colonisation
    Kaushali Trivedi
    Centre for Molecular Microbiology and Infection, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Trends Microbiol 19:456-63. 2011
    ..Refinements in cell-based and in vivo models will lead to improved understanding of the colonisation process, and hopefully to more effective vaccines and therapeutic strategies...
  26. doi request reprint New insights into pathogen recognition
    Paola Quattroni
    Centre for Molecular Microbiology and Infection, Section of Microbiology, Flowers Building, Imperial College London, London, SW7 2AZ, UK
    Expert Rev Anti Infect Ther 9:577-9. 2011
    ....
  27. ncbi request reprint Making 'sense' of metabolism: autoinducer-2, LuxS and pathogenic bacteria
    Agnès Vendeville
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Armstrong Road, Imperial College London, London SW7 2AZ, UK
    Nat Rev Microbiol 3:383-96. 2005
    ..Here, we discuss the influence that LuxS and its product, autoinducer-2, have on virulence, relating the current evidence to the preferred niche of the pathogen and the underlying mechanisms involved...
  28. ncbi request reprint Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide
    Christoph M Tang
    Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology, and Medicine, Armstrong Road, London SW7 2AZ, UK
    Gene 284:133-40. 2002
    ..The results provide an initial characterisation of the genetic basis of a key, immunodominant epitope of meningococcal LPS...
  29. doi request reprint Life on the inside: the intracellular lifestyle of cytosolic bacteria
    Katrina Ray
    Department of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, London, UK
    Nat Rev Microbiol 7:333-40. 2009
    ..can gain access to and proliferate within the host cell cytosol. Here, we discuss the mechanisms by which these cytosolic pathogens escape into the cytosol, obtain nutrients to replicate and subvert host immune responses...
  30. ncbi request reprint Signature-tagged mutagenesis: barcoding mutants for genome-wide screens
    Piotr Mazurkiewicz
    Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK
    Nat Rev Genet 7:929-39. 2006
    ..By combining whole-genome microarrays and comprehensive ordered libraries of mutants, high-throughput functional screens can now be achieved on a genomic scale...
  31. ncbi request reprint Interactions between Neisseria meningitidis and human cells that promote colonisation and disease
    Anne Corbett
    The Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Armstrong Road, Imperial College London, London, SW7 2AZ, UK
    Expert Rev Mol Med 6:1-14. 2004
    ..This article summarises the molecular basis of host-pathogen interactions at the cellular level during meningococcal carriage and disease...
  32. ncbi request reprint Finding your niche: what has been learnt from STM studies on GI colonization
    Nicholas P West
    Centre for Molecular Microbiology and Infection, Faculty of Medicine, Flowers Building, Imperial College London, London, UK SW7 2AZ
    Trends Microbiol 11:338-44. 2003
  33. doi request reprint Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis
    Nikos Tsolakos
    National Institute for Biological Standards and Control, Medicine and Healthcare Products Regulatory Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom Centre for Molecular Microbiology and Infection, Division of Infectious Diseases, Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    J Proteomics 101:63-76. 2014
    ..These observations add knowledge for the development of a protein NmB vaccine. The proteomic workflow presented here may be used for the discovery of vaccine candidates against other pathogens...