P F Sumariwalla
Affiliation: Imperial College
- Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritisPei Jin
Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
Arthritis Res Ther 10:R73. 2008..The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis...
- Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritisPercy F Sumariwalla
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
Arthritis Rheum 58:3071-80. 2008..To evaluate the therapeutic potential of the human epidermal growth factor receptor (HER) family inhibitor, herstatin, in an animal model of arthritis...
- Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717P F Sumariwalla
Kennedy Institute of Rheumatology, Imperial College London, London, UK
Rheumatology (Oxford) 48:32-8. 2009..To evaluate the clinical efficacy of a novel synthetic peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist, CLX-090717, in several in vitro cell culture systems and murine CIA, an experimental model of RA...
- P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factorP F Sumariwalla
Kennedy Institute of Rheumatology, Imperial College London, UK
Clin Exp Immunol 136:67-75. 2004..The mechanism of action involves reduced cellularity of synovium as anticipated, along with a reduction in TNF production from inflammatory cells in the synovium. The latter mechanism needs further mechanistic analysis...
- The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritisA M Malfait
Kennedy Institute of Rheumatology, Hammersmith, London, United Kingdom
Proc Natl Acad Sci U S A 97:9561-6. 2000..Taken together, these data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA...