Sandra M Sacre

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Molecular therapeutic targets in rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK
    Expert Rev Mol Med 7:1-20. 2005
  2. ncbi request reprint Endotoxin signaling in human macrophages: signaling via an alternate mechanism
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    J Endotoxin Res 10:445-52. 2004
  3. ncbi request reprint Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 178:2148-54. 2007
  4. ncbi request reprint Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 181:8002-9. 2008
  5. ncbi request reprint Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems
    Anna M Lundberg
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, 1 Aspenlea Road, Hammersmith, London, United Kingdom
    Blood 110:3245-52. 2007
  6. pmc Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Ann Rheum Dis 66:iii81-6. 2007
  7. ncbi request reprint Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith, London W6 8LH, United Kingdom
    Blood 103:2229-37. 2004
  8. ncbi request reprint Toll-like receptors: a new target in rheumatoid arthritis?
    Stefan K Drexler
    Imperial College of Science, Technology and Medicine, Kennedy Institute of Rheumatology Division, Faculty of Medicine, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK
    Expert Rev Clin Immunol 2:585-99. 2006
  9. doi request reprint Modulation of toll-like receptor function has therapeutic potential in autoimmune disease
    Felix I L Clanchy
    Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology and Medicine, Faculty of Medicine, Hammersmith, London, UK
    Expert Opin Biol Ther 10:1703-16. 2010
  10. pmc The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology, Imperial College London, and the Department of Orthopedics, Royal United Hospital, Bath, UK
    Am J Pathol 170:518-25. 2007

Detail Information

Publications10

  1. ncbi request reprint Molecular therapeutic targets in rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK
    Expert Rev Mol Med 7:1-20. 2005
    ..This review describes therapies that are approved, in clinical trials or under pre-clinical investigation at the laboratory level, particularly focusing on cytokines, although other therapeutic targets of interest are mentioned...
  2. ncbi request reprint Endotoxin signaling in human macrophages: signaling via an alternate mechanism
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    J Endotoxin Res 10:445-52. 2004
    ....
  3. ncbi request reprint Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 178:2148-54. 2007
    ..We conclude that TRAM is an adaptor protein for both TLR4 and TLR2/6 signaling in SFs, HUVECs, and murine embryonic fibroblasts, but cannot demonstrate a role in human macrophages...
  4. ncbi request reprint Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 181:8002-9. 2008
    ..Together, these data suggest that TLR8 may play a role in driving TNF production in RA. Because this receptor can be inhibited by small m.w. molecules, it may prove to be an important therapeutic target...
  5. ncbi request reprint Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems
    Anna M Lundberg
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, 1 Aspenlea Road, Hammersmith, London, United Kingdom
    Blood 110:3245-52. 2007
    ..This is the first report of such cell type- and species-specific response for any TLR stimulation and helps to explain important difficulties in correlating murine models of inflammatory diseases and human inflammation...
  6. pmc Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Ann Rheum Dis 66:iii81-6. 2007
    ....
  7. ncbi request reprint Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
    Evangelos Andreakos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith, London W6 8LH, United Kingdom
    Blood 103:2229-37. 2004
    ....
  8. ncbi request reprint Toll-like receptors: a new target in rheumatoid arthritis?
    Stefan K Drexler
    Imperial College of Science, Technology and Medicine, Kennedy Institute of Rheumatology Division, Faculty of Medicine, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK
    Expert Rev Clin Immunol 2:585-99. 2006
    ..Targeting individual TLRs or their signaling transducers may provide a more specific therapy without global suppression of the immune system...
  9. doi request reprint Modulation of toll-like receptor function has therapeutic potential in autoimmune disease
    Felix I L Clanchy
    Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology and Medicine, Faculty of Medicine, Hammersmith, London, UK
    Expert Opin Biol Ther 10:1703-16. 2010
    ..These receptors have been suggested to be involved in the initiation and/or perpetuation of many inflammatory autoimmune diseases and have become attractive candidates for the modulation of inflammation...
  10. pmc The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    Sandra M Sacre
    Kennedy Institute of Rheumatology, Imperial College London, and the Department of Orthopedics, Royal United Hospital, Bath, UK
    Am J Pathol 170:518-25. 2007
    ..Thus, TLRs not only protect against infection but may also promote the inflammatory and destructive process in RA...