Andrew S C Rice

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial
    Andrew S C Rice
    Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK Electronic address
    Lancet 383:1637-47. 2014
  2. pmc Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK
    Pain 133:47-63. 2007
  3. ncbi New treatments for neuropathic pain
    Andrew S C Rice
    Department of Anaesthetics, Imperial College, Chelsea and Westminster Hospital Campus, London SW10 9NH, United Kingdom
    Annu Rev Med 57:535-51. 2006
  4. pmc Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London SW10 9NH, UK
    Brain 130:2688-702. 2007
  5. pmc Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK
    Neurosci Lett 448:153-6. 2008
  6. pmc Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain
    Klio Maratou
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pain 13:387-98. 2009
  7. ncbi A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia
    W Paul Farquhar-Smith
    Pain Research, Imperial College, Chelsea and Westminster Campus, London, United Kingdom
    Anesthesiology 99:1391-401. 2003
  8. ncbi Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors
    W Paul Farquhar-Smith
    Pain Research, Department of Anaesthetics, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Pain 97:11-21. 2002
  9. ncbi Ultrasound vocalisation by rodents does not correlate with behavioural measures of persistent pain
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW109NH, UK
    Eur J Pain 9:445-52. 2005
  10. doi Investigation of neuropathic pain in treated leprosy patients in Ethiopia: a cross-sectional study
    Omer M O Haroun
    Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Pain 153:1620-4. 2012

Detail Information

Publications29

  1. doi EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial
    Andrew S C Rice
    Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK Electronic address
    Lancet 383:1637-47. 2014
    ..EMA401, a highly selective AT2R antagonist, is under development as a novel neuropathic pain therapeutic agent. We assessed the therapeutic potential of EMA401 in patients with postherpetic neuralgia...
  2. pmc Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK
    Pain 133:47-63. 2007
    ....
  3. ncbi New treatments for neuropathic pain
    Andrew S C Rice
    Department of Anaesthetics, Imperial College, Chelsea and Westminster Hospital Campus, London SW10 9NH, United Kingdom
    Annu Rev Med 57:535-51. 2006
    ..Only recently have drug discovery efforts have become mechanistically driven, addressing targets identified by a molecular neurobiological approach to the pathophysiology of neuropathic states...
  4. pmc Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London SW10 9NH, UK
    Brain 130:2688-702. 2007
    ..They therefore merit further investigation for the elucidation of underlying mechanisms and may prove useful for preclinical assessment of drugs for the treatment of HIV-related peripheral neuropathic pain...
  5. pmc Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW10 9NH, UK
    Neurosci Lett 448:153-6. 2008
    ..This study highlights the potential use of this rodent model and behavioural paradigm in the validation of the affective component of novel analgesic pharmacological targets and elucidation of underlying pathophysiological mechanisms...
  6. pmc Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain
    Klio Maratou
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pain 13:387-98. 2009
    ..As an external control, the RNA expression of three genes was examined by RT-PCR, while the protein levels of two were studied using western blot analysis...
  7. ncbi A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia
    W Paul Farquhar-Smith
    Pain Research, Imperial College, Chelsea and Westminster Campus, London, United Kingdom
    Anesthesiology 99:1391-401. 2003
    ..The effects of administration of the cannabinoid anandamide and the cannabimimetic palmitoylethanolamide on an NGF-induced hyperalgesia and neutrophil accumulation were examined in this study...
  8. ncbi Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors
    W Paul Farquhar-Smith
    Pain Research, Department of Anaesthetics, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Pain 97:11-21. 2002
    ..These data add to the growing evidence of a therapeutic potential for cannabinoids, and support the hypothesis that the endogenous cannabinoid system modulates the NGF-mediated components of inflammatory processes...
  9. ncbi Ultrasound vocalisation by rodents does not correlate with behavioural measures of persistent pain
    Victoria C J Wallace
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London SW109NH, UK
    Eur J Pain 9:445-52. 2005
    ..Ultrasound vocalisation was not associated with other pain behaviour in any of the inflammatory, visceral or neuropathic pain models examined and is therefore not a useful integrated correlate of pain behaviour...
  10. doi Investigation of neuropathic pain in treated leprosy patients in Ethiopia: a cross-sectional study
    Omer M O Haroun
    Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Pain 153:1620-4. 2012
    ..Depression is a common co-morbidity in patients with NP. The high prevalence and morbidity of NP in treated leprosy patients warrant clinical trials to assess the efficacy of pain therapies for leprosy-associated NP...
  11. doi A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy
    Wenlong Huang
    Department of Surgery and Cancer, Imperial College London, UK
    Pain 154:560-75. 2013
    ....
  12. pmc Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials
    Tudor J C Phillips
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital Campus, London, United Kingdom
    PLoS ONE 5:e14433. 2010
    ..There is an urgent need to develop effective pain management strategies for this condition...
  13. pmc Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling study
    Tudor J C Phillips
    Pain Research Group, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK
    Pain 155:1846-60. 2014
    ..HIV-SN participants had higher plasma triglyceride, concentrations depression, anxiety and catastrophizing scores, and prevalence of insomnia than HIV participants without HIV-SN. ..
  14. doi Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury
    Isobel J Lever
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London SW10 9NH, UK
    J Neurosci 29:3766-80. 2009
    ..This study reveals the location of FAAH in neural tissue involved in peripheral nociceptive transmission...
  15. pmc The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy
    Andreas C Themistocleous
    aNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdombDiabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United KingdomcStructural and Molecular Biology, Division of Biosciences, University College London, London, United KingdomdPain Research Group, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, United KingdomePain Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom
    Pain 157:1132-45. 2016
    ..3%) with NeuP. This study provides a firm basis to rationalise further phenotyping of painful DPN, for instance, stratification of patients with DPN for analgesic drug trials. ..
  16. doi Xenon reduces activation of transient receptor potential vanilloid type 1 (TRPV1) in rat dorsal root ganglion cells and in human TRPV1-expressing HEK293 cells
    John P M White
    Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369, Fulham Road, London, SW10 9NH, United Kingdom
    Life Sci 88:141-9. 2011
    ....
  17. doi Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies
    Maree T Smith
    aCentre for Integrated Preclinical Drug Development, Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, AustraliabSchool of Pharmacy, The University of Queensland, Brisbane, AustraliacCentre for Clinical Translation, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United KingdomdDepartment of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital Campus, London, United Kingdom
    Pain 157:S33-41. 2016
    ....
  18. ncbi Current treatment options in neuropathic pain
    Kathleen Hempenstall
    Department of Anaesthetics, The Hillingdon Hospital, Uxbridge, Middlesex, UK
    Curr Opin Investig Drugs 3:441-8. 2002
    ..This review focuses on evidence from randomized controlled trials to assess the efficacy of the currently available drug treatments...
  19. doi Comparison of psychological and physical function in neuropathic pain and nociceptive pain: implications for cognitive behavioral pain management programs
    H Clare Daniel
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, UK
    Eur J Pain 12:731-41. 2008
    ..The implications of our findings for the development of cognitive behavioral pain management programs for people with neuropathic pain are discussed...
  20. pmc Development, Validation, and Field-Testing of an Instrument for Clinical Assessment of HIV-Associated Neuropathy and Neuropathic Pain in Resource-Restricted and Large Population Study Settings
    Yohannes W Woldeamanuel
    Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 11:e0164994. 2016
    ..In conclusion, a combination of four easily and quickly assessed clinical items can be used to accurately diagnose HIV-SN. DN4-interview used in the context of bilateral feet pain can be used to identify those with neuropathic pain...
  21. pmc Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations
    Nick A Andrews
    aDepartment of Neurobiology, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA bDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA cDepartment of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada dDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA ePain Research, Department of Surgery and Cancer, Imperial College, London, United Kingdom fCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom Departments of gAnesthesiology, hNeurology, and iPsychiatry, University of Rochester, Rochester, NY, USA jDepartment of Anesthesiology, Wake Forest School of Medicine, Winston Salem, NC, USA kDepartment of Biostatistics, Harvard University, Boston, MA, USA lDepartment of Anesthesiology, University of Rochester, Rochester, NY, USA mClinical and Rehabilitative Medicine Research Program, United States Army Medical Research and Materiel Command, Fort Detrick, MD, NJ 08903-0231
    Pain 157:901-9. 2016
    ..We believe that to achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues...
  22. ncbi Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors
    Jason W Brooks
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pharmacol 439:83-92. 2002
    ..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically...
  23. pmc Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai
    Estrella Lasry-Levy
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e981. 2011
    ..The association of neuropathic pain with psychological morbidity was also evaluated...
  24. doi Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy
    Maree T Smith
    aCentre for Integrated Preclinical Drug Development bSchool of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia cDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK
    Behav Pharmacol 25:137-46. 2014
    ..Therefore, small-molecule AT2R antagonists should be investigated further as novel analgesics for the relief of ATN. ..
  25. doi Persistent pain in survivors of torture: a cohort study
    Amanda C de C Williams
    Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom
    J Pain Symptom Manage 40:715-22. 2010
    ..Refugee survivors of torture in the United Kingdom have multiple problems, of which pain may be underrecognized, given the high prevalence recorded in similar populations in Denmark...
  26. ncbi Pharmacologic management of neuropathic pain: evidence-based recommendations
    Robert H Dworkin
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 132:237-51. 2007
    ..Long-term studies, head-to-head comparisons between medications, studies involving combinations of medications, and RCTs examining treatment of central NP are lacking and should be a priority for future research...
  27. pmc Analgesic therapy in postherpetic neuralgia: a quantitative systematic review
    Kathleen Hempenstall
    Royal Hampshire County Hospital, Winchester, United Kingdom
    PLoS Med 2:e164. 2005
    ..Therefore, we have conducted a systematic review and meta-analysis for both efficacy and adverse events of analgesic therapy for PHN...
  28. ncbi Cannabimimetic eicosanoids in cancer and inflammation: an update
    Dominique Melck
    Endocannabinoid Research Group, Istituto per la Chimica di Molecule di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, NA, Italy
    Adv Exp Med Biol 507:381-6. 2002
  29. ncbi Pain following herpes zoster: the influence of changing population characteristics and medical developments
    Robert W Johnson
    Pain 128:3-5. 2007