John Reynolds

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis
    J Reynolds
    Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Invest 105:643-51. 2000
  2. ncbi request reprint Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    J Am Soc Nephrol 16:1350-9. 2005
  3. ncbi request reprint Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene
    John Reynolds
    Renal Section, Division of Medicine, MRC Clinical Sciences Centre and Imperial College Genetics and Genomics Research Institute, Imperial College, Hammersmith Hospital, London, UK
    Exp Nephrol 10:402-7. 2002
  4. ncbi request reprint Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    J Am Soc Nephrol 13:359-69. 2002
  5. ncbi request reprint Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis in the WKY rat
    J Reynolds
    Renal Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Am Soc Nephrol 12:61-70. 2001
  6. ncbi request reprint The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease
    John Reynolds
    Renal Section, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    J Pathol 200:118-29. 2003
  7. ncbi request reprint Blockade of the CD154-CD40 costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Kidney Int 66:1444-52. 2004
  8. pmc Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat
    John Reynolds
    Renal Section, Department of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom
    Am J Pathol 180:1843-51. 2012
  9. doi request reprint Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis
    John Reynolds
    Department of Medicine, Imperial College London, UK
    Nephrol Dial Transplant 27:1343-50. 2012
  10. pmc Mucosal tolerance induced by an immunodominant peptide from rat alpha3(IV)NC1 in established experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    Am J Pathol 174:2202-10. 2009

Detail Information

Publications16

  1. pmc CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis
    J Reynolds
    Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Invest 105:643-51. 2000
    ..Our results suggest a key role for B7. 1 in costimulation of Th1-like autoimmune responses in the rat, and show that glomerular injury in EAG is largely dependent on cell-mediated mechanisms...
  2. ncbi request reprint Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    J Am Soc Nephrol 16:1350-9. 2005
    ..Further work using new antigen-specific treatment strategies may provide a novel approach to the treatment of patients with anti-glomerular basement membrane disease...
  3. ncbi request reprint Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene
    John Reynolds
    Renal Section, Division of Medicine, MRC Clinical Sciences Centre and Imperial College Genetics and Genomics Research Institute, Imperial College, Hammersmith Hospital, London, UK
    Exp Nephrol 10:402-7. 2002
    ..No significant linkage was detected. These results exclude Col4a3 as a recessive susceptibility gene for EAG in the BC1 progeny...
  4. ncbi request reprint Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    J Am Soc Nephrol 13:359-69. 2002
    ..They confirm the importance of T cell-mediated immunity in the pathogenesis of this model of Goodpasture's disease. Similar therapeutic approaches may be worth investigating in human crescentic glomerulonephritis...
  5. ncbi request reprint Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis in the WKY rat
    J Reynolds
    Renal Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Am Soc Nephrol 12:61-70. 2001
    ..These results clearly demonstrate that mucosal tolerance can be induced by oral administration of GBM antigen and that this approach is effective in preventing EAG...
  6. ncbi request reprint The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease
    John Reynolds
    Renal Section, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    J Pathol 200:118-29. 2003
    ..This study defines for the first time the relationship between the immunological and pathological events during the evolution of EAG, and provides the basis for further work on the pathogenesis of Goodpasture's disease...
  7. ncbi request reprint Blockade of the CD154-CD40 costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Kidney Int 66:1444-52. 2004
    ..Our hypothesis was that blocking the interaction between CD154 (CD40L) on Th cells and CD40 on antigen-presenting cells should inhibit T-cell activation, and thus the development of EAG...
  8. pmc Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat
    John Reynolds
    Renal Section, Department of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom
    Am J Pathol 180:1843-51. 2012
    ..These results confirm the importance of Crgn1 on chromosome 13 in EAG susceptibility, mediated partly through differences in Fc receptor-mediated macrophage activation...
  9. doi request reprint Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis
    John Reynolds
    Department of Medicine, Imperial College London, UK
    Nephrol Dial Transplant 27:1343-50. 2012
    ..Engagement of PD-1 by its ligands results in a negative regulatory effect, with inhibition of downstream cellular signalling events and diminished cellular proliferation...
  10. pmc Mucosal tolerance induced by an immunodominant peptide from rat alpha3(IV)NC1 in established experimental autoimmune glomerulonephritis
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    Am J Pathol 174:2202-10. 2009
    ....
  11. doi request reprint Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone
    Phoebe E H Sharp
    Division of Immunity and Inflammation, Department of Medicine, Imperial College London, W12 0NN, UK
    Mol Immunol 50:49-56. 2012
    ....
  12. ncbi request reprint Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis
    J J Ryan
    Renal Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nephrol Dial Transplant 16:253-61. 2001
    ..We have proposed that immunization with homologous antigen is more appropriate for detailed investigation of autoimmunity in EAG...
  13. pmc Identification of a nephritogenic immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis
    J Reynolds
    Division of Medicine, Imperial College London, Hammersmith Campus, London, UK
    Clin Exp Immunol 155:311-9. 2009
    ..Identification of this immunodominant peptide will be of value in designing new therapeutic strategies for inducing mucosal tolerance in EAG, which may be applicable to patients with glomerulonephritis...
  14. ncbi request reprint Strain susceptibility to active induction and passive transfer of experimental autoimmune glomerulonephritis in the rat
    John Reynolds
    Renal Section, Division of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Nephrol Dial Transplant 21:3398-408. 2006
    ....
  15. pmc Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by 'autoantigen complementarity'
    John Reynolds
    Renal Section, Department of Medicine, Imperial College London, Hammersmith Campus, London, UK Institute of Biomedical and Environmental Science and Technology, Department of Life Sciences, University of Bedfordshire, Luton, UK Electronic address
    J Autoimmun 59:8-18. 2015
    ..The implications of this discovery may be far reaching, and other autoimmune diseases could be due to responses to these once unsuspected 'complementary' antigens. ..
  16. ncbi request reprint Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis
    Giles Walters
    Centre for Kidney Research, The Children s Hospital, Westmead, Australia
    Nephron Exp Nephrol 98:e71-81. 2004
    ..Our results show that glomerular T cells are of restricted clonality and suggest a role for antigen-specific effector T cells in the pathogenesis of EAG...