Genomes and Genes
Affiliation: Imperial College
- Sequential identification of apoptotic and necrotic cells on individual cytospin preparationsP Pantelidis
Interstitial Lung Disease Unit, Occupational and Environmental Medicine, Imperial College at the National Heart and Lung Institute, London, UK
J Immunol Methods 214:209-12. 1998..Identification of trypan blue and TUNEL positive cells in the same section permits the simultaneous assessment of necrotic and apoptotic cells...
- Analysis of tumor necrosis factor-alpha, lymphotoxin-alpha, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosisP Pantelidis
Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, Imperial College of Science, Royal Brompton Campus, 1B Manresa Road, London SW3 6LR, United Kingdom
Am J Respir Crit Care Med 163:1432-6. 2001..These findings, if independently confirmed, will be the first to suggest that disease progression in IPF may be linked to a particular genetic marker or to functional polymorphisms in other genes near that marker...
- Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosisP J Foley
Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, London, UK
Am J Respir Cell Mol Biol 25:272-7. 2001..This suggests this HLA-DR residue is an important protective marker in sarcoidosis...
- Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to sclerodermaA L Lagan
Clinical Genomics Group, National Heart and Lung Institute and Royal Brompton Hospital, Imperial College, 1B Manresa Road, London SW3 6LR, UK
Rheumatology (Oxford) 44:197-201. 2005..We set out to reproduce and to positionally clone these disease associations in a set of UK Caucasian scleroderma patients and ethnically matched controls...
- Tumour necrosis factor-alpha production in fibrosing alveolitis is macrophage subset specificP Pantelidis
Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, Royal Brompton Hospital and National Heart and Lung Institute, London, UK
Respir Res 2:365-72. 2001..CONCLUSION: By demonstrating the primary cell source of TNF-alpha in FASSc, more accurately targeted, possibly localized, anti-TNF strategies might be employed with success in the future...
- Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosisP Beirne
Dept of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, UK
Eur Respir J 34:1376-82. 2009..These findings, if they are corroborated by independent studies in other centres, have potential for clinical application and may generate novel insights into the modulation of immune profiles during disease evolution...
- Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathwaysM Conron
Kennedy Institute of Rheumatology, London, United Kingdom
Am J Respir Cell Mol Biol 25:141-9. 2001..The results of this study have implications for the future investigation of molecular pathways in inflammatory lung disease...
- BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumoniaS Veeraraghavan
Interstitial Lung Disease Unit, Dept of Occupational and Environmental Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
Eur Respir J 22:239-44. 2003....
- Intracellular cytokine profiles and T cell activation in pulmonary sarcoidosisT A Hill
Department of Clinical Ophthalmology, Institute of Ophthalmology, University College London, London, UK
Cytokine 42:289-92. 2008..The use of intracellular flow cytometry to investigate cytokine production by BAL T cells could help to indicate potential targets for future therapy...
- Single-cell analysis: a novel approach to tumour necrosis factor-alpha synthesis and secretion in sarcoidosisP Pantelidis
Interstitial Lung Disease Unit, Dept of Occupational and Environmental Medicine, Royal Brompton Hospital and National Heart and Lung Institute, London, UK
Eur Respir J 20:1179-84. 2002..This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future...
- A single round PCR method for genotyping human surfactant protein (SP)-A1, SP-A2 and SP-D gene allelesP Pantelidis
Clinical Genomics Group, Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, London, UK
Tissue Antigens 61:317-21. 2003..In this manuscript, we report the primers and conditions of a sequence specific primer-PCR methodology that enables the identification of SP-A1, SP-A2 and SP-D gene allelic variants directly on genomic DNA material...
- Ace gene I/D polymorphism and sarcoidosis pulmonary disease severityD S McGrath
Interstitial Lung Disease Unit, Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, London, SW3 6LR, UK
Am J Respir Crit Care Med 164:197-201. 2001..We conclude that the ACE I/D polymorphism has no role in sarcoidosis susceptibility in European whites and that it is not a regulatory variant in this disease...
- l-selectin gene polymorphisms and complications of sickle cell diseaseC C Ugochukwu
Department of Haematology, St Thomas Hospital, University of London, UK
Int J Lab Hematol 30:312-6. 2008..37, P > 0.05). The findings suggest that these three gene polymorphisms do not predispose to high leukocyte expression of L-selectin, or development of complications in SCD...
- Increased vitronectin and endothelin-1 in the breath condensate of patients with fibrosing lung diseaseG E Carpagnano
Institute of Respiratory Diseases, University of Bari, Bari, Italy
Respiration 70:154-60. 2003..Better understanding of mediators involved in fibrosis may be useful for early diagnosis and in clinical monitoring of disease progression...