David J Nutt

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Rationale for, barriers to, and appropriate medication for the long-term treatment of depression
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e02. 2010
  2. doi request reprint International consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e08. 2010
  3. doi request reprint Inverse agonists - What do they mean for psychiatry?
    David Nutt
    Centre for Psychiatry, Imperial College London, UK Electronic address
    Eur Neuropsychopharmacol . 2016
  4. doi request reprint Considerations on the role of buprenorphine in recovery from heroin addiction from a UK perspective
    David J Nutt
    Imperial College London, London, UK
    J Psychopharmacol 29:43-9. 2015
  5. doi request reprint Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers
    David Nutt
    Division of Brain Sciences, Centre for Neuropsychopharmacology, Imperial College London, UK Electronic address
    Neuropharmacology 88:155-63. 2015
  6. doi request reprint Where now for schizophrenia research?
    David J Nutt
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom Electronic address
    Eur Neuropsychopharmacol 24:1181-7. 2014
  7. doi request reprint CNS drug development in Europe--past progress and future challenges
    David J Nutt
    Centre for Neuropsychopharmacology, Imperial College, London, W12 0NN, UK Electronic address
    Neurobiol Dis 61:6-20. 2014
  8. doi request reprint Effects of Schedule I drug laws on neuroscience research and treatment innovation
    David J Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College, London, W12 0NN, UK
    Nat Rev Neurosci 14:577-85. 2013
  9. doi request reprint Addiction: lifestyle choice or medical diagnosis?
    David Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College, London, UK
    J Eval Clin Pract 19:493-6. 2013
  10. doi request reprint Drug harms in the UK: a multicriteria decision analysis
    David J Nutt
    Neuropsychopharmacology Unit, Imperial College, London, UK
    Lancet 376:1558-65. 2010

Detail Information

Publications59

  1. doi request reprint Rationale for, barriers to, and appropriate medication for the long-term treatment of depression
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e02. 2010
    ....
  2. doi request reprint International consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 71:e08. 2010
    ....
  3. doi request reprint Inverse agonists - What do they mean for psychiatry?
    David Nutt
    Centre for Psychiatry, Imperial College London, UK Electronic address
    Eur Neuropsychopharmacol . 2016
    ..It is therefore premature to conclude that the actions of pimavanserin in humans are due to inverse agonism, and we are of the opinion that it should be called a 5-HT2A antagonist until better evidence emerges...
  4. doi request reprint Considerations on the role of buprenorphine in recovery from heroin addiction from a UK perspective
    David J Nutt
    Imperial College London, London, UK
    J Psychopharmacol 29:43-9. 2015
    ..Progress through the recovery journey and the ability to sustain recovery will depend on individual needs and goals and on the amount of recovery capital that individuals have developed. ..
  5. doi request reprint Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers
    David Nutt
    Division of Brain Sciences, Centre for Neuropsychopharmacology, Imperial College London, UK Electronic address
    Neuropharmacology 88:155-63. 2015
    ..Tiagabine theoretically can affect both types of receptor; from these MEG results it is likely that the latter is the more prominent effect here...
  6. doi request reprint Where now for schizophrenia research?
    David J Nutt
    Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom Electronic address
    Eur Neuropsychopharmacol 24:1181-7. 2014
    ..Here we review what we consider to be the key issues and some suggested solutions. ..
  7. doi request reprint CNS drug development in Europe--past progress and future challenges
    David J Nutt
    Centre for Neuropsychopharmacology, Imperial College, London, W12 0NN, UK Electronic address
    Neurobiol Dis 61:6-20. 2014
    ..There is a very real risk that without such an integrated approach to policy reforms, innovation in psychotropic medicines will become a 'desert' in the same way that it did for antibiotics in the 1990's. ..
  8. doi request reprint Effects of Schedule I drug laws on neuroscience research and treatment innovation
    David J Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College, London, W12 0NN, UK
    Nat Rev Neurosci 14:577-85. 2013
    ....
  9. doi request reprint Addiction: lifestyle choice or medical diagnosis?
    David Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College, London, UK
    J Eval Clin Pract 19:493-6. 2013
    ..In this paper, I detail these issues and suggest ways to avoid irreparable damage to the current care provisions that are proving effective...
  10. doi request reprint Drug harms in the UK: a multicriteria decision analysis
    David J Nutt
    Neuropsychopharmacology Unit, Imperial College, London, UK
    Lancet 376:1558-65. 2010
    ..Proper assessment of the harms caused by the misuse of drugs can inform policy makers in health, policing, and social care. We aimed to apply multicriteria decision analysis (MCDA) modelling to a range of drug harms in the UK...
  11. doi request reprint Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics
    David J Nutt
    Department of Neuropsychopharmacology and Molecular Imaging, Division of Neuroscience and Mental Health, Imperial College London, London, UK
    J Psychopharmacol 24:1601-12. 2010
    ....
  12. doi request reprint What one hand giveth the other taketh away: some unpredicted effects of enantiomers in psychopharmacology
    David J Nutt
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:1137-41. 2010
    ....
  13. doi request reprint Antagonist-agonist combinations as therapies for heroin addiction: back to the future?
    David J Nutt
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital, London, UK
    J Psychopharmacol 24:141-5. 2010
    ..These principles, however, can be applied to other disorders as and when other pharmacological approaches become refined in these areas...
  14. doi request reprint Evaluation of 11C-BU99008, a PET ligand for the imidazoline2 binding sites in rhesus brain
    Christine A Parker
    Centre for Neuropsychopharmacology, Hammersmith Hospital, Imperial College London, United Kingdom
    J Nucl Med 55:838-44. 2014
    ....
  15. pmc Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis
    Robin L Carhart-Harris
    To whom correspondence should be addressed Imperial College London, Centre for Neuropsychopharmacology, Burlington Danes Building, 160 Du Cane Rd, London, UK
    Schizophr Bull 39:1343-51. 2013
    ..We suggest that this orthogonality is compromised in early psychosis, explaining similarities between its phenomenology and that of the psychedelic state and supporting the utility of psilocybin as a model of early psychosis. ..
  16. doi request reprint Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008
    Steven Kealey
    Institute of Psychiatry, De Crespigny Park, King s College London, London, United Kingdom
    J Nucl Med 54:139-44. 2013
    ..In this study, BU99008 was radiolabeled with (11)C in order to image the I(2) binding sites in vivo using PET...
  17. pmc Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers
    Inge Mick
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
    Neuropsychopharmacology 41:1742-50. 2016
    ..Our findings are consistent with growing evidence that dysregulation of endogenous opioids may have an important role in the pathophysiology of addictions. ..
  18. doi request reprint LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion
    Leor Roseman
    Centre for Neuropsychopharmacology, Department of Medicine, Imperial College London, London, W12 0NN, United Kingdom
    Hum Brain Mapp 37:3031-40. 2016
    ..This result may indicate that under LSD, with eyes-closed, the early visual system behaves as if it were seeing spatially localized visual inputs. Hum Brain Mapp 37:3031-3040, 2016. © 2016 Wiley Periodicals, Inc. ..
  19. doi request reprint Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity
    Inge Mick
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK
    Addict Biol . 2016
    ..This GABAergic dysregulation is potential target for treatment...
  20. doi request reprint Broadband cortical desynchronization underlies the human psychedelic state
    Suresh D Muthukumaraswamy
    Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF119BJ, United Kingdom, Imperial College London, Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, London W12 ONN, United Kingdom, Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom, Sir Peter Mansfield Magnetic Resonance Centre, Nottingham University, Nottingham NG7 2RD, United Kingdom, Academic Unit of Psychiatry, University of Bristol, Bristol BS8 2BN, United Kingdom, The Beckley Foundation, Beckley Park, Oxford OX3 9SY, United Kingdom, and Virginia Tech Carilion Research Institute, and Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Roanoke, Virginia 24016
    J Neurosci 33:15171-83. 2013
    ..These findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells...
  21. doi request reprint Amphetamine induced endogenous opioid release in the human brain detected with [¹¹C]carfentanil PET: replication in an independent cohort
    Inge Mick
    Division of Brain Science, Faculty of Medicine, Centre for Neuropsychopharmacology, Imperial College London, UK
    Int J Neuropsychopharmacol 17:2069-74. 2014
    ..11C]carfentanil PET is able to detect changes in binding following an oral amphetamine challenge that reflects endogenous opioid release and is suitable to characterize the opioid system in neuropsychiatric disorders...
  22. doi request reprint History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability
    Paul R A Stokes
    Psychiatric Imaging Group, MRC Clinical Sciences Centre, Imperial College London, London, UK
    J Psychopharmacol 26:144-9. 2012
    ..These findings suggest that, unlike other drugs of abuse, a history of cannabis use is not associated with alterations in striatal dopamine D(2)/D(3) receptor availability...
  23. pmc Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, University of Bristol, Bristol BS8 2BN, United Kingdom
    Proc Natl Acad Sci U S A 109:2138-43. 2012
    ..These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition...
  24. ncbi request reprint The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description
    John McGonigle
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK
    J Psychopharmacol . 2016
    ..Here we provide an overview of the fMRI battery, carried out across three centres, characterizing neuronal response to the tasks, along with exploring inter-centre differences in healthy participants...
  25. pmc Neural correlates of the LSD experience revealed by multimodal neuroimaging
    Robin L Carhart-Harris
    Centre for Neuropsychopharmacology, Department of Medicine, Imperial College London, W12 0NN, London, United Kingdom
    Proc Natl Acad Sci U S A 113:4853-8. 2016
    ....
  26. doi request reprint Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Burlington Danes Building, Imperial College London, W12 0NN, UK Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, UK Electronic address
    Neuroimage 99:158-65. 2014
    ..These findings have potentially major implications for the investigation of GABA function in brain disorders and in the development of new treatments targeting this neurotransmitter system...
  27. doi request reprint History of cigarette smoking is associated with higher limbic GABAA receptor availability
    Paul R A Stokes
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Neuroimage 69:70-7. 2013
    ....
  28. doi request reprint LSD modulates music-induced imagery via changes in parahippocampal connectivity
    Mendel Kaelen
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London W12, UK Electronic address
    Eur Neuropsychopharmacol 26:1099-109. 2016
    ..These findings suggest a plausible mechanism by which LSD works in combination with music listening to enhance certain subjective experiences that may be useful in a therapeutic context. ..
  29. doi request reprint Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients
    Csaba Orban
    Centre for Neuropsychopharmacology, Imperial College London, London, UK
    Am J Drug Alcohol Abuse 39:433-40. 2013
    ..Neurobiological models of anxiety have proposed important roles for amygdala-insula and amygdala-medial prefrontal cortex interactions in the generation and regulation of anxiety states, respectively...
  30. doi request reprint Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
    Alessandro Colasanti
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom
    Biol Psychiatry 72:371-7. 2012
    ..We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET)...
  31. doi request reprint Sleep and its disorders in translational medicine
    Louise M Paterson
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 25:1226-34. 2011
    ..This review provides examples of how research findings within the sleep field have been translated between animal models, healthy volunteers and patient populations with particular focus on the serotonergic system...
  32. pmc Measuring endogenous 5-HT release by emission tomography: promises and pitfalls
    Louise M Paterson
    Imperial College London, UK
    J Cereb Blood Flow Metab 30:1682-706. 2010
    ....
  33. doi request reprint Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task
    Liam J Nestor
    Centre for Neuropsychopharmacology, Imperial College London, UK
    Addict Biol . 2016
    ....
  34. doi request reprint Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study
    Robin L Carhart-Harris
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK Electronic address
    Lancet Psychiatry 3:619-27. 2016
    ..Here, we aimed to investigate the feasibility, safety, and efficacy of psilocybin in patients with unipolar treatment-resistant depression...
  35. pmc Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism
    Anne Lingford-Hughes
    Centre for Neuropsychopharmacology, Imperial College London, Du Cane Rd, London W12 0NN, United Kingdom Psychopharmacology Unit, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom Hammersmith Imanet Ltd, Hammersmith Hospital, Du Cane Rd, London W12 0NN, United Kingdom Electronic address
    Neuroimage 132:1-7. 2016
    ..We suggest that reduced α5 levels in the nucleus accumbens are associated with addiction since we have now shown this in dependence to two pharmacologically different substances, alcohol and opiates. ..
  36. pmc The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity
    Robin L Carhart-Harris
    Centre for Neuropsychopharmacology RLC H, DE, LTJW, LR, SB, RT, As, TMW, MB, DJN and C3NL RL, Division of Brain Sciences, Faculty of Medicine, London, London Electronic address
    Biol Psychiatry 78:554-62. 2015
    ..The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals...
  37. doi request reprint The dopamine theory of addiction: 40 years of highs and lows
    David J Nutt
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Burlington Danes Building, Imperial College London, London W12 0NN, UK
    Nat Rev Neurosci 16:305-12. 2015
    ..These observations have implications for understanding reward and treatment responses in various addictions. ..
  38. pmc Imaging endogenous opioid peptide release with [11C]carfentanil and [3H]diprenorphine: influence of agonist-induced internalization
    Darren R Quelch
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK
    J Cereb Blood Flow Metab 34:1604-12. 2014
    ....
  39. pmc Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking study
    David R Owen
    Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
    J Cereb Blood Flow Metab 34:989-94. 2014
    ..Our estimates of [(11)C]PBR28 VND and hence BPND in the healthy human brain are consistent with in vitro predictions. XBD173 blockade provides a practical means of estimating VND for TSPO targeting radioligands. ..
  40. pmc In vivo imaging of cerebral dopamine D3 receptors in alcoholism
    David Erritzoe
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK
    Neuropsychopharmacology 39:1703-12. 2014
    ..This may be relevant to the development of future therapeutic strategies to treat alcohol abuse...
  41. pmc 5-HT radioligands for human brain imaging with PET and SPECT
    Louise M Paterson
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, Burlington Danes Building, Du Cane Road, London, United Kingdom
    Med Res Rev 33:54-111. 2013
    ....
  42. doi request reprint GABAB receptors in addiction and its treatment
    Robin J Tyacke
    Neuropsychopharmacology Unit, Division of Experimental Medicine and Therapeutics, Imperial College London, London, UK
    Adv Pharmacol 58:373-96. 2010
    ..This potential is at present poorly understood or studied and warrants further investigation...
  43. doi request reprint The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description
    Louise M Paterson
    Centre for Neuropsychopharmacology, Imperial College London, London, UK
    J Psychopharmacol 29:943-60. 2015
    ..We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs. ..
  44. doi request reprint Estimating the harms of nicotine-containing products using the MCDA approach
    David J Nutt
    Imperial College London, UK
    Eur Addict Res 20:218-25. 2014
    ....
  45. doi request reprint Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..The interpretation of these findings in relation to prefrontal dopamine release is discussed...
  46. pmc The influence of different cellular environments on PET radioligand binding: an application to D2/3-dopamine receptor imaging
    Darren R Quelch
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, UK Electronic address
    Neuropharmacology 85:305-13. 2014
    ..Assessment of affinity shifts in different cellular compartments may play a crucial role for understanding if a radioligand is sensitive to endogenous release in vivo, for not just the D2/3, but other receptor systems...
  47. doi request reprint Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline₂ binding site
    Robin J Tyacke
    Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, United Kingdom
    Synapse 66:542-51. 2012
    ..This, and the amenability of BU99008 (6) to radiolabeling with a positron-emitting radioisotope, indicates its potential as a PET radioligand for imaging the I₂BS in vivo...
  48. ncbi request reprint The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study
    Andrew J Montgomery
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
    Synapse 61:637-45. 2007
    ..These results support a role for the DA system in nicotine addiction, but reveal a more complex relationship than suggested by studies in animals...
  49. doi request reprint In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer's disease
    Nazanin Mirzaei
    Division of Brain Sciences, Imperial College London, Du Cane Road, London, W12 0NN, United Kingdom
    Glia 64:993-1006. 2016
    ..The data provided support of the suitability of [(11)C]PBR28 as a tool for in vivo monitoring of microglial activation and assessment of treatment response in future studies using animal models of AD...
  50. doi request reprint γ-aminobutyric acid as a metabolite: Interpreting magnetic resonance spectroscopy experiments
    James Fm Myers
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK
    J Psychopharmacol 30:422-7. 2016
    ..In this perspective, we examine some of the considerations to be taken in the interpretation of any γ-aminobutyric acid signal measured by magnetic resonance spectroscopy. ..
  51. pmc Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men
    Sue Wilson
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College London, London, UK
    J Psychopharmacol 29:1085-91. 2015
    ....
  52. doi request reprint Effect of short-term escitalopram treatment on neural activation during emotional processing
    Eduard Maron
    Research and Development Service, and Department of Psychiatry, North Estonia Medical Centre, Tallinn, Estonia Department of Psychiatry, University of Tartu, Tartu, Estonia Faculty of Medicine, Division of Brain Sciences, Imperial College London, London, UK
    J Psychopharmacol 30:33-9. 2016
    ....
  53. doi request reprint Optimising PET approaches to measuring 5-HT release in human brain
    Robin J Tyacke
    Centre for Neuropsychopharmacology, Division of Brain Sciences, Hammersmith Hospital, Imperial College London, W12 0NN, United Kingdom
    Synapse 69:505-11. 2015
    ....
  54. doi request reprint Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety?
    David R Owen
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 27:119-22. 2013
    ..In this paper we discuss this issue in relation to psychiatry using a new and interesting example of how genotyping might help rescue an apparently failed novel treatment in anxiety disorders...
  55. doi request reprint Harms associated with psychoactive substances: findings of the UK National Drug Survey
    Celia J A Morgan
    Clinical Psychopharmacology Unit, University College London, London, UK
    J Psychopharmacol 24:147-53. 2010
    ..They also suggest that the current UK legal classification system is not acting to inform users of the harms of psychoactive substances...
  56. doi request reprint Gender differences in brain serotonin transporter availability in panic disorder
    Eduard Maron
    Department of Neuropsychopharmacology and Molecular Imaging, Imperial College London, London, UK
    J Psychopharmacol 25:952-9. 2011
    ..Distinctive functioning of the 5-HT system in males and females may underlie certain gender-dependent differences in expressions of PD...
  57. doi request reprint The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary investigation of tolerability
    Robin L Carhart-Harris
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College London, London, UK
    J Psychopharmacol 25:1562-7. 2011
    ..With appropriate care, this study supports the viability of functional magnetic resonance imaging work with psilocybin...
  58. doi request reprint Highlights of the international consensus statement on major depressive disorder
    David J Nutt
    Neuropsychopharmacology Unit, Division of Experimental Medicine, Imperial College, London, United Kingdom
    J Clin Psychiatry 72:e21. 2011
    ....
  59. ncbi request reprint Low sensitivity of the positron emission tomography ligand [11C]diprenorphine to agonist opiates
    Susan P Hume
    Hammersmith Imanet Ltd, Hammersmith Hospital, London, United Kingdom
    J Pharmacol Exp Ther 322:661-7. 2007
    ..Alternative means may be needed to address clinical issues regarding opioid receptor occupancy that are required to optimize treatment strategies...