Sandra M Newton
Affiliation: Imperial College
- Paediatric tuberculosisSandra M Newton
Department of Paediatrics, Imperial College London, London, UK
Lancet Infect Dis 8:498-510. 2008..Advances in our understanding of tuberculosis in children would provide insights and opportunities to enhance efforts to control this disease...
- Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosisKatalin A Wilkinson
National Institute for Medical Research, Mill Hill, London, UK
BMC Microbiol 9:93. 2009..We also reintroduced the 19 kDa gene in two modified forms that lacked motifs for acylation (Delta19::19NA) and O-glycosylation (Delta19::19NOG)...
- Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosisGraham R Stewart
Center for Molecular Microbiology and Infection and Wellcome Trust Center for Research in Clinical Tropical Medicine, Imperial College London, UK
Infect Immun 73:6831-7. 2005..tuberculosis with phagocytes. However, this analysis indicates that in the context of the whole bacillus, the 19-kDa lipoprotein is only one of a number of molecules that mediate the innate response to M. tuberculosis...
- Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2Katalin A Wilkinson
Wellcome Trust Center for Research in Clinical Tropical Medicine and Department of Pediatric Infectious Diseases, Faculty of Medicine, Imperial College London, Wright Fleming Institute, UK
J Immunol 174:4237-43. 2005..The demonstration that there is infection stage-specific immunity to tuberculosis has implications for vaccine design...
- Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testingSuzanne T Anderson
M B B S, Department of Pediatrics, Division of Medicine, Wright Fleming Institute, Imperial College London, London W2 1PG, UK
Am J Respir Crit Care Med 173:1038-42. 2006..The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors...
- Neutrophil-mediated innate immune resistance to mycobacteriaAdrian R Martineau
Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Wright Fleming Institute, Imperial College, London, UK
J Clin Invest 117:1988-94. 2007..Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB...
- Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigensKatalin A Wilkinson
Wellcome Trust Center for Research in Clinical Tropical Medicine, Division of Medicine, Imperial College London, Wright Fleming Institute, UK
J Infect Dis 193:354-9. 2006..These results suggest that the integrity of the bacterial cell wall is important for M. tuberculosis in avoiding immune recognition by T cells and favor a dynamic model of LTBI...
- 1alpha,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infectionAnna Coussens
Division of Mycobacterial Research, National Institute for Medical Research, London, UK
Immunology 127:539-48. 2009..1alpha,25(OH)(2)D(3) also induced secretion of IL-10 and PGE(2) from M. tuberculosis-infected PBMC. These findings represent a novel immunomodulatory role for 1alpha,25(OH)(2)D(3) in M. tuberculosis infection...
- Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stabilityJasmeet Singh Khara
Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore Section of Paediatrics, Department of Medicine, St Mary s Campus, Imperial College London, London W2 1PG, UK MRC Centre for Molecular Microbiology and Infection, Department of Medicine, Imperial College London, London SW7 2AZ, UK
J Antimicrob Chemother . 2016..We therefore systematically evaluated unnatural amino acid-modified peptides to design analogues with enhanced anti-mycobacterial activities...
- The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosisGraham R Stewart
Department of Infectious Diseases and Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, South Kensington, London SW7 2AZ, UK
Mol Microbiol 55:1127-37. 2005..These findings demonstrate that both alpha-crystallins contribute to persistent infection with M. tuberculosis and suggest that manipulation of acr expression can influence the host response to infection...