John A Marwick

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Oxidative stress modulates theophylline effects on steroid responsiveness
    John A Marwick
    National Heart and Lung Institute, Airways Disease Section, Imperial College London, Guy Scadding Building, Dovehouse Steet, London SW3 6LY, UK
    Biochem Biophys Res Commun 377:797-802. 2008
  2. doi request reprint Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice
    John A Marwick
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 179:542-8. 2009
  3. doi request reprint Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
    John A Marwick
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Ther Adv Respir Dis 4:19-34. 2010
  4. pmc Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function
    John A Marwick
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:33. 2010
  5. pmc Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD
    Anta Ngkelo
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 309:L1112-23. 2015
  6. pmc Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
    John A Marwick
    National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:11. 2010

Collaborators

Detail Information

Publications6

  1. doi request reprint Oxidative stress modulates theophylline effects on steroid responsiveness
    John A Marwick
    National Heart and Lung Institute, Airways Disease Section, Imperial College London, Guy Scadding Building, Dovehouse Steet, London SW3 6LY, UK
    Biochem Biophys Res Commun 377:797-802. 2008
    ..In conclusion, oxidative stress alters theophylline binding profile and gene expression which may result in restoration of corticosteroid function...
  2. doi request reprint Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice
    John A Marwick
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 179:542-8. 2009
    ..Recent studies have shown that histone deacetylase activity, which is critical to glucocorticoid function, is altered by oxidant stress and may be involved in the development of glucocorticoid insensitivity...
  3. doi request reprint Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease
    John A Marwick
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Ther Adv Respir Dis 4:19-34. 2010
    ....
  4. pmc Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function
    John A Marwick
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:33. 2010
    ..However, the impact of cigarette smoke exposure on the expression of mSin3a and Mi2alpha/beta and their role in glucocorticoid responsiveness is unknown...
  5. pmc Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD
    Anta Ngkelo
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 309:L1112-23. 2015
    ..In conclusion, we demonstrate for the first time that ROS-induced glucocorticoid unresponsiveness in COPD is mediated through GSK3β, acting as a ROS-sensitive hub. ..
  6. pmc Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs
    John A Marwick
    National Heart and Lung Institute, Imperial College London, UK
    J Inflamm (Lond) 7:11. 2010
    ..However, the VEGFR2-mediated survival signaling in response to oxidants/cigarette smoke (CS) is not known. We hypothesized that CS exposure leads to disruption of VEGFR2-mediated endothelial survival signaling in rat lungs...