Affiliation: Imperial College
- Pathways of IL-1β secretion by macrophages infected with clinical Mycobacterium tuberculosis strainsNitya Krishnan
MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
Tuberculosis (Edinb) 93:538-47. 2013..Taken together, these findings demonstrate that clinical strains of M. tuberculosis employ a unique caspase-1 independent pathway to stimulate IL-1β secretion from macrophages. ..
- The mechanisms and consequences of the extra-pulmonary dissemination of Mycobacterium tuberculosisNitya Krishnan
Centre for Molecular Microbiology and Infection, Division of Infectious Diseases, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom
Tuberculosis (Edinb) 90:361-6. 2010..Further understanding of the pathways, mechanisms and consequences of M. tuberculosis dissemination could have a major impact in designing novel vaccines and therapeutic strategies...
- The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivoKerstin J Williams
Centre for Molecular Medicine and Infection, Department of Medicine, Flowers Building, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
Tuberculosis (Edinb) 91:549-55. 2011..Macrophage survival and mouse infection studies also showed no significant difference between the mutant and parent strains. Therefore, we conclude that these genes are dispensable for growth in vitro and in vivo...
- Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescenceNuria Andreu
Microbiology, Department of Medicine, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
J Antimicrob Chemother 67:404-14. 2012..The aim of this work was to validate and standardize the use of luminescent M. tuberculosis strains to test the activity of antibacterial drugs in vitro and inside macrophages in a 96-well format...
- Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stressKerstin J Williams
MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London, London, SW7 2AZ, UK
Mol Microbiol 97:1142-57. 2015..tuberculosis to that in non-pathogenic mycobacteria, controlling genes involved in nitric oxide detoxification and intracellular survival instead of genes involved in nitrogen scavenging. ..
- Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profilesNitya Krishnan
Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom
PLoS ONE 6:e23870. 2011..tuberculosis and host are determined by the lineage of the infecting strain; but we were unable to show these differences are driven by lineage-specific cell-surface expressed lipids...
- Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stabilityJasmeet Singh Khara
Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore Section of Paediatrics, Department of Medicine, St Mary s Campus, Imperial College London, London W2 1PG, UK MRC Centre for Molecular Microbiology and Infection, Department of Medicine, Imperial College London, London SW7 2AZ, UK
J Antimicrob Chemother . 2016..We therefore systematically evaluated unnatural amino acid-modified peptides to design analogues with enhanced anti-mycobacterial activities...