Affiliation: Imperial College
- Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitisV Koufopanou
Department of Plant Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 94:5478-82. 1997..We conclude that coccidioidomycosis can be caused by two distinct noninterbreeding taxa. This result should aid the future study of the disease and illustrates the utility of the genealogical approach in population genetics...
- Gene genealogies, cryptic species, and molecular evolution in the human pathogen Coccidioides immitis and relatives (Ascomycota, Onygenales)V Koufopanou
Department of Plant and Microbial Biology, University of California at Berkeley, USA
Mol Biol Evol 18:1246-58. 2001..Two introns in the same gene fragment were considerably more divergent than exons and were unalignable between species complexes but had very low polymorphism within taxa...
- Adaptation for horizontal transfer in a homing endonucleaseVassiliki Koufopanou
Department of Biology, Imperial College, Silwood Park, Ascot, Berkshire, UK
Mol Biol Evol 19:239-46. 2002..The frequency of horizontal transmission must therefore be a key feature constraining the distribution and abundance of these genes...
- Sex drives intracellular conflict in yeastE Harrison
NERC Center for Population Biology, Imperial College London, Ascot, UK
J Evol Biol 27:1757-63. 2014..Our study highlights the genomic perils of sex and suggests that SGEs may play a key role in driving major evolutionary transitions, such as uniparental inheritance...
- The cost of copy number in a selfish genetic element: the 2-μm plasmid of Saccharomyces cerevisiaeEllie Harrison
NERC Center for Population Biology, Imperial College London, Silwood Park Campus, Ascot, UK
J Evol Biol 25:2348-56. 2012..Our results demonstrate the crucial importance of copy number in the evolution of yeast per 2 μm associations and pave the way for future studies examining how selection can shape the cost of multicopy elements...
- The evolutionary biology and population genetics underlying fungal strain typingJ W Taylor
Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
Clin Microbiol Rev 12:126-46. 1999..flavus. Research opportunities in the areas of genomics, correlation of clinical variation with genetic variation, amount of recombination, and standardization of approach are suggested...
- Cancer selectionArmand M Leroi
Department of Biological Sciences, Imperial College London, Silwood Park Campus, Ascot, Berks SL5 7PY, UK
Nat Rev Cancer 3:226-31. 2003....
- Degeneration and domestication of a selfish gene in yeast: molecular evolution versus site-directed mutagenesisVassiliki Koufopanou
Mol Biol Evol 22:1535-8. 2005..The domestication event also indicates that VDE has been lost in some species and that VDE has been present in yeasts for more than 50 Myr...
- Rapid evolution of yeast centromeres in the absence of driveDouda Bensasson
Division of Biology, Imperial College London, Ascot SL5 7PY, United Kingdom
Genetics 178:2161-7. 2008..We suggest that yeast centromeres suffer an elevated rate of mutation relative to other chromosomal regions and they change through a process of "centromere drift," not drive...
- Evolution of divergent DNA recognition specificities in VDE homing endonucleases from two yeast speciesKaren L Posey
Center for Genome Research, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
Nucleic Acids Res 32:3947-56. 2004..These data illustrate that homing endonucleases evolve altered specificity as they adapt to recognize alternative target sites...
- Population genetics of the wild yeast Saccharomyces paradoxusLouise J Johnson
Department of Biological Sciences, Imperial College at Silwood Park, Ascot SL5 7PY, United Kingdom
Genetics 166:43-52. 2004..1% on the basis of heterozygosity. Thus, all three modes of reproduction known in the lab (clonal replication, inbreeding, and outcrossing) have been important in molding genetic variation in this species...
- Homing endonuclease genes: the rise and fall and rise again of a selfish elementAustin Burt
Department of Biological Sciences, Imperial College London, Silwood Park, Ascot, Berkshire SL5 7PY, UK
Curr Opin Genet Dev 14:609-15. 2004..HEGs may also be domesticated by their hosts, and are currently being put to human uses...
- Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycleIsheng J Tsai
Division of Biology, Imperial College London, Silwood Park, Ascot, Berks SL5 7PY, United Kingdom
Proc Natl Acad Sci U S A 105:4957-62. 2008..Our study illustrates the utility of population genomic data in quantifying life cycles...