Marjo Riitta Jarvelin

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Stress-related eating, obesity and associated behavioural traits in adolescents: a prospective population-based cohort study
    Anne Jääskeläinen
    Finnish Institute of Occupational Health, P, O, Box 310, FI 70101 Kuopio, Finland
    BMC Public Health 14:321. 2014
  2. pmc Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits
    Karani S Vimaleswaran
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK
    BMC Genet 15:37. 2014
  3. pmc Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
  4. pmc Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling
    Marika Kaakinen
    Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
    Am J Epidemiol 172:653-65. 2010
  5. pmc Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms
    Fredrik Barrenas
    The Centre for Individualized Medication, Linkoping University Hospital, Linkoping University, Linkoping, Sweden
    Genome Biol 13:R46. 2012
  6. pmc Systematic review of worldwide variations of the prevalence of wheezing symptoms in children
    Swatee P Patel
    School of Health and Social Care, University of Greenwich, Southwood Site, Avery Hill Road, London SE9 2UG, UK
    Environ Health 7:57. 2008
  7. ncbi request reprint Early life factors and blood pressure at age 31 years in the 1966 northern Finland birth cohort
    Marjo Riitta Jarvelin
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Hypertension 44:838-46. 2004
  8. ncbi request reprint Manifestations of metabolic syndrome after hypertensive pregnancy
    Anneli Pouta
    Academy of Finland, Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, PO Box 5000, FIN 90014 University of Oulu, Finland
    Hypertension 43:825-31. 2004
  9. pmc Smoking and early pregnancy thyroid hormone and anti-thyroid antibody levels in euthyroid mothers of the Northern Finland Birth Cohort 1986
    Tuija Männistö
    Department of Clinical Chemistry, University of Oulu, Oulu, Finland
    Thyroid 22:944-50. 2012
  10. doi request reprint Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life
    Tuija Männistö
    Department of Obstetrics and Gynecology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    J Clin Endocrinol Metab 95:1084-94. 2010

Detail Information

Publications157 found, 100 shown here

  1. pmc Stress-related eating, obesity and associated behavioural traits in adolescents: a prospective population-based cohort study
    Anne Jääskeläinen
    Finnish Institute of Occupational Health, P, O, Box 310, FI 70101 Kuopio, Finland
    BMC Public Health 14:321. 2014
    ..Furthermore, we examined whether stress-related eating is predicted by early-life factors including birth size and maternal gestational health...
  2. pmc Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits
    Karani S Vimaleswaran
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK
    BMC Genet 15:37. 2014
    ..We used the data from Northern Finland Birth Cohort 1966 (NFBC66, up to n = 5,316) and Twins UK (up to n = 3,943) to replicate our initial findings from 1958BC...
  3. pmc Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
    ..Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years...
  4. pmc Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling
    Marika Kaakinen
    Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
    Am J Epidemiol 172:653-65. 2010
    ..In addition to well-established genetic determinants, many life-course factors such as physical activity, in spite of not showing mediation or interaction, had a strong independent effect on BMI...
  5. pmc Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms
    Fredrik Barrenas
    The Centre for Individualized Medication, Linkoping University Hospital, Linkoping University, Linkoping, Sweden
    Genome Biol 13:R46. 2012
    ..Complex diseases are associated with altered interactions between thousands of genes. We developed a novel method to identify and prioritize disease genes, which was generally applicable to complex diseases...
  6. pmc Systematic review of worldwide variations of the prevalence of wheezing symptoms in children
    Swatee P Patel
    School of Health and Social Care, University of Greenwich, Southwood Site, Avery Hill Road, London SE9 2UG, UK
    Environ Health 7:57. 2008
    ..Considerable variation in the prevalence of childhood asthma and its symptoms (wheezing) has been observed in previous studies and there is evidence that the prevalence has been increasing over time...
  7. ncbi request reprint Early life factors and blood pressure at age 31 years in the 1966 northern Finland birth cohort
    Marjo Riitta Jarvelin
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Hypertension 44:838-46. 2004
    ..7, -1.1) mm Hg lower systolic blood pressure. Our results support the concept that birth weight, other birth measures, and infant growth are important determinants of blood pressure and hence cardiovascular disease risk in later life...
  8. ncbi request reprint Manifestations of metabolic syndrome after hypertensive pregnancy
    Anneli Pouta
    Academy of Finland, Department of Public Health Science and General Practice, University of Oulu, Aapistie 1, PO Box 5000, FIN 90014 University of Oulu, Finland
    Hypertension 43:825-31. 2004
    ..The associations remained after adjustment for participant's own birth weight or gestational age. Women born before gestational week 37 had a 2-fold risk for gestational hypertension in their first pregnancy (RR: 2.53; 95% CI: 1.0, 6.2)...
  9. pmc Smoking and early pregnancy thyroid hormone and anti-thyroid antibody levels in euthyroid mothers of the Northern Finland Birth Cohort 1986
    Tuija Männistö
    Department of Clinical Chemistry, University of Oulu, Oulu, Finland
    Thyroid 22:944-50. 2012
    ..Our objective was to further evaluate the question of whether there is an association between smoking, before and during pregnancy, with maternal thyroid function during pregnancy and with the risk for subsequent hypothyroidism...
  10. doi request reprint Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life
    Tuija Männistö
    Department of Obstetrics and Gynecology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    J Clin Endocrinol Metab 95:1084-94. 2010
    ..Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to pregnancy complications/later maternal morbidity...
  11. ncbi request reprint The relation of tobacco smoking to tooth loss among young adults
    Pekka Ylöstalo
    Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu, Finland
    Eur J Oral Sci 112:121-6. 2004
    ..A possible explanation for this association is a combination of treatment decisions and dental diseases, which are most likely associated with smoking in an exposure-dependent manner...
  12. doi request reprint Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population
    Tuija Männistö
    Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland
    Thyroid 21:291-8. 2011
    ..The aim of this study was to calculate gestational age-specific thyrotropin (TSH), free thyroxine (fT4), and free triiodothyronine (fT3) reference intervals in an iodine-sufficient thyroid antibody-negative population...
  13. doi request reprint Offspring's blood pressure and metabolic phenotype after exposure to gestational hypertension in utero
    Satu Miettola
    National Institute for Health and Welfare, Oulu, Finland
    Eur J Epidemiol 28:87-98. 2013
    ..Maternal de novo hypertension during pregnancy is associated with offspring's elevated blood pressure level already in adolescence. GH may also be associated with unfavourable lipid profile of the offspring...
  14. doi request reprint Metabolic and reproductive characteristics of first-degree relatives of women with self-reported oligo-amenorrhoea and hirsutism
    Assi Torvinen
    Department of Child and Adolescent Health, National Public Health Institute, Oulu, Finland
    Gynecol Endocrinol 27:630-5. 2011
    ..To investigate the occurrence of oligo-amenorrhoea and hirsutism, infertility and metabolic morbidity among first-degree relatives of women with and without self-reported oligo-amenorrhoea and hirsutism...
  15. ncbi request reprint Reasons for the diagnostic discordance between clinicians and researchers in schizophrenia in the Northern Finland 1966 Birth Cohort
    Kristiina Moilanen
    Dept of Psychiatry, University of Oulu, P O 5000, 90014 University of Oulu, Finland
    Soc Psychiatry Psychiatr Epidemiol 38:305-10. 2003
    ..This poses a challenge to psychiatric research. We studied the reasons for diagnostic discordance between clinicians and researchers...
  16. ncbi request reprint Variations in prenatal sociodemographic factors associated with intellectual disability: a study of the 20-year interval between two birth cohorts in northern Finland
    Ulla Heikura
    Department of Public Health Science and General Practice, Faculty of Medicine, University of Oulu, Oulu, Finland
    Am J Epidemiol 167:169-77. 2008
    ..8, 95% confidence interval: 1.5, 5.3). A future challenge is to explore the mediating mechanisms between intellectual disability and its associated preventable intergenerational environmental or lifestyle factors...
  17. ncbi request reprint Neonatal outcome and congenital malformations in children born after in-vitro fertilization
    Sari Koivurova
    Department of Public Health Science and General Practice, University Hospital of Oulu, Oulu, Finland
    Hum Reprod 17:1391-8. 2002
    ..To evaluate the neonatal outcome and the prevalence of congenital malformations in children born after IVF in northern Finland we carried out a population-based study with matched controls...
  18. pmc Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966
    Marika Kaakinen
    Institute of Health Sciences, University of Oulu, Oulu, Finland
    PLoS ONE 7:e46557. 2012
    ..Recent research also points towards its involvement in cardiovascular homeostasis, but studies in large human samples are lacking, especially on the role of the gene cluster in blood pressure regulation...
  19. ncbi request reprint Temporal changes in incidence and prevalence of intellectual disability between two birth cohorts in Northern Finland
    Ulla Heikura
    University of Oulu, Department of Public Health Science and General Practice, Finland
    Am J Ment Retard 108:19-31. 2003
    ..The temporal changes followed generally similar patterns by gender...
  20. doi request reprint Human metabolic phenotype diversity and its association with diet and blood pressure
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Nature 453:396-400. 2008
    ..Metabolic phenotyping applied to high-quality epidemiological data offers the potential to develop an area of aetiopathogenetic knowledge involving discovery of novel biomarkers related to cardiovascular disease risk...
  21. pmc Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure
    Ian J Brown
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom
    Hypertension 57:695-701. 2011
    ..These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced...
  22. doi request reprint Full-length visfatin levels are associated with inflammation in women with polycystic ovary syndrome
    Taina K Lajunen
    Deparment of Physiology Biocenter Oulu, University of Oulu, Oulu, Finland
    Eur J Clin Invest 42:321-8. 2012
    ..It has been suggested that visfatin is an adipokine secreted from the abdominal fat influencing glucose metabolism and might therefore contribute to the metabolic disturbances in PCOS...
  23. pmc Metabolic signatures of insulin resistance in 7,098 young adults
    Peter Würtz
    Computational Medicine Research Group, Institute of Clinical Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland
    Diabetes 61:1372-80. 2012
    ..0005). Nonetheless, metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints...
  24. pmc Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology
    Magda Bictash
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    J Clin Epidemiol 63:970-9. 2010
    ....
  25. doi request reprint Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study
    Ioanna Tzoulaki
    Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, W2 1PG London, United Kingdom
    Am J Epidemiol 171:989-98. 2010
    ..These results showed that growth during the immediate postnatal period is associated with adulthood obesity and BP. Lifestyle changes from early life might be important in reducing adulthood obesity and high-BP risk...
  26. pmc Associations between pre-pregnancy obesity and asthma symptoms in adolescents
    Swatee P Patel
    Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London W2 1PG, UK
    J Epidemiol Community Health 66:809-14. 2012
    ..The high prevalence of children's asthma symptoms, worldwide, is unexplained. We examined the relation between maternal pre-pregnancy weight and body mass index (BMI), and asthma symptoms in adolescents...
  27. doi request reprint Identifying schizophrenia and other psychoses with psychological scales in the general population
    Jouko Miettunen
    Department of Psychiatry, Oulu University and Oulu University Hospital, Oulu, Finland
    J Nerv Ment Dis 199:230-8. 2011
    ..Harm avoidance was a dominant temperament dimension in individuals with psychosis compared with participants without psychiatric diagnoses. These scales are useful as vulnerability markers in studying psychoses...
  28. doi request reprint Volumes of brain, grey and white matter and cerebrospinal fluid in schizophrenia in the Northern Finland 1966 Birth Cohort: an epidemiological approach to analysis
    Päivikki Tanskanen
    University of Oulu, Department of Diagnostic Radiology, P O Box 50, FIN 90029 Oulu, Finland
    Psychiatry Res 174:116-20. 2009
    ..Our study replicates the previous findings of brain volume differences in schizophrenia on a general population level...
  29. pmc Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus
    Jatta Pirkola
    Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
    Diabetes Care 33:1115-21. 2010
    ..Research estimating risk for offspring overweight due to these exposures, separately and concomitantly, is limited...
  30. ncbi request reprint Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study
    Saara Taponen
    Departments of Clinical Chemistry, University of Oulu and Oulu University Hospital, Oulu, Finland
    J Clin Endocrinol Metab 89:2114-8. 2004
    ....
  31. pmc Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009
    ..The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling...
  32. doi request reprint High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study
    Richard H Barton
    Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Int J Epidemiol 37:i31-40. 2008
    ....
  33. pmc TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood
    Francesca Ducci
    Medical Research Council Social Genetics and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London, United Kingdom
    Biol Psychiatry 69:650-60. 2011
    ..CHRNA5-CHRNA3-CHRNB4 and TTC12-ANKK1-DRD2 gene-clusters influence smoking behavior. Our aim was to test developmental changes in their effects as well as the interplays between them and with nongenetic factors...
  34. pmc Early growth and adult respiratory function in men and women followed from the fetal period to adulthood
    Dexter Canoy
    Department of Public Health Science and General Practice, University of Oulu, Finland
    Thorax 62:396-402. 2007
    ..A study was undertaken to determine the association between early growth and adult respiratory function...
  35. doi request reprint Associations between psychotic-like symptoms and inattention/hyperactivity symptoms
    Tuula Marketta Hurtig
    Department of Child Psychiatry, Institute of Clinical Medicine, Oulu University Hospital, Oulu, Finland
    Soc Psychiatry Psychiatr Epidemiol 46:17-27. 2011
    ..Our aim was to study the association between psychotic-like symptoms and inattention/hyperactivity symptoms in a general adolescent population...
  36. doi request reprint Association of modic changes, Schmorl's nodes, spondylolytic defects, high-intensity zone lesions, disc herniations, and radial tears with low back symptom severity among young Finnish adults
    Jani Takatalo
    Institute of Clinical Medicine, University of Oulu, Oulu, Finland
    Spine (Phila Pa 1976) 37:1231-9. 2012
    ..A cross-sectional magnetic resonance imaging (MRI) study...
  37. doi request reprint Chlamydia antibodies and self-reported symptoms of oligo-amenorrhea and hirsutism: a new etiologic factor in polycystic ovary syndrome?
    Laure C Morin-Papunen
    Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland
    Fertil Steril 94:1799-804. 2010
    ..To investigate whether the systemic inflammation induced by chlamydial infections might be associated with symptoms of polycystic ovary syndrome (PCOS)...
  38. doi request reprint Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population
    Laure Morin-Papunen
    Department of Obstetrics and Gynecology, University Hospital of Oulu, Oulu, Finland
    Am J Obstet Gynecol 199:529.e1-529.e10. 2008
    ..We compared the metabolic and cardiovascular parameters of a reference group of women with those of women who used 2 contraceptive regimes that are used worldwide: the levonorgestrel-releasing intrauterine device and oral contraceptives...
  39. doi request reprint Deviant intrauterine growth and risk of schizophrenia: a 34-year follow-up of the Northern Finland 1966 Birth Cohort
    Kristiina Moilanen
    Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Schizophr Res 124:223-30. 2010
    ..Low birth weight conveys a modest risk for schizophrenia. The effects of high birth weight and deviant birth length are less clear...
  40. ncbi request reprint Co-occurrence of personality disorders with mood, anxiety, and substance use disorders in a young adult population
    Liisa Kantojärvi
    Department of Psychiatry, University of Oulu, Finland
    J Pers Disord 20:102-12. 2006
    ..The weighted co-occurrence rate of any PD varied from 28% for mood disorders to 47% for anxiety disorders. PDs, especially those in Cluster C, are highly associated with Axis I psychiatric disorders in population...
  41. ncbi request reprint A 4-fold risk of metabolic syndrome in patients with schizophrenia: the Northern Finland 1966 Birth Cohort study
    Kaisa M Saari
    Department of Psychiatry, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    J Clin Psychiatry 66:559-63. 2005
    ..Our objective was to study the prevalence of metabolic syndrome in a population-based birth cohort...
  42. ncbi request reprint The course of pregnancy and delivery and the use of maternal healthcare services after standard IVF in Northern Finland 1990-1995
    Sari Koivurova
    Department of Public Health Science and General Practice, University of Oulu, P O Box 5000, 90014 Oulu, Finland
    Hum Reprod 17:2897-903. 2002
    ..The objective of this study was to evaluate the course of pregnancy and delivery and the use of maternal healthcare after IVF...
  43. ncbi request reprint Etiological survey on intellectual disability in the northern Finland birth cohort 1986
    Ulla Heikura
    Public Health Science and General Practice, University of Oulu, Oulu 90014, Finland
    Am J Ment Retard 110:171-80. 2005
    ..The differences between the populations, despite random variation, some dissimilarities between etiological categorization and diagnostic accuracy, are in most part due to true differences between the study populations and genetic pool...
  44. pmc Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 337:a258. 2008
    ..To investigate associations of dietary iron (total, haem, and non-haem), supplemental iron, and red meat with blood pressure...
  45. pmc Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification
    Marc Chadeau-Hyam
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London W2 1PG, United Kingdom
    J Proteome Res 9:4620-7. 2010
    ..Our results show that the MWSL approach as estimated by the univariate t test is not outperformed by OPLS and offers a fast and simple method to detect disease-related discriminatory features in human NMR urinary metabolic profiles...
  46. doi request reprint Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Hypertension 51:669-75. 2008
    ..These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension...
  47. pmc Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
    Karani S Vimaleswaran
    Centre for Paediatric Epidemiology and Biostatistics and MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom
    PLoS Med 10:e1001383. 2013
    ..We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis...
  48. ncbi request reprint Ability to speak at the age of 1 year and alexithymia 30 years later
    Pirkko Kokkonen
    Department of Psychiatry, Oulu University Hospital, Oulu, Finland
    J Psychosom Res 54:491-5. 2003
    ..We studied the association between speech development in the first year of life and alexithymia in young adulthood...
  49. ncbi request reprint ADHD and comorbid disorders in relation to family environment and symptom severity
    Tuula Hurtig
    Department of Public Health Science and General Practice, University of Oulu, P O Box 5000, Oulu, Finland
    Eur Child Adolesc Psychiatry 16:362-9. 2007
    ..To examine the comorbidity of ADHD in association with family environment and the severity of ADHD...
  50. doi request reprint Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort
    Marja Vääräsmäki
    Department of Clinical Sciences Obstetrics and Gynecology, Oulu University Hospital and University of Oulu, Oulu, Finland
    Am J Epidemiol 169:1209-15. 2009
    ..These findings highlight the importance of prevention strategies among children born to women with GDM...
  51. pmc Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation
    Leon M Smith
    Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Anal Chem 81:4847-56. 2009
    ....
  52. pmc The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size
    Anokhi Ali Khan
    Department of Epidemiology and Biostatistics, Medical Research Council Health Protection Agency Centre for Environment and Health, Imperial College London, London, United Kingdom
    PLoS ONE 7:e38216. 2012
    ..We aimed to determine whether the addition of genetic variance magnified the observed associations...
  53. pmc The impact of gestational thyroid hormone concentrations on ADHD symptoms of the child
    Fanni Päkkilä
    Departments of Obstetrics and Gynecology F P, A L H, M V, E S and Clinical Chemistry A R, and Clinic of Child Psychiatry I M, University of Oulu and Oulu University Hospital, 90029 OYS, Oulu, Finland Institute of Health Sciences F P, M R J, University of Oulu, 90220 Oulu, Finland Department of Children, Young People, and Families F P, A P, H M S, A B, M R J, National Institute for Health and Welfare, 00271 Helsinki, Finland Epidemiology Branch T M, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 and Department of Epidemiology and Biostatistics M R J, Imperial College London, London SW7 2AZ, United Kingdom
    J Clin Endocrinol Metab 99:E1-8. 2014
    ..Maternal hypothyroidism during pregnancy is associated with adverse neuropsychological development in the offspring...
  54. doi request reprint Non-participation in a field survey with respect to psychiatric disorders
    Marianne Haapea
    Department of Psychiatry, University of Oulu and Oulu University Hospital, Oulu, Finland
    Scand J Public Health 36:728-36. 2008
    ..We had a unique opportunity to explore psychiatric morbidity and non-participation in a large epidemiological survey including questionnaires and a clinical examination...
  55. pmc Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption
    Silke S Heinzmann
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom
    Am J Clin Nutr 92:436-43. 2010
    ..New food biomarkers are needed to objectively evaluate the effect of diet on health and to check adherence to dietary recommendations and healthy eating patterns...
  56. ncbi request reprint Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples
    Leon M Smith
    Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK
    Anal Chem 79:5682-9. 2007
    ..Both methods either alone or in combination have the potential for general applications to any complex mixture analysis where the sample contains compounds with a range of diffusion coefficients...
  57. pmc Relation of trihalomethane concentrations in public water supplies to stillbirth and birth weight in three water regions in England
    Mireille B Toledano
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
    Environ Health Perspect 113:225-32. 2005
    ..Further work is needed looking at cause-specific stillbirths and effects of other disinfection by-products and to help differentiate between alternative (noncausal) explanations and those that may derive from the water supply...
  58. pmc Interpreting posterior relative risk estimates in disease-mapping studies
    Sylvia Richardson
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom
    Environ Health Perspect 112:1016-25. 2004
    ..5- to 2-fold). Larger (3-fold) excess risks are detected almost certainly using this rule, even when based on small expected counts, although the mean of the posterior distribution is typically smoothed to about half the true value...
  59. pmc Dietary starch intake of individuals and their blood pressure: the International Study of Macronutrients and Micronutrients and Blood Pressure
    Ian J Brown
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, London, UK
    J Hypertens 27:231-6. 2009
    ..Cross-sectional data from the International Study of Macronutrients and Micronutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary starch intake to blood pressure in men and women from four countries...
  60. pmc Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity
    Robin G Walters
    Department of Genomics of Common Disease, Imperial College London, London, United Kingdom
    PLoS ONE 8:e58048. 2013
    ..Nevertheless, we show that such studies are potentially valuable for the identification of variants making an appreciable contribution to complex disease...
  61. pmc Fine-scale estimation of location of birth from genome-wide single-nucleotide polymorphism data
    Clive J Hoggart
    Department of Epidemiology and Biostatistics, Imperial College, London W2 1PG, United Kingdom
    Genetics 190:669-77. 2012
    ..A method with such accuracy is potentially valuable in population genetics and forensics...
  62. pmc Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Nat Genet 41:1170-2. 2009
    ..13 (95% CI 0.09-0.17) g/dl lower per copy of allele A (P = 1.6 x 10(-13)). Our findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance...
  63. pmc Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966
    Ulla Sovio
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 5:e1000409. 2009
    ....
  64. doi request reprint High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics and Medical Research Council Centre for the Epidemiology of Child Health, University College London Institute of Child Health, WC1N 1EH, London, UK
    J Nutr 141:843-8. 2011
    ....
  65. pmc Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development
    Ulla Sovio
    Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom
    PLoS Genet 7:e1001307. 2011
    ..The associated shifts in developmental timing have clinical importance with respect to known relationships between AR and both later-life BMI and metabolic disease risk...
  66. pmc Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966
    Jessica L Buxton
    Section of Investigative Medicine, Department of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 9:e99133. 2014
    ..Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing...
  67. ncbi request reprint Family type and criminal behaviour of male offspring: the Northern Finland 1966 Birth Cohort Study
    Anu Sauvola
    Department of Psychiatry, University of Oulu, Finland
    Int J Soc Psychiatry 48:115-21. 2002
    ..Unstable family environment during childhood is known to predispose to juvenile delinquency...
  68. ncbi request reprint Teenage smoking and substance use as predictors of severe alcohol problems in late adolescence and in young adulthood
    Kaisa Riala
    Department of Psychiatry, University of Oulu, Box 5000, Oulu FIN 90014, Finland
    J Adolesc Health 35:245-54. 2004
    ..To study the association between adolescent alcohol use, smoking, other substance use, and later substance-use-related problems in a large general population sample in Northern Finland...
  69. ncbi request reprint Predictors of female criminality: findings from the Northern Finland 1966 birth cohort
    Liisa Kemppainen
    Department of Psychiatry, University of Oulu, Finland
    J Am Acad Child Adolesc Psychiatry 41:854-9. 2002
    ..Thus there is a need for original studies into the perinatal contribution to the etiology of female offending...
  70. doi request reprint Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study
    Tuija Männistö
    Department of Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland
    J Clin Endocrinol Metab 94:772-9. 2009
    ..There are only a few large prospective studies involving evaluation of the effect of maternal thyroid dysfunction on offspring and observations are inconsistent...
  71. doi request reprint Temperament profiles in personality disorders among a young adult population
    Liisa Kantojärvi
    Department of Psychiatry, Oulu University and Oulu University Hospital, Oulu, Finland
    Nord J Psychiatry 62:423-30. 2008
    ..PD clusters were associated with different profiles of temperament, lending some support for Cloninger's typology...
  72. pmc Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
    Anthi Kelempisioti
    Oulu Center for Cell Matrix Research, Biocenter and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Aapistie 7 PO Box 5000, 90014 Oulu, Finland
    BMC Med Genet 12:153. 2011
    ..Focusing on young age can be valuable in determining genetic predisposition to DD...
  73. pmc Chlorination disinfection by-products and risk of congenital anomalies in England and Wales
    Mark J Nieuwenhuijsen
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, London, United Kingdom
    Environ Health Perspect 116:216-22. 2008
    ..Increased risk of various congenital anomalies has been reported to be associated with trihalomethane (THM) exposure in the water supply...
  74. pmc Design issues in small-area studies of environment and health
    Paul Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, London, UK
    Environ Health Perspect 116:1098-104. 2008
    ..We focus on etiologic research, where the aim is to make inferences about spatially varying environmental factors influencing the risk of disease...
  75. ncbi request reprint Down syndrome in births near landfill sites
    Lars Jarup
    The Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Prenat Diagn 27:1191-6. 2007
    ..The aim of the study was to examine the risk of giving birth to a child with Down syndrome associated with residence near landfill sites in England and Wales...
  76. pmc Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases
    Hariklia Eleftherohorinou
    Division of Medicine, Department of Paediatrics, Imperial College London, London, United Kingdom
    PLoS ONE 4:e8068. 2009
    ..Our analysis suggests that genetic contribution to common inflammatory diseases operates through multiple genes interacting in functional pathways...
  77. ncbi request reprint Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature
    Liisa Lauren
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 32:862-76. 2003
    ....
  78. ncbi request reprint Cloninger's Temperament dimensions, socio-economic and lifestyle factors and metabolic syndrome markers at age 31 years in the Northern Finland Birth Cohort 1966
    Ulla Sovio
    Imperial College London, UK
    J Health Psychol 12:371-82. 2007
    ..Our results suggest that temperament is associated with metabolic syndrome markers and this association may be partly mediated by lifestyle factors and socio-economic status in adulthood...
  79. ncbi request reprint Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 79:2629-40. 2007
    ..This approach should be of value in considering interpopulation patterns of drug metabolism in epidemiological and pharmacogenetic studies...
  80. pmc Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    Jaspal S Kooner
    National Heart and Lung Institute NHLI, Imperial College London, Hammersmith Hospital, London, UK
    Nat Genet 43:984-9. 2011
    ..001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D...
  81. doi request reprint Salt intakes around the world: implications for public health
    Ian J Brown
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, UK
    Int J Epidemiol 38:791-813. 2009
    ..Comprehensive, contemporaneous sodium intake data from around the world are needed to inform national/international public health initiatives to reduce sodium consumption...
  82. ncbi request reprint Kidney disease mortality and environmental exposure to mercury
    Susan Hodgson
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    Am J Epidemiol 165:72-7. 2007
    ....
  83. doi request reprint Water consumption and use, trihalomethane exposure, and the risk of hypospadias
    Nina Iszatt
    Department of Epidemiology and Biostatistics and MRC HPA Centre for Environment and Health, Imperial College London, London, United Kingdom
    Pediatrics 127:e389-97. 2011
    ..Ingestion of drinking-water-disinfection byproducts such as trihalomethanes (THMs) has been associated with hypospadias in a small sample. We examined risk of hypospadias and exposure to THMs through water consumption and use...
  84. doi request reprint Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study
    Ioanna Tzoulaki
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, W2 1PG, London, UK
    Eur Heart J 29:1049-56. 2008
    ..Our aim was to investigate relationships between fetal growth, weight over the life course, and low-grade inflammation measured by serum high sensitivity C-reactive protein (CRP) levels at 31 years...
  85. doi request reprint Infant locomotive development and its association with adult blood pressure
    Demetris Pillas
    Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, W2 1PG, UK
    Eur J Pediatr 173:1309-17. 2014
    ..38 (95 % CI 0.15 to 0.62)-mm Hg higher DBP were estimated for each month of later achievement (P = 0.012 for SBP; P = 0.001 for DBP). No association was identified for non-locomotive neuromotor development...
  86. pmc Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity
    Beatriz Valcárcel
    Department of Epidemiology and Biostatistics, School of Public Health, MRC HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK
    J R Soc Interface 11:20130908. 2014
    ..This study highlights the advantage of using molecular associations as an alternative phenotype when studying the genetic basis of complex traits and diseases. ..
  87. doi request reprint Childhood attention-deficit/hyperactivity disorder symptoms are risk factors for obesity and physical inactivity in adolescence
    Natasha Khalife
    Imperial College London, UK
    J Am Acad Child Adolesc Psychiatry 53:425-36. 2014
    ..We explored whether childhood conduct disorder (CD) symptoms are related to adolescent obesity/physical inactivity...
  88. pmc Prenatal glucocorticoid treatment and later mental health in children and adolescents
    Natasha Khalife
    Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
    PLoS ONE 8:e81394. 2013
    ..Animal studies demonstrate a clear link between prenatal exposure to glucocorticoids (GC) and altered offspring brain development. We aim to examine whether prenatal GC exposure programs long-term mental health in humans...
  89. pmc MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS
    Paul F O'Reilly
    Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
    PLoS ONE 7:e34861. 2012
    ....
  90. pmc Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study
    Ivan K S Yap
    Department of Surgery and Cancer, Faculty of Medicine, School of Public Health, Imperial College London, United Kingdom
    J Proteome Res 9:6647-54. 2010
    ..These findings indicate the importance of environmental influences (e.g., diet), endogenous metabolism, and mammalian-gut microbial cometabolism, which may help explain north-south China differences in cardiovascular disease risk...
  91. pmc Mobile phone base stations and early childhood cancers: case-control study
    Paul Elliott
    Small Area Health Statistics Unit, MRC HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary s Campus, London W2 1PG
    BMJ 340:c3077. 2010
    ..To investigate the risk of early childhood cancers associated with the mother's exposure to radiofrequency from and proximity to macrocell mobile phone base stations (masts) during pregnancy...
  92. pmc Long-term associations of outdoor air pollution with mortality in Great Britain
    Paul Elliott
    Small Area Health Statistics Unit, Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    Thorax 62:1088-94. 2007
    ..Recent studies have indicated long-term effects on mortality of particulate and sulphur dioxide (SO(2)) pollution, but uncertainties remain over the size of any effects, potential latency and generalisability...
  93. pmc Placental size is associated with mental health in children and adolescents
    Natasha Khalife
    Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
    PLoS ONE 7:e40534. 2012
    ..We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and later as adolescents at 16 years...
  94. doi request reprint Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits
    Sean J Costelloe
    Center for Cardiovascular Genetics, Institute of Cardiovascular Science, The Royal Free London NHS Foundation Trust, Pond St, London, UK
    Circ Cardiovasc Genet 5:555-60. 2012
    ..Copy number variants (CNVs) are a major form of genomic variation, which may be implicated in complex disease phenotypes. However, investigation of the role of CNVs in coronary heart disease (CHD) traits has been limited...
  95. pmc Maternal cholestasis during pregnancy programs metabolic disease in offspring
    Georgia Papacleovoulou
    Institute of Reproductive and Developmental Biology, Hammersmith Hospital, Imperial College London, London, United Kingdom
    J Clin Invest 123:3172-81. 2013
    ..We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring. ..
  96. ncbi request reprint Birthweight and blood pressure in five European birth cohort studies: an investigation of confounding factors
    Rebecca Hardy
    Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Eur J Public Health 16:21-30. 2006
    ..This study investigates the impact of potential confounding variables on the birthweight-blood pressure association in birth cohort studies from different time periods and geographical locations in Europe...
  97. pmc Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response
    Alexessander Couto Alves
    Department of Epidemiology and Biostatistics, Imperial College London, MRC HPA Centre for Environment and Health, Imperial College London, London, United Kingdom
    PLoS ONE 8:e74821. 2013
    ..C3AR1 is also significantly associated with allergic sensitisation in GWAS data. ..
  98. doi request reprint Genetic variation in SCN10A influences cardiac conduction
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, UK
    Nat Genet 42:149-52. 2010
    ..05) and a lower risk of ventricular fibrillation (P = 0.01). Our findings provide new insight into the pathogenesis of cardiac conduction, heart block and ventricular fibrillation...
  99. ncbi request reprint Hemoglobin concentration in pregnancy and perinatal mortality: a London-based cohort study
    Mark P Little
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, St Mary s Campus, Norfolk Place, United Kingdom
    Am J Obstet Gynecol 193:220-6. 2005
    ..The objective of the study was to determine the association between maternal hemoglobin concentration during pregnancy and perinatal mortality...
  100. ncbi request reprint Assessment of uncertainty in a probabilistic model of consumer exposure to pesticide residues in food
    Helen Ferrier
    Department of Environmental Science and Technology, Imperial College London, SW7 2BP, London, UK
    Food Addit Contam 23:601-15. 2006
    ..The findings have important implications for how probabilistic modelling should be conducted, communicated and used by policy and decision makers as part of consumer risk assessment of pesticides...
  101. pmc Spatial epidemiology: current approaches and future challenges
    Paul Elliott
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    Environ Health Perspect 112:998-1006. 2004
    ....