Genomes and Genes
Clive J Hoggart
Affiliation: Imperial College
- A risk model for lung cancer incidenceClive Hoggart
Department of Epidemiology and Biostatistics, Imperial College London, St Mary s Campus, Paddington, London, United Kingdom
Cancer Prev Res (Phila) 5:834-46. 2012..Our model is generalizable and straightforward to implement. Its accuracy can be attributed to its modeling of lifetime exposure to smoking...
- Fine-scale estimation of location of birth from genome-wide single-nucleotide polymorphism dataClive J Hoggart
Department of Epidemiology and Biostatistics, Imperial College, London W2 1PG, United Kingdom
Genetics 190:669-77. 2012..A method with such accuracy is potentially valuable in population genetics and forensics...
- Sequence-level population simulations over large genomic regionsClive J Hoggart
Department of Epidemiology and Public Health, Imperial College, London W2 1PG, United Kingdom
Genetics 177:1725-31. 2007....
- Genome-wide significance for dense SNP and resequencing dataClive J Hoggart
Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London, UK
Genet Epidemiol 32:179-85. 2008..We compare our results for sequence data to those derived by the HapMap Consortium and find notable differences which may be due to the small sample sizes used in the HapMap estimate...
- Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studiesClive J Hoggart
Department of Epidemiology and Public Health, Imperial College, London, United Kingdom
PLoS Genet 4:e1000130. 2008....
- Fregene: simulation of realistic sequence-level data in populations and ascertained samplesMarc Chadeau-Hyam
Department of Epidemiology and Public Health, Imperial College, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
BMC Bioinformatics 9:364. 2008..We describe here main functionalities of both FREGENE and SAMPLE, a companion program that can replicate association study datasets...
- Genome-wide association study reveals multiple loci associated with primary tooth development during infancyDemetris Pillas
Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
PLoS Genet 6:e1000856. 2010..Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years...
- invertFREGENE: software for simulating inversions in population genetic dataPaul F O'Reilly
Department of Epidemiology and Biostatistics, Imperial College
Bioinformatics 26:838-40. 2010..We describe previously unreported signatures of inversions in SNP data observed in invertFREGENE results and a known inversion in humans...
- Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile ChildrenJethro A Herberg
Section of Paediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, London, United Kingdom
JAMA 316:835-45. 2016..Because clinical features do not reliably distinguish bacterial from viral infection, many children worldwide receive unnecessary antibiotic treatment, while bacterial infection is missed in others...
- MultiPhen: joint model of multiple phenotypes can increase discovery in GWASPaul F O'Reilly
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
PLoS ONE 7:e34861. 2012....
- The effect of genomic inversions on estimation of population genetic parameters from SNP dataNafisa Katrin Seich Al Basatena
Department of Immunology, Imperial College London, London W2 1PG, United Kingdom
Genetics 193:243-53. 2013....
- Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathwaysHariklia Eleftherohorinou
Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London W2 1PG, UK
Hum Mol Genet 20:3494-506. 2011....
- Predicting IVIG resistance in UK Kawasaki diseaseSarah Davies
Department of Paediatric Infectious Diseases, St Mary s Hospital, Imperial College Healthcare NHS Trust, London, UK
Arch Dis Child 100:366-8. 2015..The KS does not predict IVIG resistance or CAA in our population. This highlights the need for biomarkers to identify children at increased risk of CAA, and to select patients for anti-inflammatory treatment in addition to IVIG. ..
- Assessing the relative ages of admixture in the bovine hybrid zones of Africa and the Near East using X chromosome haplotype mosaicismAbigail R Freeman
Smurfit Institute of Genetics, Trinity Colege, Dublin, Ireland
Genetics 173:1503-10. 2006....
- Control of confounding of genetic associations in stratified populationsClive J Hoggart
Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom
Am J Hum Genet 72:1492-1504. 2003..With only 32 markers informative for ancestry, the efficiency of the analysis is 70%. These methods can deal with both confounding and selection bias in genetic-association studies, making family-based designs unnecessary...
- Skin pigmentation, biogeographical ancestry and admixture mappingMark D Shriver
Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
Hum Genet 112:387-99. 2003..The implications and applications of ancestry estimates in biomedical research are discussed...