Nicholas C Grassly

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Biological challenges to effective vaccines in the developing world
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, Norfolk Place, London W2 1PG, UK The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India
    Philos Trans R Soc Lond B Biol Sci 370:. 2015
  2. doi request reprint The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK Christian Medical College, Vellore, Tamil Nadu, India Electronic address
    Lancet Infect Dis 16:905-14. 2016
  3. pmc The final stages of the global eradication of poliomyelitis
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120140. 2013
  4. doi request reprint Waning intestinal immunity after vaccination with oral poliovirus vaccines in India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Infect Dis 205:1554-61. 2012
  5. doi request reprint Asymptomatic wild-type poliovirus infection in India among children with previous oral poliovirus vaccination
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    J Infect Dis 201:1535-43. 2010
  6. doi request reprint Mucosal immunity after vaccination with monovalent and trivalent oral poliovirus vaccine in India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Infect Dis 200:794-801. 2009
  7. ncbi request reprint New strategies for the elimination of polio from India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, UK
    Science 314:1150-3. 2006
  8. pmc The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 2:e341. 2008
  9. ncbi request reprint Protective efficacy of a monovalent oral type 1 poliovirus vaccine: a case-control study
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet 369:1356-62. 2007
  10. pmc Seasonal infectious disease epidemiology
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Proc Biol Sci 273:2541-50. 2006

Detail Information

Publications42

  1. pmc Biological challenges to effective vaccines in the developing world
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, Norfolk Place, London W2 1PG, UK The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India
    Philos Trans R Soc Lond B Biol Sci 370:. 2015
    ....
  2. doi request reprint The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK Christian Medical College, Vellore, Tamil Nadu, India Electronic address
    Lancet Infect Dis 16:905-14. 2016
    ..Because administration of an antibiotic has the potential to resolve environmental enteropathy and clear bacterial pathogens, we aimed to assess whether antibiotics would improve oral poliovirus vaccine immunogenicity...
  3. pmc The final stages of the global eradication of poliomyelitis
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120140. 2013
    ..I document the role of research in the GPEI's response to these challenges and ultimately the feasibility of achieving a world without poliomyelitis. ..
  4. doi request reprint Waning intestinal immunity after vaccination with oral poliovirus vaccines in India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Infect Dis 205:1554-61. 2012
    ..Mucosal immunity is thought to wane over time but the rate of loss of protection has not been examined...
  5. doi request reprint Asymptomatic wild-type poliovirus infection in India among children with previous oral poliovirus vaccination
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    J Infect Dis 201:1535-43. 2010
    ....
  6. doi request reprint Mucosal immunity after vaccination with monovalent and trivalent oral poliovirus vaccine in India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Infect Dis 200:794-801. 2009
    ..Persistent wild-poliovirus transmission, particularly in India, has raised questions about the degree of mucosal immunity induced by oral poliovirus vaccine (OPV) in tropical countries...
  7. ncbi request reprint New strategies for the elimination of polio from India
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, UK
    Science 314:1150-3. 2006
    ..We analyze strategies to counteract this and show that switching to monovalent vaccine may finally interrupt virus transmission...
  8. pmc The natural history of trachoma infection and disease in a Gambian cohort with frequent follow-up
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 2:e341. 2008
    ....
  9. ncbi request reprint Protective efficacy of a monovalent oral type 1 poliovirus vaccine: a case-control study
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet 369:1356-62. 2007
    ..A high-potency monovalent oral type 1 poliovirus vaccine (mOPV1) was developed in 2005 to tackle persistent poliovirus transmission in the last remaining infected countries. Our aim was to assess the efficacy of this vaccine in India...
  10. pmc Seasonal infectious disease epidemiology
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Proc Biol Sci 273:2541-50. 2006
    ..The synthesis of seasonal infectious disease epidemiology attempted by this paper highlights the need for further empirical and theoretical work...
  11. ncbi request reprint Methods to estimate the number of orphans as a result of AIDS and other causes in Sub-Saharan Africa
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary s Campus, London, United Kingdom
    J Acquir Immune Defic Syndr 39:365-75. 2005
    ..To derive methods to estimate and project the fraction of children orphaned by AIDS and other causes...
  12. pmc The future of the HIV pandemic
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, Norfolk Place, London W2 1PG, England
    Bull World Health Organ 83:378-82. 2005
    ....
  13. ncbi request reprint Comparison of household-survey estimates with projections of mortality and orphan numbers in sub-Saharan Africa in the era of HIV/AIDS
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College, London
    Popul Stud (Camb) 58:207-17. 2004
    ..Reducing adult mortality from causes other than AIDS brings the model estimates into close agreement with the surveys. This suggests that the fraction of orphans attributable to AIDS is greater than estimated previously...
  14. ncbi request reprint Host immunity and synchronized epidemics of syphilis across the United States
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nature 433:417-21. 2005
    ..We further demonstrate increased synchrony of syphilis oscillations across cities over time, providing empirical evidence for an increasingly connected sexual network in the United States...
  15. pmc Estimating household and community transmission of ocular Chlamydia trachomatis
    Isobel M Blake
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    PLoS Negl Trop Dis 3:e401. 2009
    ..The potential impact of more efficient, targeted treatment of infected households depends on the relative contribution of community and household transmission of infection, which have not previously been estimated...
  16. pmc Targeting antibiotics to households for trachoma control
    Isobel M Blake
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 4:e862. 2010
    ..Here we explore whether alternative, targeted approaches are effective antibiotic-sparing strategies...
  17. pmc The development of an age-structured model for trachoma transmission dynamics, pathogenesis and control
    Manoj Gambhir
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 3:e462. 2009
    ..We present an age-structured mathematical model of trachoma transmission and disease to predict the impact of interventions on the prevalence of blinding trachoma...
  18. doi request reprint Implications of a circulating vaccine-derived poliovirus in Nigeria
    Helen E Jenkins
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    N Engl J Med 362:2360-9. 2010
    ....
  19. pmc The effect of mass immunisation campaigns and new oral poliovirus vaccines on the incidence of poliomyelitis in Pakistan and Afghanistan, 2001-11: a retrospective analysis
    Kathleen M O'Reilly
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK
    Lancet 380:491-8. 2012
    ..We aimed to establish why incidence is rising in these countries despite programme innovations including the introduction of new vaccines...
  20. doi request reprint Effectiveness of immunization against paralytic poliomyelitis in Nigeria
    Helen E Jenkins
    Medical Research Council Centre for Outbreak Analysis and Modeling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
    N Engl J Med 359:1666-74. 2008
    ..Understanding the relative contribution of these vaccines and the improved coverage to the decline in incident cases is essential for future planning...
  21. ncbi request reprint Modelling trachoma for control programmes
    Manoj Gambhir
    Department of Infectious Disease Epidemiology, Faculty of Medicine, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, UK
    Adv Exp Med Biol 673:141-56. 2010
    ..This novel model structure reproduces many age- and time-dependent epidemiological patterns observed in endemic settings and allows the dynamic effect of treatment on infection and disease sequelae to be gauged...
  22. pmc A statistical model of the international spread of wild poliovirus in Africa used to predict and prevent outbreaks
    Kathleen M O'Reilly
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom
    PLoS Med 8:e1001109. 2011
    ..A quantitative understanding of the factors that predict the distribution and timing of outbreaks will enable their prevention and facilitate the completion of global eradication...
  23. pmc Spatial Dynamics and High Risk Transmission Pathways of Poliovirus in Nigeria 2001-2013
    Tara D Mangal
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS ONE 11:e0163065. 2016
    ..Poliovirus transmission in Nigeria is predominantly localised, occurring between spatially contiguous areas. Outbreak response should be guided by knowledge of high-probability pathways to ensure vulnerable children are protected...
  24. pmc Population Immunity against Serotype-2 Poliomyelitis Leading up to the Global Withdrawal of the Oral Poliovirus Vaccine: Spatio-temporal Modelling of Surveillance Data
    Margarita Pons-Salort
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, London, United Kingdom
    PLoS Med 13:e1002140. 2016
    ..Achieving high levels of serotype-2 population immunity before OPV2 withdrawal was critical to avoid subsequent outbreaks of serotype-2 vaccine-derived polioviruses (VDPV2s)...
  25. pmc Monitoring trends in HIV prevalence among young people, aged 15 to 24 years, in Manicaland, Zimbabwe
    Kimberly A Marsh
    Department of Infectious Disease Epidemiology, Imperial College London, UK
    J Int AIDS Soc 14:27. 2011
    ..Changes in socio-demographic characteristics and reported sexual behaviour are investigated...
  26. doi request reprint Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised controlled trial
    Jacob John
    Christian Medical College, Vellore, Tamil Nadu, India
    Lancet 384:1505-12. 2014
    ..We aimed to assess the effect of IPV on intestinal immunity in children previously vaccinated with OPV...
  27. doi request reprint Key issues in the persistence of poliomyelitis in Nigeria: a case-control study
    Tara D Mangal
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK Electronic address
    Lancet Glob Health 2:e90-7. 2014
    ..We aimed to quantitatively analyse the key factors sustaining transmission of poliomyelitis in Nigeria and to calculate clinical efficacy estimates for the oral poliovirus vaccines (OPV) currently in use...
  28. pmc Pandemic potential of a strain of influenza A (H1N1): early findings
    Christophe Fraser
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    Science 324:1557-61. 2009
    ..Transmissibility is therefore substantially higher than that of seasonal flu, and comparable with lower estimates of R0 obtained from previous influenza pandemics...
  29. doi request reprint Mathematical models of infectious disease transmission
    Nicholas C Grassly
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Nat Rev Microbiol 6:477-87. 2008
  30. pmc Preventing Vaccine-Derived Poliovirus Emergence during the Polio Endgame
    Margarita Pons-Salort
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, London, United Kingdom
    PLoS Pathog 12:e1005728. 2016
    ..A failure to implement this risk-based approach could mean these SIAs actually increase the risk of VDPV2 emergence and spread. ..
  31. pmc Systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge
    Thomas R Hird
    Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London, United Kingdom
    PLoS Pathog 8:e1002599. 2012
    ..The impact of IPV on poliovirus transmission in countries where fecal-oral spread is common is unknown but is likely to be limited compared with OPV...
  32. ncbi request reprint Trachoma: transmission, infection, and control
    Manoj Gambhir
    Department of Infectious Disease Epidemiology, Imperial College, London, UK
    Lancet Infect Dis 7:420-7. 2007
    ..The implications of disease transmission and pathogenesis for trachoma control programmes are discussed...
  33. doi request reprint The epidemiology of non-polio enteroviruses: recent advances and outstanding questions
    Margarita Pons-Salort
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, London, UK
    Curr Opin Infect Dis 28:479-87. 2015
    ....
  34. doi request reprint The duration of intestinal immunity after an inactivated poliovirus vaccine booster dose in children immunized with oral vaccine: a randomised controlled trial
    Jacob John
    Christian Medical College, Vellore, Tamil Nadu, India
    J Infect Dis . 2016
    ..In 2014 two studies showed that inactivated poliovirus vaccine (IPV) boosts intestinal immunity in children previously immunized with oral vaccine (OPV). As a result IPV was introduced in mass campaigns to help achieve polio eradication...
  35. pmc The role of older children and adults in wild poliovirus transmission
    Isobel M Blake
    Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 111:10604-9. 2014
    ..Bringing the immunization response to the Tajikistan outbreak forward by 2 wk would have prevented an additional 130 cases (21%), highlighting the importance of early outbreak detection and response. ..
  36. pmc The Burden of Typhoid and Paratyphoid in India: Systematic Review and Meta-analysis
    Jacob John
    Department of Community Health, Christian Medical College, Vellore, India
    PLoS Negl Trop Dis 10:e0004616. 2016
    ..The decision about whether to introduce a public vaccination programme needs to be based on an understanding of disease burden and the age-groups and geographic areas at risk...
  37. pmc Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame
    Edward Pk Parker
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, London, UK
    Expert Rev Vaccines 14:1113-23. 2015
    ..We conclude that the implementation of IPV in both routine and supplementary immunization activities has the potential to play a key role in halting poliovirus transmission, and thereby hasten the eradication of polio. ..
  38. ncbi request reprint Antiretroviral therapy to treat and prevent HIV/AIDS in resource-poor settings
    Geoff P Garnett
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London University, UK
    Nat Med 8:651-4. 2002
  39. ncbi request reprint The economic impact of HIV/AIDS on the education sector in Zambia
    Nicholas C Grassly
    Department of Infectious Disease Epidemiology and the Partnership for Child Development, Faculty of Medicine, Imperial College London, UK
    AIDS 17:1039-44. 2003
    ..To estimate and project the economic impact of HIV/AIDS on the supply of education in Zambia...
  40. ncbi request reprint Estimating the global burden of HIV/AIDS: what do we really know about the HIV pandemic?
    Neff Walker
    UNICEF, New York, New York 10017, USA
    Lancet 363:2180-5. 2004
    ..We explain the reason for moving to the use of plausibility bounds, the factors that determine the width of the bounds, and the implications for policy makers and programme managers...
  41. pmc Back to basics in HIV prevention: focus on exposure
    Elizabeth Pisani
    Family Health International, Bangkok, Thailand
    BMJ 326:1384-7. 2003
  42. ncbi request reprint Can we reverse the HIV/AIDS pandemic with an expanded response?
    John Stover
    Futures Group International, Glastonbury, CT, USA
    Lancet 360:73-7. 2002
    ..Analyses suggest that if the successes achieved in some countries in prevention of transmission can be expanded to a global scale by 2005, about 29 million new infections could be prevented by 2010...