Manuel B Graeber

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Dementia with Lewy bodies: disease concept and genetics
    Manuel B Graeber
    Department of Neuropathology, Division of Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Neurogenetics 4:157-62. 2003
  2. pmc A free community approach to classifying disease
    Manuel B Graeber
    Department of Neuropathology, Faculty of Medicine, Imperial College London, Hammersmith Hospitals Trust, London, United Kingdom
    PLoS Med 1:e16. 2004
  3. ncbi request reprint The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability
    D C Duke
    University Department of Neuropathology, Faculty of Medicine, Division of Neuroscience and Mental Health, Imperial College London and Hammersmith Hospitals Trust, Charing Cross Campus, Fulham Palace Road, London, W6 8RF, UK
    Neurogenetics 8:83-94. 2007
  4. pmc Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies
    Linda B Moran
    Imperial College London and Hammersmith Hospitals Trust, University Department of Neuropathology, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Acta Neuropathol 115:471-8. 2008
  5. pmc Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation
    Linda B Moran
    University Department of Neuropathology, Imperial College, University of London, Hammersmith Hospitals Trust, London, UK
    Neurogenetics 9:1-13. 2008
  6. doi request reprint Up-regulation of metallothionein gene expression in parkinsonian astrocytes
    Gregory J Michael
    Centre for Neuroscience and Trauma, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, UK
    Neurogenetics 12:295-305. 2011
  7. doi request reprint Striatal beta-amyloid deposition in Parkinson disease with dementia
    Michail E Kalaitzakis
    University Department of Neuropathology, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospitals Trust, London, UK
    J Neuropathol Exp Neurol 67:155-61. 2008
  8. pmc Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
    Emilie Croisier
    Department of Neuropathology, Division of Neuroscience and Mental Health, Imperial College London, and Hammersmith Hospitals Trust, London, UK
    J Neuroinflammation 2:14. 2005
  9. ncbi request reprint Microglia in gemistocytic astrocytomas
    Fatemeh Geranmayeh
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience and Mental Health, Hammersmith Hospitals Trust, London, England
    Neurosurgery 60:159-66; discussion 166. 2007
  10. ncbi request reprint The microglial gene regulatory network activated by interferon-gamma
    Linda B Moran
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience, and Hammersmith Hospitals Trust, London, UK
    J Neuroimmunol 183:1-6. 2007

Collaborators

  • Michail E Kalaitzakis
  • Fatemeh Geranmayeh
  • J Q Trojanowski
  • Hitoshi Takahashi
  • Linda B Moran
  • Emilie Croisier
  • Gregory J Michael
  • Ronald K B Pearce
  • D C Duke
  • Richard B Banati
  • Rupert Egensperger
  • Georg W Kreutzberg
  • Cristian Achim
  • Sharmin Esmailzadeh
  • Lynne Christian
  • Lorraine Hickey
  • Lynne M Christian
  • Maria Derkacs
  • R K B Pearce
  • L B Moran
  • Dawn C Duke
  • David T Dexter
  • Alexander Maassen
  • Gerhard Hager
  • Henry de F Webster
  • Manuel Deprez
  • Caterina Giannini
  • Charles Duyckaerts
  • Samuel Ludwin
  • Yoshio Hashizume
  • Francoise Gray
  • Roland Auer
  • Atsushi Sasaki
  • Hans H Goebel
  • Yngve Olsson
  • James Lowe
  • Matthew P Frosch
  • Peter Lantos
  • Bernd W Scheithauer
  • David I Graham
  • James W Ironside
  • Dirk Troost
  • Matti Haltia
  • Yoh Matsumoto
  • Markus Tolnay
  • Adriana Cardozo
  • Catherine Bergeron
  • Rob de Vos
  • Kenji Ikeda
  • Margaret Esiri

Detail Information

Publications15

  1. ncbi request reprint Dementia with Lewy bodies: disease concept and genetics
    Manuel B Graeber
    Department of Neuropathology, Division of Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Neurogenetics 4:157-62. 2003
    ..The literature on genetic findings in this complex disease is critically discussed...
  2. pmc A free community approach to classifying disease
    Manuel B Graeber
    Department of Neuropathology, Faculty of Medicine, Imperial College London, Hammersmith Hospitals Trust, London, United Kingdom
    PLoS Med 1:e16. 2004
  3. ncbi request reprint The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability
    D C Duke
    University Department of Neuropathology, Faculty of Medicine, Division of Neuroscience and Mental Health, Imperial College London and Hammersmith Hospitals Trust, Charing Cross Campus, Fulham Palace Road, London, W6 8RF, UK
    Neurogenetics 8:83-94. 2007
    ..These findings support the view that glial cells can be primarily affected in PD emphasizing the importance of using a whole tissue approach when investigating degenerative CNS disease...
  4. pmc Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies
    Linda B Moran
    Imperial College London and Hammersmith Hospitals Trust, University Department of Neuropathology, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Acta Neuropathol 115:471-8. 2008
    ....
  5. pmc Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation
    Linda B Moran
    University Department of Neuropathology, Imperial College, University of London, Hammersmith Hospitals Trust, London, UK
    Neurogenetics 9:1-13. 2008
    ..The need for systematic human tissue banking, following the highest possible professional and ethical standard to enable sustainability, becomes evident...
  6. doi request reprint Up-regulation of metallothionein gene expression in parkinsonian astrocytes
    Gregory J Michael
    Centre for Neuroscience and Trauma, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, UK
    Neurogenetics 12:295-305. 2011
    ..However, it is possible that astrocytes are themselves affected by the disease process which may explain their comparatively modest and previously overlooked response...
  7. doi request reprint Striatal beta-amyloid deposition in Parkinson disease with dementia
    Michail E Kalaitzakis
    University Department of Neuropathology, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospitals Trust, London, UK
    J Neuropathol Exp Neurol 67:155-61. 2008
    ..Striatal Abeta deposition was type-independent of Alzheimer disease changes in the cortex and was minimal in nondemented PD cases. We conclude that Abeta deposition in the striatum strongly correlates with dementia in PD...
  8. pmc Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
    Emilie Croisier
    Department of Neuropathology, Division of Neuroscience and Mental Health, Imperial College London, and Hammersmith Hospitals Trust, London, UK
    J Neuroinflammation 2:14. 2005
    ..We have tested the hypothesis that if microglia play a primary role in Parkinson's disease pathogenesis, the microglial "activated" phenotype should be associated with histopathological and/or clinical features of the disease...
  9. ncbi request reprint Microglia in gemistocytic astrocytomas
    Fatemeh Geranmayeh
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience and Mental Health, Hammersmith Hospitals Trust, London, England
    Neurosurgery 60:159-66; discussion 166. 2007
    ..Microglial cells, a feature of this astrocytoma variant, are of increasing interest in the context of glioma growth...
  10. ncbi request reprint The microglial gene regulatory network activated by interferon-gamma
    Linda B Moran
    University Department of Neuropathology, Imperial College London, Faculty of Medicine, Division of Neuroscience, and Hammersmith Hospitals Trust, London, UK
    J Neuroimmunol 183:1-6. 2007
    ..In addition, genes of similar function that are differentially regulated are less likely to be false positives than single unrelated genes...
  11. ncbi request reprint Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
    Emilie Croisier
    University Department of Neuropathology, Imperial College London and Hammersmith Hospitals Trust, Charing Cross Campus, Fulham Palace Road, London, UK
    Acta Neuropathol 112:517-30. 2006
    ..Examples from the spectrum of alpha-synucleinopathies are presented...
  12. ncbi request reprint Mitochondria in activated microglia in vitro
    Richard B Banati
    School of Medical Radiation Sciences, and Ramaciotti Centre for Brain Imaging Brain Mind Research Institute, University of Sydney, East Street PO Box 170, Lidcombe NSW 1825, Australia
    J Neurocytol 33:535-41. 2004
    ....
  13. ncbi request reprint Global democratic consensus on neuropathological disease criteria
    Cristian Achim
    Lancet Neurol 1:340. 2002
  14. doi request reprint Controversies over the staging of alpha-synuclein pathology in Parkinson's disease
    Michail E Kalaitzakis
    Acta Neuropathol 116:125-8; author reply 129-31. 2008
  15. ncbi request reprint Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts
    Manuel B Graeber
    Department of Neuropathology, Faculty of Medicine, Imperial College, London, United Kingdom
    Brain Pathol 12:385-90. 2002
    ..Importantly, a number of new cell death forms have been described in the literature and there is good reason to pay attention to these emerging concepts as they may provide a rationale for the development of disease-specific therapies...