Affiliation: Imperial College
- Intestinal entry of prionsS Ghosh
Gastrointestinal Unit, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
Z Gastroenterol 40:37-9. 2002..The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system...
- Management of Crohn's disease from efficacy, quality of life and health economic perspectivesSubrata Ghosh
Department of Gastroenterology, Imperial College London, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
Expert Rev Pharmacoecon Outcomes Res 3:587-98. 2003..This review gives an overview of patient-focused management of Crohn's disease and the rapid evolution in therapy, with pharmacoeconomic analysis where available...
- Natalizumab for active Crohn's diseaseSubrata Ghosh
Western General Hospital, Edinburgh, United Kingdom
N Engl J Med 348:24-32. 2003..In chronic inflammatory conditions such as Crohn's disease, the migration of leukocytes from the circulation into the parenchyma and their activation within inflammatory sites are mediated in part by alpha4 integrins...
- Alpha 4 integrin blockade in inflammatory bowel diseaseS Ghosh
Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Ann Rheum Dis 62:ii70-2. 2003
- Therapeutic value of alpha-4 integrin blockade in inflammatory bowel disease:the role of natalizumabSubrata Ghosh
Imperial College London, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
Expert Opin Biol Ther 3:995-1000. 2003..Natalizumab was well-tolerated in this study. The Phase III trial results are awaited...
- Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's diseaseDavid A van Heel
Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Inflamm Bowel Dis 12:598-605. 2006..Rare NOD2 variants occur, but it is difficult to both identify them and assess their functional effect. We assessed the true frequency of defective muramyl dipeptide sensing in Crohn's disease and developed a rapid diagnostic assay...
- Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agentsTania Marchbank
Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary University of London, London, UK
Am J Pathol 171:1462-73. 2007..We conclude that administration of PSTI may provide a novel method of stabilizing intestinal mucosa against noxious agents and stimulating repair after injury...
- Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epitheliumMatt Butler
Department of Gastroenterology, Imperial College London Faculty of Medicine, London, UK
Eur J Immunol 36:864-74. 2006..Thus, polarised epithelial cell monolayers create a 'tolerogenic' environment which modulates the activity of DC. These results highlight the regulatory importance of the epithelial microenvironment at mucosal surfaces...
- Synergistic enhancement of Toll-like receptor responses by NOD1 activationDavid A van Heel
Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London Hammersmith Campus, London, UK
Eur J Immunol 35:2471-6. 2005..Cross-talk between cytosolic NOD1 and membrane-bound TLR enhances responses to the multiple antigens simultaneously presented by a microbe...
- Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor gamma ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells--potential for dietary modulation of peroxisome proliferator-activated rRachel Marion-Letellier
Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, United Kingdom
Am J Clin Nutr 87:939-48. 2008..The fatty acid content of defined formula diets may play a role in mediating the antiinflammatory effect, but the mechanism is unclear...
- Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal painAyesha Akbar
Department of Gastroenterology, Imperial College London, UK
Gut 59:767-74. 2010..We investigated TRPV1-immunoreactive fibres in rectosigmoid biopsies taken from such patients with correlation to abdominal pain severity...
- Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's diseaseDavid A van Heel
Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London, UK
Lancet 365:1794-6. 2005....
- Survey on the use of adalimumab as maintenance therapy in Crohn's disease in England and IrelandEvangelos A Russo
Hammersmith Hospital, London, UK
Eur J Gastroenterol Hepatol 22:334-9. 2010..Adalimumab is effective in inducing and maintaining response/remission in patients with Crohn's disease either naive to biological therapies or after secondary failure of infliximab...
- Beyond TNF, Th1 and Th2 in inflammatory bowel diseaseMatthew Shale
Gastrointestinal Section, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Gut 57:1349-51. 2008
- Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 developmentPeter Mitchell
Department of Immunology, Division of Medicine, Faculty of Medicine, Imperial College at Hammersmith Hospital, London, United Kingdom
Infect Immun 75:810-9. 2007..Our results raise the possibility that in chronic H. pylori infection DCs become exhausted after prolonged antigen exposure leading to suboptimal Th1 development. This effect may contribute to persistence of H. pylori infection...
- Learning the lessons of antitumour necrosis factor therapy-associated psoriasisMatt Shale
Imperial College London, Hammersmith Hospital, London, United Kingdom
Can J Gastroenterol 23:674-6. 2009..Therefore, withdrawal of therapy is generally not required for this adverse effect but referral to a dermatologist may be desirable for confirmation of diagnosis and treatment...
- Effect of fish oil enriched enteral diet on inflammatory bowel disease tissues in organ culture: differential effects on ulcerative colitis and Crohn's diseaseDoris Meister
Gastrointestinal Unit, University of Edinburgh, Western General Hospital, United Kingdom
World J Gastroenterol 11:7466-72. 2005..To investigate the influence of fish oil enriched enteral diet on intestinal tissues taken from Crohn's disease (CD), ulcerative colitis (UC) and non-inflamed non-IBD control patients in vitro...
- NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's diseaseMatt Butler
Department of Gastroenterology, Imperial College London, Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
J Crohns Colitis 1:106-15. 2007..As a consequence, Crohn's disease patients with defective NOD2 may be predisposed to the generation of strongly polarised Th1 responses against common commensal microorganisms...
- Gut mucosal immunity to tissue transglutaminase in untreated celiac disease and other gastrointestinal disordersAnna Dahele
Department of Medical Sciences, University of Edinburgh, Western General Hospital, Scotland
Dig Dis Sci 47:2325-35. 2002..In conclusion, whole gut lavage IgA anti-tissue transglutaminase antibody concentrations are higher in untreated celiac disease than in other gastrointestinal diseases...
- Infliximab in refractory coeliac diseaseRakesh Chaudhary
Gastroenterology Section, Imperial College London, Hammersmith Hospital, UK
Eur J Gastroenterol Hepatol 17:603-4. 2005..Refractory coeliac disease poses a therapeutic challenge to clinicians and carefully selected patients may benefit from anti-TNF therapy...
- Characterization of inflammatory bowel disease with urinary metabolic profilingHorace R T Williams
Department of Gastroenterology and Hepatology, Imperial College London, London, UK
Am J Gastroenterol 104:1435-44. 2009..This study tested the hypothesis that such metabolites differ between IBD and control cohorts, and that using multivariate pattern-recognition analysis, the cohorts could be distinguished by urine NMR spectroscopy...
- Mechanism of intestinal entry of infectious prion protein in the pathogenesis of variant Creutzfeldt-Jakob diseaseSubrata Ghosh
Department of Gastroenterology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
Adv Drug Deliv Rev 56:915-20. 2004..The relative importance of the several potential portals of intestinal entry of infectious prion proteins is uncertain but may determine susceptibility of the population and also potential preventive strategies...
- Novel treatment options for inflammatory bowel disease: targeting alpha 4 integrinFrancesco Lanzarotto
Imperial College London, Hammersmith Hospital, London, UK
Drugs 66:1179-89. 2006..Initial safety evaluation suggests that PML is very rare, despite its occurrence in one patient with CD receiving open-label natalizumab treatment...
- Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repairRaymond J Playford
Centre for Gastroenterology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
Gastroenterology 131:809-17. 2006..Their potential role in maintaining gastrointestinal mucosal integrity and repair is, however, unclear...
- Incidence of juvenile-onset Crohn's disease in Scotland: association with northern latitude and affluenceEmma L Armitage
Gastrointestinal Unit, University of Edinburgh Department of Medical Sciences, Western General Hospital, Scotland, United Kingdom
Gastroenterology 127:1051-7. 2004..Many studies have investigated genetic influence or possible links with childhood events. We aimed to study sociodemographic and/or geographic distribution of juvenile=onset Crohn's disease in Scotland...
- Coeliac disease and the risk of infectionsJulian R F Walters
Department of Gastroenterology, Imperial College Healthcare NHS Trust and Imperial College London, UK
Gut 57:1034-5. 2008
- Ulcerative colitis and colon cancer: strategies for cancer preventionSimon Campbell
Milton Keynes General Hospital, Eaglestone, Milton Keynes, London, UK
Dig Dis 20:38-48. 2002..Nevertheless, optimal medical management and adherence to a surveillance programme geared to detect dysplasia might still be the best risk reduction strategy...
- An evaluation of the use of serum 7-alpha-hydroxycholestenone as a diagnostic test of bile acid malabsorption causing watery diarrheaW Gordon Brydon
Department of Clinical Biochemistry, Western General Hospital, Edinburgh, UK
Can J Gastroenterol 25:319-23. 2011..The radionuclide selenium-labelled homocholic acid-taurine whole body retention test is expensive, labour intensive and of limited availability...
- A common CTLA4 haplotype associated with coeliac diseaseKaren A Hunt
Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK
Eur J Hum Genet 13:440-4. 2005..Loss of tolerance to dietary antigens in coeliac disease may be mediated in part by heritable variants in co-signalling genes regulating T-cell responses...
- Growth factors and trefoil peptides in gastrointestinal health and diseaseRaymond J Playford
Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Curr Opin Pharmacol 4:567-71. 2004....
- Ustekinumab for the treatment of Crohn's disease: can it find its niche?Ebby G Simon
Department of Gastroenterology, Christian Medical College, Vellore, India NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospitals NHS Trust and The University of Nottingham, Nottingham, UK
Therap Adv Gastroenterol 9:26-36. 2016..We here review the published literature and describe a potential clinical role for its use in this disease cohort. ..
- Endoscopic and histologic features of sodium phosphate bowel preparation-induced colonic ulceration: case report and reviewDavid A Watts
Gastrointestinal Unit and Department of Pathology, Western General Hospital, Edinburgh, Scotland, UK
Gastrointest Endosc 55:584-7. 2002
- Successful infliximab treatment for steroid-refractory celiac disease: a case reportHelen R Gillett
Gastrointestinal Unit, University Department of Medical Sciences, Western General Hospital, Edinburgh, Scotland
Gastroenterology 122:800-5. 2002..It is concluded that infliximab is an effective treatment that may be considered in a small number of patients with refractory celiac disease, resistant to other therapy...
- Bioactive natural compounds for the treatment of gastrointestinal disordersSubrata Ghosh
Department of Gastroenterology, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
Clin Sci (Lond) 104:547-56. 2003....
- The classics in perspectiveJulian Panes
Department of Gastroenterology, Hospital Clinic Barcelona, CIBER EHD, Barcelona, Spain
Gut 56:1184-6. 2007
- Operational feasibility of implementing community-based zinc supplementation: impact on childhood diarrheal morbidityDhirendra N Gupta
National Institute of Cholera and Enteric Diseases, Beliaghata, Kolkata 700010, India
Pediatr Infect Dis J 26:306-10. 2007..To determine the effect of zinc supplementation on diarrheal incidence and to discover any operational constraints of zinc supplementation at the community level...
- Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's diseaseDavid A van Heel
Gastroenterology Section, Imperial College London Hammersmith Campus, UK
Eur J Immunol 36:1629-35. 2006..Responses to specific NOD1 agonists are unaffected by NOD2 genotype, suggesting independent action of the NOD1 and NOD2 pathways...
- Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failureDanay Cibrian
Center for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190 Playa 10600, Havana, Cuba
Clin Sci (Lond) 110:563-73. 2006..In view of these findings, further studies appear justified...
- Infliximab use in Crohn's disease: impact on health care resources in the UKDerek P Jewell
Gastroenterology Unit, University of Oxford, Sheffield, UK
Eur J Gastroenterol Hepatol 17:1047-52. 2005..To quantify the impact of infliximab therapy on health care resource utilization in the UK...