Affiliation: Imperial College
- Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UKJulie Fox
Department of HIV, Guys and St Thomas NHS Trust Kings College London, St Thomas Hospital, London, UK
AIDS 24:2397-401. 2010..To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK...
- Transmitted drug-resistant HIV-1 in primary HIV-1 infection; incidence, evolution and impact on response to antiretroviral therapyJ Fox
Department of Infectious Diseases, Imperial College, London, UK
HIV Med 7:477-83. 2006....
- Reductions in HIV transmission risk behaviour following diagnosis of primary HIV infection: a cohort of high-risk men who have sex with menJulie Fox
Department of Genitourinary Medicine and Infectious Disease, Clinical Trials Centre, Winston ChurchillBuilding, Imperial College London, St Mary s Hospital Campus, London W2 1PG, UK
HIV Med 10:432-8. 2009..We explored the potential impact on HIV transmission-risk behaviour of PHI diagnosis in men who have sex with men (MSM)...
- Human immunodeficiency virus (HIV)-specific T helper responses fail to predict CD4+ T cell decline following short-course treatment at primary HIV-1 infectionJ Fox
Department of Genitourinary Medicine and Infectious Disease, Division of Medicine, Wright Fleming Institute, Imperial College London, London, UK
Clin Exp Immunol 152:532-7. 2008..Long-term (>3 years) preservation of virus-specific CD4+ cells occurred in 45% of patients receiving SCART in PHI. There was no correlation between either the presence or magnitude of these responses and clinical outcome...
- Risk of HIV transmission in discordant partnersJulie Fox
Imperial College London, UK
J HIV Ther 12:48-53. 2007
- How safe is safer sex? High levels of HSV-1 and HSV-2 in female sex workers in LondonJ Fox
Department of Genitourinary Medicine and Infectious Disease, Imperial College London, UK
Epidemiol Infect 134:1114-9. 2006..Sex workers are candidates for HSV vaccine efficacy or intervention studies...
- Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohortSarah Fidler
Imperial College, St Mary s Hospital, London, UK
AIDS 21:1283-91. 2007..To investigate the effect of a short course of HAART during primary HIV infection (PHI) on rate of CD4 cell and viral load change...
- Virological blips and predictors of post treatment viral control after stopping ART started in Primary HIV infectionSarah Fidler
1Department of Genitourinary Medicine and Infectious Disease, Imperial College, London, UK 2University College London, London, UK 3Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, CH 4Guys and St Thomas Hospital NHS Trust, Westminster Bridge Road, London SE1 7EH, UK 5Clinical and Epidemiological Sciences, FHI 360, Durham, NC, USA 6Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain 7 Peter Medawar Building for Pathogen Research, Nuffield Dept of Medicine, Oxford University, UK Oxford Martin School, Oxford, UK Oxford NIHR Biomedical Research Centre, Oxford, UK
J Acquir Immune Defic Syndr . 2016..Few individuals commencing antiretroviral therapy (ART) in primary HIV infection (PHI) maintain undetectable viraemia following treatment cessation. Associated factors remain unclear given the importance of the phenomenon to cure research...
- Comparative potency of three antiretroviral therapy regimes in primary HIV infectionSarah Fidler
Department of GUM and Communicable Diseases, Wright Fleming Institute, Jefferiss Trust Laboratories, London, UK
AIDS 20:247-52. 2006..To best achieve the most rapid reduction in primary viraemia we compared three different ART regimens in PHI...
- Primary HIV infection: to treat or not to treat?Sarah Fidler
Department of GUM and HIV, Division of Medicine, Imperial College, UK
Curr Opin Infect Dis 21:4-10. 2008..The aim of this article is to review new data on the use of antiretroviral therapy in primary HIV infection...
- Prevalence of primary genotypic resistance in a UK centre: Comparison of primary HIV-1 and newly diagnosed treatment-naive individualsJulie Fox
St Mary s Hospital, London, UK
AIDS 21:237-9. 2007..Variations in the prevalence of TrDR-HIV-1 may reflect the heterogeneity of methodologies and definitions used for resistance...
- The clinical implications of antiretroviral pharmacogenomicsJulie Fox
St Mary s Hospital, Clinical Trials Centre, Winston Churchill Wing, Division of Medicine, Imperial College London, Praed Street, London W2 1NY, UK
Pharmacogenomics 7:587-96. 2006..This review summarizes the key findings in the growing knowledge between human genetics and response to antiretroviral drugs and how these findings may be effectively applied in a clinical context...
- Sexual transmission of HIV-1Julie Fox
Department of HIV, Faculty of Medicine, Harrison Unit, Lambeth Wing, Guys and St Thomas NHS Trust Kings College London, Westminster Bridge Road, London, UK
Antiviral Res 85:276-85. 2010..This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010...
- An overview of the relative risks of different sexual behaviours on HIV transmissionOlamide Dosekun
Guys and St Thomas NHS Trust, London, UK
Curr Opin HIV AIDS 5:291-7. 2010..0005-0.0026 per coital act. The risk of acquiring HIV from a single contact varies enormously and is dependant upon the infectiousness of the HIV-positive individual and the susceptibility to HIV of their sexual partner...
- The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cARTSarah Fidler
Department of Genitourinary Medicine and Infectious Diseases, Imperial College, London, UK
J Int AIDS Soc 17:19820. 2014..This analysis aims to investigate the effect of cART duration and the rate of viral blips while on cART initiated in PHI, and other factors on maintaining viral control for those stopping cART...
- Brief Report: Enhanced Normalization of CD4/CD8 Ratio With Earlier Antiretroviral Therapy at Primary HIV InfectionJohn Thornhill
Department of Medicine, Imperial College, London, United Kingdom Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom Medical Research Council Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent s Hospital, Sydney, Australia HIV Prevention Unit, Medical Research Council, Durban, South Africa Projeto Praça Onze, Hospital Escola Sao Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil Division of Infectious Diseases, Ospedale San Raffaele, Milan, Italy Department of HIV, Faculty of Medicine, Guys and St Thomas NHS Trust Kings College London, United Kingdom and Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 73:69-73. 2016..Despite antiretroviral therapy (ART), recovery of CD4/CD8 ratio in chronic HIV infection is incomplete; we hypothesize enhanced CD4/CD8 ratio recovery with earlier treatment initiation in recently infected individuals...
- Primary HIV infection: a medical and public health emergency requiring rapid specialist managementSarah Fidler
Imperial College London, London, UK
Clin Med (Lond) 16:180-3. 2016..This paper summarises the presentation and management of PHI, incorporating current research and guideline changes and discusses the role of PHI in onward transmission. ..
- Raltegravir-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome - implications for clinical practice and patient safetyMelissa E O Perry
Department of Genito Urinary Medicine, Guys and St Thomas NHS Foundation Trust, London, UK
Int J STD AIDS 24:639-42. 2013..Clinicians should be aware of raltegravir-induced DRESS syndrome as well as the potential for drug-drug interactions due to protease inhibitor-based therapy...
- Sexual transmission of single human immunodeficiency virus type 1 virions encoding highly polymorphic multisite cytotoxic T-lymphocyte escape variantsAnita Milicic
The Peter Medawar Building for Pathogen Research and The James Martin 21st Century School, Nuffield Department of Clinical Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
J Virol 79:13953-62. 2005..In donors who are themselves controlling an early, acute infection, the precise timing of onward transmission is a crucial determinant of the viral variants available to compose the inoculum...
- HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral reboundThomas J Scriba
Peter Medawar Building for Pathogen Research and Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
J Clin Invest 115:443-50. 2005..The turnover of these virus-specific cells increased and they adopted an effector phenotype when viremia returned...
- Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United KingdomJulie Fox
AIDS 22:666-8. 2008
- Development and evaluation of a real-time nucleic acid sequence based amplification assay for rapid detection of influenza ACatherine Moore
Wales Specialist Virology Centre, NPHS Microbiology Cardiff, University Hospital of Wales, Cardiff, United Kingdom
J Med Virol 74:619-28. 2004..In conclusion, the real-time influenza A assay demonstrated clinical usefulness in both hospital and community populations...
- Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer stainingThomas J Scriba
The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
J Immunol 175:6334-43. 2005..These cells would not be detectable with normal flow-cytometric techniques...
- An unusual abacavir reactionJulie Fox
AIDS 22:1520-2. 2008
- Sex in the suburbsJulie Fox
St Mary s Hospital, Paddington, London, United Kingdom
Aust Fam Physician 32:358-63. 2003..Many suburban sexual health clinics exist in Australasia. However, sexual health research has hitherto been restricted to populations from major metropolitan centres...