R Foresti

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
    Philip Sawle
    Department of Surgical Research, Vascular Biology Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 145:800-10. 2005
  2. pmc Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 372:381-90. 2003
  3. pmc Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 339:729-36. 1999
  4. ncbi request reprint Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H1976-84. 2001
  5. ncbi request reprint Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
    Free Radic Biol Med 28:1303-12. 2000
  6. ncbi request reprint Homocysteine attenuates endothelial haem oxygenase-1 induction by nitric oxide (NO) and hypoxia
    P Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    FEBS Lett 508:403-6. 2001
  7. ncbi request reprint Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 275:13613-20. 2000
  8. ncbi request reprint Interaction of heme with nitroxyl or nitric oxide amplifies heme oxygenase-1 induction: involvement of the transcription factor Nrf2
    P Naughton
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 48:885-94. 2002
  9. ncbi request reprint Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 83:568-77. 1998
  10. ncbi request reprint Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats
    Sophie Lanone
    INSERM U 700 and U 683, Faculte de Medecine Xavier Bichat, Universite Paris VII, Paris, France
    FASEB J 19:1890-2. 2005

Collaborators

  • R Motterlini
  • J E Clark
  • Ian J S Fairlamb
  • R M Winslow
  • V Calabrese
  • T Ansari
  • Diego Monti
  • Patrick J Farmer
  • Andreas Friebe
  • Jawed Alam
  • Jozef Dulak
  • Giovanni Scapagnini
  • Colin J Green
  • Philip Sawle
  • Hadil Abuarqoub
  • A Sandouka
  • C J Green
  • Sandip K Bains
  • Patrick Naughton
  • Judit Varadi
  • B E Mann
  • Sophie Lanone
  • Elisabeth Balogun
  • Elizabeth Balogun
  • Harparkash Kaur
  • Martha Hoque
  • P Naughton
  • P Sawle
  • Sangeeta Atwal
  • Jo Howard
  • Benjamin E Moulton
  • Magdalena Jarzykowska
  • Istvan Lekli
  • Levente Szendrei
  • Bela Juhasz
  • Edit Varga
  • Gergo Szabo
  • Arpad Tosaki
  • Rudolf Gesztelyi
  • Ildiko Bacskay
  • Istvan Bak
  • Benjamin Moulton
  • Anne K Duhme-Klair
  • Jehad Hammad
  • B J Fuller
  • Ciara T O'Brien
  • Jason M Lynam
  • E Balogun
  • Michel Aubier
  • Jorge Boczkowski
  • Marc Conti
  • Camille TaillĂ©
  • Delphine Goven
  • Abdelhamid Almolki
  • Jamel El-Benna
  • Y Tayem
  • T R Johnson
  • Jacques Callebert
  • Tony R Johnson
  • Brian E Mann
  • Bertrand Dureuil
  • B Fuller
  • SĂ©bastien Bloc
  • Pengfei Gong
  • Erin Killeen
  • Martin N Hughes
  • M Hoque

Detail Information

Publications35

  1. pmc Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
    Philip Sawle
    Department of Surgical Research, Vascular Biology Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 145:800-10. 2005
    ....
  2. pmc Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 372:381-90. 2003
    ....
  3. pmc Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 339:729-36. 1999
    ..These results indicate the ability of ONOO- to modulate the expression of the stress protein HO-1 and suggest that the haem oxygenase pathway contributes to protection against the cytotoxic action of ONOO-...
  4. ncbi request reprint Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection
    R Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 3UJ, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H1976-84. 2001
    ..These results indicate that the HO-1-bilirubin pathway can effectively defend hypoxic cardiomyocytes against reoxygenation injury and highlight the issue of heme availability in the cytoprotective action afforded by HO-1...
  5. ncbi request reprint Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
    Free Radic Biol Med 28:1303-12. 2000
    ..These data indicate that curcumin is a potent inducer of HO-1 in vascular endothelial cells and that increased heme oxygenase activity is an important component in curcumin-mediated cytoprotection against oxidative stress...
  6. ncbi request reprint Homocysteine attenuates endothelial haem oxygenase-1 induction by nitric oxide (NO) and hypoxia
    P Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    FEBS Lett 508:403-6. 2001
    ..These novel findings indicate that hyperhomocysteinemia interferes with crucial signaling pathways required by cells to respond and adapt to stressful conditions...
  7. ncbi request reprint Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 275:13613-20. 2000
    ....
  8. ncbi request reprint Interaction of heme with nitroxyl or nitric oxide amplifies heme oxygenase-1 induction: involvement of the transcription factor Nrf2
    P Naughton
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 48:885-94. 2002
    ....
  9. ncbi request reprint Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
    R Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 83:568-77. 1998
    ..These results provide evidence for a crucial role of the heme oxygenase/CO pathway in the regulation of blood pressure under stress conditions in vivo...
  10. ncbi request reprint Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats
    Sophie Lanone
    INSERM U 700 and U 683, Faculte de Medecine Xavier Bichat, Universite Paris VII, Paris, France
    FASEB J 19:1890-2. 2005
    ..These findings indicate that bilirubin can act as an effective agent to reduce mortality and counteract hypotension elicited by endotoxin through mechanisms involving a decreased NOS2 induction secondary to inhibition of NAD(P)H oxidase...
  11. ncbi request reprint Carbon monoxide-releasing molecules (CO-RMs) modulate respiration in isolated mitochondria
    A Sandouka
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 51:425-32. 2005
    ..In summary, the results indicate that HO-1 induction and enhanced CO decrease renal oxygen consumption and alter mitochondrial function suggesting that CO could be a physiological regulator of mitochondrial oxidative phosphorylation...
  12. ncbi request reprint Treatment with CO-RMs during cold storage improves renal function at reperfusion
    A Sandouka
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Kidney Int 69:239-47. 2006
    ..CO-RMs are effective therapeutic agents that deliver CO during kidney cold preservation and can be used to ameliorate vascular activity, energy metabolism and renal function at reperfusion...
  13. ncbi request reprint Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
    Jozef Dulak
    Division of Cardiology, Innsbruck University, Innsbruck, Austria
    Antioxid Redox Signal 4:229-40. 2002
    ..As CO and iron, respectively the inducer and the inhibitor of VEGF synthesis, are concomitantly produced during the degradation of heme, these data indicate that HO by-products may differentially modulate VEGF production...
  14. ncbi request reprint The interaction of nitric oxide with distinct hemoglobins differentially amplifies endothelial heme uptake and heme oxygenase-1 expression
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Harrow, Middlesex, HA1 3UJ, UK
    J Pharmacol Exp Ther 317:1125-33. 2006
    ..In conclusion, our data indicate a novel role for NO in the modulation of heme transport and HO-1 induction in endothelial cells, which may be relevant for hematological disorders characterized by disruption of the heme-NO equilibrium...
  15. ncbi request reprint Regulation of heme oxygenase-1 by redox signals involving nitric oxide
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Antioxid Redox Signal 4:615-24. 2002
    ....
  16. ncbi request reprint Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 90:E17-24. 2002
    ..In the long term, transition metal carbonyls could be utilized for the therapeutic delivery of CO to alleviate vascular- and immuno-related dysfunctions. The full text of this article is available at http://www.circresaha.org...
  17. ncbi request reprint Interaction of bilirubin and biliverdin with reactive nitrogen species
    Harparkash Kaur
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Y Block, Middlesex HA1 3UJ, Harrow, UK
    FEBS Lett 543:113-9. 2003
    ....
  18. ncbi request reprint Reviewing the use of carbon monoxide-releasing molecules (CO-RMs) in biology: implications in endotoxin-mediated vascular dysfunction
    R Foresti
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    Cell Mol Biol (Noisy-le-grand) 51:409-23. 2005
    ..Thus, it emerges that CO-RMs could exert important biological actions in the context of endotoxic-mediated dysfunction...
  19. pmc Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 142:453-60. 2004
    ....
  20. ncbi request reprint CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    FASEB J 19:284-6. 2005
    ....
  21. ncbi request reprint Induction of heme oxygenase 1 by nitrosative stress. A role for nitroxyl anion
    Patrick Naughton
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 277:40666-74. 2002
    ..These findings indicate that heme oxygenase can act both as a sensor to and target of redox-based mechanisms involving NO and extend our knowledge on the biological function of HO-1 in response to nitrosative stress...
  22. ncbi request reprint Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels
    Vittorio Calabrese
    Biochemistry and Molecular Biology Section, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurosci Res 70:580-7. 2002
    ....
  23. ncbi request reprint Bioactive properties of iron-containing carbon monoxide-releasing molecules
    Philip Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    J Pharmacol Exp Ther 318:403-10. 2006
    ..Thus, iron-based carbonyls mediate pharmacological responses that are achieved through liberation of CO and the nature of the substituents in the organic ligand have a profound effect on both the rate of CO release and cytotoxicity...
  24. doi request reprint Use of carbon monoxide as a therapeutic agent: promises and challenges
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, HA1 3UJ, Harrow, Middlesex, UK
    Intensive Care Med 34:649-58. 2008
    ....
  25. ncbi request reprint Heme oxygenase-1 mediates the anti-inflammatory actions of 2'-hydroxychalcone in RAW 264.7 murine macrophages
    Hadil Abuarqoub
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Rd, Harrow, Middlesex, HA1 3UJ, UK
    Am J Physiol Cell Physiol 290:C1092-9. 2006
    ..These findings strongly suggest that 2-HC exerts anti-inflammatory actions via activation of the HO-1 pathway and help to elucidate the mechanisms underlying the potential therapeutic value of chalcones...
  26. ncbi request reprint Therapeutic applications of carbon monoxide-releasing molecules
    Roberto Motterlini
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Expert Opin Investig Drugs 14:1305-18. 2005
    ....
  27. ncbi request reprint Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, HA1 3UJ, United Kingdom
    J Pharmacol Exp Ther 312:686-93. 2005
    ..Thus, this study identified novel plant constituents that highly induce HO-1 in endothelial cells and investigated some of the mechanisms involved in this effect...
  28. doi request reprint Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity
    Sandip K Bains
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Arterioscler Thromb Vasc Biol 30:305-12. 2010
    ..Here, we examined the HO response in endothelial cells exposed to human sickle blood and determined whether this response is beneficial for SCD...
  29. ncbi request reprint Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    James E Clark
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Circ Res 93:e2-8. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  30. ncbi request reprint Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery
    Judit Varadi
    Department of Pharmacology, Health Science Center, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary
    Life Sci 80:1619-26. 2007
    ..In conclusion, CORM-3 exerts beneficial effects against ischemia/reperfusion-induced injury through its abilities to release CO which mediates a cardioprotective action by regulating tissue Na(+), K(+), and Ca(2+) levels...
  31. ncbi request reprint Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells
    Elizabeth Balogun
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem Biophys Res Commun 308:950-5. 2003
    ..These findings highlight the feasibility of modulating HO-1 expression during hypothermic storage to confer tissues a better protection to counteract the damage characteristic of organ transplantation...
  32. ncbi request reprint Curcumin reduces cold storage-induced damage in human cardiac myoblasts
    Hadil Abuarqoub
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Exp Mol Med 39:139-48. 2007
    ..Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold-storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms...
  33. ncbi request reprint Bioactivity and pharmacological actions of carbon monoxide-releasing molecules
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Curr Pharm Des 9:2525-39. 2003
    ....
  34. pmc Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    Elisabeth Balogun
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 371:887-95. 2003
    ..Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway...
  35. doi request reprint Structure-activity relationships of methoxychalcones as inducers of heme oxygenase-1
    Philip Sawle
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom
    Chem Res Toxicol 21:1484-94. 2008
    ..This study provides additional information on the structural features that methoxychalcones and natural antioxidants need to possess to be considered as therapeutic agents for maximizing HO-1 expression and activity...