Affiliation: Imperial College
- Primary HIV infection: a medical and public health emergency requiring rapid specialist managementSarah Fidler
Imperial College London, London, UK
Clin Med (Lond) 16:180-3. 2016..This paper summarises the presentation and management of PHI, incorporating current research and guideline changes and discusses the role of PHI in onward transmission. ..
- HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment - a study protocol for a cluster randomised trialRichard Hayes
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Trials 15:57. 2014..We describe the rationale and design of a trial to evaluate this hypothesis...
- Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconvertersAstrid Gall
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Retrovirology 10:8. 2013....
- Primary HIV infection: to treat or not to treat?Sarah Fidler
Department of GUM and HIV, Division of Medicine, Imperial College, UK
Curr Opin Infect Dis 21:4-10. 2008..The aim of this article is to review new data on the use of antiretroviral therapy in primary HIV infection...
- Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohortSarah Fidler
Imperial College, St Mary s Hospital, London, UK
AIDS 21:1283-91. 2007..To investigate the effect of a short course of HAART during primary HIV infection (PHI) on rate of CD4 cell and viral load change...
- Comparative potency of three antiretroviral therapy regimes in primary HIV infectionSarah Fidler
Department of GUM and Communicable Diseases, Wright Fleming Institute, Jefferiss Trust Laboratories, London, UK
AIDS 20:247-52. 2006..To best achieve the most rapid reduction in primary viraemia we compared three different ART regimens in PHI...
- Virological blips and predictors of post treatment viral control after stopping ART started in Primary HIV infectionSarah Fidler
1Department of Genitourinary Medicine and Infectious Disease, Imperial College, London, UK 2University College London, London, UK 3Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, CH 4Guys and St Thomas Hospital NHS Trust, Westminster Bridge Road, London SE1 7EH, UK 5Clinical and Epidemiological Sciences, FHI 360, Durham, NC, USA 6Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain 7 Peter Medawar Building for Pathogen Research, Nuffield Dept of Medicine, Oxford University, UK Oxford Martin School, Oxford, UK Oxford NIHR Biomedical Research Centre, Oxford, UK
J Acquir Immune Defic Syndr . 2016..Few individuals commencing antiretroviral therapy (ART) in primary HIV infection (PHI) maintain undetectable viraemia following treatment cessation. Associated factors remain unclear given the importance of the phenomenon to cure research...
- Sexual and reproductive health in a UK cohort of young adults perinatally infected with HIVAdam P Croucher
Jefferiss Wing, St Mary s Hospital, Imperial College Healthcare NHS Trust, London, UK
Sex Transm Infect 89:392-4. 2013..To assess sexual health and behaviour outcomes of young adults with perinatally acquired HIV-1 (PaHIV), and audit sexual health interventions against published standards of care...
- Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infectionElizabeth Hamlyn
Imperial College, London, UK
AIDS 26:887-90. 2012..Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus...
- Human immunodeficiency virus (HIV)-specific T helper responses fail to predict CD4+ T cell decline following short-course treatment at primary HIV-1 infectionJ Fox
Department of Genitourinary Medicine and Infectious Disease, Division of Medicine, Wright Fleming Institute, Imperial College London, London, UK
Clin Exp Immunol 152:532-7. 2008..Long-term (>3 years) preservation of virus-specific CD4+ cells occurred in 45% of patients receiving SCART in PHI. There was no correlation between either the presence or magnitude of these responses and clinical outcome...
- Virological and immunological effects of short-course antiretroviral therapy in primary HIV infectionSarah Fidler
Wright Fleming Institute, Department of GUM and Communicable Diseases, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
AIDS 16:2049-54. 2002..We sought to investigate whether a short course of antiretroviral therapy (SCART) at PHI was sufficient to preserve HIV-specific cellular immunity...
- Reductions in HIV transmission risk behaviour following diagnosis of primary HIV infection: a cohort of high-risk men who have sex with menJulie Fox
Department of Genitourinary Medicine and Infectious Disease, Clinical Trials Centre, Winston ChurchillBuilding, Imperial College London, St Mary s Hospital Campus, London W2 1PG, UK
HIV Med 10:432-8. 2009..We explored the potential impact on HIV transmission-risk behaviour of PHI diagnosis in men who have sex with men (MSM)...
- Intimate relationships in young adults with perinatally acquired HIV: partner considerationsClare Greenhalgh
Department of Clinical Psychology, Royal Holloway, University of London, London, UK
AIDS Care 25:447-50. 2013..These findings have important implications for supporting young people in disclosing their HIV status to intimate partners in appropriate ways. Suggestions for future research are offered...
- Transition to adult services - a positive stepSamuel Kim
a Imperial College London, London, UK
AIDS Care . 2016..Despite a marked increase in clinic attendees and unchanged levels of service provision, patient satisfaction remained high. Patients strongly value the provision of dedicated services for young people...
- Brief Report: Enhanced Normalization of CD4/CD8 Ratio With Earlier Antiretroviral Therapy at Primary HIV InfectionJohn Thornhill
Department of Medicine, Imperial College, London, United Kingdom Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom Medical Research Council Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda Kirby Institute University of New South Wales and Centre for Applied Medical Research, St Vincent s Hospital, Sydney, Australia HIV Prevention Unit, Medical Research Council, Durban, South Africa Projeto Praça Onze, Hospital Escola Sao Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil Division of Infectious Diseases, Ospedale San Raffaele, Milan, Italy Department of HIV, Faculty of Medicine, Guys and St Thomas NHS Trust Kings College London, United Kingdom and Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
J Acquir Immune Defic Syndr 73:69-73. 2016..Despite antiretroviral therapy (ART), recovery of CD4/CD8 ratio in chronic HIV infection is incomplete; we hypothesize enhanced CD4/CD8 ratio recovery with earlier treatment initiation in recently infected individuals...
- HIV-1-specific CD4(+) responses in primary HIV-1 infection predict disease progressionJohn Frater
aNuffield Department of Clinical Medicine, John Radcliffe Hospital bPeter Medawar Building for Pathogen Research cInstitute for Emerging Infections, The Oxford Martin School dOxford National Institute of Health Research Biomedical Research Centre, Oxford eMedical Research Council Clinical Trials Unit fMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK gMwanza Intervention Trials Unit, Mwanza, Tanzania hDivision of Medicine, Wright Fleming Institute, Imperial College, London, UK Fiona Ewings and Jacob Hurst contributed equally to the writing of this article
AIDS 28:699-708. 2014..The SPARTAC trial randomized 366 participants in primary HIV infection (PHI) to different short-course therapies. The aim of this study was to investigate how early immune responses in PHI impacted clinical progression in SPARTAC...
- Antiretroviral treatment of primary HIV infection to reduce onward transmissionElizabeth Hamlyn
GUM HIV, HIV Clinical Trials Unit, Imperial College London, London, UK
Curr Opin HIV AIDS 5:283-90. 2010..This review will discuss the role of antiretroviral therapy to treat primary HIV infection (PHI) as a strategy to prevent onward viral transmission...
- Postexposure prophylaxis, preexposure prophylaxis or universal test and treat: the strategic use of antiretroviral drugs to prevent HIV acquisition and transmissionJonathan Weber
Faculty of Medicine, Imperial College London, St Mary s Hospital, London, UK
AIDS 24:S27-39. 2010..Specifically, we consider the evidences for and against targeting HIV-uninfected individuals compared with enhanced HIV testing and treatment of HIV-infected individuals in terms of impact on viral transmission...
- Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UKJulie Fox
Department of HIV, Guys and St Thomas NHS Trust Kings College London, St Thomas Hospital, London, UK
AIDS 24:2397-401. 2010..To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK...
- Survival following HIV infection of a cohort followed up from seroconversion in the UKFiona M Ewings
MRC Clinical Trials Unit, London, UK
AIDS 22:89-95. 2008..To estimate changes over calendar time in survival following HIV seroconversion in the era of HAART and to provide updated survival estimates...
- Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infectionGenevieve E Martin
aPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK bMRC Clinical Trials Unit at University College London, London, UK cDepartment of Paediatrics, University of Oxford, Oxford, UK dHarvard Medical School, Boston, MA, USA eHIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa fResearch Department of Infection and Population Health, University College London, London, UK gDivision of Medicine, Wright Fleming Institute, Imperial College, London, UK hThe Oxford Martin School, Oxford, UK iOxford National Institute of Health Research Biomedical Research Centre, Oxford, UK
AIDS . 2017..Understanding the efficacy of novel interventions aimed at curing HIV requires characterisation of both natural viral control and the effect of ART on viral control after treatment interruption...
- The effect of short-course antiretroviral therapy initiated in primary HIV-1 infection on interleukin-6 and D-dimer levelsElizabeth Hamlyn
aImperial College London bKings College Hospital NHS Foundation Trust cMedical Research Council Clinical Trials Unit at University College London, London, UK dKirby Institute, University of New South Wales, Sydney, Australia eBrighton and Sussex University Hospitals, Brighton, UK fOspedale San Raffaele, Milan, Italy gProjeto Praça Onze, Hospital Escola Sao Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil hHospital Clinic Institut d investigacions Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain iLondon School of Hygiene and Tropical Medicine, London, UK Kholoud Porter and Sarah Fidler contributed equally to the writing of this manuscript
AIDS 29:1355-61. 2015..The effect of ART interruption in primary HIV-1 infection on these biomarkers is unknown...
- Importance of Self-Motivation and Social Support in Medication Adherence in HIV-Infected Adolescents in the United Kingdom and Ireland: A Multicentre HYPNet StudySung Hee Kim
1School of Medicine, Imperial College London, London, United Kingdom
AIDS Patient Care STDS 29:354-64. 2015..Education and motivational strategies may confer the biggest impact on sustained ART adherence amongst this vulnerable group. ..
- Risk of HIV transmission in discordant partnersJulie Fox
Imperial College London, UK
J HIV Ther 12:48-53. 2007
- Prevalence of primary genotypic resistance in a UK centre: Comparison of primary HIV-1 and newly diagnosed treatment-naive individualsJulie Fox
St Mary s Hospital, London, UK
AIDS 21:237-9. 2007..Variations in the prevalence of TrDR-HIV-1 may reflect the heterogeneity of methodologies and definitions used for resistance...
- Sexual transmission of HIV-1Julie Fox
Department of HIV, Faculty of Medicine, Harrison Unit, Lambeth Wing, Guys and St Thomas NHS Trust Kings College London, Westminster Bridge Road, London, UK
Antiviral Res 85:276-85. 2010..This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010...
- Tenofovir Disoproxil Fumarate Fails to Prevent HIV Acquisition or the Establishment of a Viral Reservoir: Two Case ReportsJulie Fox
Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas NHS Trust, London, UK
Infect Dis Ther 5:65-71. 2016..Rapid antiretroviral intensification at diagnosis of acute HIV infection failed to limit immune dysfunction or prevent the establishment of a viral reservoir. ..
- Baseline CD4 Count and Adherence to Antiretroviral Therapy: A Systematic Review and Meta-AnalysisPeter Bock
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa Independent consultant Department of Health, Western Cape Government, Cape Town, South Africa London School of Hygiene and Tropical Medicine, London, United Kingdom Precision Global Health, Vancouver, Canada Department of Medicine, Clinical Trial Units, Imperial College, London, United Kingdom Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa and Division of Infectious Diseases, Imperial College London, London, United Kingdom
J Acquir Immune Defic Syndr 73:514-521. 2016....
- Low levels of HIV test coverage in clinical settings in the U.K.: a systematic review of adherence to 2008 guidelinesRahma Elmahdi
Department of Infectious Disease Epidemiology, Imperial College London, London, UK
Sex Transm Infect 90:119-24. 2014..To quantify the extent to which guideline recommendations for routine testing for HIV are adhered to outside of genitourinary medicine (GUM), sexual health (SH) and antenatal clinics...
- Advancing the HIV cure agenda: the next 5 yearsJohn Thornhill
aDivision of Medicine, Wright Fleming Institute, Imperial College, London bCollaborative HIV Eradication of Reservoirs UK BRC CHERUB cImperial National Institute of Health Research Biomedical Research Centre, London dNuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research eInstitute for Emerging Infections, The Oxford Martin School fOxford National Institute of Health Research Biomedical Research Centre, Oxford, UK Sarah Fidler and John Frater contributed equally to the writing of this article
Curr Opin Infect Dis 28:1-9. 2015..To explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years...
- The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cARTSarah Fidler
Department of Genitourinary Medicine and Infectious Diseases, Imperial College, London, UK
J Int AIDS Soc 17:19820. 2014..This analysis aims to investigate the effect of cART duration and the rate of viral blips while on cART initiated in PHI, and other factors on maintaining viral control for those stopping cART...
- Adherence to antiretroviral therapy in adolescents living with HIV: systematic review and meta-analysisSung Hee Kim
aSchool of Medicine bInfectious Disease Epidemiology, School of Public Health cCommunicable Diseases Section, Department of Medicine, Imperial College London, London, UK
AIDS 28:1945-56. 2014..We undertook a systematic review and meta-analysis of published studies reporting adherence to ART for AYA living with HIV...
- Crossing the divide: transition care services for young people with HIV-their viewsHannah Bundock
Department of Cardiology, St Mary s Hospital, London, UK
AIDS Patient Care STDS 25:465-73. 2011..This service evaluation illustrates that careful transition can be a positive event for young people with PaHIV, comparable to that of a well-established diabetes services...
- Optimizing antiretroviral therapy in adolescents with perinatally acquired HIV-1 infectionCaroline Foster
The 900 Clinic, Jefferies Wing, Imperial College Healthcare NHS Trust, London, W2 1NY, UK
Expert Rev Anti Infect Ther 8:1403-16. 2010..Careful follow-up of this early perinatal cohort as they enter adulthood will inform the future management of the growing numbers of adolescents surviving worldwide as access to therapy increases...
- Laboratory adverse events and discontinuation of therapy according to CD4(+) cell count at the start of antiretroviral therapySophie Jose
aResearch Department of Infection and Population Health, UCL bImperial College London Department of Medicine, London cThe Lothian University Hospitals NHS Trust, Edinburgh dSt George s Healthcare NHS Trust, London eBrighton and Sussex University Hospitals NHS Trust, Brighton fKings College Hospital NHS Foundation Trust and King s College London gChelsea and Westminster NHS Foundation Trust, London hNorth Bristol NHS Trust, Bristol iRoyal Free Hampstead NHS Trust, London jSouth Tees Hospital NHS Foundation Trust, Middlesbrough kMortimer Market Centre, University College Medical School, London, UK
AIDS 28:1333-9. 2014..We compared rates of laboratory-defined adverse events (LDAEs) according to CD4(+) cell count at ART initiation...
- Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysisKalpana Sabapathy
London School of Hygiene and Tropical Medicine, London, UK
PLoS Med 9:e1001351. 2012..Improving access to HIV testing is a key priority in scaling up HIV treatment and prevention services. Home-based voluntary counselling and testing (HBT) as an approach to delivering wide-scale HIV testing is explored here...
- Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAARTRebecca Sutherland
MRC Human Immunology Unit, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford OX3 7LJ, UK
AIDS 20:821-9. 2006..To determine whether long-term HAART in chronic HIV-1 infection restores fully functional Mycobacterium tuberculosis (MTB)-specific CD4 T-cell responses...
- HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral reboundThomas J Scriba
Peter Medawar Building for Pathogen Research and Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
J Clin Invest 115:443-50. 2005..The turnover of these virus-specific cells increased and they adopted an effector phenotype when viremia returned...
- Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United KingdomJulie Fox
AIDS 22:666-8. 2008
- Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer stainingThomas J Scriba
The Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
J Immunol 175:6334-43. 2005..These cells would not be detectable with normal flow-cytometric techniques...
- Resistance to HIV drugs in UK may be lower in some areasJulie M Fox
BMJ 332:179-80. 2006