Affiliation: Imperial College
- Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PETP Edison
Division of Neuroscience, Imperial College London, Hammersmith Campus, London, UK
Neuroimage 70:423-33. 2013..Route 1 used individually segmented structural magnetic resonance images (MRI) for each subject while Route 2 used a standardised [(11)C]PIB PET template...
- Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?P Edison
Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College, London, UK
Neuroimage 60:1716-23. 2012..3) Determine the test-retest reliability in AD subjects. 4) Demonstrate the application of target-to-pons ratio in subjects with elevated cerebellar [(11)C]PIB binding...
- Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomographyP Edison
Imperial College London, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W120NN, UK
J Neurol Neurosurg Psychiatry 79:1331-8. 2008..The aim of this study was to quantify in vivo amyloid load in DLB and PDD compared with control subjects and subjects with Parkinson's disease (PD) without dementia...
- Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET studyPaul Edison
MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
Neurobiol Dis 32:412-9. 2008..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
- Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibilityPaul Edison
Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College London, UK
Neuroimage 48:329-38. 2009..Patlak analysis of [11C]PIB binding was the least reproducible...
- Technical aspects of amyloid imaging for Alzheimer's diseasePaul Edison
Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Alzheimers Res Ther 3:25. 2011..In the present short review we discuss the properties of amyloid imaging agent [11C]Pittsburgh Compound B, the different modalities of molecular imaging, image processing and data analysis, and newer amyloid imaging agents...
- A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195Alexander N Anderson
Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
Neuroimage 36:28-37. 2007..The reference-to-target ratio and the Logan graphical approach were significantly less reliable and less sensitive...
- Reference and target region modeling of [11C]-(R)-PK11195 brain studiesFederico E Turkheimer
Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
J Nucl Med 48:158-67. 2007....
- Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementiaPaul Edison
Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK
Neuropsychopharmacology 38:938-49. 2013..Significant microglial activation may be a factor in driving the disease process in PDD. Given this, agents that affect microglial activation could have an influence on disease progression...
- Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementiaZhen Fan
Neurology Imaging Unit, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
Alzheimers Dement 11:608-21.e7. 2015..Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation...
- Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?Zhen Fan
Neurology Imaging Unit, Imperial College London, Hammersmith Campus, London, United Kingdom
J Nucl Med 56:707-13. 2015..Here, we investigated whether different TSPO genotypes influence cognitive function, amyloid load, and disease progression over time...
- Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's diseaseZhen Fan
1 Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
Brain 138:3685-98. 2015....
- Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directionsJames Varley
Neurology Imaging Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
Alzheimers Dement 11:1110-20. 2015..It is our view that a multimodal investigation into neuroinflammation in AD, Parkinson's disease dementia, FTD and HD will yield valuable pathological insights which will usefully inform development of therapeutic targets and biomarkers...
- Imaging biomarkers in tauopathiesMelanie Dani
Neurology Imaging Unit, Division of Neuroscience, Imperial College London, UK
Parkinsonism Relat Disord 22:S26-8. 2016..Here, we discuss the challenges posed in developing selective tau ligands as biomarkers, their state of development and the new clinical information that has been revealed...
- The role of neuroinflammation in dementiasGiuseppe Pasqualetti
Division of Brain Sciences, Department of Medicine, Imperial College London, 1st Floor B Block, Du Cane Road, London, W12 0NN, UK
Curr Neurol Neurosci Rep 15:17. 2015..Furthermore, we discuss the neuroimaging techniques that are currently used for the study of neuroinflammation in human brain. ..