Paul Edison

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Alterations in Glucose Metabolism in Alzheimer's Disease
    Valeria Calsolaro
    Division of Brain Sciences, Department of Medicine, Imperial College London, Neurology Imaging Unit, Imperial College London, W12 0NN, UK
    Recent Pat Endocr Metab Immune Drug Discov 10:31-39. 2016
  2. doi request reprint Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET
    P Edison
    Division of Neuroscience, Imperial College London, Hammersmith Campus, London, UK
    Neuroimage 70:423-33. 2013
  3. doi request reprint Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
    P Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College, London, UK
    Neuroimage 60:1716-23. 2012
  4. doi request reprint Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography
    P Edison
    Imperial College London, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    J Neurol Neurosurg Psychiatry 79:1331-8. 2008
  5. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
  6. doi request reprint Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College London, UK
    Neuroimage 48:329-38. 2009
  7. pmc Technical aspects of amyloid imaging for Alzheimer's disease
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Alzheimers Res Ther 3:25. 2011
  8. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
  9. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
  10. doi request reprint Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer's Disease and Parkinson's Disease Dementia?
    Grazia D Femminella
    Neurology Imaging Unit, Imperial College London, London, UK
    J Alzheimers Dis 51:1275-89. 2016

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Alterations in Glucose Metabolism in Alzheimer's Disease
    Valeria Calsolaro
    Division of Brain Sciences, Department of Medicine, Imperial College London, Neurology Imaging Unit, Imperial College London, W12 0NN, UK
    Recent Pat Endocr Metab Immune Drug Discov 10:31-39. 2016
    ..Epidemiological and pathophysiological studies showed a link between AD and diabetes, particularly in relation to insulin resistance...
  2. doi request reprint Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET
    P Edison
    Division of Neuroscience, Imperial College London, Hammersmith Campus, London, UK
    Neuroimage 70:423-33. 2013
    ..Route 1 used individually segmented structural magnetic resonance images (MRI) for each subject while Route 2 used a standardised [(11)C]PIB PET template...
  3. doi request reprint Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
    P Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College, London, UK
    Neuroimage 60:1716-23. 2012
    ..3) Determine the test-retest reliability in AD subjects. 4) Demonstrate the application of target-to-pons ratio in subjects with elevated cerebellar [(11)C]PIB binding...
  4. doi request reprint Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography
    P Edison
    Imperial College London, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    J Neurol Neurosurg Psychiatry 79:1331-8. 2008
    ..The aim of this study was to quantify in vivo amyloid load in DLB and PDD compared with control subjects and subjects with Parkinson's disease (PD) without dementia...
  5. doi request reprint Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    Paul Edison
    MRC Clinical Sciences Centre, Cyclotron Building Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 32:412-9. 2008
    ..MMSE scores in AD subjects correlated with levels of cortical microglial activation but not with amyloid load. The inverse correlation between MMSE and microglial activation is compatible with a role of microglia in neuronal damage...
  6. doi request reprint Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Hammersmith Hospital, Imperial College London, UK
    Neuroimage 48:329-38. 2009
    ..Patlak analysis of [11C]PIB binding was the least reproducible...
  7. pmc Technical aspects of amyloid imaging for Alzheimer's disease
    Paul Edison
    Medical Research Council Clinical Sciences Centre and Division of Neuroscience, Imperial College London, Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Alzheimers Res Ther 3:25. 2011
    ..In the present short review we discuss the properties of amyloid imaging agent [11C]Pittsburgh Compound B, the different modalities of molecular imaging, image processing and data analysis, and newer amyloid imaging agents...
  8. ncbi request reprint A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195
    Alexander N Anderson
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, UK
    Neuroimage 36:28-37. 2007
    ..The reference-to-target ratio and the Logan graphical approach were significantly less reliable and less sensitive...
  9. ncbi request reprint Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
    ....
  10. doi request reprint Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer's Disease and Parkinson's Disease Dementia?
    Grazia D Femminella
    Neurology Imaging Unit, Imperial College London, London, UK
    J Alzheimers Dis 51:1275-89. 2016
    ..The influence of neuroinflammation on neuronal function and hippocampal atrophy in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) is still unclear...
  11. pmc Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia
    Paul Edison
    Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK
    Neuropsychopharmacology 38:938-49. 2013
    ..Significant microglial activation may be a factor in driving the disease process in PDD. Given this, agents that affect microglial activation could have an influence on disease progression...
  12. ncbi request reprint Flutriciclamide (18F-GE180) PET: First-in-Human PET Study of Novel Third-Generation In Vivo Marker of Human Translocator Protein
    Zhen Fan
    Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 57:1753-1759. 2016
    ..In this first study, we evaluated the optimum scan duration and kinetic modeling strategies for 18F-GE180 PET in (older) healthy controls...
  13. doi request reprint Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia
    Zhen Fan
    Neurology Imaging Unit, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Alzheimers Dement 11:608-21.e7. 2015
    ..Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation...
  14. doi request reprint Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?
    Zhen Fan
    Neurology Imaging Unit, Imperial College London, Hammersmith Campus, London, United Kingdom
    J Nucl Med 56:707-13. 2015
    ..Here, we investigated whether different TSPO genotypes influence cognitive function, amyloid load, and disease progression over time...
  15. doi request reprint Imaging biomarkers in tauopathies
    Melanie Dani
    Neurology Imaging Unit, Division of Neuroscience, Imperial College London, UK
    Parkinsonism Relat Disord 22:S26-8. 2016
    ..Here, we discuss the challenges posed in developing selective tau ligands as biomarkers, their state of development and the new clinical information that has been revealed...
  16. doi request reprint An early and late peak in microglial activation in Alzheimer's disease trajectory
    Zhen Fan
    Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Brain . 2017
    ..If so, anti-microglial agents targeting the pro-inflammatory phenotype would be most beneficial in the later stages of the disease...
  17. doi request reprint Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease
    Zhen Fan
    1 Neurology Imaging Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Brain 138:3685-98. 2015
    ....
  18. doi request reprint Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer's Disease and Other Neurodegenerative Diseases
    Valeria Calsolaro
    Neurology Imaging Unit, Imperial College London, 1st Floor B Block, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
    CNS Drugs 29:1023-39. 2015
    ..Here we review the underlying mechanism of insulin and GLP-1 signalling in the CNS, as well as the preclinical data for the use of GLP-1 analogues such as liraglutide, exenatide and lixisenatide in neurodegenerative diseases. ..
  19. doi request reprint Neuroinflammation in Alzheimer's disease: Current evidence and future directions
    Valeria Calsolaro
    Neurology Imaging Unit, Imperial College London, UK
    Alzheimers Dement 12:719-32. 2016
    ....
  20. doi request reprint Imaging neuroinflammation in Alzheimer's disease and other dementias: Recent advances and future directions
    James Varley
    Neurology Imaging Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
    Alzheimers Dement 11:1110-20. 2015
    ..It is our view that a multimodal investigation into neuroinflammation in AD, Parkinson's disease dementia, FTD and HD will yield valuable pathological insights which will usefully inform development of therapeutic targets and biomarkers...
  21. doi request reprint The role of neuroinflammation in dementias
    Giuseppe Pasqualetti
    Division of Brain Sciences, Department of Medicine, Imperial College London, 1st Floor B Block, Du Cane Road, London, W12 0NN, UK
    Curr Neurol Neurosci Rep 15:17. 2015
    ..Furthermore, we discuss the neuroimaging techniques that are currently used for the study of neuroinflammation in human brain. ..