Muireann Coen

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 25:2412-22. 2012
  2. doi request reprint Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom
    J Proteome Res 11:2427-40. 2012
  3. doi request reprint A metabonomic approach for mechanistic exploration of pre-clinical toxicology
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW72AZ, UK
    Toxicology 278:326-40. 2010
  4. ncbi request reprint Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis
    Muireann Coen
    School of Molecular and Microbial Biosciences, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Clin Infect Dis 41:1582-90. 2005
  5. doi request reprint High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Magn Reson Chem 47:S62-7. 2009
  6. doi request reprint Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom
    J Proteome Res 8:5175-87. 2009
  7. doi request reprint Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity
    Young Shick Hong
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Magn Reson Chem 47:S47-53. 2009
  8. ncbi request reprint Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity
    Muireann Coen
    Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, U K
    Anal Chem 79:8956-66. 2007
  9. doi request reprint Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies
    Elizabeth J Want
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK
    Anal Chem 82:5282-9. 2010
  10. ncbi request reprint Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse
    Muireann Coen
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    J Pharm Biomed Anal 35:93-105. 2004

Collaborators

Detail Information

Publications31

  1. doi request reprint Comparative NMR-based metabonomic investigation of the metabolic phenotype associated with tienilic acid and tienilic acid isomer
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 25:2412-22. 2012
    ..This approach is applicable to the future study of pharmacologically and structurally similar compounds and represents a refined means of identification of biomarkers of toxicity...
  2. doi request reprint Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom
    J Proteome Res 11:2427-40. 2012
    ....
  3. doi request reprint A metabonomic approach for mechanistic exploration of pre-clinical toxicology
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW72AZ, UK
    Toxicology 278:326-40. 2010
    ..The metabonomic approach holds considerable promise and potential to significantly advance our understanding of the mechanistic bases for adverse drug reactions...
  4. ncbi request reprint Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis
    Muireann Coen
    School of Molecular and Microbial Biosciences, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Clin Infect Dis 41:1582-90. 2005
    ..Metabonomics rapidly defines metabolic profiles of biological fluids through the use of high-throughput analytical techniques combined with statistical pattern recognition tools...
  5. doi request reprint High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    Magn Reson Chem 47:S62-7. 2009
    ....
  6. doi request reprint Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis
    Muireann Coen
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom
    J Proteome Res 8:5175-87. 2009
    ..This systems level metabonomic approach has provided new mechanistic insights into differential response to galN and is widely applicable to the study of interindividual variation in metabolism for any xenobiotic intervention...
  7. doi request reprint Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity
    Young Shick Hong
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK
    Magn Reson Chem 47:S47-53. 2009
    ..Finally, the chemical shift difference between that of the anomeric H1 proton of alpha-glucose and residual water is confirmed as a suitable internal temperature calibration method...
  8. ncbi request reprint Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity
    Muireann Coen
    Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, U K
    Anal Chem 79:8956-66. 2007
    ..This approach is generic and can be applied to correlate the covarying signals for any spin-active nuclei where there is parallel or serial collection of data...
  9. doi request reprint Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies
    Elizabeth J Want
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, UK
    Anal Chem 82:5282-9. 2010
    ..The UPLC-MS approach to BA analysis offers a sensitive and reproducible tool that will be of great value in exploring both markers and mechanisms of hepatotoxicity and can readily be extended to clinical studies of liver damage...
  10. ncbi request reprint Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse
    Muireann Coen
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    J Pharm Biomed Anal 35:93-105. 2004
    ....
  11. pmc Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
    Ruey Leng Loo
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 81:5119-29. 2009
    ..The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling...
  12. doi request reprint High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
    Olaf Beckonert
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London, UK
    Nat Protoc 5:1019-32. 2010
    ....
  13. doi request reprint HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies
    Konstantina Spagou
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Anal Chem 83:382-90. 2011
    ....
  14. doi request reprint Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery
    Caroline J Sands
    Department of Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom
    Anal Chem 81:6458-66. 2009
    ..Additionally, this tool could prove useful for applications outside of metabolic analysis, for example, in process chemistry for following chemical reactions and equilibria and detecting impurities...
  15. doi request reprint Data-driven approach for metabolite relationship recovery in biological 1H NMR data sets using iterative statistical total correlation spectroscopy
    Caroline J Sands
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, United Kingdom
    Anal Chem 83:2075-82. 2011
    ..I-STOCSY, thus, represents a significant advance in correlation based analysis and visualization, providing insight into inter- and intrametabolite relationships following metabolic perturbations...
  16. doi request reprint Processing and modeling of nuclear magnetic resonance (NMR) metabolic profiles
    Timothy M D Ebbels
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK
    Methods Mol Biol 708:365-88. 2011
    ..Finally, we discuss the contributions of statistical techniques such as statistical total correlation spectroscopy, and other correlation-based methods have made to the process of structural characterization for unknown metabolites...
  17. doi request reprint Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response
    Katharine Cunningham
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    J Proteome Res 11:4630-42. 2012
    ..Given the widespread use of INH for the treatment of tuberculosis, this pharmacometabonomic screening approach may have translational potential for patient stratification to minimize adverse events...
  18. doi request reprint Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification
    Judith M Fonville
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Anal Chem 82:1811-21. 2010
    ....
  19. pmc Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer
    Michael Kyriakides
    Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK
    Arch Toxicol 90:3073-3085. 2016
    ..In contrast, AMAP administration caused minimal, transient, distinct metabolic perturbations and by 6 h the metabolic profiles of AMAP-treated mice were indistinguishable from those of controls...
  20. doi request reprint Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing
    Judith M Fonville
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Anal Chim Acta 705:72-80. 2011
    ..1.1 of the freely available K-OPLS software package for both R and Matlab to enable easy application of K-OPLS for non-linear prediction modeling...
  21. doi request reprint NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology
    Muireann Coen
    Department of Biomolecular Medicine, Surgery, Oncology, Reproductive Biology and Anesthetics Division, Faculty of Medicine, Imperial College London, London, UK
    Chem Res Toxicol 21:9-27. 2008
    ..The use of biological fluids as a source of whole organism metabolic information enhances the use of this approach in minimally invasive longitudinal studies...
  22. doi request reprint Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis
    Caroline J Sands
    Section of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Am J Gastroenterol 110:159-69. 2015
    ..Here, we sought to determine whether a metabonomic approach could be used to identify signatures reflective of the dynamic, pathological metabolic perturbations associated with fibrosis in chronic hepatitis C (CHC) patients...
  23. ncbi request reprint Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
    Elaine Holmes
    Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
    Anal Chem 79:2629-40. 2007
    ..This approach should be of value in considering interpopulation patterns of drug metabolism in epidemiological and pharmacogenetic studies...
  24. ncbi request reprint An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy
    Muireann Coen
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
    Chem Res Toxicol 16:295-303. 2003
    ..These findings could indicate a mitochondrial inability to use pyruvate in the citric acid cycle and also reveal the impairment of fatty acid beta-oxidation in liver mitochondria of such treated mice...
  25. doi request reprint Cluster analysis statistical spectroscopy using nuclear magnetic resonance generated metabolic data sets from perturbed biological systems
    Steven L Robinette
    Biomolecular Medicine, Sir Alexander Fleming Building, Division of Surgery, Oncology, Reproductive Biology, and Anesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, United Kingdom
    Anal Chem 81:6581-9. 2009
    ....
  26. pmc Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy
    Muireann Coen
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    Antimicrob Agents Chemother 50:4018-26. 2006
    ..Direct NMR-based observation of metabolic alterations in yeast cultures reveals changes in key metabolic pathways and should be evaluated formally as a rapid technique for determining susceptibility to antifungal drugs...
  27. pmc Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study
    Léa Maitre
    Department of Epidemiology and Biostatistics, Medical Research Council Public Health England MRC PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG, London, UK
    BMC Med 14:177. 2016
    ....
  28. pmc Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study
    Léa Maitre
    Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    BMC Med 12:110. 2014
    ..As metabolic syndrome has previously been shown to be associated with PB in this cohort, we sought to gain further insight into PB-linked metabolic phenotypes and to define new predictive biomarkers...
  29. ncbi request reprint Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids
    Bridgette M Beckwith-Hall
    Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, London, UK
    Analyst 127:1283-8. 2002
    ..Furthermore, analysis of the orthogonal variation provided an explanation of the systematic analytical/biological changes responsible for confounding the original NMR data...
  30. pmc Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat
    Michael Kyriakides
    Biomolecular Medicine, Division of Computational Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK
    Toxicol Sci 142:105-16. 2014
    ....
  31. doi request reprint Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis
    Eszter Bohus
    Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes Endre u 9, Budapest 1092, Hungary
    J Proteome Res 7:4435-45. 2008
    ..The variety of observed systemic responses suggests that this approach may be of general value in the assessment of other animal models or human pancreatitis...