F Chung

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Therapy for cough: active agents
    K F Chung
    Royal Brompton Hospital, National Heart and Lung Institute, London, England
    Pulm Pharmacol Ther 15:335-8. 2002
  2. pmc Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma
    F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Mediators Inflamm 10:51-9. 2001
  3. ncbi request reprint Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Mol Biotechnol 18:213-32. 2001
  4. ncbi request reprint Pathophysiology and therapy of chronic cough
    K F Chung
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, London, UK
    Minerva Med 96:29-40. 2005
  5. pmc Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids
    K F Chung
    Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 127:1145-50. 1999
  6. ncbi request reprint Non-invasive biomarkers of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Pediatr Pulmonol Suppl 18:41-4. 1999
  7. ncbi request reprint Assessing the burden of respiratory disease in the UK
    F Chung
    Royal Brompton and Harefield NHS Trust, London, U K
    Respir Med 96:963-75. 2002
  8. ncbi request reprint Anti-IgE therapy of asthma
    K Fan Chung
    National Heart and Lung Institute, London, UK
    Curr Opin Investig Drugs 3:1157-60. 2002
  9. ncbi request reprint Cough: potential pharmacological developments
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Opin Investig Drugs 11:955-63. 2002
  10. ncbi request reprint Assessment and measurement of cough: the value of new tools
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Pulm Pharmacol Ther 15:267-72. 2002

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Therapy for cough: active agents
    K F Chung
    Royal Brompton Hospital, National Heart and Lung Institute, London, England
    Pulm Pharmacol Ther 15:335-8. 2002
    ..Large scale trials of these novel compounds have not been tried in cough in man, but there is a serious need for more effective antitussives devoid of side-effects...
  2. pmc Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma
    F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Mediators Inflamm 10:51-9. 2001
    ..Stimulation of IL-10 production by antigen-specific T-cells during immunotherapy may lead to anergy through inhibition of CD28-costimulatory molecule signalling by IL-10s anti-inflammatory effect on basophils, mast cells and eosinophils...
  3. ncbi request reprint Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Mol Biotechnol 18:213-32. 2001
    ..The important outcome of this is that new preventive and curative treatments may ensue...
  4. ncbi request reprint Pathophysiology and therapy of chronic cough
    K F Chung
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, London, UK
    Minerva Med 96:29-40. 2005
    ..Currently-available antitussives such as dextromethorphan or codeine are modestly successful in controlling cough. New antitussives may be developed that act on the sensory receptors or prevent their sensitisation...
  5. pmc Induction of eotaxin expression and release from human airway smooth muscle cells by IL-1beta and TNFalpha: effects of IL-10 and corticosteroids
    K F Chung
    Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 127:1145-50. 1999
    ..Thus, human airway smooth muscle cells can release eotaxin and could be an important source of chemokine production during airway inflammatory events...
  6. ncbi request reprint Non-invasive biomarkers of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Pediatr Pulmonol Suppl 18:41-4. 1999
    ....
  7. ncbi request reprint Assessing the burden of respiratory disease in the UK
    F Chung
    Royal Brompton and Harefield NHS Trust, London, U K
    Respir Med 96:963-75. 2002
    ..K. and they will continue to present a growing challenge; special support is needed to tackle this burden...
  8. ncbi request reprint Anti-IgE therapy of asthma
    K Fan Chung
    National Heart and Lung Institute, London, UK
    Curr Opin Investig Drugs 3:1157-60. 2002
    ..Omalizumab is a useful addition to the treatment armamentarium for patients with moderate-to-severe asthma...
  9. ncbi request reprint Cough: potential pharmacological developments
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Opin Investig Drugs 11:955-63. 2002
    ..Large scale trials of these novel compounds have not been carried out in cough in man but there is a serious need for more effective antitussives devoid of side effects...
  10. ncbi request reprint Assessment and measurement of cough: the value of new tools
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Pulm Pharmacol Ther 15:267-72. 2002
    ..We need a greater assessment and evaluation of all these tools...
  11. ncbi request reprint Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    N Lazzeri
    Thoracic Medicine and Cardiothoracic Surgery, National Heart and Lung Institute, London; Pharmacology Department, Dagenham Research Centre, Dagenham, Essex; and Unit of Critical Care Medicine, Royal Brompton Hospital, IC School of Medicine, London, UK
    Am J Respir Cell Mol Biol 24:44-48. 2001
    ..Thus, when HASM cells are activated with cytokines they release PGE2, which acts as a "braking mechanism" to limit the coproduction of GM-CSF. Moreover, agents that elevate cAMP also reduce GM-CSF formation by these cells...
  12. doi request reprint Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    P Bhavsar
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 63:784-90. 2008
    ....
  13. ncbi request reprint Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies
    G Caramori
    Dept of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur Respir J 18:466-73. 2001
    ..Finally, no evidence was found for an increased expression of GATA-4 and GATA-6 in asthma...
  14. pmc Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:1009-14. 1989
    ..Most of the bronchoconstriction is not inhibited by antimuscarinic agents; the underlying mechanisms require further investigation...
  15. doi request reprint Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma
    P Macedo
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Clin Exp Allergy 39:1668-76. 2009
    ..About 5-10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy...
  16. doi request reprint Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
    P Bhavsar
    Section of Airways Disease, National Heart and Lung Institute, Imperial College and Royal Brompton and Harefield NHS Trust Hospital, London, UK
    Eur Respir J 35:750-6. 2010
    ..Corticosteroid insensitivity in severe asthma patients may be improved by inhibitors of p38 MAPK...
  17. ncbi request reprint Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma
    S Lim
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, United Kingdom
    Am J Respir Crit Care Med 164:273-6. 2001
    ..Low-dose theophylline induced antiinflammatory effects in asthma, reflected by a fall in airway eosinophils with no change in exhaled NO or changes in lung function...
  18. pmc Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma
    E L van Rensen
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK
    Thorax 56:935-40. 2001
    ..CONCLUSION: The effects of IL-5 appear to be mainly in the circulation, inducing peripheral mobilisation of eosinophils to the circulation without any effect on eosinophil mobilisation in the lungs or on bronchial responsiveness...
  19. ncbi request reprint Effect of theophylline on airway responses to inhaled platelet-activating factor in man
    K F Chung
    Dept of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, UK
    Eur Respir J 2:763-8. 1989
    ..Our results suggest that theophylline has negligible influence on the airway effects of PAF...
  20. ncbi request reprint Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man
    K F Chung
    Department of Thoracic Medicine, Brompton Hospital, London, England
    J Allergy Clin Immunol 81:1192-8. 1988
    ..Ketotifen inhibits PAF-induced wheal and flare in the skin, which is probably histamine dependent. The airway effects of PAF are unlikely to be mediated by histamine release...
  21. ncbi request reprint Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness
    A J Wardlaw
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, England
    Am Rev Respir Dis 141:386-92. 1990
    ..1 (GSEM 1.40) to 8.7 (1.44) mg/ml (n = 12, p less than 0.02) 3 days after PAF. Inhaled lyso-PAF was inactive in all these respects.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. pmc Effect of formoterol, a long-lasting beta 2-adrenoceptor agonist, against methacholine-induced bronchoconstriction
    A Nix
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Br J Clin Pharmacol 29:321-4. 1990
    ..2- and 2.9-fold at 2 and 5 h respectively). 4. Thus, formoterol has a protective effect against methacholine-induced bronchoconstriction which lasts for at least 5 h...
  23. ncbi request reprint Capsaicin-induced bronchodilation in mild asthmatic subjects: possible role of nonadrenergic inhibitory system
    J W Lammers
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, United Kingdom
    J Appl Physiol 67:856-61. 1989
    ..This reflex could not be distinguished from that caused by coughing or by deep inhalation. A defect in nonadrenergic mechanisms, at least in mild asthma, seems unlikely...
  24. pmc Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:102-7. 1989
    ..Thus a therapeutic dose of salbutamol caused partial inhibition of platelet activating factor induced bronchoconstriction and had a minimal effect on the increased bronchial responsiveness following platelet activating factor...
  25. ncbi request reprint Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, England
    Allergy Proc 10:333-7. 1989
    ..These observations support an important role for PAF in asthama; the availability of specific PAF antagonists will allow us to test this hypothesis...
  26. ncbi request reprint Differential expression of IL-10 receptor by epithelial cells and alveolar macrophages
    S Lim
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, UK
    Allergy 59:505-14. 2004
    ..Reduced IL-10 may result in exaggerated and more prolonged inflammatory responses in asthmatic airways. IL-10 acting through the IL-10 receptor (IL-10R) stimulates the transcription factors STAT1 and STAT3...
  27. ncbi request reprint Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha: modulation by dexamethasone
    E B Haddad
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Mol Pharmacol 57:1123-31. 2000
    ..Nuclear run-on experiments demonstrate that the induction of B1 and the up-regulation of B2 receptors as well as the inhibitory effect of dexamethasone are entirely mediated through post-transcriptional mechanisms...
  28. pmc Capsaicin cough sensitivity in bronchiectasis
    A Torrego
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 61:706-9. 2006
    ..A study was undertaken to determine whether cough sensitivity is increased in bronchiectatic patients...
  29. ncbi request reprint Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects
    G M Nichol
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am Rev Respir Dis 142:576-80. 1990
    ..Nasal PD was measured before and after placebo or furosemide, and again after MBS inhalation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  30. ncbi request reprint Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma
    R G Stirling
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 164:1403-9. 2001
    ..Further, IL-5 causes terminal maturation of the eosinophil by increasing CCR3 expression, potentially affecting CCR3-dependent chemotaxis by eosinophils and lymphocytes...
  31. pmc Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London
    Thorax 44:108-15. 1989
    ....
  32. ncbi request reprint Expression of respiratory mucins in fatal status asthmaticus and mild asthma
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Histopathology 40:367-73. 2002
    ..The effect of inhaled corticosteroids on the expression of these mucins was also investigated...
  33. ncbi request reprint Cytokines in chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Eur Respir J Suppl 34:50s-59s. 2001
    ..The role of these cytokines needs to be defined and there is a potential for anticytokine therapy in chronic obstructive pulmonary disease...
  34. ncbi request reprint Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects
    K F Chung
    Dept of Medicine, Charing Cross and Westminster Medical School, London, UK
    Eur Respir J 1:890-5. 1988
    ..The distribution of inhaled aerosol, but not the dose, is largely dependent on airway calibre. The differences in PI between normal and asthmatic subjects may at best be explained by the differences in central airway calibre...
  35. ncbi request reprint Contribution of upregulated airway endothelin-1 expression to airway smooth muscle and epithelial cell DNA synthesis after repeated allergen exposure of sensitized Brown-Norway rats
    M Salmon
    National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Cell Mol Biol 23:618-25. 2000
    ..Such processes may underlie increased proliferation of resident cells leading to airway wall remodeling in asthmatics...
  36. ncbi request reprint Role for platelet-activating factor in asthma
    K F Chung
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Lipids 26:1277-9. 1991
    ..The interaction between PAF and eosinophils may be crucial in the pathogenesis of bronchial hyperresponsiveness in asthma. A role for PAF in asthma can now be studied using the recently developed antagonists of the PAF receptor...
  37. ncbi request reprint Effect of cigarette smoking on haem-oxygenase expression in alveolar macrophages
    L Atzori
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:530-5. 2004
    ..We concluded that HO-2 expression is reduced in alveolar macrophages of smokers, possibly due to the oxidative stress of cigarette smoke. This may in turn lead to reduced protection against further oxidative insults...
  38. ncbi request reprint Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma
    E Bucchioni
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Respir Med 98:651-5. 2004
    ..The detection of LTs and histamine in exhaled breath condensate may be useful in monitoring asthma...
  39. pmc Failure of sputum eosinophilia after eotaxin inhalation in asthma
    D Bumbacea
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Thorax 59:372-5. 2004
    ..The effects of eotaxin inhalation on sputum and blood eosinophils, exhaled nitric oxide (NO), and bronchial responsiveness were determined...
  40. pmc Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough
    A Niimi
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Thorax 59:608-12. 2004
    ..Increased hydrogen and reduced chloride ionic environments of the airways are conducive to the stimulation of cough. However, the constituents of the local milieu of the airways of patients with chronic cough are unknown...
  41. ncbi request reprint Resolution of allergic airways inflammation but persistence of airway smooth muscle proliferation after repeated allergen exposures
    S Y Leung
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Clin Exp Allergy 34:213-20. 2004
    ..Chronic inflammation in asthmatic airways can lead to characteristic airway smooth muscle (ASM) thickening and pathological changes within the airway wall...
  42. ncbi request reprint Chronic cough: future directions in chronic cough: mechanisms and antitussives
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton Hospital, London, UK
    Chron Respir Dis 4:159-65. 2007
    ..Future directions in chronic cough include the pathophysiological mechanisms of the enhanced cough reflex, and the discovery of effective antitussives that can successfully alleviate chronic cough...
  43. ncbi request reprint Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219
    J C Kidney
    Department of Thoracic Medicine, Royal Brompton National Heart and Lung Hospital, London, England
    Am Rev Respir Dis 147:215-7. 1993
    ..ICI 204,219 did not inhibit PAF-induced neutropenia. PAF-induced bronchoconstriction is mediated largely by the release of sulfidopeptide leukotrienes in normal men...
  44. doi request reprint Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
    K F Chung
    Section of Airways Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK
    Eur Respir J 31:1334-56. 2008
    ..Treatments may be targeted to patients with specific mechanisms...
  45. doi request reprint Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough
    K F Chung
    National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, UK
    Pulm Pharmacol Ther 24:267-71. 2011
    ..This would focus the problem on the cough symptomatology and lead to greater focus on understanding the mechanisms of cough sensitisation, with the ultimate aim of obtaining more effective antitussives...
  46. doi request reprint Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College, MRC Asthma UK Centre for Allergic Mechanisms in Asthma and Biomedical Research Unit, Royal Brompton Hospital, London, UK
    Ann N Y Acad Sci 1203:85-91. 2010
    ..Antioxidants may prove to be beneficial in inhibiting inflammatory responses and restoring corticosteroid function...
  47. ncbi request reprint Airflow obstruction after substance P aerosol: contribution of airway and pulmonary edema
    J O Lotvall
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    J Appl Physiol (1985) 69:1473-8. 1990
    ..We conclude that the inability of hyperinflation to fully reverse changes in RL after SP may be due to the formation of both airway and pulmonary edema, which may also contribute to the deterioration in RL...
  48. ncbi request reprint RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol
    N Lazzeri
    Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 433:231-5. 2001
    ..These data suggest that, in settings where cyclo-oxygenase activity is low, both drugs may relieve the symptoms of airway diseases by reducing RANTES production...
  49. ncbi request reprint Effective antitussives for the cough patient: an unmet need
    K F Chung
    National Heart and Lung Institute, Imperial College London and Royal Brompton and Harefield NHS Trust, London SW3, UK
    Pulm Pharmacol Ther 20:438-45. 2007
    ..Patients with chronic cough are in desperate need of effective antitussives that can be used either on demand or on a long-term basis...
  50. pmc Increased neutrophils and cytokines, TNF-alpha and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough
    A Jatakanon
    Department of Thoracic Medicine, Imperial College School of Medicine, London, UK
    Thorax 54:234-7. 1999
    ..The pathogenesis of non-asthmatic chronic dry cough remains unclear...
  51. ncbi request reprint Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung
    D A Groneberg
    Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK
    Respir Med 96:81-6. 2002
    ..MUC5AC and MUC5B are expressed in the same histological pattern in CF compared to normal tissues with an increase of MUC5AC-positive cells due to goblet cell hyper- and metaplasia...
  52. ncbi request reprint Regulation of human lung epithelial cell numbers by diesel exhaust particles
    H Bayram
    Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Eur Respir J 27:705-13. 2006
    ..Therefore, low-dose diesel exhaust particle exposure may lead to lung epithelial cell hyperplasia...
  53. doi request reprint Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13
    A S Williams
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Guy Scadding Building, Dovehouse St, London SW3 6LY, UK
    Eur Respir J 32:571-8. 2008
    ..In conclusion, interleukin-13 augments ozone-induced airway hyperresponsiveness and neutrophilic inflammation, possibly through modulation of certain cytokines induced by ozone exposure...
  54. ncbi request reprint Cytokines as targets in chronic obstructive pulmonary disease
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3, UK
    Curr Drug Targets 7:675-81. 2006
    ..Other treatments such as phosphodiesterase 4 inhibitors have anti-cytokine effects that may underlie their beneficial effects in COPD...
  55. ncbi request reprint Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma
    K F Chung
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Sci STKE 2005:pe47. 2005
    ..However, other PGE2 receptor subtypes may also have beneficial effects, and a greater understanding of the signaling pathways of these receptor subtypes will help to clarify the role of these receptors in asthma...
  56. ncbi request reprint Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma
    S Lim
    National Heart and Lung Institute, Imperial College School of Medicine, and Royal Brompton Hospital, London, UK
    Allergy 55:489-95. 2000
    ..We determined the effect of late-phase responses to allergen challenge of mildly allergic asthmatic patients on the expression and release of the cytokines IL-10 and MIP-1alpha from peripheral blood monocytes...
  57. doi request reprint Pro-oxidant iron in exhaled breath condensate: a potential excretory mechanism
    S Mumby
    Critical Care Medicine, National Heart and Lung Institute Imperial College London, Royal Brompton Campus, Royal Brompton Hospital, Sydney St, London SW3 6NP, UK
    Respir Med 105:1290-5. 2011
    ..Secondly, to measure levels of pro-oxidant iron in EBC from asthmatics after exposure to polluting city environments...
  58. ncbi request reprint Systematic assessment of difficult-to-treat asthma
    D S Robinson
    Dept of Allergy, Upper Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Eur Respir J 22:478-83. 2003
    ..Systematic evaluation of difficult asthma is useful as it can identify alternative or additional diagnoses, psychiatric illness or nonconcordance with therapy in a substantial proportion of cases (32% in the present series)...
  59. ncbi request reprint Drugs to suppress cough
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, SW3, UK
    Expert Opin Investig Drugs 14:19-27. 2005
    ....
  60. ncbi request reprint Regulation of protease-activated receptor-1 in mononuclear cells by neutrophil proteases
    N Roche
    Department of Thoracic Medicine, Imperial College School of Medicine at National Heart and Lung Institute, London, UK
    Respir Med 97:228-33. 2003
    ..These findings may be of relevance to the pathogenesis of COPD...
  61. pmc Salmeterol/fluticasone combination in the treatment of COPD
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
    Int J Chron Obstruct Pulmon Dis 1:235-42. 2006
    ..While long-acting beta2-agonists such as Sal can be recommended for treatment of moderate COPD, addition of inhaled steroid therapy such as FP should be considered in more severe disease...
  62. ncbi request reprint Measurement of cough
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Respir Physiol Neurobiol 152:329-39. 2006
    ..How the information obtained between these different measurements interrelate needs to be determined...
  63. ncbi request reprint Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity
    K F Chung
    National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London SW3 6LY, UK
    Eur Respir J 27:230-2. 2006
    ..This is the first case of persistent cough caused by hypereosinophilic syndrome characterised by FIP1L1-PDGFRA fusion gene and aberrant tyrosine kinase activity...
  64. ncbi request reprint Repeated allergen inhalation induces cytoskeletal remodeling in smooth muscle from rat bronchioles
    Clare G McVicker
    King s College London School of Medicine, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, London, United Kingdom
    Am J Respir Cell Mol Biol 36:721-7. 2007
    ..Such a mechanism may have relevance for AHR found in allergic asthma...
  65. ncbi request reprint Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats
    Tung Jung Huang
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 437:187-94. 2002
    ..In this acute model of allergic inflammation, differential modulation of Th1 and Th2 cytokines may determine the effects of various immunomodulators on airway inflammation and bronchial hyperresponsiveness...
  66. ncbi request reprint Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation
    Paul R Eynott
    National Heart and Lung Institute, Imperial College School of Science, Technology and Medicine, London, United Kingdom
    J Pharmacol Exp Ther 304:22-9. 2003
    ..We conclude that nitric oxide derived during allergic inflammation is involved in the expression of eosinophilic inflammation and not in epithelial or airway smooth muscle cell DNA synthesis induced by chronic allergen exposure...
  67. ncbi request reprint Overview: why are corticosteroids ineffective in COPD?
    Ian M Adcock
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Curr Opin Investig Drugs 3:58-60. 2002
  68. ncbi request reprint Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone
    Robert Newton
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London SW3, UK
    Eur J Pharmacol 441:193-202. 2002
    ..Arachidonic acid release in response to bradykinin was markedly enhanced by prior incubation with interleukin-1 beta and this was prevented by the prior addition of dexamethasone...
  69. ncbi request reprint Combination therapy of long-acting beta2-adrenoceptor agonists and corticosteroids for asthma
    K Fan Chung
    Imperial College, National Heart and Lung Institute, London, UK
    Treat Respir Med 3:279-89. 2004
    ..Improvements in combination therapy include a once-daily preparation and possible combination of inhaled corticosteroids with newer drugs such as phosphodiesterase IV inhibitors...
  70. ncbi request reprint IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:3557-65. 2006
    ..This negative feedback regulatory circuit could be essential in protecting the airways from inflammatory damage after allergen inhalation...
  71. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  72. ncbi request reprint Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle
    Matthew C Catley
    National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Mol Pharmacol 70:697-705. 2006
    ..We therefore suggest that IKK inhibitors may be of considerable benefit in inflammatory airways diseases, particularly in COPD or severe asthma, in which corticosteroids are ineffective...
  73. ncbi request reprint Airway inflammation and remodelling changes in patients with chronic cough: do they tell us about the cause of cough?
    Akio Niimi
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 17:441-6. 2004
    ..Changes in the airway wall mucosa and epithelium may be important in the pathogenesis of cough receptor sensitization...
  74. pmc Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase
    Paul R Eynott
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY
    Br J Pharmacol 140:1373-80. 2003
    ..SP600125 did not alter bronchial hyper-responsiveness observed after chronic allergen exposure. Pathways regulated by JNK positively regulate ASM cell proliferation and allergic cellular inflammation following chronic allergen exposure...
  75. pmc Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats
    Paul R Eynott
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Immunology 112:446-53. 2004
    ..The role of JNK mitogen-activated protein kinase activation may be limited in the pathogenesis of bronchial hyperresponsiveness after single allergen exposure...
  76. ncbi request reprint Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
    Ratko Djukanovic
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
    Am J Respir Crit Care Med 170:583-93. 2004
    ..The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to methacholine in mild to moderate asthma...
  77. ncbi request reprint Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charité Faculty of Medicine, Humboldt Universitat zu Berlin, Germany
    Am J Respir Crit Care Med 170:1276-80. 2004
    ..Our findings indicate that TRPV-1 receptors may contribute to an enhanced cough reflex and the cough response in chronic persistent cough of diverse causes...
  78. ncbi request reprint Current and future prospects for drugs to suppress cough
    K Fan Chung
    National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    IDrugs 6:781-6. 2003
    ....
  79. doi request reprint New targets for drug development in asthma
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 372:1073-87. 2008
    ..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality...
  80. ncbi request reprint Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma
    K Fan Chung
    National Heart and Lung Institute, Imperial College, London, UK
    Expert Opin Pharmacother 5:439-46. 2004
    ..Omalizumab is well-tolerated by asthma patients and represents a new approach to the treatment of the moderate-to-severe asthmatic patient. It is likely that it will first be used at the more severe end of the asthmatic diathesis...
  81. pmc Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats
    Paul R Eynott
    National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK
    Immunology 109:461-7. 2003
    ..Therefore, CsA and SAR943 have no effect on chronic eosinophilic inflammation, while SAR943, but not CsA, had a small effect on the proliferation of ASM and epithelium...
  82. pmc A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
    Kazuhiro Ito
    Thoracic Medicine, Imperial College School of Science, Technology, and Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 99:8921-6. 2002
    ..Thus we have shown that low-dose theophylline exerts an anti-asthma effect through increasing activation of HDAC which is subsequently recruited by corticosteroids to suppress inflammatory genes...
  83. pmc Models of chronic obstructive pulmonary disease
    David A Groneberg
    Pneumology and Immunology, Otto Heubner Centre, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Respir Res 5:18. 2004
    ..Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations...
  84. ncbi request reprint Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma
    Borja G Cosio
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 170:141-7. 2004
    ..Glucocorticoids and theophylline may downregulate the inflammatory response by modulating HAT and HDAC activity, and nuclear factor-kappaB activation...
  85. ncbi request reprint Mucus and fatal asthma
    David A Groneberg
    Am J Med 116:66-7; author reply 67. 2004
  86. ncbi request reprint Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma
    Katsuyuki Tomita
    Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, United Kingdom
    Clin Immunol 102:258-66. 2002
    ..These results suggest that IL-10 synthesis is attenuated in severe persistent asthma compared to mild asthma and that this cannot be explained by the increase in the CD14(+)CD16(+) monocytes in asthma...
  87. pmc Glucocorticoids reverse IL-1beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases
    Judith C W Mak
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY
    Br J Pharmacol 135:987-96. 2002
    ..In light of data obtained in this study, we propose that both the decrease in AC activity and the increase in GRK activity, which are reversed by dexamethasone, may underlie beta(2)-adrenoceptor desensitization...
  88. ncbi request reprint Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers
    Katsuyuki Tomita
    Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, London, United Kingdom
    Am J Respir Crit Care Med 166:724-31. 2002
    ..Thus, oxidative stress induced by cigarette smoking may contribute to the chronicity of inflammation in the airway, through a reduction of apoptosis...
  89. ncbi request reprint Intrinsic differences of the airway epithelium in childhood allergic asthma
    K Fan Chung
    Am J Respir Crit Care Med 174:1066-7. 2006
  90. ncbi request reprint Airway obstruction in chronic obstructive pulmonary disease
    K Fan Chung
    N Engl J Med 351:1459-61; author reply 1459-61. 2004
  91. ncbi request reprint Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages
    Nicolas Roche
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    J Allergy Clin Immunol 111:367-73. 2003
    ....
  92. ncbi request reprint Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease
    David A Groneberg
    Otto Heubner Centre, Pneumology and Immunology, Free University Berlin and Humboldt University, D 13353 Berlin, Germany
    Biol Chem 386:53-9. 2005
    ..The present data on neurotrophin-specific transcriptional down-regulation of NT-3 in human COPD indicate a pathophysiological role for neurotrophins in COPD...
  93. ncbi request reprint Neuropeptide Y (NPY)
    David A Groneberg
    Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charite School of Medicine, Free University and Humboldt University, Berlin, Germany
    Pulm Pharmacol Ther 17:173-80. 2004
    ..However, since selective antagonists and agonists and gene-depleted animals for the different receptors are now available, NPY may be of value for future strategies in airway nerve modulation...
  94. ncbi request reprint Inhibition of chemokine production from human airway smooth muscle cells by fluticasone, budesonide and beclomethasone
    Matthias John
    Department of Pneumology, University Hospital Charite, Schumannstr 20 21, Berlin 10098, Germany
    Pulm Pharmacol Ther 17:41-7. 2004
    ....
  95. ncbi request reprint Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids
    Waldo Mattos
    Department of Thoracic Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Chest 122:1543-52. 2002
    ..Matrix metalloproteinases (MMPs) are a group of enzymes capable of degrading the ECM. They are released along with their inhibitors, tissue inhibitor of MMP (TIMP)...
  96. ncbi request reprint Kinase inhibitors and airway inflammation
    Ian M Adcock
    Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, United Kingdom
    Eur J Pharmacol 533:118-32. 2006
    ....
  97. ncbi request reprint Protease-activated receptor 2 in regulation of bronchomotor tone: effect of tobacco smoking
    Paul Andre Risse
    Laboratoire de Biologie et Pharmacologie Respiratoire, UFR Biomédicale des Saint Pères, Universite de Versailles, Paris, France
    Life Sci 75:991-1002. 2004
    ..The role of airway protease-activated receptor 2 may be to maintain smooth muscle tone homeostasis...
  98. pmc Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells
    Shaoping Xie
    Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 6:148. 2005
    ..We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases...
  99. ncbi request reprint Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats
    Lyn M Moir
    Department of Asthma, Allergy and Respiratory Science, The Guy s, King s and St Thomas School of Medicine, King s College London, London SE1 9RT, UK
    Am J Physiol Lung Cell Mol Physiol 284:L148-59. 2003
    ..Thus, OA exposure induces structural changes in bronchiole ASM content and in agonist responsiveness ex vivo that resemble remodeling in asthma...
  100. ncbi request reprint Expression and activity of histone deacetylases in human asthmatic airways
    Kazuhiro Ito
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY UK
    Am J Respir Crit Care Med 166:392-6. 2002
    ..The increase in HAT activity and reduced HDAC activity in asthma may underlie the increased expression of multiple inflammatory genes, and this is reversed, at least in part, by treatment with inhaled steroids...
  101. ncbi request reprint Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness
    Paul R Eynott
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 452:123-33. 2002
    ..NO generated through NOS2 contributes to allergen-induced bronchial hyperresponsiveness but not to bronchial eosinophilia, indicating that these are independently expressed...