Nish Chaturvedi

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc South Asians have elevated postexercise blood pressure and myocardial oxygen consumption compared to Europeans despite equivalent resting pressure
    Nish Chaturvedi
    National Heart and Lung Institute, Imperial College Academic Health Sciences Centre, London, UK
    J Am Heart Assoc 1:e000281. 2012
  2. pmc High prevalence of lack of knowledge of symptoms of acute myocardial infarction in Pakistan and its contribution to delayed presentation to the hospital
    Muhammad S Khan
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 7:284. 2007
  3. pmc Self-rated health in Pakistan: results of a national health survey
    Khabir Ahmad
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 5:51. 2005
  4. pmc Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent
    William D Strain
    Institute of Biomedical and Clinical Science, Peninsula Medical School Exeter, University of Exeter, UK
    BMC Cardiovasc Disord 10:3. 2010
  5. pmc Knowledge of modifiable risk factors of heart disease among patients with acute myocardial infarction in Karachi, Pakistan: a cross sectional study
    Muhammad S Khan
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Cardiovasc Disord 6:18. 2006
  6. ncbi request reprint Ethnic differences in vascular stiffness and relations to hypertensive target organ damage
    Nish Chaturvedi
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London at St Mary s, Norfolk Place, London, UK
    J Hypertens 22:1731-7. 2004
  7. ncbi request reprint Commentary: Socioeconomic status and diabetes outcomes; what might we expect and why don't we find it?
    N Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Int J Epidemiol 33:871-3. 2004
  8. ncbi request reprint The burden of diabetes and its complications: trends and implications for intervention
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College at St Mary s, Norfolk Place, London, UK
    Diabetes Res Clin Pract 76:S3-12. 2007
  9. pmc Ethnic differences in cardiovascular disease
    Nish Chaturvedi
    International Centre for Circulatory Health and Department of Epidemiology and Public Health, Faculty of Medicine at St Mary s, Imperial College London, Norfolk Place, London W2 1PG, UK
    Heart 89:681-6. 2003
  10. pmc The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) -- a prospective population-based study
    Therese Tillin
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 61:1777-86. 2013

Detail Information

Publications81

  1. pmc South Asians have elevated postexercise blood pressure and myocardial oxygen consumption compared to Europeans despite equivalent resting pressure
    Nish Chaturvedi
    National Heart and Lung Institute, Imperial College Academic Health Sciences Centre, London, UK
    J Am Heart Assoc 1:e000281. 2012
    ..Elevated recovery BP after exercise predicts stroke, independently of resting values. We hypothesized that South Asians would have adverse postexercise hemodynamics and sought explanations for this...
  2. pmc High prevalence of lack of knowledge of symptoms of acute myocardial infarction in Pakistan and its contribution to delayed presentation to the hospital
    Muhammad S Khan
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 7:284. 2007
    ..We conducted an observational study to determine the delay in presentation to hospital, and its associates among patients experiencing first Acute Myocardial Infarction (AMI) in Karachi, Pakistan...
  3. pmc Self-rated health in Pakistan: results of a national health survey
    Khabir Ahmad
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Public Health 5:51. 2005
    ..We determined the prevalence of and risk factors for poor/fair SRH among individuals aged > or =15 years in Pakistan (n = 9442)...
  4. pmc Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent
    William D Strain
    Institute of Biomedical and Clinical Science, Peninsula Medical School Exeter, University of Exeter, UK
    BMC Cardiovasc Disord 10:3. 2010
    ....
  5. pmc Knowledge of modifiable risk factors of heart disease among patients with acute myocardial infarction in Karachi, Pakistan: a cross sectional study
    Muhammad S Khan
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Cardiovasc Disord 6:18. 2006
    ....
  6. ncbi request reprint Ethnic differences in vascular stiffness and relations to hypertensive target organ damage
    Nish Chaturvedi
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London at St Mary s, Norfolk Place, London, UK
    J Hypertens 22:1731-7. 2004
    ..People of Black African descent have greater risks of hypertensive target organ damage than would be anticipated for given levels of blood pressure. Arterial stiffness may further account for ethnic differences in risk...
  7. ncbi request reprint Commentary: Socioeconomic status and diabetes outcomes; what might we expect and why don't we find it?
    N Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Int J Epidemiol 33:871-3. 2004
  8. ncbi request reprint The burden of diabetes and its complications: trends and implications for intervention
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College at St Mary s, Norfolk Place, London, UK
    Diabetes Res Clin Pract 76:S3-12. 2007
    ..However, more information is required about the long-term sustainability of these changes, and programmes also need to be adapted to meet the needs of developing countries...
  9. pmc Ethnic differences in cardiovascular disease
    Nish Chaturvedi
    International Centre for Circulatory Health and Department of Epidemiology and Public Health, Faculty of Medicine at St Mary s, Imperial College London, Norfolk Place, London W2 1PG, UK
    Heart 89:681-6. 2003
  10. pmc The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) -- a prospective population-based study
    Therese Tillin
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 61:1777-86. 2013
    ..This study sought to determine whether ethnic differences in diabetes, dyslipidemia, and ectopic fat deposition account for ethnic differences in incident cardiovascular disease...
  11. pmc Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes
    Alun D Hughes
    International Centre for Circulatory Health, NHLI Division, Faculty of Medicine, Imperial College London and Imperial College Healthcare NHS Trust, London, United Kingdom
    PLoS ONE 8:e76680. 2013
    ..Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people. ..
  12. ncbi request reprint Measurement of pulse wave velocity: site matters
    Therese Tillin
    International Centre for Circulatory Health, St Mary s Hospital, Hammersmith Hospital and Imperial College, London, UK
    J Hypertens 25:383-9. 2007
    ..However, a comparison of associations between PWV measured at different sites and atherosclerosis in coronary, carotid and femoral arteries has not been made...
  13. doi request reprint Determinants of retinal microvascular architecture in normal subjects
    Alun D Hughes
    Clinical Pharmacology, NHLI Division, International Centre for Circulatory Health, Faculty of Medicine, Imperial College London, UK
    Microcirculation 16:159-66. 2009
    ....
  14. doi request reprint Differential effects of adiposity and childhood growth trajectories on retinal microvascular architecture
    Robyn J Tapp
    International Centre for Circulatory Health, NHLI, St Mary s Hospital and Imperial College London, London, UK Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia
    Microcirculation 20:609-16. 2013
    ..We hypothesized that trajectories of adiposity across childhood would be associated with retinal microcirculatory diameters at age 12 years, independent of BP...
  15. ncbi request reprint Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factors
    W David Strain
    International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College London at St Mary s, Hammersmith Hospital, London, UK
    Am J Hypertens 19:889-96. 2006
    ..We hypothesized that arterial stiffness, an independent cardiovascular risk factor, would be more prevalent with diabetes and in African Caribbeans with diabetes than Europeans...
  16. pmc Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a U.K. tri-ethnic prospective cohort study (SABRE--Southall And Brent REvisited)
    Therese Tillin
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK
    Heart 100:60-7. 2014
    ..To evaluate QRISK2 and Framingham cardiovascular disease (CVD) risk scores in a tri-ethnic U.K. population...
  17. ncbi request reprint Soluble vascular cell adhesion molecule-1 and soluble E-selectin are associated with micro- and macrovascular complications in Type 1 diabetic patients
    Sabita S Soedamah-Muthu
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK, and Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    J Diabetes Complications 20:188-95. 2006
    ..Therefore, the main objective is to examine the relationship between soluble (s) vascular cell adhesion molecule-1 (sVCAM-1) and sE-selectin and retinopathy, albuminuria, and cardiovascular disease (CVD) in Type 1 diabetic patients...
  18. doi request reprint Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes
    Sharleet Mahal
    International Centre for Circulatory Health, NHLI Division, Faculty of Medicine, Imperial College London and Imperial College Healthcare NHS Trust, London, U K
    Clin Sci (Lond) 117:229-36. 2009
    ..African-Caribbean people with diabetes have wider retinal arterioles and this could contribute to enhanced microvascular damage in this ethnic group...
  19. doi request reprint Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy
    Andrew S P Sharp
    Department of Cardiology, International Centre for Circulatory Health, St Mary s Hospital and Imperial College London, 59 61 North Wharf Road, Paddington, London W2 1LA, UK
    Eur Heart J 31:747-52. 2010
    ....
  20. ncbi request reprint Microalbuminuria and coronary heart disease risk in an ethnically diverse UK population: a prospective cohort study
    Therese Tillin
    National Heart and Lung Institute, Imperial College at St Mary s, Norfolk Place, London W2 IPG, UK
    J Am Soc Nephrol 16:3702-10. 2005
    ..These differences suggest that the pathogenesis of kidney disease and its link with CHD differ by ethnicity and gender...
  21. doi request reprint Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy
    Andrew Sharp
    International Centre for Circulatory Health, St Mary s Hospital and Imperial College London, London, United Kingdom
    J Am Coll Cardiol 52:1015-21. 2008
    ..We investigated whether diastolic function differs between hypertensive patients of African-Caribbean or white European origin and established whether differences could be explained by confounding variables...
  22. ncbi request reprint South Asian men have different patterns of coronary artery disease when compared with European men
    Therese Tillin
    International Centre for Circulatory Health, St Mary s Hospital, Hammersmith Hospital and Imperial College, 59 North Wharf Road, London W2 1LA, UK
    Int J Cardiol 129:406-13. 2008
    ..To compare patterns of coronary artery disease in British South Asian and White European men...
  23. ncbi request reprint Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage
    William D Strain
    International Centre for Circulatory Health, Faculty of Medicine, Imperial College London at St Mary s, London, UK
    J Hypertens 23:133-40. 2005
    ..People of Black African descent have increased risks of vascular target-organ damage not explained by greater blood pressures...
  24. ncbi request reprint Indian Asian men have less peripheral arterial disease than European men for equivalent levels of coronary disease
    Nish Chaturvedi
    NHLI Division, Faculty of Medicine, Imperial College London, UK
    Atherosclerosis 193:204-12. 2007
    ..This paradox, and reasons for it, have not been explored. We compared ethnic differences in peripheral arterial disease for a given level of coronary disease...
  25. pmc African Caribbeans have greater subclinical cerebrovascular disease than Europeans: this is associated with both their elevated resting and ambulatory blood pressure and their hyperglycaemia
    Dean Shibata
    aDepartment of Radiology, University of Washington Medical Centre, Seattle, Washington, USA bNational Heart and Lung Institute, Imperial College London cDepartment of Radiology, St Mary s Hospital, Imperial College NHS Healthcare Trust, London, UK
    J Hypertens 31:2391-9. 2013
    ..Stroke is elevated in people of black African descent, but evidence for excess subclinical cerebrovascular disease is conflicting, and the role of risk factors in determining any ethnic differences observed unexplored...
  26. pmc Left-ventricular structure in the Southall And Brent REvisited (SABRE) study: explaining ethnic differences
    Chloe M Park
    International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, and Imperial College Healthcare National Health Service Trust, London, UK
    Hypertension 61:1014-20. 2013
    ..Left-ventricular remodeling rather than hypertrophy may explain the increased risk of heart failure in people of African Caribbean origin...
  27. ncbi request reprint Risk factors for coronary heart disease in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study
    Sabita S Soedamah-Muthu
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
    Diabetes Care 27:530-7. 2004
    ..The goal of the study was to examine risk factors in the prediction of coronary heart disease (CHD) and differences in men and women in the EURODIAB Prospective Complications Study...
  28. doi request reprint Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
    Lancet 372:1394-402. 2008
    ..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes...
  29. pmc Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort
    Therese Tillin
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, UK
    Diabetes Care 36:383-93. 2013
    ..To determine the extent of, and reasons for, ethnic differences in type 2 diabetes incidence in the U.K...
  30. doi request reprint South Asians have adverse cerebrovascular haemodynamics, despite equivalent blood pressure, compared with Europeans. This is due to their greater hyperglycaemia
    Rajaram Bathula
    National Heart and Lung Institute, Imperial College Academic Health Sciences Centre, London, UK
    Int J Epidemiol 40:1490-8. 2011
    ..We hypothesized that it is the greater hyperglycaemia in South Asians that increases stroke risk, by adversely affecting cerebrovascular haemodynamics...
  31. ncbi request reprint The role of diabetes and components of the metabolic syndrome in stroke and coronary heart disease mortality in U.K. white and African-Caribbean populations
    Therese Tillin
    National Heart and Lung Institute, Imperial College at St Mary s, Norfolk Place, London W2 1PG, U K
    Diabetes Care 29:2127-9. 2006
  32. pmc Impact of size at birth on the microvasculature: the Avon Longitudinal Study of Parents and Children
    Robyn J Tapp
    International Centre for Circulatory Health, NHLI, Imperial College London, St Mary s Campus, London W2 1LA, United Kingdom
    Pediatrics 120:e1225-8. 2007
    ..The impact of early life factors on the microvasculature is relatively unknown...
  33. pmc Adverse effect of diabetes and hyperglycaemia on arterial stiffness in Europeans, South Asians, and African Caribbeans in the SABRE study
    Chloe M Park
    aUCL Institute of Cardiovascular Science, University College LondonbInstitute of Population Health, St Georges UniversitycInternational Centre for Circulatory Health, Imperial College LondondImperial College NHS Trust, London, UK
    J Hypertens 34:282-9. 2016
    ..Ethnic minority groups in the U.K. experience marked differences in cardiovascular disease risk. We investigated differences in arterial central haemodynamics, stiffness, and load in a tri-ethnic population-based cohort...
  34. pmc Midlife hypertensive status and cognitive function 20 years later: the Southall and Brent revisited study
    Clare Taylor
    King s College London Institute of Psychiatry, London, UK
    J Am Geriatr Soc 61:1489-98. 2013
    ..To investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later...
  35. pmc Feasibility and reproducibility of left ventricular rotation by speckle tracking echocardiography in elderly individuals and the impact of different software
    Chloe M Park
    International Centre for Circulatory Health, Imperial College London, London, United Kingdom
    PLoS ONE 8:e75098. 2013
    ..We assessed the feasibility, reproducibility and within patient temporal variability of 2DSTE in a large community based sample of older adults. We additionally compared 2DSTE results to those generated by 3DSTE...
  36. doi request reprint The role of antihypertensive therapy in reducing vascular complications of type 2 diabetes. Findings from the DIabetic REtinopathy Candesartan Trials-Protect 2 study
    Therese Tillin
    International Centre for Circulatory Health, Imperial College London, London, UK
    J Hypertens 29:1457-62. 2011
    ..Recent trials question previously accepted low blood pressure targets in type 2 diabetes to reduce complication risk. We explored this question in the DIabetic REtinopathy Candesartan Trials-Protect 2 clinical trial...
  37. doi request reprint Ethnic differences in heart rate: can these be explained by conventional cardiovascular risk factors?
    Rajaram Bathula
    Department of Clinical Pharmacology, Imperial College London, St Mary s Campus, London, UK
    Clin Auton Res 18:90-5. 2008
    ..This study investigated ethnic differences in heart rate, sympathovagal balance, and baroreflex sensitivity (BRS) to establish if they were explained by dysglycaemia/insulin resistance...
  38. pmc Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
    Therese Tillin
    UCL Institute of Cardiovascular Science, 170 Tottenham Court Road, London, W1T 7HA, UK
    Diabetologia 58:968-79. 2015
    ..In a unique cohort of European and South Asian men, we compared cross-sectional associations between AAs, metabolic and obesity traits, and longitudinal associations with incident diabetes...
  39. ncbi request reprint Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke
    Nicholas Witt
    National Heart and Lung Institute Division, Department of Clinical Pharmacology, International Centre for Circulatory Health, Faculty of Medicine, Imperial College London, United Kingdom
    Hypertension 47:975-81. 2006
    ..A detailed assessment of the retinal microvascular network from digitized photographs may be useful in the noninvasive assessment of target organ damage and cardiovascular risk...
  40. doi request reprint Glycemic control and all-cause mortality risk in type 1 diabetes patients: the EURODIAB prospective complications study
    Danielle A J M Schoenaker
    School of Population Health D A J M S, University of Queensland, Brisbane, 4006 Queensland, Australia Department of Diabetes, la Pitié Hospital and University Pierre et Marie Curie, 75013 Paris, France INSERM CESP D S, U 1018, 94805 Villejuif, France National Heart and Lung Institute N C, Imperial College London, London W2 1PG, United Kingdom Department of Epidemiology and Public Health J H F, University College London, London WC1E 6BT, United Kingdom and Division of Human Nutrition S S S M, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Clin Endocrinol Metab 99:800-7. 2014
    ..Glycemic targets and the benefit of intensive glucose control are currently under debate because intensive glycemic control has been suggested to have negative effects on mortality risk in type 2 diabetes patients...
  41. doi request reprint A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes
    Alun David Hughes
    International Centre for Circulatory Health, NHLI Division, Faculty of Medicine, Imperial College London and Imperial College Healthcare NHS Trust, London, UK
    Int J Cardiol 167:1329-32. 2013
    ..We compared the effect of pioglitazone vs. placebo on left ventricular (LV) diastolic and systolic function in people with type 2 diabetes...
  42. pmc Arterial pressure: agreement between a brachial cuff-based device and radial tonometry
    Chloe M Park
    aInternational Centre for Circulatory Health, Imperial College London and Imperial College Healthcare NHS Trust bDepartment of Bioengineering, Imperial College London, London, UK
    J Hypertens 32:865-72. 2014
    ..We compared these estimates with those obtained using radial tonometry as well as with invasively acquired measurements of aortic BP in a limited number of individuals...
  43. pmc Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate
    Mark A Peterzan
    International Centre for Circulatory Health, National Heart and Lung Institute, Faculty of Medicine, Imperial College London and Imperial College Healthcare National Health Service Trust, London, United Kingdom
    Hypertension 59:1104-9. 2012
    ..Hydrochlorothiazide, chlorthalidone, and bendroflumethiazide have markedly different potency. This may account for differences in the antihypertensive effect between hydrochlorothiazide and chlorthalidone using standard dose ranges...
  44. ncbi request reprint Ethnicity and risk of diabetes-related lower extremity amputation: a population-based, case-control study of African Caribbeans and Europeans in the United kingdom
    Sandra Leggetter
    Department of Epidemiology and Public Health, University College London, London, England
    Arch Intern Med 162:73-8. 2002
    ..This may be due to differences in care or pathophysiological characteristics. We therefore determined diabetes-related amputation rates in African Caribbeans vs Europeans in the United Kingdom, where care delivery is more equitable...
  45. doi request reprint Differential effects of antihypertensive treatment on the retinal microcirculation: an anglo-scandinavian cardiac outcomes trial substudy
    Simon Thom
    International Centre for Circulatory Health, 59 61 North Wharf Rd, Paddington, London W2 1NY, United Kingdom
    Hypertension 54:405-8. 2009
    ..Photographic assessment of the retinal vascular network may be a useful approach to evaluating microvascular structural responses in clinical trials of antihypertensive therapy...
  46. doi request reprint Protein intake in relation to risk of hypertension and microalbuminuria in patients with type 1 diabetes: the EURODIAB Prospective Complications Study
    Wieke Altorf-van der Kuil
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Hypertens 31:1151-9. 2013
    ....
  47. ncbi request reprint The DIabetic Retinopathy Candesartan Trials (DIRECT) Programme, rationale and study design
    Nish Chaturvedi
    International Centre for Circulatory Health Department of Epidemiology and Public Health, Imperial College at St Mary s, London, W2 1PG, UK
    J Renin Angiotensin Aldosterone Syst 3:255-61. 2002
    ..The main secondary endpoint for each study is change in urinary albumin excretion rate. A positive outcome of the DIRECT Programme would be an important step forward in the clinical management of patients with diabetes...
  48. ncbi request reprint Circulating and urinary transforming growth factor beta1, Amadori albumin, and complications of type 1 diabetes: the EURODIAB prospective complications study
    Nish Chaturvedi
    Department of Epidemiology and Public Health, Imperial College of Medicine at St Mary s, London, UK
    Diabetes Care 25:2320-7. 2002
    ..We sought to examine the role of both urinary and circulating TGF-beta1 and its promoter Amadori albumin in the vascular complications of type 1 diabetes...
  49. pmc Air pollution and cardiovascular mortality with over 25years follow-up: A combined analysis of two British cohorts
    Hakim Moulay Dehbi
    MRC PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK Electronic address
    Environ Int . 2016
    ..There are comparatively fewer studies in Europe, and in the UK particularly, than in North America. We examined associations in two British cohorts with >25years of follow-up...
  50. pmc The association of nonalcoholic fatty liver disease with central and peripheral blood pressure in adolescence: findings from a cross-sectional study
    Sumaiya Patel
    aSchool of Social and Community Medicine bMRC Integrative Epidemiology Unit at the University of Bristol, Bristol cInstitute of Cardiovascular Science, University College London, London dUniversity Hospitals Bristol National Health Service Foundation Trust, Bristol eInstitute of Cellular Medicine C D, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne fInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, UK
    J Hypertens 33:546-52; discussion 553. 2015
    ..We aimed to determine the association of nonalcoholic fatty liver disease (NAFLD) with central and peripheral blood pressure (BP), in a general adolescent population and to examine whether associations are independent of adiposity...
  51. doi request reprint Association of parental blood pressure with retinal microcirculatory abnormalities indicative of endothelial dysfunction in children
    Muhammad Islam
    aClinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan bHealth Services and Systems Research, Duke NUS Graduate Medical School, Singapore, Singapore cDivision of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA dNational Heart and Lung Institute, Imperial College London, London, UK N C and A D H contributed equally to the writing of the article
    J Hypertens 32:598-605. 2014
    ..We examined the relationship between parental blood pressure (BP) and offspring retinal microvasculature in Pakistani trios [father, mother, and child (aged 9-14 years)]...
  52. ncbi request reprint The renin-angiotensin-aldosterone system and the eye in diabetes
    W David Strain
    Faculty of Medicine, Imperial College at St Mary s, London, W2 1PG, UK
    J Renin Angiotensin Aldosterone Syst 3:243-6. 2002
    ..This may be due to antagonism of activation of mitogen-activated protein kinase, which is a potent cellular proliferation stimulator, by Ang II, although this needs further evaluation...
  53. ncbi request reprint Pulse pressure is associated with age and cardiovascular disease in type 1 diabetes: the Eurodiab Prospective Complications Study
    Miranda T Schram
    Institute for Cardiovascular Research and Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    J Hypertens 21:2035-44. 2003
    ..In addition, we determined the association of mean arterial pressure and pulse pressure with incident cardiovascular disease...
  54. doi request reprint Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
    Anne Katrin Sjølie
    Department of Ophthalmology, Odense University Hospital, Odense, Denmark
    Lancet 372:1385-93. 2008
    ..Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes...
  55. pmc Age and sex interaction in reported help seeking in response to chest pain
    Joy Adamson
    Health Sciences, University of York, Heslington, York
    Br J Gen Pract 58:318-23. 2008
    ..There is a growing literature suggesting that access to cardiology services is affected by age. However, there is a dearth of studies that have considered age and sex in conjunction...
  56. ncbi request reprint Prevalence and predictors of smoking in Pakistan: results of the National Health Survey of Pakistan
    Khabir Ahmad
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Eur J Cardiovasc Prev Rehabil 12:203-8. 2005
    ..We analysed data collected during a nationwide cross-sectional household survey to estimate the prevalence of and identify factors associated with smoking in Pakistan...
  57. ncbi request reprint Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: the EURODIAB prospective complications study
    Manon V Van Hecke
    Department of Ophthalmology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, Netherlands
    Diabetes Care 28:1383-9. 2005
    ....
  58. ncbi request reprint Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction?
    W David Strain
    Clinical Microvascular Research, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Rd, Exeter EX2 5AX, UK
    Diabetes 54:1816-22. 2005
    ..This may represent shared mechanistic pathways and causative or con-sequential changes in the microvasculature and supports the hypothesis that microvascular dysfunction may contribute to large vessel pathophysiology...
  59. ncbi request reprint Children in South Asia have higher body mass-adjusted blood pressure levels than white children in the United States: a comparative study
    Tazeen H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
    Circulation 111:1291-7. 2005
    ....
  60. ncbi request reprint General practitioners' approach to hypertension in urban Pakistan: disturbing trends in practice
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, PO Box 3500, Stadium Road, Karachi, 74800, Pakistan
    Circulation 111:1278-83. 2005
    ..Control of blood pressure (BP) remains suboptimal worldwide. The objective of this study was to determine whether (primary) general practitioners' (GPs) approach to high BP is in accordance with international guidelines...
  61. ncbi request reprint Explanations for the high risk of diabetes-related amputation in a Caribbean population of black african descent and potential for prevention
    Anselm J M Hennis
    Chronic Disease Research Centre, Tropical Medicine Research Institute, University of the West Indies, Jemmott s Lane, Bridgetown, Barbados, West Indies
    Diabetes Care 27:2636-41. 2004
    ..S., but are lower in African Caribbeans in the U.K., whereas anecdotal reports suggest high rates in the Caribbean. We aimed to establish the incidence and risk factors for diabetes-related LEA in a Caribbean population...
  62. ncbi request reprint Ethnic differences and determinants of proteinuria among South Asian subgroups in Pakistan
    Tazeen H Jafar
    Department of Medicine, Aga Khan University, Karachi, Pakistan
    Kidney Int 64:1437-44. 2003
    ..Prevalence of proteinuria is high in South Asians. However, ethnic subgroup differences and determinants of proteinuria within the South Asian population have not been explored...
  63. ncbi request reprint Ethnicity, socio-economic position and gender--do they affect reported health-care seeking behaviour?
    Joy Adamson
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, BS8 2PR Bristol, UK
    Soc Sci Med 57:895-904. 2003
    ....
  64. ncbi request reprint Ethnic subgroup differences in hypertension in Pakistan
    Tazeen H Jafar
    Department of Community Health Sciences, Tufts University Medical School, Boston, Massachusetts, USA
    J Hypertens 21:905-12. 2003
    ..We conducted this study to explore the variations in hypertension within ethnic subgroups among South Asians...
  65. ncbi request reprint Ethnic differences in microvascular structure and function
    William D Strain
    J Hypertens 23:1434-5; author reply 1435-6. 2005
  66. ncbi request reprint Heart disease epidemic in Pakistan: women and men at equal risk
    Tazeen H Jafar
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Am Heart J 150:221-6. 2005
    ..We conducted this study to determine the prevalence of coronary artery disease (CAD) and its risk factors in Karachi, Pakistan...
  67. ncbi request reprint Does microalbuminuria predict diabetic nephropathy?
    Han Henrik Parving
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Diabetes Care 25:406-7. 2002
  68. pmc Relationship between risk factors and mortality in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study (PCS)
    Sabita S Soedamah-Muthu
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 31:1360-6. 2008
    ..The purpose of this study was to examine risk factors for mortality in patients with type 1 diabetes...
  69. ncbi request reprint Use of albumin creatinine ratio and urine albumin concentration as a screening test for albuminuria in an Indo-Asian population
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, The Aga Khan University, PO Box 3500, Stadium Road, Karachi, Pakistan
    Nephrol Dial Transplant 22:2194-200. 2007
    ..We compared the use of spot urine albumin concentration and urine albumin to creatinine excretion ratio for detection of albuminuria in this population...
  70. pmc Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy
    Gabriella Gruden
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes 57:1966-70. 2008
    ..We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients...
  71. pmc Prevalence of overweight and obesity and their association with hypertension and diabetes mellitus in an Indo-Asian population
    Tazeen H Jafar
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    CMAJ 175:1071-7. 2006
    ....
  72. ncbi request reprint Treatment and prevention of obesity--are there critical periods for intervention?
    Debbie A Lawlor
    Int J Epidemiol 35:3-9. 2006
  73. ncbi request reprint Adiponectin is inversely associated with renal function in type 1 diabetic patients
    Casper G Schalkwijk
    Department of Clinical Chemistry, Institute for Cardiovascular Research, Vrije Universiteit, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 91:129-35. 2006
    ..We examined the relation of adiponectin with several cardiovascular risk factors and with micro- and macrovascular outcomes in type 1 diabetic patients...
  74. ncbi request reprint Electrocardiographic left ventricular hypertrophy in type 1 diabetes: prevalence and relation to coronary heart disease and cardiovascular risk factors: the Eurodiab IDDM Complications Study
    Sara Giunti
    Department of Internal Medicine, University of Turin, 14, C so A M Dogliotti, I 10126, Torino, Italy
    Diabetes Care 28:2255-7. 2005
  75. ncbi request reprint Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus
    Nish Chaturvedi
    Contemp Clin Trials 28:780. 2007
  76. ncbi request reprint Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study
    Miranda T Schram
    Institute for Cardiovascular Research, and Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 26:2165-73. 2003
    ..Inflammatory activity is increased in type 1 diabetes and may predispose to vascular disease. Its origin is not clear. We therefore investigated determinants of inflammation in type 1 diabetes...
  77. pmc Effect of general practitioner education on adherence to antihypertensive drugs: cluster randomised controlled trial
    Nudrat Noor Qureshi
    Clinical Epidemiology Unit, Department of Community Health Sciences, Aga Khan University, P O Box 3500, Stadium Road, Karachi, 74800, Pakistan
    BMJ 335:1030. 2007
    ..To determine the impact of a simple educational package for general practitioners on adherence to antihypertensive drugs...
  78. ncbi request reprint Vascular risk factors and diabetic neuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    N Engl J Med 352:341-50. 2005
    ..We studied risk factors for the development of distal symmetric neuropathy in 1172 patients with type 1 diabetes mellitus from 31 centers participating in the European Diabetes (EURODIAB) Prospective Complications Study...
  79. ncbi request reprint Incidence and risk factors of prolonged QTc interval in type 1 diabetes: the EURODIAB Prospective Complications Study
    Sara Giunti
    Department of Internal Medicine, University of Torino, I 10126 Torino, Italy
    Diabetes Care 30:2057-63. 2007
    ..As part of the EURODIAB Prospective Complication Study, we have assessed the 7-year incidence and risk factors of prolonged QTc in people with type 1 diabetes...
  80. ncbi request reprint Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study
    Miranda T Schram
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 46:232-7. 2005
    ..These findings suggest that the formation of advanced glycation end products is an important pathway in the development of arterial stiffness in young type 1 diabetic individuals...
  81. ncbi request reprint Proteinuria in South Asian children: prevalence and determinants
    Tazeen H Jafar
    Section of Nephrology, Department of Medicine, Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    Pediatr Nephrol 20:1458-65. 2005
    ..Further studies are needed to determine factors in early life that may differentially predispose certain ethnic groups to proteinuria...